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专访传奇国际设计大师ron Arad:创造前所未有的设计

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包装与设计 2024年第2期 4-33页

作者： ron Arad 不详

他是国际设计界的传奇人物,毕业于著名的英国伦敦建筑联盟学院(Architectural Association,简称AA),集产品设计师、家具设计师、建筑设计师、艺术家多重身份于一身.他创作的工作室限量版艺术作品一次又一次地成功转为市场畅销产品,而他... 详细信息

他是国际设计界的传奇人物,毕业于著名的英国伦敦建筑联盟学院(Architectural Association,简称AA),集产品设计师、家具设计师、建筑设计师、艺术家多重身份于一身.他创作的工作室限量版艺术作品一次又一次地成功转为市场畅销产品,而他设计的工业产品又如艺术品,令人大开眼界,吸引了全球各大知名博物馆争相展示和收藏.

关键词：工业产品建筑设计师设计大师限量版家具设计师畅销产品产品设计师多重身份

美国ST Paper的差异化经营:灵活生产,推动绿色能源使用

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生活用纸 2024年第5期24卷 58-59页

作者： ron Thiry ST Paper

随着美国家族企业独立生活用纸生产商ST Paper最新投资项目——PrimeLineTM W 2000于2023年1月在位于美国明尼苏达州Duluth的工厂启动,公司已为进一步扩张做好了准备。Tissue World杂志采访了ST Paper公司的高级副总裁兼首席运营官ron T... 详细信息

随着美国家族企业独立生活用纸生产商ST Paper最新投资项目——PrimeLineTM W 2000于2023年1月在位于美国明尼苏达州Duluth的工厂启动,公司已为进一步扩张做好了准备。Tissue World杂志采访了ST Paper公司的高级副总裁兼首席运营官ron Thiry。

关键词：家族企业差异化经营生活用纸绿色能源首席运营官 ST

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评价标记“你说”和“别说”的用法比较

汉语学习 2024年第2期 10-21页

作者：周莉董涵容吉林大学文学院吉林长春130012 上海师范大学对外汉语学院上海200234

本文主要探讨评价标记“你说”和“别说”的功能差异及成因。研究发现,二者差异主要体现在评价话语的信息结构、后续话语形式和语音停顿等方面,这些差异取决于二者语义功能的不同:一是评价对象不同;二是互动性不同。二者源结构在会话不... 详细信息

本文主要探讨评价标记“你说”和“别说”的功能差异及成因。研究发现,二者差异主要体现在评价话语的信息结构、后续话语形式和语音停顿等方面,这些差异取决于二者语义功能的不同:一是评价对象不同;二是互动性不同。二者源结构在会话不同序列位置的不同用法,即“别说”处于引发序列的语用推理和“你说”处于回应序列的引述回应决定了二者功能的差异。本文最后总结出言者引发评论时使用评价标记“你说/别说”的条件。

关键词：评价标记 “你说” “别说” 互动差异

Pathogenesis and clinical features of severe hepatitis E virus infection

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World Journal of Virology 2024年第2期13卷 19-33页

作者： László Orosz Károly Péter Sárvári Áron Dernovics András Rosztóczy Klára Megyeri Department of Medical Microbiology University of SzegedSzeged 6720Csongrád-CsanádHungary Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Csongrád-CsanádHungary

The hepatitis E virus(HEV),a member of the Hepeviridae family,is a small,non-enveloped icosahedral virus divided into eight distinct genotypes(HEV-1 to HEV-8).Only genotypes 1 to 4 are known to cause diseases in *** 1 and 2 commonly spread via fecal-oral transmission,often through the consum-ption of contaminated *** 3 and 4 are known to infect pigs,deer,and wild boars,often transferring to humans through inadequately cooked *** hepatitis caused by HEV in healthy individuals is mostly asymptomatic or associated with minor symptoms,such as ***,in immunosup-pressed individuals,the disease can progress to chronic hepatitis and even escalate to *** pregnant women,an HEV infection can cause fulminant liver failure,with a potential mortality rate of 25%.Mortality rates also rise amongst cirrhotic patients when they contract an acute HEV infection,which can even trigger acute-on-chronic liver failure if layered onto pre-existing chronic liver *** the prevalence of HEV infection continues to rise worldwide,highlighting the particular risks associated with severe HEV infection is of major medical *** text offers a brief summary of the characteristics of hepatitis developed by patient groups at an elevated risk of severe HEV infection.

