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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 59-60页

作者： Ishizu T. Osoegawa m. J.-I. Kira 夏峰 Department of Neurology Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashiku Fukuoka 812-8582 Japan Prof.

There are two distinct subtypes of multiple sclerosis in Asians, opticospinal (OS- multiple sclerosis) and conventional (C- multipie sclerosis). In OS- mu ltiple sclerosis, selective and severe involvement of the optic nerves and spina l cord is characteristic, though its mechanisms are unknown. The present study a imed to find out possible differences in the cytokine/chemokine profiles in CSF between OS- multiple sclerosis and C- multiple sclerosis and to delineate the relationships between these profiles and neuroimaging and pathological features. Sixteen cytokines/chemokines, namely interieukin (IL)- 1β , IL- 2, IL- 4, I L- 5, IL- 6, IL- 7, IL- 8, IL- 10, IL- 12 (p70), IL- 13, IL- 17, interfe ron (IFN)- γ , tumour necrosis factor (TNF)- α , granulocyte colony- stimul ating factor (G- CSF), monocyte chenioattractant protein- 1 (mCP- 1) and macr ophage inflammatory protein- 1β (mIP- 1β ), were measured simultaneously in CSF supernatants from 40 patients with relapsing- remitting multiple sclerosis (20 OS- multiple sclerosis and 20 C- multiple sclerosis) at relapse and 19 con trol patients with spinocerebellar degeneration (SCD), together with intracellul ar production of IFN- γ and IL- 4 in CSF CD4+ T cells. In CSF supernatants relative to controls, IL- 17, mIP- 1β ,IL- 1β and IL- 13 were only signi ficantly increased in OS- multiple sclerosis patients, while TNF- α was only significantly increased in C- multiple sclerosis patients, using a cut- off l evel of 1 pg/ml. IL- 8 was significantly elevated in both OS- multiple scleros is and C- multiple sclerosis patients. mCP- 1 was significantly decreased in b oth OS- multiple sclerosis and C- multiple sclerosis patients, while IL- 7 wa s only significantly decreased in C- multiple sclerosis patients. IL- 17, IL- 8 and IL- 5 were significantly higher in OSmultiple sclerosis patients than in C- multiple sclerosis patients. The increases in IL- 17 and IL- 8 in OS mult iple sclerosis were still significant even after excl

关键词：多发性硬化症 IL-17/IL-8 髓鞘粒细胞浸润肿瘤坏死因子趋化因子集落刺激因子免疫调节治疗髓过氧化物酶嗜中性

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从内到外看创新

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科技创业 2014年第3期 51-54页

作者：奥尔登.早司

不创新，就灭亡”，这已经成为很多公司的座右铭。但企业究竟该如何创新？毫无疑问，已经有太多关于这一课题的著述，然而很多高管在面对一系列根本问题时仍不确定该如何操作。例如，当公司倾力发展核心业务时，他们如何让一个前景看好... 详细信息

不创新，就灭亡”，这已经成为很多公司的座右铭。但企业究竟该如何创新？毫无疑问，已经有太多关于这一课题的著述，然而很多高管在面对一系列根本问题时仍不确定该如何操作。例如，当公司倾力发展核心业务时，他们如何让一个前景看好的方案得到必要的资源？为什么那么多绝妙的发明失败了，而另一些似乎平平无奇的创意却获得了成功？这些基本问题正是最近两本新书--杰勒德·泰利斯（Gerard J. Tel is）的《不懈的创新：如何打造一种称雄市场的文化》（Unrelenting Innovation：How to Build a Culture for market Dominance）和罗恩·阿德纳（ron Adner）的《广角镜头：一项创新新战略》（The Wide Lens：A New Strategy for Innovation）--的主题。这两本书相映成趣：前一本着眼于公司的内部工作，而后一本聚焦于公司的外部环境。

关键词：创新 Strategy Build 核心业务广角镜头 Wide Lens 外部环境

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1999年8月河源新丰江m_L4.9级地震

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华南地震 2000年第2期20卷 57-61页

作者：徐起浩缪维成张国荣秦乃岗吴业彪广东省地震局广东广州510070

分析了这次地震的宏观影响场、地质构造及地震序列等特征 ,结果表明 ,这次地震的Ⅵ度极震区为NW走向 ,范围较大但破坏相对较轻 ,震源深度达 10km左右。

关键词：宏观地震烈度调查发震断裂新丰江地震

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治疗颈总动脉狭窄的脑保护措施:我们现在的立场是什么?

