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Frontiers of Environmental Science & Engineering 2023年第12期17卷 59-69页

作者： Tianyi Chen Lizbeth Taylor-Edmonds Susan Andrews ron Hofmann Department of Civil and mineral Engineering University of TorontoTorontoOntario M5S 1A4Canada

Residual H_(2)O_(2)from UV/H_(2)O_(2)treatment can be quenched by thiosulfate,bisulfite,and chlorine,but the kinetics of these reactions have not been reported under the full range of practical *** this study,the rates of H_(2)O_(2)quenching by these compounds were compared in different water matrices,temperatures,pH,and when using different forms of bisulfite and *** general,it was confirmed that thiosulfate would be too slow to serve as a quenching agent in most practical *** pH 7-8.5,chlorine tends to quench H_(2)O_(2)more than 20 times faster than bisulfite in the various conditions *** important observation was that in lightly-buffered water(e.g.,alkalinity of 20 mg/L as CaCO_(3)),the form of chlorine can have a large impact on quenching rate,with gaseous chlorine slowing the reaction due to its lowering of the pH,and hypochlorite having the opposite *** impacts will become less significant when water buffer capacity(i.e.,alkalinity)increases(e.g.,to 80 mg/L as CaCO_(3)).In addition,water temperature should be considered as the time required to quench H_(2)O_(2)by chlorine at 4℃is up to 3 times longer than at 20℃.

关键词： UV/H_(2)O_(2) H_(2)O_(2) quenching Chlorine type Water alkalinity Temperature

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen m.Labandeira Arturo Fraga-Bau David Arias ron Elena Alvarez-Rodriguez Pablo Vicente-Alba Javier Lago-Garma Ana I.Rodriguez-Perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and molecular Neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

The measurement of proprioceptive accuracy:A systematic literature review

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Journal of Sport and Health Science 2023年第2期12卷 219-225页

作者： Àron Horváth Eszter Ferentzi Kristóf Schwartz Nina Jacobs Pieter meyns Ferenc Köteles Doctoral School of Psychology ELTE Eötvös Loránd UniversityKazinczy street 23-27Budapest 1075Hungary Institute of Health Promotion and Sport Sciences ELTE Eötvös Loránd UniversityPrielle Kornélia Street 47-49Budapest 1117Hungary Rehabilitation Research(REVAL) Faculty of Rehabilitation SciencesUniversity of HasseltMartelarenlaan 42Hasselt 3500Belgium

Background:Proprioceptive accuracy refers to the individual’s ability to perceive proprioceptive information,that is,the information referring to the actual state of the locomotor system,which originates from mechanoreceptors located in various parts of the locomotor system and from tactile receptors located in the *** accuracy appears to be an important aspect in the evaluation of sensorimotor functioning;however,no widely accepted standard assessment *** this systematic review,our goal was to identify and categorize different methods that are used to assess different aspects of proprioceptive ***:A literature search was conducted in 5 different databases(Pubmed,SPORTDiscus,PsycINFO,ScienceDirect,and SpringerLink).Results:Overall,1139 scientific papers reporting 1346 methods were included in this *** methods assess 8 different aspects of proprioception:(a)the perception of joint position,(b)movement and movement extent,(c)trajectory,(d)velocity,and the sense of(e)force,(f)muscle tension,(g)weight,and(h)*** apply various paradigms of psychophysics(i.e.,the method of adjustment,constant stimuli,and limits).Conclusion:As the outcomes of different tasks with respect to various body parts show no associations(i.e.,proprioceptive accuracy is characterized by site-specificity and method-specificity),the appropriate measurement method for the task needs to be chosen based on theoretical considerations and/or ecological validity.

关键词： Assessment Kinesthesia motor control Proprioception Proprioceptive accuracy

Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status

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Bone Research 2023年第4期11卷 876-894页

作者： Ananya Nandy ron C.m.Helderman Santosh Thapa Shobana Jayapalan Alison Richards Nikita Narayani michael P.Czech Clifford J.Rosen Elizabeth Rendina-Ruedy Department of medicine Division of Clinical PharmacologyVanderbilt University Medical CenterNashvilleTN 37232USA Program in molecular medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605USA maine medical Center Research Institute ScarboroughMEUSA molecular Physiology and Biophysics Vanderbilt UniversityNashvilleTN 37232USA