关键词： Hepatitis E virus Cirrhosis Acute-on-chronic liver failure Pregnancy Immune dysfunction Open reading frames 1-4

PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分子（英文）

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PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分...

Optical waveguiding along nanometer slits

2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：谭哲琼 Pragney Deme Keerti Boyapati Annet A.M.Duivenvoorden ron M.A.Heeren Caitlin M.Tressler Norman James Haughey Kristine Glunde

Background Triple-negative breast cancer(TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBC that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating *** We sought to identify novel therapeutic targets in TNBC by combining genomic and functional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid profile to critical cancer cell properties. Our studies were performed in a large panel of human breast cancer cell lines and patient *** Comprehensive lipid profiling revealed that phospholipid metabolism is reprogrammed in TNBC cells. We discovered that patatin-like phospholipase domain-containing lipase 8(PNPLA8)is overexpressed in TNBC cell lines and tissues from breast cancer patients. Silencing of PNPLA8disrupted phospholipid metabolic reprogramming in TNBC, particularly affecting the levels of phosphatidylglycerol(PG), phosphatidylcholine(PC), lysophosphatidylcholine(LPC) and glycerophosphocholine(GPC). We showed that PNPLA8 is essential in regulating cell viability,migration and antioxidation in TNBC cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3β and MAPK *** Our study highlights PNPLA8 as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC, which could be further developed as a novel molecular treatment target.

关键词： PNPLA8 Breast cancer Triple negative Phospholipid Metabolism reprogramming Eicosanoids Migration Invasion Proliferation

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Advanced Photonics 2023年第4期5卷 7-8页

作者： Yuen-ron Shen University of California Department of PhysicsBerkeleyCaliforniaUnited States

Optical field confinement is a topic of immense interest in optical sci-ence and *** and confining an optical wave in spatial dimensions not only reduces the size of its footprint,but greatly enhan-ces its field stren... 详细信息

关键词： interaction wave field

基于Copula函数的金沙江流域云龙与松华坝水库入库径流丰枯遭遇分析

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中国农村水利水电 2024年第7期 10-18页

作者：孙治才阿长松孙岩杨荣赞云南省水利水电勘测设计院有限公司云南昆明650021 云南省水利水电勘测设计研究院云南昆明650021 云南大学云南昆明650021

通过Copula函数进行建模,采用P-Ⅲ分布分别对金沙江流域承担昆明市供水的两座重要水库——云龙水库和松华坝水库入库径流在三大时间尺度(全年、汛期、非汛期)上进行边缘分布函数的拟合,对拟合的边缘分布函数进行联合分布函数的构建,并... 详细信息

通过Copula函数进行建模,采用P-Ⅲ分布分别对金沙江流域承担昆明市供水的两座重要水库——云龙水库和松华坝水库入库径流在三大时间尺度(全年、汛期、非汛期)上进行边缘分布函数的拟合,对拟合的边缘分布函数进行联合分布函数的构建,并对联合分布函数采用K-S检验法进行拟合优度检验,采用图形分析计算法、AIC准则和BIC准则对联合分布函数进行拟合优选,最后通过优选出来的Copula函数对两座水库在三大时间尺度上进行丰枯遭遇分析。主要结论如下:两座水库全年与非汛期入库径流最优Copula函数均为Gumbel Copula函数、汛期为Frank Copula函数。三大时间尺度上两座水库的丰平枯同步概率之和(全年0.734,汛期0.541,非汛期0.728)均大于三大时间尺度上两座水库的丰平枯异步概率之和(全年0.266,汛期0.459,非汛期0.272);在所有丰平枯组合中,两座水库的同丰概率在所有丰平枯组合情况中最高(全年同丰0.310,汛期同丰0.232,非汛期同丰0.308),表明两座水库在所有丰平枯组合中同为丰水年的可能性最大;在全年和非汛期时间尺度上两座水库为枯枯的概率(全年同枯0.298,非汛期0.296)相差不大且均大于两座水库在汛期时间尺度上为枯枯的概率(汛期同枯0.232),因此在两座水库进行实际调度的过程中,特别是在枯水年应考虑两座水库的丰枯同步性。该研究结果可在金沙江流域的水库群联合优化调度中提供一定的决策参考依据。

