检索结果-南通市图书馆

Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna brichkina roman Suezov Magdalena Huber institute of Systems immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

in a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

Gut Microbiota and Cytokine Profile in Cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第8期12卷 689-700页

作者： irina Efremova roman Maslennikov Anna Kudryavtseva Anastasia Avdeeva George Krasnov Mikhail Diatroptov Vyacheslav bakhitov Salekh Aliev Natalia Sedova Maria Fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev Anna Levshina Vladimir ivashkin Department of internal Medicine Gastroenterology and HepatologySechenov UniversityMoscowRussia Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia V.A.Nasonova Research institute of Rheumatology MoscowRussia Consultative and Diagnostic Center 2 of the Moscow Health Department MoscowRussia First Hospital Surgery Department Pirogov Russian National Research Medical UniversityMoscowRussia Department of Clinical Laboratory Diagnostics FGBOU DPO“Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation”MoscowRussia The interregional Public Organization“Scientific Community for the Promotion of the Clinical Study” MoscowRussia

background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in *** study aimed to evaluate the correlations between ***:in the blood plasma of cirrhosis patients and controls,27 cytokines were examined using a multiplex *** plasma levels of nitrites(stable metabolites of the endothelial dysfunction biomarker nitric oxide)and lipopolysaccharide(LPS)were *** fecal microbiota was assessed by 16S rRNA gene ***:Levels of iL-1b,iL-2,iL-6,iL-13,iP-10,iFN-g,TNF-a,LPS,and nitrites were higher in cirrhosis patients than in controls,while levels of iL-4,iL-7,and PDGF-bb were *** LPS level was directly correlated with the levels of iL-1b,iL1-Ra,iL-9,iL-17,PDGF-bb,iL-6,TNF-a,and *** nitrite level was significantly directly correlated with the levels of TNF-a,GM-CSF,iL-17,and iL-12,and inversely correlated with the iL-7 ***-a levels were directly correlated with ascites severity and the abundance of Negativicutes,Enterobacteriaceae,Veillonellaceae,and Klebsiella,while inversely correlated with the abundance of Firmicutes,Clostridia,and ***-g levels were directly correlated with the abundance of bacteroidaceae,Lactobacillaceae,bacteroides,and Megasphaera,and inversely correlated with the abundance of Verrucomicrobiota,Akkermansiaceae,Coriobacteriaceae,Akkermansia,Collinsella,and ***-1b levels were directly correlated with the abundance of Comamonadaceae and Enterobacteriaceae and inversely correlated with the abundance of Marinifilaceae and ***-6 levels were directly correlated with the abundance of Enterobacteriaceae,hepatic encephalopathy,and ascites severity,and inversely correlated with the abundance of Peptostreptococcaceae,Streptococcaceae,and ***:The abundance of harmful gut microbiota taxa and endotoxinemia directly correlates with the levels of proinflammatory cytokines.

关键词： Endotoxin Leaky gut Gut microbiome Systemic inflammation Gut-liver axis Endotoxemia

Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第5期16卷 822-831页

作者： irina Efremova roman Maslennikov Elena Poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov Maria Fedorova Filipp romanikhin Maria Zharkova Oxana Zolnikova Gyunay bagieva Vladimir ivashkin Department of internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of Scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of Pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

bACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–Pugh cirrhosis classes b and C and 15 healthy *** fecal microbiome was assessed using 16S rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 *** Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin

关键词： Dysbiosis Gut intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

Microstructure and martensitic transformation in quaternary NiTiHfV alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年第10期34卷 3282-3294页

作者： Aleksandr V.SHUiTCEV Yi REN Ze-zhong ZHANG roman N.VASiN bin SUN Li Li Yun-xiang TONG international Joint Laboratory of Advanced Nanomaterials of Heilongjiang Province College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Frank Laboratory of Neutron Physics Joint Institute for Nuclear Research141980DubnaRussia Center of Testing and Analysis College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China

The effect of age hardening on the microstructure,martensitic transformation behavior,and shape memory properties of the(Ni_(50)Ti_(30)Hf_(20))_(95)V_(5)alloy was investigated by scanning electron microscopy,transmission electron microscopy,X-ray diffraction,differential scanning calorimetry,microhardness,and bending *** results demonstrate a significant influence of V addition on the microstructure of the alloy.V addition leads to the formation of a(Ni,V)_(2)(Ti,Hf)-type Laves phase,which coexists with b19'martensite at room *** at 550℃results in precipitation hardening due to the formation of nano-scale orthorhombic H-phase,with the peak hardness observed after 3 h of *** alloy at peak hardness state exhibits higher transformation strain and lower unrecovered strain compared to the solution-treated *** aged sample achieves a maximum transformation strain of 1.56%under 500 MPa.

