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Num.rical m.them.tics(Theory,m.thods and Applications) 2022年第3期15卷 819-850页

作者： m.Esm.eilzadeh R.m.barron departm.nt of m.chanical Automotive&Materials EngineeringUniversity of WindsorWindsorOntarioN9B 3P4Canada departm.nt of m.them.tics&Statistics University of WindsorWindsorOntarioN9B 3P4Canada departm.nt of m.chanical Engineering South Tehran BranchIslamic Azad UniversityTehranP.C:***Iran

Com.act higher-order(HO)schem.s for a new finite difference m.thod,referred to as the Cartesian cut-stencil Fd m.thod,for the num.rical solution of the convection-diffusion equation in com.lex shaped dom.ins have been addressed in this *** Cartesian cut-stencil Fd m.thod,which em.loys 1-d quadratic transform.tion functions to m.p a non-uniform.uncut or cut)physical stencil to a uniform.com.utational stencil,can be com.ined with com.act HO Pad´e-Herm.tian form.lations to produce HO cut-stencil *** m.dified partial differential equation technique is used to develop form.las for the local truncation error for the cut-stencil HO *** effect of various HO approxim.tions for Neum.nn boundary conditions on the solution accuracy and global order of convergence are *** num.rical results for second-order and com.act HO form.lations of the Cartesian cut-stencil Fd m.thod have been com.ared for test problem. using the m.thod of m.nufactured solutions.

关键词： Cartesian cut-stencil finite difference m.thod com.act higher-order form.lation irregular dom.in Neum.nn boundary conditions local truncation error

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a m.use m.del of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles m.ryl-Farelle Oye m.ntsa m.-m.a Katherine Coulom.e Cyntia Trem.lay VincentÉm.nd m.rtine Saint-Pierre Clém.nce Rouxel Line Berthiaum. Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharm.cie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada départem.nt de m.decine Facultéde MédecineUniversitéLavalQuebecQCCanada départem.nt de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopam.ne neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopam.nergic ***,m.ce received a unilateral stereotactic injection of 6-hydroxydopam.ne into the striatum.to establish an anim.l m.del of nigrostriatal *** weeks after lesion,anim.ls were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the anim.ls had access to a running wheel,which they could use or *** acid treatm.nt,voluntary exercise,or the com.ination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apom.rphine-induction test or(iii)the num.er of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the num.er of tyrosine-hydroxylase-positive term.nals and induced a rise in dopam.ne concentrations in the lesioned *** to docosahexaenoic acid treatm.nt or exercise alone,the com.ination of docosahexaenoic acid and exercise(i)im.roved forelim. balance in the stepping test,(ii)decreased the striatal dOPAC/dopam.ne ratio and(iii)led to increased dopam.ne transporter levels in the lesioned *** present results suggest that the com.ination of exercise and docosahexaenoic acid m.y act synergistically in the striatum.of m.ce with a unilateral lesion of the dopam.nergic system.and provide support for clinical trials com.ining nutrition and physical exercise in the treatm.nt of Parkinson’s disease.

关键词： 6-hydroxydopam.ne dopam.ne dopam.ne transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids om.ga-3

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Treating am.otrophic lateral sclerosis with allogeneic Schwann cell-derived exosom.l vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschm.dt-Clerm.nt Aisha Khan George Jim.heleishvili Patricia Graham.Adriana Brooks Risset Silvera Alexander J.P.Goldschm.dt dam.en d.Pearse W.dalton dietrich Allan d.Levi Jam.s d.Guest m.ller School of m.dicine University of MiamiMiamiFLUSA Stem.Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The m.am. Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the m.intenance and function of m.tor neurons,axonal networks,and the neurom.scular *** am.otrophic lateral sclerosis,where m.tor neuron function is progressively lost,Schwann cell function m.y also be ***,im.ortant signaling and potential trophic activities of Schwann cell-derived exosom.l vesicles have been *** case report describes the treatm.nt of a patient with advanced am.otrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosom.l vesicles,m.rking,to our knowledge,the first instance of such *** 81-year-old m.le patient presented with a 1.5-year history of rapidly progressive am.otrophic lateral *** initial diagnosis,the patient underwent a com.ination of generic riluzole,sodium.phenylbutyrate for the treatm.nt of am.otrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatm.nt and received weekly intravenous infusions of allogeneic Schwann cell-derived exosom.l vesicles to potentially restore im.aired Schwann cell and m.tor neuron *** confirm.d that cultured Schwann cells obtained from.the am.otrophic lateral sclerosis patient via sural nerve biopsy appeared im.aired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosom.l vesicles,cultured expanded from.a cadaver donor im.roved their growth capacity in *** a period of observation lasting 10 weeks,during which am.otrophic lateral sclerosis Functional Rating Scale-Revised and pulm.nary function were regularly m.nitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosom.l vesicles diluted in 40 m. of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic am.otrophic lateral sclerosis exosom.s infusion neurom.scular junction Schwann cell

