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Elective operation after acute complicated diverticulitis:Is it still mandatory?

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World Journal of Gastroenterology 2014年第25期20卷 8166-8172页

作者： valérie Bridoux Marlène Antor Lilian Schwarz Julien Cahais Haitham Khalil Francis Michot Jean-Jacques Tuech Department of Digestive Surgery Rouen University Hospital

AIM: To investigate recurrence rates, patterns and complications after nonoperatively managed complicated diverticulitis (CD).

关键词： Diverticulosis Diverticular abscess Hinchey classification Percutaneous drainage Recurrent diverticulitis

Existence of Periodic Solutions for an Output Hidden Feedback Elman Neural Network

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Journal of Software Engineering and Applications 2020年第12期13卷 348-363页

作者： valéry Covachev Zlatinka Covacheva Institute of Mathematics and Informatics Bulgarian Academy of Sciences Sofia Bulgaria

We first recall the sufficient conditions for the existence of a periodic output of a modified Elman neural network with a periodic input found by using Mawhin’s continuation theorem of coincidence degree theory. Using this result, we obtain sufficient conditions for the existence of a periodic output for an output hidden feedback Elman neural network with a periodic input. Examples illustrating these sufficient conditions are given.

关键词： Elman Neural Network Periodic Input and Output Mawhin’s Continuation Theorem

Comparison of gastrointestinal parasite communities in vervet monkeys

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Integrative Zoology 2017年第6期12卷 512-520页

作者： Kim valENTA Dennis TWINOMUGISHA Kathleen GODFREY Cynthia LIU valérie A.M.SCHOOF Tony L.GOLDBERG Colin A.CHAPMAN McGill School of Environment McGill UniversityMontrealQuebecCanada Makerere University Biological Field Station KampalaUganda Bilingual Biology Program Department of Multidisciplinary StudiesGlendon CampusYork UniversityTorontoOntarioCanada Department of Pathobiological Sciences School of Veterinary MedicineUniversity of Wisconsin-MadisonMadisonWisconsinUSA Wildlife Conservation Society BronxNew YorkUSA

Globally,habitat degradation is accelerating,especially in the *** to interface habitats can increase environmental overlap among nonhuman primates,people,and domestic animals and change stress levels in wildlife,leading to changes in their risk of parasite ***,the direction and consequences of these changes are unclear,since animals may benefit by exploiting human resources(e.g.,improving nutritional health by eating nutritious crops)and decreasing susceptibility to infection,or interactions with humans may lead to chronic stress and increased susceptibility to *** monkeys are an excellent model to understand parasitic disease transmission because of their tolerance to anthropogenic *** we quantify the gastrointestinal parasites of a group of vervet monkeys(Chlorocebus aethiops)near Lake Nabugabo,Uganda,that frequently overlaps with people in their use of a highly modified *** compare the parasites found in this population to seven other sites where vervet monkey gastrointestinal parasites have been identi*** vervets of Lake Nabugabo have the greatest richness of parasites documented to *** discuss how this may reflect differences in sampling intensity or differences in the types of habitat where vervet parasites have been sampled.

关键词： anthropogenic disturbance disease gastrointestinal parasite habitat degradation Nabugabo vervet zoonotic disease

Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation

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Cellular & Molecular Immunology 2018年第4期15卷 367-376页

作者： Stéphanie Bussières-Marmen valérie Vinette Jeremy Gungabeesoon Isabelle Aubry Luis Alberto Pérez-Quintero Michel L Tremblay Department of Biochemistry McGill UniversityMontréalQuébecCanada Rosalind and Morris Goodman Cancer Research Centre MontréalQuébecCanada Department of Microbiology and Immunology McGill UniversityMontréalQuébecCanada