关键词： shape memory alloys NiTiHfV H-phase Laves phase martensitic transformation

Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah Chung Tak Hang Chan roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry i Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and bioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase b(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HiF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-borràs Marta balanyà-Segura aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase b receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated Trkb/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorb

State of the art in research on the gut-liver and gut-brain axis in poultry

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and biotechnology 2023年第4期14卷 1315-1328页

作者： aleksandra beldowska Marcin barszcz aleksandra Dunislawska Department of Animal biotechnology and Genetics Bydgoszcz University of Science and TechnologyMazowiecka 28Bydgoszcz 85-084Poland Department of Animal Nutrition The Kielanowski Institute of Animal Physiology and NutritionPolish Academy of SciencesInstytucka 3Jabłonna 05-110Poland

The relationship between the intestines and their microbiota,the liver,and the neuronal system is called the gutliver-brain *** relationship has been studied and observed for a relatively short time but is considered in the development of research focused on,e.g.,liver diseases and intestinal *** role of the gut microbiota in this relationship is crucial,as it acts on poultry’s performance and feed utilization,affecting meat and egg *** correct composition of the intestinal microbiota makes it possible to determine the essential metabolic pathways and biological processes of the individual components of the microbiota,allowing further speculation of the role of microbial populations on internal organs such as the liver and brain in the *** gut microbiota forms a complex,dense axis with the autonomic and enteric nervous *** symbiotic relationship between the liver and gut microbiota is based on immune,metabolic and neuroendocrine regulation,and *** the other hand,the gut-brain axis is a bidirectional interaction and information transfer system between the gastrointestinal tract and the central nervous *** following paper will discuss the current state of knowledge of the gut-liver-brain axis of poultry,including factors that may affect this complex relationship.

关键词： Chicken Crosstalk interaction intestines Microbiota

Recent progress of inverted organic-inorganic halide perovskite solar cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第4期79卷 168-191页

作者： Dongyang Li Yulan Huang Zhiwei Ren Abbas Amini aleksandra b.Djurišic Chun Cheng Gang Li Department of Electronic and information Engineering Research institute for Smart Energy(RiSE) The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Energy Materials for Electric Power Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Physics The University of Hong KongHong Kong 999077China Centre for infrastructure Engineering Western Sydney UniversityPenrith 2751NSWAustralia

in recent years,inverted perovskite solar cells(iPSCs)have attracted significant attention due to their low-temperature and cost-effective fabrication processes,hysteresis-free properties,excellent stability,and wide *** efficiency gap between iPSCs and regular structures has shrunk to less than 1%.Over the past few years,iPSC research has mainly focused on optimizing power conversion efficiency to accelerate the development of *** review provides an overview of recent improvements in the efficiency of iPSCs,including interface engineering and novel film production techniques to overcome critical *** and integrated applications of iPSCs are also ***,prospects for further development of iPSCs are discussed,including the development of new materials,methods,and device structures for novel iPSCs to meet the requirements of commercialization.

关键词： inverted perovskite solar cells interface engineering Additive engineering Tandem solar cells integrated solar cells

On the Homology of the Dual de Rham Complex

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2022年第10期38卷 1666-1676页

作者： roman MiKHAiLOV Laboratory of Modern Algebra and Applications St.Petersburg State University14th Line29bSaint Petersburg199178Russia St.Petersburg Department of Steklou Mathematical institute Fontanka 27SaintPetersburg191023Russia

We study the homology of the dual de Rham complex as functors on the category of abelian *** give a description of homology of the dual de Rham complex up to degree 7 for free abelian groups and present a corrected ve... 详细信息

关键词： Dual de Rham complex polynomial functor divided powers derived functors