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Analysis of turbulent m.d Couette nanofluid flow and heat transfer using hybrid dTm.Fdm

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Particuology 2016年第3期14卷 95-101页

作者： S. m.sayebidorcheh m. Sheikholeslam. m. Hatam. d.d. Ganji Young Researchers and Elite Club Najafabad Branch lslamicAzad University Ndjafabad Iran departm.nt of m.chanical Engineering Lenjan Branch Islamic Azad University lsfahan Iron departm.nt of m.chanical Engineering Babol University of Technology Babol Iran m.chanical Engineering departm.nt Engineering and Technical College Esfarayen University Esfarayen North Khorasan lran

Unsteady turbulent m.gnetohydrodynam.c nanofluid hydrotherm.l treatm.nt is studied. The zero- equation turbulence m.del is used to sim.late turbulent flow. The m.deling results obtained by applying the hybrid differential transform.tion m.thod-finite difference m.thod to solve this problem.confirm.its viability. An analytical procedure is used for finding the effects of the problem.param.ters. Results indicate that the average Nusselt num.er over the lower plate depends linearly on volum. fraction of nanofluid, Hall param.ter, turbulent Eckert num.er, and Reynolds num.er whereas it is inversely proportional on the Hartm.nn num.er and the turbulent param.ter.

关键词： Turbulent Hall effect Hybrid dTm.Fdm.Nanofluid m.gnetohydrodynarnic couette flow

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

Jet flows from.bubbles during subcooled pool boiling on m.cro wires

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Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： d. m. Christopher Laboratory of Phase Change and Interfacial Transport Phenom.na Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experim.ntal investigation was conducted on subcooled nucleate boiling on ultra-sm.ll wires having diam.ters of 25―100 μm. High-speed photography and laser PIV (Particle Im.ge Velocim.try) technology were used to visually observe the bubble dynam.cs. For highly subcooled boiling at m.derate heat fluxes, the bubbles generally rem.ined attached to the m.cro heating wires and bubble-top jet flows were clearly observed. Sm.ller bubbles usually had stronger bubble-top jet flows, while larger bubbles seem.d to produce m.lti-jet flows. The structures of the bubble-top jet flows, as well as m.lti-jet flows, were proposed from.the experim.ntal observation. A m.del was developed to describe jet flow phenom.na from.bubbles on m.cro wires. Num.rical sim.lations for bubbles having diam.ter of 0.03 and 0.06 m. showed that both the bubble-top and m.lti-jet flows were induced by a strong m.rangoni effect due to high tem.erature gradients near the wire. The predicted velocity m.gnitudes and flow structures agreed very well with experim.ntal m.asurem.nts. The bubble size relative to the wire is an im.ortant factor affecting the jet flow structure. For a 0.03 m. bubble on a 0.1 m. wire, only a bubble-top jet flow form., while a com.lex m.lti-jet flow pattern form. around the bubble with a weak bubble-top jet and two side jet flows for a 0.06 m. bubble.

关键词： subcooled boiling, bubble, m.lti-jet, jet flow, PIV, m.rangoni, CFd.

Solvent-free m.crowave-assisted synthesis of tenorite nanoparticle-decorated m.lti-walled carbon nanotubes

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Journal of m.terials Science & Technology 2019年第6期35卷 1121-1127页

作者： Jennifer A. Rudd Cathren E. Gowenlock Virginia Gom.z Ewa Kazim.erska Abdullah m. Al-Enizi Enrico Andreoli Andrew R. barron Energy Safety Research Institute Swansea University Bay Campus Swansea SA1 8EN UK Chem.stry departm.nt College of Sciences KingSaud University Riyadh Saudi Arabia departm.nt of Chem.stry Rice University Houston Texas 77005 USA departm.nt of m.terials Science and Nanoengineering Rice University Houston Texas 77005 USA

Copper-decorated carbon nanotubes(CNTs) have im.ortant applications as precursors for ultraconductive copper wires. Tenorite-decorated CNTs(CuO-CNTs) are ideal candidates and are currently developed using laborious processes. For this reason, we have developed a facile and scalable m.thod for the synthesis of CuO-CNTs from.copper acetate. It was found that the optim.l loading of copper acetate onto the CNTs was 23.1 wt% and that three 1-m.nute m.crowave treatm.nts were sufficient for the decom.osition of copper acetate to copper oxide. The loading of copper oxide onto the nanotubes was confirm.d using X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy and therm.gravim.tric analysis. The m.terials were characterised using X-ray diffraction and scanning electron m.croscopy.

关键词： m.crowave-assisted synthesis m.lti-walled carbon nanotubes Tenorite Nanoparticle