检索结果-南通市图书馆

Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism

引用

Cell Research 2007年第2期17卷 151-162页

作者： romankholodenko IrinaKholodenko Viktor Sorokin AnnaTolmazova OlgaSazonova AntonBuzdin Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 16/10 Miklukho-MaklayaMoscow 117997Russia Russian State Medical University Ostrovityanova 1Moscow 117312Russia

Retinal progenitor cells (RPCs) are neural stem cells able to differentiate into any normal adult retinal cell type,except for pigment epithelial cells. Retinoic acid (RA) is a powerful growth/differentiation factor that generallycauses growth inhibition,differentiation and/or *** this study,we demonstrate that RA not only affectsmouse RPC differentiation but also improves cell survival by reducing spontaneous apoptotic rate without affectingRPC *** enhanced cell survival was accompanied by a significant upregulation of the expression ofprotein kinase A (PKA) and several protein kinase C (PKC) *** of cells grown in RA-free mediawith 8-bromoadenosine3′,5′-cyclic monophosphate,a known activator of PKA,resulted in an anti-apoptotic effectsimilar to that caused by RA;whereas the PKA inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesul-fonamide dihydrochloride led to a significant (～32%) increase in *** contrast,treatment of RPCs withany of two PKC selective inhibitors,2,2′,3,3′,4,4′-hexahydroxy-1,1′-biphenyl-6,6′-dimethanol dimethyl ether andbisindolylmaleimide Ⅺ,led to diminished apoptosis;while a PKC activator,phorbol 12-myristate 13-acetate,in-creased *** and other data suggest that the effect of RA on RPC survival is mostly due to the increasedanti-apoptotic activity elicited by PKA,which might in turn be antagonized by *** a mechanism is a newexample of tight regulation of important biological processes triggered by *** the detailed mechanismsremain to be elucidated,we provide evidence that the pro-survival effect of RA on RPCs is not mediated by changedexpression of p53 or bcl-2,and appears to be independent of β-amyloid,Fas ligand,TNF-α,ganglioside GM1 andceramide C 16-induced apoptotic pathways.

关键词： retinal progenitor cells apoptosis retinoic acid protein kinase A protein kinase C

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：