关键词：金沙江流域 Copula函数丰枯遭遇概率分析

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多层螺旋CT在急性肺栓塞中的检出率及影像特征分析

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中国医疗器械信息 2024年第10期30卷 124-126页

作者：周若兰吴义荣云霄县中医院MRCT 福建漳州363300

目的:分析多层螺旋CT在急性肺栓塞诊断中的应用价值,观察多层螺旋CT对急性肺栓塞的检出率及影像学特征。方法:将院内2020年1月~2023年6月接收的疑似急性肺栓塞20例作为本次观察对象,均采取多层螺旋CT,以血管造影检查为金标准,分析多层螺... 详细信息

目的:分析多层螺旋CT在急性肺栓塞诊断中的应用价值,观察多层螺旋CT对急性肺栓塞的检出率及影像学特征。方法:将院内2020年1月~2023年6月接收的疑似急性肺栓塞20例作为本次观察对象,均采取多层螺旋CT,以血管造影检查为金标准,分析多层螺旋CT对疾病的检出率(准确率、灵敏度、特异度、阴性预测值、阳性预测值)及多层螺旋CT影像学特征。结果:以血管造影检查为金标准,检出16例患者为急性肺栓塞,为阳性,其余4例患者为阴性;多层螺旋CT检出真阴性4例,真阳性16例,假阴性0例,假阳性0例;多层螺旋CT与金标准对急性肺栓塞的检出率比较,差异无统计学意义(P>0.05)。结论:急性肺栓塞诊断中多层螺旋CT具有较高的疾病检出率,灵敏度与特异度均相对较高,检出率与金标准差异较小,能够为临床提供更高质量的影像学图片方便临床观察病情特征,为后续诊疗提供参考。

关键词：多层螺旋CT 急性肺栓塞影像学特征

An eighteen‑year longitudinal examination of school victimization and weapon use in California secondary schools

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World Journal of Pediatrics 2023年第11期19卷 1082-1093页

作者： Rami Benbenishty ron Avi Astor Ilan Roziner Hebrew University of Jerusalem JerusalemIsrael and Universidad Andrés BelloSantiagoChile Crump Chair in Social Welfare Luskin School of Public Affairs and School of Education and Information StudiesUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Sackler School of Medicine Department of Communication DisordersTel Aviv UniversityTel AvivIsrael

Background School safety has been a major public health issue in the United States and internationally for more than three *** policies and programs have been developed and implemented to prevent school violence,improve the school climate,and increase *** are only a few peer-reviewed studies of changes in school violence over *** study examined changes over time in school victimization,weapon involvement and school climate,comparing change trajectories by gender and race and different change trajectories among *** A longitudinal study of the biennial California Healthy Kids Survey in secondary schools from 2001 to *** representative sample included 6,219,166 students in grades 7,9,and 11(48.8%male)from 3253 schools(66%high schools).Results All victimization and weapon involvement items had significant and substantial linear *** largest reduction involved being in a physical fight(from 25.4%to 11.0%).There were reductions in weapon involvement(d=0.46)and victimization(d=0.38).Biased-based victimization only declined slightly(d=−0.05).School belongingness and safety increased(d=0.27),adult support increased a small amount(d=0.05),and student participation declined(d=−0.10).Changes were smallest among White ***-five percent of the schools showed the same pattern of *** The findings are in contrast to the public’s concerns that school violence is a growing *** in school violence may result from social investment in school safety.A distinction should be made between school shootings and other forms of school violence.

关键词： School violence School climate Weapons