T-cell protein tyrosine phosphatase(TC-PTP)has a critical role in the development of the immune system and has been identified as a negative regulator of ***-nucleotide polymorphisms in the TC-PTP locus have been associated with increased susceptibility to inflammatory bowel diseases(IBDs)in *** further understand how TC-PTP is related to IBDs,we investigated the role of TC-PTP in maintaining the intestinal epithelial barrier using an in vivo genetic *** epithelial cell(IEC)-specific deletion of TC-PTP was achieved in a mouse model at steady state and in the context of dextran sulphate sodium(DSS)-induced ***(KO)of TC-PTP in IECs did not result in an altered intestinal ***,upon DSS treatment,IECspecific TC-PTP KO mice displayed a more severe colitis phenotype with a corresponding increase in the immune response and inflammatory cytokine *** absence of TC-PTP caused an altered turnover of IECs,which is further explained by the role of the tyrosine phosphatase in colonic stem cell(CoSC)*** results suggest a novel role for TC-PTP in regulating the homeostasis of CoSC *** supports the protective function of TC-PTP against IBDs,independently of its previously demonstrated role in intestinal immunity.

关键词： Colonic stem cells DSS-induced colitis intestinal epithelial barrier TC-PTP

Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders

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World Journal of Gastroenterology 2017年第11期23卷 2029-2036页

作者： Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre valérie Bridoux Eric Vérin Anne-Marie Leroi INSERM U1073 Service de Physiologie DigestiveCHU Rouen INSERM U1073 Service de Chirurgie DigestiveCHU Rouen EA 3830 Pole 3RCHU RouenGroupe de Recherche sur le Handicap Ventilatoire INSERM CIC 0204

AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for *** The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of *** Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI.

关键词： Neurogenic bowel dysfunction Fecal incontinence Constipation Obstructed defecation Transanal irrigation

Assessment of the Anaerobic Speed Reserve during Specific High-Intensity Exercise in Judo Athletes

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Journal of Science in Sport and Exercise 2022年第3期4卷 266-274页

作者： Emerson Franchini Rafael Lima Kons valéria Leme Gonçalves Panissa Daniele Detanico Martial Arts and Combat Sports Research Group School of Physical Education and SportUniversity of São PauloSão PauloBrazil Biomechanics Laboratory Center of SportsFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil

Purpose This study aimed to describe self-selected intensity and its relationship to performance during a high-intensity all-out judo protocol,and to verify whether athletes with different anaerobic speed reserve(ASR)perform differently during a high-intensity all-out interval uchi-komi(judo-specific skill).Methods We analyzed the performance of 28 judo athletes as a whole group and divided into groups,according to their *** performed several judo-specific protocols using a specific skill:maximal speed sprint(MSS)and maximal aerobic speed(MAS),and high-intensity intermittent uchi-komi protocol(12×20 s all-out:10 s passive recovery).Results The main results demonstrated a decrease in the number of repetitions and an increase in heart rate across the *** with greater ASR performed a higher number of repetitions,compared to the low ASR group,and they were able to exercise at a higher percentage of the MAS(low ASR=126%;SD=13%;high ASR=152%,SD=l9%)and at a lower percentage of MSS compared to the low ASR group(low ASR=84%,SD=7%;high ASR=76%,SD=11%).However,both groups exercised at a similar percentage of their own ASR during the protocol(low ASR=50%,SD=20%;high ASR=53%,SD=19%).Conclusions Athletes with different ASR seem to set their pace at around 50%of their ASR within an all-out uchi-komi ***,the ASR is useful for predicting performance during high-intensity judo-specific interval exercise intervals.

关键词： Combat sports Rating of perceived exertion Pace All-out exercise

Gα_(i/o)偶联受体介导的腺苷酸环化酶“超敏化”研究进展

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药学学报 2016年第9期51卷 1349-1355页

作者：徐如强 val J.Watts 郑州大学生命科学学院河南郑州450001 Department of Medicinal Chemistry and Molecular Pharmacology College of PharmacyPurdue University

大多数Gα_(i/o)偶联受体(Gαi/o-coupled receptors)在持续激活条件下能够导致细胞内腺苷酸环化酶(adenylyl cyclase,AC)活性增强和随后的环腺苷酸(cyclic adenosine monophosphate,c AMP)浓度增加,通常将这种现象称作AC"超敏化(supersensitization)"。它是一种细胞适应性反应机制,普遍认为是造成药物依赖性的原因。AC"超敏化"可能在精神病和抑郁症等许多由于细胞功能的改变而引起的中枢神经系统紊乱疾病(CNS disorder diseases)中发挥重要影响。本文对Gα_(i/o)偶联受体介导AC"超敏化"的研究历史与现状进行了综述,并讨论了存在的问题与未来展望。

