检索结果-南通市图书馆

E-selectin ligand complexes adopt an extended high-affinity conformation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2016年第1期8卷 62-72页

作者： Roland C.preston roman p.Jakob Florian p.C.Binder Christoph p.Sager Beat Ernst Timm Maier Institute of Molecular pharmacy Universitat Basel4056 BaselSwitzerland Biozentrum Universitat Basel4056 BaselSwitzerland

E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx(sLex).Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding ***-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation,which is identified as a high-affinity binding state of E-selectin by molecular dynamics ***-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in *** permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte *** detailed molecular view of the binding site paves the way for the design of a new generation of selectin *** is of special interest,since their therapeutic potentialwas recently demonstrated with the pan-selectin antagonists GMI-1070(Rivipansel).

关键词： inﬂammation leukocyte adhesion E-selectin glycomimetic antagonist sialyl Lewisx conformational change

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSpB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

SoundMeGood: A Trust Model Supporting preliminary Trust Establishment Between Mutually Unknown Entities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SoundMeGood: A Trust Model Supporting Preliminary Trust Esta...

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

作者： roman pánek pavel Tyl Institute of Computer Science of the Czech Republic Technical University of Liberec

The paper proposes a SoundMeGood trust model being able to establish a preliminary trust level among unknown users in a distributed environment. Computation of preliminary level of trust is based on similarities among users based on various components of their profiles. As a metric used for similarity computation has been used and experimentally evaluated DTW* algorithm.

关键词： Trust Social Network Trust Management System Distributed Systems.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris porras-Reyes Rebeca Garcia-roman Alma D.Campos-parra posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第5期16卷 822-831页

作者： Irina Efremova roman Maslennikov Elena poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov Maria Fedorova Filipp romanikhin Maria Zharkova Oxana Zolnikova Gyunay Bagieva Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of Scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–pugh cirrhosis classes B and C and 15 healthy *** fecal microbiome was assessed using 16S rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 *** presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;p=0.048].patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of Bacilli,proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);p=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);p=0.123].A high level of presepsin

关键词： Dysbiosis Gut Intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新的皂用杀菌剂

日用化学品科学 1987年第1期 42-44页

作者： Daniel p.roman 陈桔阿

本文论述一种杰出的皮肤抗菌化合物——3,4,4’-三氯化碳酸替苯胺 (TCC)。早在1957年Beaver等发表了TCC及其有关化合物的合成,同时,初步报道了它们的体外活性。TCC是经氯化的二苯脲,其结构如下:

关键词：微球菌皮肤解剖部位细菌数抑菌浓度 TCC 百分数抑菌剂受检人员体外活性

Influence of Geological Factor on Indoor Radon Concentrations in Dwelling of Queretaro,Mexico

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Geology 2014年第12期4卷 627-635页

作者： Rocio García Martínez Anatoliy Kotsarenko roman pérez Enriquez Jose Antonio López Cruz Abeyro Svetlana Koshevaya Jesús Efrén Ospina Norena Centro de Ciencias de la Atmósfera Universidad Nacional Autónoma de MéxicoCiudad UniversitariaMéxico CityMéxico Universidad Autónoma del Carmen(UNACAR) Facultad de IngenieríaCiudad del CarmenMéxico Centro de Geociencias Universidad Nacional Autónoma de MéxicoCampus JuriquillaQuerétaroMéxico CIICAp Autonomous University of State Morelos(UAEM)CuernavacaMéxico programa de Investigación de Cambio Climático Universidad Nacional Autónoma de MéxicoCiudad UniversitariaMéxico CityMéxico

