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Effect of pipe installation and external load on buried steel pipe responses:Experimental and numerical investigations

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Underground Space 2024年第2期15卷 44-58页

作者： Yadong Zhang ron Chik-Kwong Wong Jianfeng Chen Wei Su Department of Civil Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

During pipe installation,compacting soil at pipe sides causes an initial pipe deformation which is known as the"peaking"***,in conventional pipe design codes,only pipe deformation caused by vertical overburden is considered while the"peaking"effect is *** this study,a full-scale test was conducted on a Grade X52 steel pipe with a diameter of 600 mm to investigate the impacts of both soil compaction and vertical overburden on pipe *** compaction and external load were found to elongate and shorten the vertical pipe diameter,***"peaking"effect was observed during the installation procedure accompanied by the highest pipe stress measured at the pipe ***,a two-dimensional finite element model was created and validated based on the calculated pipe stresses from the experimental study.A parametric study was performed thereafter to numerically study the impacts of soil water content,pipe wall thickness,compaction pressure,and lift thickness on pipe responses due to soil compaction and external *** increase in the"peaking"effect is observed with increasing soil water content and compaction pressure,while an increase in pipe wall thickness or lift thickness would cause a decrease in the"peaking"effect.

关键词： X52 steel Soil compaction External load Peaking effect Pipe deflection Soil arching

专访传奇国际设计大师ron Arad:创造前所未有的设计

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包装与设计 2024年第2期 4-33页

作者： ron Arad 不详

他是国际设计界的传奇人物,毕业于著名的英国伦敦建筑联盟学院(Architectural Association,简称AA),集产品设计师、家具设计师、建筑设计师、艺术家多重身份于一身.他创作的工作室限量版艺术作品一次又一次地成功转为市场畅销产品,而他... 详细信息

他是国际设计界的传奇人物,毕业于著名的英国伦敦建筑联盟学院(Architectural Association,简称AA),集产品设计师、家具设计师、建筑设计师、艺术家多重身份于一身.他创作的工作室限量版艺术作品一次又一次地成功转为市场畅销产品,而他设计的工业产品又如艺术品,令人大开眼界,吸引了全球各大知名博物馆争相展示和收藏.

关键词：工业产品建筑设计师设计大师限量版家具设计师畅销产品产品设计师多重身份

美国ST Paper的差异化经营:灵活生产,推动绿色能源使用

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生活用纸 2024年第5期24卷 58-59页

作者： ron Thiry ST Paper

随着美国家族企业独立生活用纸生产商ST Paper最新投资项目——PrimeLineTM W 2000于2023年1月在位于美国明尼苏达州Duluth的工厂启动,公司已为进一步扩张做好了准备。Tissue World杂志采访了ST Paper公司的高级副总裁兼首席运营官ron T... 详细信息

随着美国家族企业独立生活用纸生产商ST Paper最新投资项目——PrimeLineTM W 2000于2023年1月在位于美国明尼苏达州Duluth的工厂启动,公司已为进一步扩张做好了准备。Tissue World杂志采访了ST Paper公司的高级副总裁兼首席运营官ron Thiry。

关键词：家族企业差异化经营生活用纸绿色能源首席运营官 ST

维普期刊数据库博看期刊评论

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评价标记“你说”和“别说”的用法比较

汉语学习 2024年第2期 10-21页

作者：周莉董涵容吉林大学文学院吉林长春130012 上海师范大学对外汉语学院上海200234

本文主要探讨评价标记“你说”和“别说”的功能差异及成因。研究发现,二者差异主要体现在评价话语的信息结构、后续话语形式和语音停顿等方面,这些差异取决于二者语义功能的不同:一是评价对象不同;二是互动性不同。二者源结构在会话不... 详细信息

本文主要探讨评价标记“你说”和“别说”的功能差异及成因。研究发现,二者差异主要体现在评价话语的信息结构、后续话语形式和语音停顿等方面,这些差异取决于二者语义功能的不同:一是评价对象不同;二是互动性不同。二者源结构在会话不同序列位置的不同用法,即“别说”处于引发序列的语用推理和“你说”处于回应序列的引述回应决定了二者功能的差异。本文最后总结出言者引发评论时使用评价标记“你说/别说”的条件。