Bone formation is a highly energy-demanding process that can be impacted by metabolic *** has been considered the principal substrate for osteoblasts,although fatty acids are also important for osteoblast ***,we report that osteoblasts can derive energy from endogenous fatty acids stored in lipid droplets via lipolysis and that this process is critical for bone *** such,we demonstrate that osteoblasts accumulate lipid droplets that are highly dynamic and provide the molecular mechanism by which they serve as a fuel source for energy generation during osteoblast *** cytoplasmic lipolysis leads to both an increase in lipid droplet size in osteoblasts and an impairment in osteoblast *** fatty acids released by lipolysis from these lipid droplets become critical for cellular energy production as cellular energetics shifts towards oxidative phosphorylation during nutrient-depleted *** vivo,conditional deletion of the ATGL-encoding gene Pnpla2 in osteoblast progenitor cells reduces cortical and trabecular bone parameters and alters skeletal lipid ***,our data demonstrate that osteoblasts store fatty acids in the form of lipid droplets,which are released via lipolysis to support cellular bioenergetic status when nutrients are *** in this process result in impairment of bone formation,specifically reducing ATP production and overall osteoblast function.

关键词： endogenous maintain osteoblast

Geostatistical modelling and mapping of nematode-based soil ecological quality indices in a polluted nature reserve

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Pedosphere 2021年第5期31卷 670-682页

作者： Israel O.IKOYI Gerard B.m.HEUVELINK ron G.m.DE GOEDE Wageningen University&Research Soil Biology GroupWageningen 6700 AA(The Netherlands) Current address:University of Limerick School of Natural SciencesDepartment of Biological SciencesLimerick V94T9PX(Ireland) Wageningen University&Research Soil Geography and Landscape GroupWageningen 6700 AA(The Netherlands)

Nematodes are indicators of soil quality and soil *** of the relationships between nematode-based soil quality indices and environmental properties is beneficial for assessing environmental threats on soil *** study evaluated the spatial distribution of nematode-based soil quality indices in a 23-ha heavy metal-polluted nature reserve using geostatistical *** expected that a selection of abiotic soil properties(pH and moisture,clay,organic matter,cadmium(Cd),and zinc(Zn)contents)could explain a significant portion of the spatial variation of the indices and that regression kriging could more accurately model their spatial distribution than ordinary kriging.A stratified simple random sampling scheme was used to select 80 locations where soil samples were taken to extract nematodes and derive the *** area had a distinct gradient in soil properties with Cd and Zn content ranging from 0.07 to 68.9 and 5.3 to 1329 mg kg^(-1),*** regression models were fitted to describe the relationships between the indices and soil *** also modelling the spatial correlation structure of regression residuals using spherical semivariograms,regression kriging was used to produce maps of the *** regression models explained between 21% and 44% of the total original variance in the *** pH was a significant explanatory variable in almost all cases,while heavy metal conent had a remarkably low *** some cases,the regression residuals had spatial *** validation indicated that in all cases,regression kriging performed slightly better because of having lower values of the root mean square prediction error and a mean prediction error closer to zero than ordinary *** study showed the importance of soil properties in explaining the spatial distribution of biological soil quality indices in ecological risk assessment.

关键词： ecological risk assessment heavy metals model validation regression kriging semivariance analysis soil property spatial structure

Spermine induced reversible collapse of deoxyribonucleic acid-bridged nanoparticle-based assemblies

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Nano Research 2018年第1期11卷 383-396页

作者： Kristian L. Goeken Richard B. m. Schasfoort Vinod Subramaniam ron Gill mIRA Institute for Biomedical Technology and Technical medicine University of Twente Dfienerlolaan 5 7522 NB Enschede the Netherlands Vrije UniversiteitAmsterdam De Boelelaan 1105 1081 HVAmsterdam the Netherlands Saxion University of Applied Sciences M. H. Tromplaan 28 7513 A8 Enschede the Netherlands

DNA-linked 2D and 3D nano-assemblies find use in a diverse set of applications, ranging from DNA-origami in drug delivery and medical imaging, to DNA-linked nanoparticle structures for use in plasmonics and （bio）sensing. However, once these structures have been fully assembled, few options are available to modulate structure geometry. Here, we investigated the use of the polycation spermine to induce DNA collapse in small oligonucleotide-linked （54 bp） gold nanoparticle structures by monitoring shifts in the localized surface plasmon resonance （LSPR） peak and by comparing the data with finite-difference time-domain （FDTD） simulations. Our data shows that low concentrations of spermine can be applied to induce large changes in DNA conformation, leading to a significant reduction in interparticle distance （from - 25 to - 3 nm） and enhanced plasmonic coupling. The DNA collapse is near-instantaneous and reversible, and its application at low and high DNA densities is demonstrated with surface plasmon resonance imaging （SPRi）, showing the potential of spermine to dynamically modulate distances and geometry in DNA-based nano-assemblies.