关键词： G蛋白偶联受体腺苷酸环化酶环腺苷酸敏感化信号转导药物依赖性中枢神经系统紊乱

Evaluation of Spectral Scale Effects in Estimation of Vegetation Leaf Area Index Using Spectral Indices Methods

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Chinese Geographical Science 2016年第6期26卷 731-744页

作者： du Huishi JIANG Hailing ZHANG Lifu MAO Dehua WANG Zongming Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China College of Tourism and Geographical Science Jilin Normal UniversitySiping 136000China Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijing 100101China

Spectral index methodology has been widely used in Leaf Area Index(LAI) retrieval at different spatial scales. There are differences in the spectral response of different remote sensors and thus spectral scale effect generated during the use of spectral indices to retrieve LAI. In this study, PROSPECT, leaf optical properties model and Scattering by Arbitrarily Inclined Layers(SAIL) model, were used to simulate canopy spectral reflectance with a bandwidth of 5 nm and a Gaussian spectral response function was employed to simulate the spectral data at six bandwidths ranging from 10 to 35 nm. Additionally, for bandwidths from 5 to 35 nm, the correlation between the spectral index and LAI, and the sensitivities of the spectral index to changes in LAI and bandwidth were analyzed. Finally, the reflectance data at six bandwidths ranging from 40 to 65 nm were used to verify the spectral scale effect generated during the use of the spectral index to retrieve LAI. Results indicate that Vegetation Index of the Universal Pattern Decomposition(VIUPD) had the highest accuracy during LAI retrieval. Followed by Normalized Difference Vegetation Index(NDVI), Modified Simple Ratio Indices(MSRI) and Triangle Vegetation Index(TVI), although the coefficient of determination R^2 was higher than 0.96, the retrieved LAI values were less than the actual value and thus lacked validity. Other spectral indices were significantly affected by the spectral scale effect with poor retrieval results. In this study, VIUPD, which exhibited a relatively good correlation and sensitivity to LAI, was less affected by the spectral scale effect and had a relatively good retrieval capability. This conclusion supports a purported feature independent of the sensor of this model and also confirms the great potential of VIUPD for retrieval of physicochemical parameters of vegetation using multi-source remote sensing data.

关键词： spectral index vegetation leaf area index radiative transfer model spectral response scale effect

Benefits of heterospecific aggregation on necromass: in fluence of temperature, group density, and compositi on on fitness-related traits

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Insect Science 2021年第1期28卷 144-152页

作者： Larissa Komo valery Hedouin Damien Charabidze CHU Lille EA 7367—UTML—Unite de Taphonomie Medico-LegaleUniversity of Lille59000 LilleFrance

Necrophagous blowflies(Diptera:Calliphoridae)such as Calliphora vicina,a cold-tolerant species,and L ucilia serie ata,a warm-adapted species,are pioneer carrion・*** these two species have different temperature preferences,larvae aggregate actively and often feed simultaneously on *** hypothesis to be tested was that *** benefits from the association with *** at lower temperatures(i.e.,15℃)and that *** derives greater benefits from this association at higher temperatures(i.e.,28℃).Therefore,both species were raised at these two constant temperatures from first instars to adults under three different conditions:monospecific low-density,monospecific high-density,and heterospecific *** time until larval migration,surface area of puparia,and survival rates were determined for each *** between these fitness-related traits were found between species,temperatures,group densities,and species *** 28°C,*** larvae bred in heterospecific groups migrated significantly earlier and in higher numbers than that under same density conspecific con・ditions,with a lower mortality *** 15°C,both species benefited from high-density heterospecific associations,expressed by faster development and larger *** conclusion,necrophagous larvae benefited from heterospecific aggregations at suboptima 1 temperatures by adapting their migration time to that of the faster *** temperature changes throughout the day and over the year,the beneficiary of such a collective association also *** costs involved and deviations to the temperature-size rule highlight the complexity of the carrion ecosystem.

关键词： carrion ecology development rhythm flies forensic entomology lifehistory traits mutualism