In this study, radon-222 concentrations were measured within 34 houses distributed in the northern, southern, and central areas of the city of Querétaro in 2007. The objective of this study was to establish the spatial distribution of radon with respect to geological faults and its relation to certain environmental variables. For each sampling site, the radon-222 concentration was analyzed as a function of various climate variables, relative humidity, temperature, and atmospheric pressure, in addition to the ventilation of the house and distance of each site from any geological faults in the area. A multivariate statistical technique was used to analyze these variables based on two components. For component 1, the relative humidity and temperature had the greatest weight, 0.677 and 0.492, respectively, while for component 2, the greatest weights corresponded to radon and the temperature with 0.693 and 0.609, respectively. The average radon concentration across the entire sampling period was 38.92 Bq/m3, the minimum detected value was 6.01 Bq/m3?for site 91GAG0607, and the maximum detected value was 225.95 Bq/m3?for site 91CAM20907. This last value is outside the standards permitted by the Environmental protection Agency of the United Stated, which is 148 Bq/m3?for indoor environments. With respect to geological faults and their relationship to radon-222, the concentrations for the sampling sites had no relationship to the closeness or distance to these faults.

关键词： Indoor Radon Geology Building Characteristics and Seasonal Variations

In-silico synthesis of lowest-pressure high-T_(c) ternary superhydrides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1119-1125页

作者： roman Lucrezi Simone Di Cataldo Wolfgang von der Linden Lilia Boeri Christoph Heil Institute of Theoretical and Computational physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomeItaly Enrico Fermi Research Center Via Panisperna 89 A00184RomeItaly

We report the theoretical prediction of two high-performing hydride superconductors BaSiH_(8)and SrSiH_(8).They are thermodynamically stable above pressures of 130 and 174 Gpa,respectively,and metastable below *** anharmonic phonon calculations,we determine the minimum pressures of dynamical stability to be around 3 Gpa for BaSiH8 and 27 Gpa for SrSiH_(8),and using the fully anisotropic Migdal-Eliashberg theory,we predict Tc’s around 71 and 126 K,*** also introduce a method to estimate the lowest pressure of synthesis,based on the calculation of the enthalpy barriers protecting the BaSiH_(8)Fm3¯m structure from decomposition at various *** kinetic pressure threshold is sensibly higher than the one based on dynamic stability,but gives a much more rigorous limit for synthesizability.

关键词： synthesis stability high

Utility of short-term telemetry heart rhythm monitoring and CHA2DS2-VASc stratification in patients presenting with suspected cerebrovascular accident

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2023年第2期15卷 56-63页

作者： Tanzim Bhuiya Sherif roman Taner Aydin Bhakti patel roman Zeltser Amgad N Makaryus Department of Cardiology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11553United States Department of Cardiology St.Joseph’s University Medical CenterPatersonNJ 07503United States Department of Cardiology Nassau University Medical CenterEast MeadowNY 11554United States

BACKGROUND Inpatient telemetry heart rhythm monitoring overuse has been linked to higher healthcare *** To evaluate if CHA2DS2-VASc score could be used to indicate if a patient admitted with possible cerebrovascular accident(CVA)or transient ischemic attack(TIA)requires inpatient telemetry *** A total of 257 patients presenting with CVA or TIA and placed on telemetry monitoring were analyzed *** investigated the utility of telemetry monitoring to diagnose atrial fibrillation/flutter and the CHA2DS2-VASc scoring tool to stratify the risk of having CVA/TIA in these *** In our study population,63(24.5%)of the patients with CVA/TIA and telemetry monitoring were determined to have no ischemic neurologic *** the 194(75.5)patients that had a confirmed CVA/TIA,only 6(2.3%)had an arrhythmia detected during their inpatient telemetry monitoring *** with a confirmed CVA/TIA had a statistically significant higher CHA2DS2-VASc score compared to individuals without an ischemic event(3.59 vs 2.61,ppercentage of inpatient arrhythmias identified,further research should focus on discretionary use of inpatient telemetry on higher risk patients to diagnose the arrhythmias commonly leading to CVA/TIA.A prospective study assessing event rate of CVA/TIA in patients with higher CHA2DS2-VASc score should be performed to validate the CHA2DS2-VASc score as a possible risk stratifying tool for patients at risk for CVA/TIA.

关键词： Telemetry monitoring CHA2DS2-VASc score Arrhythmia Atrial fibrillation