关键词：评价标记 “你说” “别说” 互动差异

A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway

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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen Valentin Verges Caroline Birer Williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun ron P.Dirks Sarah Ellen O’Connor Michael Krogh Jensen Sebastien Besseau Vincent Courdavault Biomole´cules et Biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties. Figure roots

Pathogenesis and clinical features of severe hepatitis E virus infection

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World Journal of Virology 2024年第2期13卷 19-33页

作者： László Orosz Károly Péter Sárvári Áron Dernovics András Rosztóczy Klára Megyeri Department of Medical Microbiology University of SzegedSzeged 6720Csongrád-CsanádHungary Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Csongrád-CsanádHungary

The hepatitis E virus(HEV),a member of the Hepeviridae family,is a small,non-enveloped icosahedral virus divided into eight distinct genotypes(HEV-1 to HEV-8).Only genotypes 1 to 4 are known to cause diseases in *** 1 and 2 commonly spread via fecal-oral transmission,often through the consum-ption of contaminated *** 3 and 4 are known to infect pigs,deer,and wild boars,often transferring to humans through inadequately cooked *** hepatitis caused by HEV in healthy individuals is mostly asymptomatic or associated with minor symptoms,such as ***,in immunosup-pressed individuals,the disease can progress to chronic hepatitis and even escalate to *** pregnant women,an HEV infection can cause fulminant liver failure,with a potential mortality rate of 25%.Mortality rates also rise amongst cirrhotic patients when they contract an acute HEV infection,which can even trigger acute-on-chronic liver failure if layered onto pre-existing chronic liver *** the prevalence of HEV infection continues to rise worldwide,highlighting the particular risks associated with severe HEV infection is of major medical *** text offers a brief summary of the characteristics of hepatitis developed by patient groups at an elevated risk of severe HEV infection.

关键词： Hepatitis E virus Cirrhosis Acute-on-chronic liver failure Pregnancy Immune dysfunction Open reading frames 1-4

Relevance of plasma lipoproteins and small metabolites in assessment of nutritional status among patients with severe injuries

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Journal of Intensive Medicine 2024年第4期4卷 496-507页

作者： Esmee A.H.Verheul Suzan Dijkink Pieta Krijnen Aswin Verhoeven Martin Giera Roula Tsonaka Jochem M.Hoogendoorn Sesmu M.Arbous ron Peters Inger B.Schipper Department of Trauma Surgery Leiden University Medical CenterLeidenThe Netherlands Acute Care Network West Netherlands LeidenThe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Data Sciences Leiden University Medical CenterLeidenThe Netherlands Department of General Surgery Haaglanden Medical CenterThe HagueThe Netherlands Department of Intensive Care Leiden University Medical CenterLeidenThe Netherlands Department of Intensive Care Haaglanden Medical CenterThe HagueThe Netherlands

Background:This study aimed to identify plasma lipoproteins and small metabolites associated with high risk of malnutrition during intensive care unit(ICU)stay in patients with severe ***:This observational prospective exploratory study was conducted at two level-1 trauma centers in the *** patients(aged≥18 years)who were admitted to the ICU for more than 48 h between July 2018 and April 2022 owing to severe injuries(polytrauma,as defined by Injury Severity Scores of≥16)caused by blunt trauma were eligible for *** least squares discriminant analysis was used to analyze the relationship of 112 lipoprotein-related components and 23 small metabolites with the risk of malnutrition(mod-ified Nutrition Risk in Critically Ill score).Malnutrition was diagnosed based on Subjective Global Assessment *** relationship of lipoprotein properties and small metabolite concentrations with malnutrition(during ICU admission)was evaluated using mixed effects logistic ***:Overall,51 patients were ***(very)low-density lipoprotein([V]LDL)(free)cholesterol and phospholipid levels,low particle number,and higher levels of LDL triglycerides were associated with a higher risk of malnutrition(variable importance in projection[VIP]value>1.5).Low levels of most(V)LDL and intermediate-density lipoprotein subfractions and high levels of high-density lipoprotein Apo-A1 were associated with the diagnosis of malnutrition(VIP value>1.5).Increased levels of dimethyl sulfone,trimethylamine N-oxide,creatinine,N,N-dimethylglycine,and pyruvic acid and decreased levels of creatine,methionine,and acetoacetic acid were also indicative of malnutrition(VIP value>1.5).Overall,14 lipoproteins and 1 small metabolite were significantly associated with a high risk of malnutrition during ICU admission(P<0.05);however,the association did not persist after correcting the false discovery rate(P=0.35 for all).Conclusion:Increased triglyceride in sev