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放射学实践 2002年第6期17卷 529-529页

作者： S.müller-hulsbeck 关键华中科技大学同济医学院附属同济医院

颈总动脉分叉处常常是血管领域中一个有争议的主题。这些争议不仅在影像诊断中明显 ,而且在治疗中尤其如此。放置支架作为一项治疗方法 ,其争议还在于行血管成形术时是否不必或必须有脑保护。Th啨ｒｏｎ及其同事首先在颈血管成形和支架... 详细信息

颈总动脉分叉处常常是血管领域中一个有争议的主题。这些争议不仅在影像诊断中明显 ,而且在治疗中尤其如此。放置支架作为一项治疗方法 ,其争议还在于行血管成形术时是否不必或必须有脑保护。Th啨ｒｏｎ及其同事首先在颈血管成形和支架植入术中描述了脑保护的概念。通常有 3种临时的脑保护措施 ,即气囊阻塞、过滤篮及颈内动脉的返流装置。这些措施所提供的相当程度的保护作用 ,在体外和初步临床研究中已经知道 ,甚至在保护的情况下 ,栓塞仍可能发生。此外 ,尚不清楚为防止卒中要阻止的最小栓子是多大 ,以及与脑微血栓有何关系。临床证据表明保护措施应用的优点是有利于介入治疗取得良好的结果 ,但这些措施是否应该常规应用仍是要讨论的问题 ,需进一步临床研究来确定。

关键词：治疗颈总动脉狭窄脑保护

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小麦种质抗麦二叉蚜基因的命名(摘要)

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麦类作物学报 1989年第1期 8-8页

作者： J.m.Tyler 童学军

麦二叉蚜[Schizaphis graminum(ron-dani)]是一种普通小麦(Triticum aesti-vum L.)害虫。1980年前在小麦种质中只记录有两种麦二叉蚜抗源。近五年中,又鉴别出另外的三个抗源,既然现在有五种抗源,那么对

关键词：小麦种质麦二叉蚜二叉蚜属抗源种质库基因摘要

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放射状视神经切开术中大量出血性视网膜脱离

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 45-45页

作者： Takaya K. Suzuki Y. Nakazawa m. 王静波 Department of Ophthalmology Hirosaki University School of Medicine 5 Zaifu-cho Hirosaki 036- 8562 Japan

Background: We encountered obvious arterial bleeding from the incision site during radial optic neurotomy (ron) in a 55- year-old woman with central retinal vein occlusion (CRVO) and report the findings herein. Case report: The patient initially demonstrated a retinal hemorrhage and macular edema due to a left CRVO. Her corrected visual acuity was 0.5 OS. Since her symptoms did not improve and were aggravated, even though she received an oral anticoagulant drug orally, ron was performed 2 months after the onset of symptoms. During surgery, obvious arterial bleeding started from the ron incision site and it was not arrested although the infusion bottle was fully elevated. However, a subsequent infusion of liquid perfluorocarbon successfully stopped the bleeding by direct pressure. Hemorrhagic retinal detachment occurred in the nasal quadrant and postoperative vitreous hemorrhage was treated surgically. The hemorrhagic retinal detachment was gradually absorbed and replaced by fibrous scar tissue. Two years after the surgery, no expansion of retinal detachment has been observed and correctedvisual acuity is being maintained at 0.2 OS. Conclusion: We conclude that ron for CRVO carries a risk of arterial bleeding and that infusion of liquid perfluoro-carbon seems to be effective to arrest arterial bleeding from the ron site.

关键词：视网膜脱离灌注瓶视网膜出血玻璃体积血动脉出血切口位置黄斑水肿矫正视力全氟化碳直接压

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CEPC Technical Design Report

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Radiation Detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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