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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue han Yan Su Yiming Zhou Minhui Xu Jiyan Xu zhengliang Ma Xiaoping gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron.transfer(SET) mechanism.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Fron.ier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Determination of rill erodibility and critical shear stress of saturated purple soil slopes

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International Soil and Water Conservation Research 2022年第1期10卷 38-45页

作者： Dandan Li Xiaoyan Chen zhen han Xiaojie gu Yanhai Li College of Resources and Environ.ent/Key Laboratory of Eco-environ.ent in Three Gorges Region(Ministry of Education) Southwest UniversityChongqing400716China College of Forest.guizhou University GuiyangGuizhou Province550000China

The hydrological conditions near the soil surface influence the soil erosion process,as determined by the soil erodibility and critical shear *** soil erodibility and critical shear stress of saturated purple soil slopes were computed and compared with those of unsaturated purple soil *** detachment capacities computed through the numerical method(NM),modified numerical method(MNM)and analytical method(AM),from rill erosion experiments on saturated purple soil slopes at different flow rates(2,4,and 8 L min-1)and slope gradients(5,10,15,and 20°),were used to comparatively compute the soil erodibility and critical shear *** computed soil erodibilities and critical shear stresses were also compared with those of unsaturated purple soil *** the different slope gradients ranging from 5°to 20°,there were no significant differences in the soil erodibilities of the saturated purple soil and also in those of the unsaturated purple *** critical shear stresses slightly varied with the slope *** saturated purple soil was relatively significantly more susceptible to *** NM overestimated the soil erodibility of both saturated and unsaturated soils by 31%and underestimated the critical shear *** MNM yielded the same soil erodibility and critical shear stress values as the *** results of this study supply parameters for modeling rill erosion of saturated purple soil slope.

关键词： Critical shear stress Erodibility Detachment capacity Rill erosion Saturated purple soil

Promising natural lysine specific demethylase 1 inhibitors for cancer treatment:advances and outlooks

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Chinese Journal of Natural Medicines 2022年第4期20卷 241-257页

作者： LI Zhong-Rui gu Meng-zhen XU Xiao ZhanG Jing-han ZhanG Hai-Li han Chao Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Lysine specific demethylase 1(LSD1),a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9,has become a potential therapeutic target for cancer ***1 mediates many cellular signaling pathways and regulates cancer cell proliferation,invasion,migration,and *** research has focused on the exploration of its pharmacological *** products are a major source of compounds with abundant scaffold diversity and structural complexity,which have made a major contribution to drug discovery,particularly anticancer *** this review,we briefly highlight recent advances in natural LSD1 inhibitors over the past *** present a comprehensive review on their discovery and identification process,natural plant sources,chemical structures,anticancer effects,and structure-activity relationships,and finally provide our perspective on the development of novel natural LSD1 inhibitors for cancer therapy.

关键词： Histone lysine demethylase LSD1 inhibitor Natural product Anticancer

Janus(BNNS/ANF)-(AgNWs/ANF)thermal conductivity composite films with superior electromagnetic interference shielding and Joule heating performances

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Nano Research 2022年第5期15卷 4747-4755页

