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Consort观点：报告随机试验时变更结局的危害

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英国医学杂志中文版 2017年第9期20卷 491-494页

作者： Altman douglas g Moher David Schulz Kenneth F 陈立敏(译者) Centre for Statistics in Medicine and UK EQUATOR Centre Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal SciencesUniversity of Oxford Oxford UK Ottawa Hospital Research Institute and Canadian EQUATOR Centre University of Ottawa Ottawa Canada FHI 360 Durham NC USA University of North Carolina School of Medicine Chapel Hill NC USAAccepted 13 January 2017 中华医学杂志英文版编辑部

严格而透明的临床试验可以增强试验结果的可信度。随机试验必须有一个研究方案，该方案需要给出计划进行的试验细节、概述预计采用的分析方法，并反映研究者间的重要想法。

关键词：医疗卫生行业临床试验医学研究分析方法

Is iron overload in alcohol-related cirrhosis mediated by hepcidin?

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World Journal of gastroenterology 2009年第46期15卷 5864-5866页

作者： Tariq Iqbal Azzam Diab douglas g Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias Department of gastroenterology University Hospital BirminghamVincent Drive Depart ment of Cancer Studies University of BirminghamVincent Drive Department of Hematology University Hospital BirminghamVincent Drive

In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver *** demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum *** ferritin level falls with increasing hepcidin production after *** inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this *** suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future.

关键词： Alcohol Iron Anaemia Hepcidin Cirrhosis

The Superconductivity in Fe-Based Family of Superconductors and Its Electronic Structure Analysis in Presence of Dopants Rh and Pd

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Journal of Quantum Information Science 2022年第4期12卷 111-124页

作者： ronald Columbié-Leyva Alberto López-Vivas[1† ] Ulises Miranda Ilya g. Kaplan Instituto de Investigación en Materiales UNAM CDMX México Baltic Scientific Instruments Riga Latvia

The discovered in 2008 Fe-based superconductors (SC) are a paramagnetic semimetal at ambient temperature and in some cases they become superconductor upon doping. In spite of so many years since its discovery it is still not known the mechanism that leads to superconductivity. The electronic structure study is used for determining key features of the SC mechanism in these materials. The calculations were performed using the modern suite of programs MOLPRO 2021. We performed quantum calculations of a cluster embedded in a background charge distribution that represents the infinite crystal. The Natural Population Analysis was used for determining the charge and spin distribution in the studied materials. As follows from our results, the possible mechanism for superconductivity corresponds to the RVB theory proposed by Anderson for high Tc superconductivity in cuprates.

关键词： Iron-Based High-Tc Superconductors Superconductivity Embeded Cluster Method Natural Bonding Orbitals Analysis

Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features

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World Journal of gastrointestinal Endoscopy 2010年第1期2卷 15-19页

作者： Jill C Moore Joel S Bentz Kristen Hilden douglas g Adler Division of gastroenterology and Hepatology Department of Internal MedicineUniversity of Utah School of MedicineSalt Lake CityUT 84132United States Department of Pathology University of Utah School of MedicineSalt Lake CityUT 84132United States

giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed *** tumors have distinctive endoscopic,clinical,and cytological *** cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal *** true origin of these lesions remains unclear at this *** are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is *** risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic *** of these differences can significantly affect patient *** lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors.

关键词： Osteoclastic Pleomorphic giant cell tumor Pancreas Endoscopic Pathologic Clinical Feature

Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model

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Burns & Trauma 2013年第2期1卷 87-94页

作者： Zhe-Wei Fei Vernon R. Young Xiao-Ming Lu Andrew B. Rhodes ronald g.Tompkins Alan J. Fischman Yong-Ming Yu Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Laboratory of Human Nutrition Massachusetts Institute of Technology Cambridge MA 02142 USA

Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (gSH) synthesis in severely burned patients. To determine whether WB gSH metabolism is an indicator of the status of gSH metabolism in one or more of the major organs, we used a burn rabbit model to determine gSH concentrations and rates of synthesis in WB, liver, lungs, kidney, and skeletal muscle. L-[1-13C]-cysteine was infused intravenously for 6 h in rabbits at 3 days post-burn and in sham burn controls. WB and organ 13C-enrichment of cysteine and gSH was determined by gas chromatography/mass spectrometry. Plasma cysteine metabolic flux was increased significantly (P g burn injury. WB, liver, and lung gSH concentrations (P = 0.054, P gSH synthesis (P gSH transport out of the liver after burn injury. Hence, there is a differential impact of burn injury on tissue and organ gSH status, with WB qualitatively reflecting the changes in lung and liver. It will be important to determine whether these changes are due to alterations in the intrinsic capacity for gSH synthesis and/or availability of amino acid precursors of gSH.

