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Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders:A translational viewpoint

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Neuroprotection 2024年第3期2卷 228-242页

作者： Svea-Solveig Mennen Maren Franta Martin Begemann Justus B.H.Wilke roman schroder Umer Javed Butt Jonathan-Alexis Cortés-Silva Umut Cakir Marie Gura Markus de Marees Vinicius Daguano Gastaldi Johannes Burtscher Julie Schanz Matthias Bohn Martin Burtscher Andreas Fischer Luise Poustka Peter Hammermann Markus Stadler Fred Luhder Manvendra Singh Klaus-Armin Nave Kamilla Woznica Miskowiak Hannelore Ehrenreich Clinical Neuroscience Max Planck Institute for Multidisciplinary SciencesCity CampusGottingenGermany Georg-August-University GottingenGermany Department of Sports Medicine Ruhr UniversityBochumGermany Institute of Sports Science University of LausanneLausanneSwitzerland Department of Clinical Chemistry and Interdisciplinary UMG Laboratory University Medical Center GottingenGottingenGermany Clinical Pharmacy Georg-August-UniversityGottingenGermany Faculty of Sports Science University of InnsbruckInnsbruckAustria Department of Child and Adolescent Psychiatry&Psychotherapy Center for Psychosocial MedicineUniversity Hospital HeidelbergHeidelbergGermany HBL Investmentpartners GmbH München-FrankfurtGermany Datico Sport&Health GmbH BurghausenGermany Institute for Neuroimmunology and Multiple Sclerosis Research University Medical Center GottingenGottingenGermany Department of Neurogenetics Max Planck Institute for Multidisciplinary SciencesCity CampusGottingenGermany Frederiksberg Hospital and Department of Psychology Neurocognition and Emotion in Affective Disorders(NEAD)CentreCopenhagen Affective Disorder Research CentrePsychiatric Centre CopenhagenUniversity of CopenhagenCopenhagenDenmark Experimental Medicine Department of Psychiatry and PsychotherapyCentral Institute of Mental HealthMedical Faculty MannheimHeidelberg UniversityMannheimGermany

Hypoxia is more and more perceived as pivotal physiological driving force,allowing cells in the brain and elsewhere to acclimate to lowered oxygen(O_(2)),and abridged *** mediating transcription program is induced by inspiratory hypoxia but also by intensive motor-cognitive tasks,provoking a relative decrease in O_(2) in relation to the acutely augmented *** termed this fundamental,demand-dependent drop in O_(2) availability"functional hypoxia."Major players in the hypoxia response are hypoxia-inducible factors(HIFs)and associated *** are transcription factors,stabilized by low O_(2) accessibility,and control expression of a multitude of *** in oxygen,however,can also be sensed via other pathways,among them the thiol-oxidase(2-aminoethanethiol)*** the far-reaching biological response to hypoxia,hitherto mostly observed in rodents,we initiated a translational project,combining mild to moderate inspiratory with functional *** had identified this combination earlier to benefit motor-cognitive attainment in mice.A total of 20 subjects were included:13 healthy individuals and 7 patients with depression and/or autism spectrum ***,we show that motor-cognitive training under inspiratory hypoxia(12%O_(2))for 3.5 h daily over 3 weeks is optimally *** present first signals of beneficial effects on general well-being,cognitive performance,physical fitness and *** in serum increases under hypoxia and flow cytometry analysis of blood reveals several immune cell types to be mildly modulated by *** obtain reliable information regarding the"add-on"value of inspiratory on top of functional hypoxia,induced by motor-cognitive training,a single-blind study—with versus without inspiratory hypoxia—is essential and outlined here.

关键词： brain cognition erythropoietin functional hypoxia high-parameter flow cytometry immune cells oxygen saturation physical fitness plasticity

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