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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

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Light(Science & Applications) 2020年第1期9卷 346-357页

作者： Timur ermatov roman e.noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of electrical engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPe LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

Modifying light–matter interactions with perovskite nanocrystals inside antiresonant photonic crystal fiber

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Photonics Research 2021年第8期9卷 1462-1469页

作者： ANDReY A.MACHNeV ANATOLY P.PUSHKAReV PAVeL TONKAeV roman e.noskov KRISTINA R.RUSIMOVA PeTeR J.MOSLeY SeRGeY V.MAKAROV PAVeL B.GINZBURG IVAN I.SHISHKIN School of electrical engineering Tel Aviv UniversityTel Aviv 69978Israel Department of Physics and engineering ITMO UniversitySaint Petersburg 197101Russia Centre for Photonics and Photonic Materials Department of PhysicsUniversity of BathBath BA27AYUK Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia

Structured environments are employed in a plethora of applications to tailor dynamics of light–matter interaction processes by modifying the structure of electromagnetic *** promising example of such a system is antiresonant photonic crystal fibers(AR-PCFs),which allow light–analyte interactions in a very long *** we probe contribution of microstructuring and nontrivial mode hierarchy on light–matter interactions in AR-PCFs by investigating lifetime shortening of perovskite(CsPbBr3)nanocrystals grown to fiber *** crystals have been deposited using a wet chemistry approach and then excited by a supercontinuum source in the 450–500 nm *** spectra have been measured and analyzed via the time-correlated single photon counting(TCSPC)technique,unravelling contributions of core and cladding *** lifetime imaging inside an AR-PCF enables mapping input of various electromagnetic channels into light–matter interaction *** results pave the way for tailoring the dynamics of high-order quantum processes,promoting the concept of AR-PCF as a light-driven reactor.

关键词： fiber light resonant

Microalgae contribution in enhancing the circular economy drive of biochemical conversion systems-A review

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Carbon Resources Conversion 2024年第2期7卷 95-109页

作者： Kelechi e.Anyaoha Felix Krujatz Isla Hodgkinson roman Maletz Christina Dornack Technische Universität Dresden Chair of Waste Management and Circular EconomyPratzschwitzer Str.1501796 PirnaGermany Institute of Natural Materials Technology RadebergGermany Biotopa gGmbH Center for Applied Aquaculture and Bioeconomy RadebergGermany Department of Agricultural engineering Imo State Polytechnic OmumaNigeria

The global impact of greenhouse gas emissions requires concerted efforts to reduce emissions and energy use,and to increase carbon capture and *** the circular economy in CO_(2)sequestration systems optimises resource use and reduces the emissions burden throughout the supply *** capture from anaerobic digestion,composting and fermentation(particularly ethanol)processes offers great opportunities for climate change *** waste/by-products generated from these processes can limit the need to source nutrients from outside the system and increase the potential for circular *** integration of microalgae cultivation with each of anaerobic digestion,composting and ethanol fermentation processes provides a new model for climate change mitigation of biogenic CO_(2)and circular *** this model is limited by high energy consumption and nutrient demand,seasonal variability,operational efficiency and end-user requirements,further research and policy support will go a long way in realising the associated benefits,including in CO_(2)fixation,nutrient recovery,waste remediation and as an alternative source of animal feed.

关键词： Circular economy Anaerobic digestion Composting Microalgae

Taxonomy,distribution,and contemporary exposure of terrestrial mammals to floods and human pressure across different areas for biodiversity conservation in China

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Integrative Zoology 2024年第3期19卷 458-467页

作者： roman SHARNUUD eric I.AMeCA MOe Key Laboratory for Biodiversity Science&ecological engineering College of Life SciencesBeijing Normal UniversityBeijingChina Climate Change Specialist Group Species Survival CommissionInternational Union for Conservation of NatureGlandSwitzerland