关键词： Burn injury glutathione glutathione concentration synthesis rate whole blood

Basic Statistics for Business & Economics (Business Statistics) 5th

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Statistical techniques in business & economics / douglas A. Lind, William g. Marchal, Samuel A. Wathen. 12th ed.

丛书名： Business Statistics

2006年

作者： douglas A. Lind William g. Marchal Samuel A. Wathen

ISBN: (纸本)0071244611;9780071244619

A practical, step-by-step introduction to the design of pricing engines with VBA This book teaches students and practitioners the numerics and design of a powerful pricing tool in VBA. It leads the reader through the basics of VBA, from simple procedural code to the advanced design of systems and object-style applications. It also covers Monte Carlo and lattice methods and their implementation in

关键词： Social sciencesStatistical methods.EconomicsStatistical methods.Industrial managementStatistical methods.Commercial statistics.

来源：畅想之星图书光盘版（南... 评论

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Breast cancer resistance protein(BCRP/ABCg2):its role in multidrug resistance and regulation of its gene expression

丛书名： Mcgraw-Hill/Irwin series. Operations and decision sciences.

2005年

作者： douglas A. Lind William g. Marchal Samuel A. Wathen.

Student CD-ROM includes tutorials, quizzes, solved problems, data sets, and data files.

ISBN: (数字)0072868244

ISBN: (纸本)0072868252

Student CD-ROM includes tutorials, quizzes, solved problems, data sets, and data files.

关键词： Social sciences

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Chinese Journal of Cancer 2012年第2期31卷 73-99页

作者： Takeo Nakanishi douglas D.Ross Department of Membrane Transport and Biopharmaceutics Kanazawa University School of Pharmaceutical SciencesKanazawa 920-1192Japan University of Maryland greenebaum Cancer Center the Departments of Medicine Pathology and Pharmacology and Experimental TherapeuticsUniversity of Maryland School of Medicineand the Baltimore VA Medical CenterBaltimoreMaryland 21201USA

Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily g member 2(ABCg2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer *** physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis *** recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical ***,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer *** BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor ***,blocking BCRP-mediated active efflux may provide a therapeutic benefit for *** the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated *** evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated ***,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer ***,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of *** biological events seem involved in a complicated *** the events would be an essential first step to developing a method to modulate BCRP function to aid patients with *** review will present a sy

关键词：多重耐药性基因表达调控组蛋白修饰乳腺癌过氧化物酶体增殖物激活受体分子机制多药耐药肿瘤细胞

The maximum likelihood identification method applied to insect morphometric data

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Zoological Systematics 2017年第1期42卷 46-58页

作者： Jean-Pierre Dujardin Sebastien Dujardin Dramane Kaba Soledad Santillan-guayasamin Anita g.Villacis Sitha Piyaselakul Suchacla Sumruayphol Yudthana Samung ronald Morales Vargas IRD UMR 177 IRD-CIRAD INTERTRYP Campus international de Baillarguet Montpellier France Ecole des Technologies Numdriques Appliquees Paris France Institut Pierre Riehet Institut National de Sante Publique Abidjan Cote d'Ivoire Center for Research on Health in Latin America School of Biological Sciences Pontifical Catholic University of Ecuador Quito Ecuador Av. 12 de Oetubre 1076y Roca Department of Anatomy Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 10700 Thailand Department of Medical Entomology Faculty of Tropical Medicine Mahidol University Bangkok 10400 Thailand

To distinguish species or populations using morphometric data is generally processed through multivariate analyses, in particular the discriminant analysis. We explored another approach based on the maximum likelihood method. Simple statistics based on the assumption of normal distribution at a single variable allows to compute the chance of observing a particular data （or sample） in a given reference group. When data are described by more than one variable, the maximum likelihood （MLi） approach allows to combine these chances to find the best fit for the data. Such approach assumes independence between variables. The assumptions of normal distribution of variables and independence between them are frequently not met in morphometrics, but improvements may be obtained after some mathematical transformations. Provided there is strict anatomical correspondence of variables between unknown and reference data, the MLi classification produces consistent classification. We explored this approach using various input data, and compared validated classification scores with the ones obtained after the Mahalanobis distance-based classification. The simplicity of the method, its fast computation, performance and versatility, make it an interesting complement to other classification techniques.

关键词： Medical entomology morphometrics classification probability Mahalanobisdistance.