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Outcomes of nonresected main-duct intraductal papillary mucinous neoplasms of the pancreas

World Journal of Gastroenterology 2015年第9期21卷 2658-2667页

作者： Mathieu Daudé Fabrice Muscari Camille Buscail Nicolas carrère Philippe Otal Janick Selves Louis Buscail Barbara Bournet Department of Gastroenterology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance Department of Digestive Surgery CHU Toulouse Rangueil and PurpanUniversity of Toulouse31059 ToulouseFrance Department of Public Health and Epidemiology CHU Rennes PontchaillouUniversity of Rennes35033 RennesFrance Department of Radiology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance Department of Pathology CHU Toulouse PurpanUniversity of Toulouse31300 ToulouseFrance

AiM:To compare characteristics and outcomes of resected and nonresected main-duct and mixed intraductal papillary mucinous neoplasms of the pancreas(iPMN).METHODS:Over a 14-year period,50 patients who did not undergo surgery for resectable main-duct or mixed iPMN,for reasons of precluding comorbidities,age and/or refusal,were compared with 74 patients who underwent resection to assess differences in rates of survival,recurrence/occurrence of malignancy,and prognostic *** study participants had dilatation of the main pancreatic duct by ≥ 5 mm,with or without dilatation of the branch *** of the nonsurgical patients showed evidence of mucus upon perendoscopic retrograde cholangiopancreatography or endoscopic ultrasound and/or after fine needle *** the surgical patients,pathologic analysis of resected specimens confirmed a diagnosis of iPMN with involvement of the main pancreatic duct or of both branch ducts as well as the main pancreatic *** and biologic follow-ups were conducted for all patients at least annually,through hospitalization or consultation every six months during the first year of follow-up,together with abdominal imaging analysis(magnetic resonance cholangiopancreatography or computed tomography) and,if necessary,endoscopic ultrasound with or without fine needle ***:The overall five-year survival rate of patients who underwent resection was significantly greater than that for the nonsurgical patients(74% vs 58%; P =0.019).The parameters of age(iated with better survival(P in pancreatic duct diameter > 10 mm,branch ductdiameter > 30 mm,or presence of extra pancreatic cancers did not significantly influence the *** the nonsurgical patients,pancreatic malignancy occurred in 36% of cases within a mean time of 33 mo(median:29 mo; range:8-141 mo).Comparison of the nonsurgical patients who experienced disease progression

关键词： Main-duct intraductal papillary mucinous neoplasms

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iNSTALLATiON OF 42 KW SOLAR PHOTOVOLTAiCS AND 50 KW WiND TURBiNE SYSTEMS

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Journal of Green Building 2013年第3期8卷 78-94页

作者： Yudan Xie Byungik Chang Kenneth Starcher David carr Gerald Chen Kenneth Leitch Alternative Energy institute West Texas A&M University University of New Haven School of Engineering and Computer Science West Texas A&M University

iNTRODUCTiON A solar photovoltaic(PV)system and a wind turbine system are to be utilized to reduce energy use from the electrical grid consumption at West Texas A&M University(WTAMU)through the use of renewable ***’s Alternative Energy institute(AEi)performed the installation of the PV/wind turbine systems.A 42 kW PV system located at the Palo Duro Research Facility(PDRF)is suitable to offset the energy use of the PDRF since the energy consumed by the facility is primarily during the daytime,with a peak energy use of approximately 225 *** expected energy match of 42 kW compared to the typical daily energy consumption of the building(75-80 kW)will have a significant impact on grid energy cost for this office and research space.A 50 kW wind turbine.

关键词： SOLAR utilized system

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innovative seismic retrofitting strategy of added stories isolation system

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Frontiers of Structural and Civil Engineering 2013年第1期7卷 13-23页

作者： Min-Ho CHEY J.Geoffrey CHASE John B.MANDER Athol J.carr School of Architecture&Art Yanbian University of Science&TechnologyYanji 133000China Department of Mechanical Engineering University of CanterburyChristchurch 8140New Zealand Zachry Department of Civil Engineering Texas A&M UniversityTexas 77843USA Department of Civil&Natural Resources Engineering University of CanterburyChristchurch 8140New Zealand

The seismic performance of“added stories isolation”(ASi)systems are investigated for 12-story moment resisting *** newly added and isolated upper stories on the top of the existing structure are rolled to act as a large tuned mass damper(TMD)to overcome the limitation of the size of tuned mass,resulting to“12+2”and“12+4”stories building *** isolation layer,as a core design strategy,is optimally designed based on optimal TMD design principle,entailing the insertion of passive flexible laminated rubber bearings to segregate two or four upper stories from a conventionally constructed lower superstructure *** performance metrics are presented for 30 earthquake records from the 3 suites of the SAC *** history analyses are used to compute various response performances and reduction factors across a wide range of seismic hazard *** show that ASi systems can effectively manage seismic response for multi-degree-of freedom(MDOF)systems across a broader range of ground motions without requiring burdensome extra *** results include the identification of differences in the number of added story by which the suggested isolation systems remove energy.