作者： Yixin han Kunpeng Ruan Junwei gu Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Highly thermal conductivity materials with excellent electromagnetic interference shielding and Joule heating performances are ideal for thermal management in the next generation of communication industry,artificial intelligence and wearable *** this work,silver nanowires(AgNWs)are prepared using silver nitrate as the silver source and ethylene glycol as the solvent and reducing agent,and boron.nitride(BN)is performed to prepare BN nanosheets(BNNS)with the help of isopropyl alcohol and ultrasonication-assisted peeling method,which are compounded with aramid nanofibers(ANF)prepared by chemical dissociation,respectively,and the(BNNS/ANF)-(AgNWs/ANF)thermal conductivity and electromagnetic interference shielding composite films with Janus structures are prepared by the"vacuum-assisted filtration and hot-pressing"***(BNNS/ANF)-(AgNWs/ANF)composite films exhibit"one side insulating,one side conducting"performance,the surface resistivity of the BNNS/ANF surface is 4.7×10^(13) Ω,while the conductivity of the AgNWs/ANF surface is 5,275 S/*** Janus(BNNS/ANF)-(AgNWs/ANF)composite film with thickness of 95 pm has a high in-plane thermal conductivity coefficient of 8.12 W/(m·K)and superior electromagnetic interference shielding effectiveness of 70 *** obtained composite film also has excellent tensile strength of 122.9 MPa and tensile modulus and 2.7 *** also has good temperature-voltage response characteristics(high Joule heating temperature at low supply voltage(5 V,215.0℃),fast response time(10 s)),excellent electrical stability and reliability(stable and constant real-time relative resistance under up to 300 cycles and 1,500 s of tensile-bending fatigue work tests).

关键词： thermal conductivity composite film Janus structure aramid nanofibers electromagnetic interference shielding performance Joule heating

Design of a 162.5 MHz continuous-wave normal-conducting radiofrequency electron.gun

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Nuclear Science and Techniques 2020年第11期31卷 50-59页

作者： Cheng Wang Zi-han Zhu Zeng-Gong Jiang Qi-Sheng Tang zhen-Tang Zhao Qiang gu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

A high-gradient radiofrequency(RF)gun operated in continuous-wave(CW)mode is required in various accelerating *** to the high RF power loss,a traditional normal-conducting(NC)RF electron.gun has difficulty meeting the requirement of generating a high-repetition-rate electron.*** development of a scheme for a CW NC-RF gun is urgently *** as a photoinjector of a high-repetition-rate free-electron.laser(FEL),an electron.gun operated in CW mode and the VHF band is *** analysis of the reentrant gun cavity is presented in this paper to increase the gradient and decrease the power density and power *** to the analysis results,the design of a162.5 MHz gun cavity is optimized by a multi-objective evolutionary algorithm to achieve better performance in CW *** and thermal analyses are also deliberated in the design to coordinate with RF and mechanical *** optimized 162.5 MHz gun cavity can be operated in CW mode to generate a high-repetition-rate beam with voltage up to 1 MV and gradient up to 32.75 MV/m at the cathode.

关键词： High-repetition-rate beam Radiofrequency gun Continuous-wave mode Multi-objective evolutionary algorithm

Network Coding-Aware Routing Protocol in Wireless Mesh Networks

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Tsinghua Science and Technology 2015年第1期20卷 40-49页

作者： Yan gu han han Xujie Li Jie guo College of Computer and Information Hohai University

Network coding mechanisms, such as COPE, can improve network throughput effectively in Wireless Mesh Networks（WMN）. While the Hybrid Wireless Mesh Protocol（HWMP） is suitable for WMN, its extension with COPE does not provide any added benefits; specifically, HWMP cannot establish paths with more coding opportunities. As a result, the advantages of network coding cannot be exploited sufficiently. This paper proposes improvements upon HWMP with a new, network Coding-Aware routing protocol（CAHWMP） for WMN. In the CAHWMP protocol, we propose a coding criterion based on data streams to devise an algorithm for actively detecting coding opportunities during path discovery. CAHWMP subsequently establishes paths using the codingaware routing metric, which can balance channel resource consumption and the gain due to sharing resources introduced by network coding. Simulation results show that CAHWMP can establish paths with more coding opportunities; as a result, it improves network performance such as network throughput.

关键词： wireless mesh network network coding-aware Hybrid Wireless Mesh Protocol(HWMP) COPE mechanism coding criterion

Autophagy contributes to kainic acid- induced neuron.l death in rat striatum through mitochondria- mediated apoptotic pathway

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中国药理通讯 2006年第4期23卷 26-27页

作者： Wang Yan han ron.Liang Zhong- Qin Tao Lu -Yang gu zhen - lun Qin zheng - Hong Department of Pharmacology Soochow University School of Medicine Suzhou 215123