关键词： Trauma Severely injured Metabolites Lipoproteins Malnutrition Nutritional status

Social Data:CESSDA Best Practices

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Data Intelligence 2020年第1期2卷 220-229,316页

作者： ron Dekker Main Office of the Consortium of Social Science Data Archives Parkveien 20BergenNorway

The European Commission report“Turning FAIR into reality”provides an index of 27 FAIR Action Plan *** index is used for a self-assessment on CESSDA,the Consortium of European Social Science Data *** is performing well on“Concepts for FAIR implementation”,“Skills for FAIR”,and“Investment in FAIR”;there is work in progress on“FAIR culture”,and work to start up on“FAIR ecosystem”and especially on“Incentives and metrics for FAIR data and services”.Next,an analysis on the FAIR components,reveals that CESSDA has accomplished the“F”,is working on the“A”-considering the sensitivity and security requirements of social data,just started on“I”,and that there is lack of clarity on what should be in“R”.On Findability,the CESSDA Data Catalogue is explained,showing the building blocks that need to be in place before one can produce a *** article ends with a forward look on CESSDA’s deployment on the FAIR principles.

关键词： Social data Distributed infrastructure FAIR Action Plan Data catalogue

The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery

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Neural Regeneration Research 2021年第9期16卷 1751-1759页

作者： Maya Ross ron Ofri Koret School of Veterinary Medicine The Hebrew University of JerusalemRehovotIsrael

Inherited retinal degenerations are a leading and untreatbale cause of blindness, and as such they are targets for gene therapy. Numerous gene therapy treatments have progressed from laboratory research to clinical trails, and a pioneering gene therapy received the first ever FDA approval for treating patients. However, currently retinal gene therapy mostly involves subretinal injection of the therapeutic agent, which treats a limited area, entails retinal detachment and other potential complications, and requires general anesthesia with consequent risks, costs and prolonged recovery. Therefore there is great impetus to develop safer, less invasive and cheapter methods of gene delivery. A promising method is intravitreal injection, that does not cause retinal detachment, can lead to pan-retinal transduction and can be performed under local anesthesia in outpatient clinics. Intravitreally-injected vectors face several obstacles. First, the vector is diluted by the vitreous and has to overcome a long diffusion distance to the target cells. Second, the vector is exposed to the host's immune response, risking neutralization by pre-existing antibodies and triggering a stronger immune response to the injection. Third, the vector has to cross the inner limiting membrane which is both a physical and a biological barrier as it contains binding sites that could cause the vector's sequestration. Finally, in the target cell the vector is prone to proteasome degradation before delivering the transgene to the nucleus. Strategies to overcome these obstacles include modifications of the viral capsid, through rational design or directed evolution, which allow resistance to the immune system, enhancement of penetration through the inner limiting membrane or reduced degradation by intracellular proteasomes. Furthermore, physical and chemical manipulations of the inner limiting membrane and vitreous aim to improve vector penetration. Finally, compact non-viral vectors that can overcome

关键词： adeno-associated virus animal model blindness gene therapy inner limiting membrane photoreceptors retina retinitis pigmentosa vitreous