关键词： added stories seismic isolation tuned mass damper parametric optimization statistical method

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多途径丝裂原激活的蛋白激酶介导一氧化氮引起的肝癌细胞凋亡

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肿瘤 2004年第5期24卷 459-463页

作者：任正刚刘银坤 Ziqiu Wang Sid Kar Brian i.carr 复旦大学肝癌研究所复旦大学附属中山医院美国匹兹堡大学肝癌中心Pittsburgh 15213

目的研究非离子型的diazeniumdiolate类一氧化氮供体引起肝癌细胞凋亡的分子机制。方法利用免疫印迹、免疫沉淀、凝胶阻滞实验研究一氧化氮供体处理Hep3B肝癌细胞后,丝裂原激活的蛋白激酶、AP-1的激活以及和Hep3B肝癌细胞凋亡的关系... 详细信息

目的研究非离子型的diazeniumdiolate类一氧化氮供体引起肝癌细胞凋亡的分子机制。方法利用免疫印迹、免疫沉淀、凝胶阻滞实验研究一氧化氮供体处理Hep3B肝癌细胞后,丝裂原激活的蛋白激酶、AP-1的激活以及和Hep3B肝癌细胞凋亡的关系。结果一氧化氮可引起细胞外信号调节蛋白激酶、c-jun N末端激酶和p38激酶的激活,特别是细胞外信号调节的蛋白激酶的持续激活,其中细胞外信号调节的蛋白激酶和c-jun N末端激酶的特异的阻断剂U0126和JNK抑制剂Ⅱ可阻断AP-1的激活和Hep3B细胞的凋亡,而p38激酶的阻断剂SB203580不能阻断AP-1的激活和Hep3B肝癌细胞的凋亡。结论一氧化氮通过激活细胞外信号调节蛋白激酶、c-jun N末端激酶,进而激活AP-1而引起Hep3B肝癌细胞的凋亡。

关键词：肝肿瘤 Hep3B细胞蛋白激酶类丝裂原激活的一氧化氮细胞凋亡

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Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastroenterology 2014年第38期20卷 14018-14032页

作者： Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman carr Faheez Mohamed Alexander H Mirnezami Section of Biosurgery and Surgical Technology Department of Surgery and CancerImperial College London10th Floor QEQM BuildingSt Mary’s Hospital National Pseudomyxoma Peritonei Centre Hampshire Hospitals Foundation Trust Somers Cancer Research Building University of Southampton Cancer Sciences DivisionSouthampton University Hospital NHS Trust

AiM: To systematically review the available evidence regarding cytoreductive surgery (CRS) and intraperitoneal chemotherapy (iPC) for colorectal peritoneal metastases (CPM).

关键词： Colorectal cancer Peritoneal metastasis Cytoreductive surgery intraperitoneal chemotherapy Hyperthermic intraperitoneal chemotherapy

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ELECTRiCAL CONDUCTiViTY OF iODiNE DOPED POLY(PHTHALOCYANiNATOSiLOXANE)/PPTA BLEND FiBERS

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Chinese Journal of Polymer Science 1988年第3期6卷 208-215页

作者：周啸 J.W.Lyding T.J.Marks S.H.carr Department of Chemical Engineering Tsinghua University Beijing Materials Research Center Northwestern University U.S.A.

Poly（phthalocyaninatosiloxane）, [Si（Pc）O]n, with the number average degree of polymerization of about 130 was prepared by heating its monomer Si（Pc）（OH）2, in solid state at 420℃for 42 hrs at 10-3 torr dynamic vacuum. The [Si（Pc）O]n powder was iodine doped with i2-bensene solution for 48 hrs. Pure iodine doped poly（phthalocyaninatosiloxune）, {[Si（Pc）O]iy}n, fibers and {[Si（Pc）O]iy}n/poly（p-pbenylene terephthalamide） blend fibers were wet-spun with dry nltrogen-sealed Teflon lined device. D.C. electrical conductivity of the fibers was measured by the four-probe method with an automated charge transport measurement system from 80K to room temperature. it was found that the dependence of conductivity, σ, on temperature, T, could fit a group of thermal fluctuation-induced tunnelling （TFiT） equations, and that the dependence of conductivity on volume fraction, φ, of the iodine doped {[Si（Pc）O]iy}n could fit a group of modified percolation equations. A thrce-dimensioual composite plot of σ-1 / T-φshows that these two groups of equations match each other quite well. it has been pointed out that for the blend fibers their composition is the most important factor for both mechanical and electrical properties.