关键词： nanoparticles spermine deoxyribonucleic acid localized surface plasmonresonance surface plasmon resonanceimaging

Geometric and Photometric Data Fusion in Non-Rigid Shape Analysis

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Numerical mathematics(Theory,methods and Applications) 2013年第1期6卷 199-222页

作者： Artiom Kovnatsky Dan Raviv michael m.Bronstein Alexander m.Bronstein ron Kimmel Institute of Computational Science Faculty of InformaticsUniversitàdella Svizzera ItalianaLuganoSwitzerland School of Electrical Engineering Tel Aviv UniversityIsrael Technion–Israel Institute of Technology Computer Science DepartmentHaifaIsrael

In this paper,we explore the use of the diffusion geometry framework for the fusion of geometric and photometric information in local and global shape *** construction is based on the definition of a diffusion process on the shape manifold embedded into a high-dimensional space where the embedding coordinates represent the photometric *** results show that such data fusion is useful in coping with different challenges of shape analysis where pure geometric and pure photometric methods fail.

关键词： Laplace-Beltrami operator diffusion equation heat kernel descriptors 3D shape retrieval deformation invariance

Binary interactions with high accretion rates onto main sequence stars

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Research in Astronomy and Astrophysics 2016年第7期16卷 153-160页

作者： Sagiv Shiber ron Schreier Noam Soker Department of Physics Technion-Israel Institute of TechnologyHaifa 32000Israel

Energetic outflows from main sequence stars accreting mass at very high rates might account for the powering of some eruptive objects, such as merging main sequence stars, major eruptions of luminous blue variables, e.g., the Great Eruption of Eta Carinae, and other intermediate luminosity optical transients（ILOTs; red novae; red transients）. These powerful outflows could potentially also supply the extra energy required in the common envelope process and in the grazing envelope evolution of binary systems. We propose that a massive outflow/jets mediated by magnetic fields might remove energy and angular momentum from the accretion disk to allow such high accretion rate flows. By examining the possible activity of the magnetic fields of accretion disks, we conclude that indeed main sequence stars might accrete mass at very high rates, up to≈10^-2m⊙yr^-1for solar type stars, and up toion≈1 m⊙yr^-1for very massive stars. We speculate that magnetic fields amplified in such extreme condits might lead to the formation of massive bipolar outflows that can remove most of the disk＇s energy and angular momentum. It is this energy and angular momentum removal that allows the very high mass accretion rate onto main sequence stars.

关键词： stars AGB and post-AGB stars jets (stars ) binaries(including multiple) close

Effect of controlled rolling on the martensitic hardenability of dual phase steel

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International Journal of minerals,metallurgy and materials 2009年第2期16卷 165-169页

作者： mohammad Ajmal masood Ahmed Tindyala ron Priestner Department of metallurgical & materials Engineering University of Engineering & TechnologyG.T. Road Lahore-54890Pakistan manchester materials Science Center University of Manchester Institute of Science and Technology (UMIST)ManchesterM1 7HSUK

The C-mn and C-mn-Nb steels were thermo-mechanically processed to develop dual phase steel and to study the effect of controlled rolling on the martensitic hardenability of austenite. The steel specimens were intercritically annealed at 790℃, rolled at that temperature to the reductions of 10%, 23%, and 47% and immediately cooled at different rates. Quantitative metallography was used to construct the microstructure map, which illustrated that increasing deformation progressively reduced the proportion of new ferrite formed at all cooling rates and increased the amount of martensite at fast and intermediate rates. The martensitic hardenability of austenite remaining after all the rolling reductions was plotted as a function of cooling rates. It was observed that for the austenite-martensite conversion efficiencies greater than about 25%, controlled rolling increased the martensitic hardenability of austenite.

关键词： controlled rolling dual phase steel intercritical annealing hardenability phase transformation