A significant research focus is placed on identifying animal species and areas at future risk to human-induced alterations of the environment and long-term changes in climatic ***,the extent to which exposure to extreme climatic events and intense human pressure can increase the risk of harmful impacts on species remains poorly *** on terrestrial mammals in China,one of the world’s megadiverse countries,we investigated patterns of contemporary exposure to floods and human pressures and determined their taxonomic representation and distribution across three major area-based conservation schemes,namely,national nature reserves(NNRs),priority areas for biodiversity conservation(PABCs),and key biodiversity areas(KBAs).Among the 440 species assessed with moderate or high exposure to floods,327(∼75%)also qualified as moderate or high in exposure to intense human *** species mainly belong to the orders Chiroptera,eulipotyphla,and ***,there were 305,311,and 311 species with moderate or high exposure to flood and intense human pressure represented across NNRs,PABCs,and KBAs,*** findings support the prioritization of KBAs for expansion of site-based protection efforts such as NNRs in China,considering threats to species from exposure to adverse effects from both extreme climate and human pressure.

关键词： conservation floods human pressure mammals taxonomy

Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity

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Journal of Geriatric Cardiology 2024年第1期21卷 130-134页

作者： Viacheslav A.Korepanov Tariel A.Atabekov Tatiana Yu.Rebrova roman e.Batalov Sergey A.Afanasiev Cardiology Research Institute Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

Chronic heart failure(CHF)is a clinical syndrome manifested by reduced pumping ability of the heart,increased pressure in heart chambers in both physical activity and at *** symptoms of this syndrome are dyspnea,undue fatigability,peripheral edema,which follow structural and functional changes of the myocardium.[1]The growing incidence of CHF,especially among elderly people,is an urgent problem for medicine in the vast majority of industrialized *** instance,in Russian Federation,CHF is diagnosed in about 7%of cardiovascular *** the same time,this indicator varies from 0.3%in young people(20-29 years old)to 70%in the older age group.[2,3].

关键词： severity instance pumping

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina Pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini roman A.Zubarev Fermín e.González Laboratory of experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSe164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

Themechanism of resistance to CDK4/6 inhibition and novel combination therapy with RNR inhibition for chemo-resistant bladder cancer

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Cancer Communications 2024年第6期44卷 700-704页

作者： Zhichao Tong Yubo Zhao Shiyu Bai Benedikt ebner Lou Lienhard Yuling Zhao Ziqi Wang Qi Pan Pengyu Guo Thilo Bracht Barbara Sitek Jürgen e.Gschwend Wanhai Xu roman Nawroth Department of Urology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Klinikum rechts der IsarTechnical university of MunichMunichGermany Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Ludwig-Maximilians-University of MunichMunichGermany Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Medizinisches Proteom-Center Ruhr-Universität BochumBochumGermany Clinic for Anesthesiology Intensive Care and Pain TherapyUniversity Medical Center Knappschaftskrankenhaus BochumBochumGermany

Bladder cancer(BCa)is the most prevalent urological cancer worldwide[1].A significant proportion of BCa(89%)exhibits molecular alterations in the cell cycle pathway,and targeting cyclin-dependent kinases 4 and 6(CDK4/6)is deemed as a promising therapeutic strategy[2].Selective inhibitors of CDK4/6(CDK4/6is)have been approved by the US Food and Drug Administration(FDA)[3].

关键词： bladder CDK4 alterations

Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTLU İsmail e.KILIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

CLASSIFICATIONS OF DUPIN HYPeRSURFACeS IN LIe SPHeRe GeOMeTRY

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Acta Mathematica Scientia 2024年第1期44卷 1-36页

作者： Thomas e.CeCIL Department of Mathematics and Computer Science College of the Holy CrossWorcesterMA01610USA

This is a survey of local and global classification results concerning Dupin hypersurfaces in S^(n)(or R^(n))that have been obtained in the context of Lie sphere *** emphasis is on results that relate Dupin hypersurfaces to isoparametric hypersurfaces in *** with these classification results,many important concepts from Lie sphere geometry,such as curvature spheres,Lie curvatures,and Legendre lifts of submanifolds of S^(n)(or R^(n)),are described in *** paper also contains several important constructions of Dupin hypersurfaces with certain special properties.

关键词： Dupin hypersurfaces isoparametric hypersurfaces Lie sphere geometry Lie sphere transformations Lie curvatures