关键词： ELECTRiCAL CONDUCTiViTY OF iODiNE DOPED POLY PHTHALOCYANiNATOSiLOXANE PPTA BLEND FiBERS

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ion quasi-periodic mixing generated by rolled-up KH vortex in dayside LLBL during southward iMF

Ion quasi-periodic mixing generated by rolled-up KH vortex i...

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第十二届全国日地空间物理学术讨论会

作者： H．Rème i．Dandouras C．M．carr Centre d’Etude Spatiale des Rayonnements BP 434631028 Toulouse cedex 4France The Blackett Laboratory Imperial CollegeLondon SW7 2BZUK

＜正＞During the interval 06:16-07:30 UT on 24 August 2005,a persistent high-speed solar wind with southward iMF swept across the Earth’s magnetopause,and meanwhile TC-1 detected the quasi-periodic mixing of ions ass...

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A compressed and oscillating magnetotail observed by TC1 during the enhancement and fluctuation of solar wind dynamic pressure

A compressed and oscillating magnetotail observed by TC1 dur...

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第十四届全国日地空间物理学术研讨会

作者： i.Dandouras H.Rème C.M.carr Centre d’Etude Spatiale des Rayonnements BP4346 31028 Toulouse cedex 4 France The Blackett Laboratory Imperial College London SW7 2BZ UK

During the interval from 0615-0730UT on 24 August 2005, the near-Earth magnetotail displayed multiple responses to the combined changes in solar wind dynamic pressure and interplanetary magnetic field (iMF). The magnetotail was highly compressed by a strong interplanetary shock due to the dynamic pressure enhancement (5nPa), and the large shrinkage of magnetotail made a northern lobe/mantle move inward to the position of inbound TC1 satellite that was initially in the plasma sheet. Meanwhile, the dynamic pressure fluctuation behind the shock drove the quasi-periodic oscillations of the magnetopause, lobe-mantle boundary and geomagnetic field at the same frequencies, one dominant frequency is around 3mHz and the other is around 5mHz. The oscillation of the lobe-mantle boundary caused the alternate entries of TC1 into the northern lobe and the plasma mantle. in contrast to a single squeezed/deformed magnetotail by a solar wind discontinuity moving tailward, the compressed and oscillating magnetotail can better indicate the dynamic evolution of magnetotail when solar wind dynamic pressure increases and fluctuates remarkably. Furthermore, it is found that the considerable oxygen ions (O+) appeared in the lobe after the southward turning of iMF.

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A Pilot Study on the New USDA Meal Pattern for School Breakfast in a Sample of First-Grade Students

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Food and Nutrition Sciences 2012年第9期3卷 1329-1333页

作者： Noelle carr Sibylle Kranz Department of Nutrition Science Purdue University West Lafayette Indiana USA

Background: The United States Department of Agriculture (USDA) recently modified the school breakfast program (SBP) to improve children’s nutrition. Based on the new patterns, schools must offer larger amounts of fruits, grains, and proteins/meats to children;the amounts of fluid foods (milk and juice) remained the same. This study examined the effect of the new food pattern on student’s consumption and food cost. Methods: The amounts and cost of foods served and wasted for one week in first grade students attending two elementary schools (n = 812) were measured. One school received the current SBP pattern (control breakfast, average number of students attending breakfast n = 81), the other school’s breakfast reflected the proposed changes (test breakfast, n = 82). To test the hypothesis that the test breakfast leads to significantly increased food cost and food waste compared to the control breakfast, the weekly average amount of the served solid and fluid foods (grams and milliliters) as well as their waste were compared between the two groups using paired student’s t-test in STATA 11 (significance at p-value irmed the hypothesis in that the test breakfast was associated with significantly higher food cost (by approximately $100/week) and solid food waste but there was no change in milk and juice consumption. Conclusions: This exploratory study indicates that a significant portion of the additional foods served to first-graders to improve their nutritional status were not consumed but wasted. Further studies in larger samples and including students from all grades are needed to examine this issue fully.

关键词： School Breakfast Meal Pattern intake Recommendation

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Managing Co-morbidities and Side Effects during Long-term ART

Managing Co-morbidities and Side Effects during Long-term AR...

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中华医学会第五次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议

作者： Andrew carr HiV Immunology and Infectious Diseases Unit Clinical Research ProgramCentre for Applied Medical Research St Vincent's Hospital and University of New South Wales SydneyAustralia

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