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Small renal masses in kidney transplantation:Overview of clinical impact and management in donors and recipients

Asian Journal of Urology 2022年第3期9卷 208-214页

作者： Alberto Piana Iulia Andras Pietro Diana Paolo Verri Andrea Gallioli Riccardo Campi Thomas Prudhomme Vital Hevia romain Boissier Alberto Breda Angelo Territo Department of Urology Fundacio PuigvertAutonoma University of BarcelonaSpain Department of Urology San Luigi Gonzaga HospitalUniversity of TurinOrbassanoTurinItaly Urology Department Iuliu Hatieganu University of Medicine and Pharmacy and Municipal HospitalCluj-NapocaRomania Unit of Urological Robotic Surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Department of Urology and Kidney Transplantation Toulouse University HospitalToulouseFrance Hospital Universitario Ramon y Cajal.Alcala University Instituto Ramon y Cajal de Investigacion Sanitaria(IRYCIS)MadridSpain Aix-Marseille universite service de chirurgie urologique et de transplantation renaleCHU ConceptionAP-HMMarseilleFrance

Kidney transplantation is the best replacement treatment for the end-stage renal ***,the imbalance between the number of patients on a transplant list and the number of organs available constitutes the crucial limitation of this *** expand the pool of organs amenable for transplantation,kidneys coming from older patients have been employed;however,the combination of these organs in conjunction with the chronic use of immunosuppressive therapy increases the risk of incidence of graft small renal *** narrative review aims to provide the state of the art on the clinical impact and management of incidentally diagnosed small renal tumors in either donors or *** to the most updated evidence,the use of grafts with a small renal mass,after bench table tumor excision,may be considered a safe option for high-risk patients in *** the other hand,an early small renal mass finding on periodic ultrasound-evaluation in the graft should allow to perform a conservative treatment in order to preserve renal ***,in case of a renal tumor in native kidney,a radical nephrectomy is usually recommended.

关键词： Small renal mass Renal cancer Kidney transplantation Nephron-sparing treatment

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Pilot Study on the Intercalibration of a Categorisation System for FAlRer Digital Objects Related to Sensitive Data in the Life Sciences

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Data Intelligence 2022年第2期4卷 196-211页

作者： Christian Ohmann romain David Monica Cano Abadia Florence Bietrix Jan-Willem Boiten Steve Canham Maria Luisa Chiusano Walter Dastru Arnaud Laroquette Dario Longo Michaela Theresia Mayrhofer Maria Panagiotopoulou Audrey Richard Pablo Emilio Verde European Clinical Research Infrastructure Network(ECRIN) Paris 75013France European Research Infrastructure on Highly Pathogenic Agents(ERINHA AISBL) Brussels 10ooBelgium Biobanking and Biomolecular Resources Research Infrastructure(BBMRI) Graz 8010Austria European Infrastructure for Translational Medicine(EATRIS) Amsterdam 1081 HZThe Netherlands European Advanced Translational Research Infrastructure(EATRIS)/Lygature Utrecht 3521 ALThe Netherlands European Marine Biological Resource Centre(EMBRC)Department of Agricultural Sciences University Federico Il of Naples via UniversitaNaples 80138Italy Department of Molecular Biotechnology and Health Sciences Molecular Imaging CenterUniversity of TorinoTorino I-10125Italy European Marine Biological Resource Centre(EMBRC) Paris 75252France European Research Infrastructure for Biological and Biomedical Imaging(Euro-Biolmaging) Torino 10126Italy European Research Infrastructure on Highly Pathogenic Agents(ERINHA AISBL) Brussels 1000Belgium Coordination Centre for Clinical Trials Heinrich Heine University Dusseldorf Ringgold standard institutionNordrhein-Westfalen 40225Germany

Sharing sensitive data is a specific challenge for research infrastructures in the field of life *** that reason a toolbox has been developed,providing resources for researchers who wish to share and use sensitive data,to support the workflows for handling these kinds of digital *** and community approved annotations are required to be compliant with FAIR principles(Findability,Accessibility,Interoperability,Reusability).The toolbox makes use of a tagging(categorisation)system,allowing consistent labelling and categorisation of digital objects,in terms relevant to data sharing tasks and activities.A pilot study was performed within the Horizon 2020 project EOSC-Life,in which 2 experts from 6 life sciences research infrastructures were recruited to independently assign tags to the same set of 10 to 25 resources related to sensitive data management and data sharing(in total 110).Summary statistics of agreement and observer variation per research infrastructure are *** pilot study has shown that experts were able to attribute tags but in most cases with a considerable observer variation between *** the context of CWFR(Canonical Workflow Frameworks for Research),this indicates the necessity for careful definition,evaluation and validation of parameters and processes related to workflow *** results from this pilot study were used to tackle this issue by revising the categorisation system and providing an updated version.

关键词： Sensitive data CWFR EOSC-Life Life sciences Toolbox Categorisation system Tagging FAIR

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bFGF诱导MEF生成的条件培养基对人胚胎干细胞生长的影响

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分子细胞生物学报 2009年第3期42卷 193-199页

作者：周轶平 ROCHAT Anne HATZFELD Antoinette PEIFFER Isabelle BARBET romain HATZFELD Jacques 李玛琳昆明医学院云南省天然药物药理重点实验室昆明650031 法国国家科学研究中心人干细胞研究室昆明医学院云南省高校生物医学工程研究中心昆明650031

为了探讨低浓度bFGF诱导小鼠胚胎成纤维细胞(MEF)生成的条件培养基对人胚胎干细胞(hESC)生长分化的影响,以系列浓度的bFGF作用于MEF上,收集条件培养基(bFGF-MCM),用于hES2细胞的无滋养层培养。以不添加bFGF而收集的MEF条件培养基(MCM)... 详细信息

为了探讨低浓度bFGF诱导小鼠胚胎成纤维细胞(MEF)生成的条件培养基对人胚胎干细胞(hESC)生长分化的影响,以系列浓度的bFGF作用于MEF上,收集条件培养基(bFGF-MCM),用于hES2细胞的无滋养层培养。以不添加bFGF而收集的MEF条件培养基(MCM)为阴性对照,同样浓度的bFGF添加于SR培养基(bFGF-SR)为空白对照。通过形态学特征和碱性磷酸酶染色法对hES2的生长分化状态进行评估。结果发现,培养一周内,未分化hES2克隆的比率,阴性对照为23%;空白对照组为13%-31%。当bFGF浓度为0.1,0.3,1,4ng/ml时,bFGF-MCM组未分化克隆的比率分别为44%,74%,77%和78%,与阴性和空白对照组相比,未分化克隆的比率均有不同程度提高,差异有统计学意义(P<0.01)。该结果揭示了经bFGF诱导的MEF细胞所产生的条件培养基具备了维持hES细胞正常生长而不分化的能力。对bFGF-MCM的深入分析,有望更好地了解hESC的生长与分化机制。

关键词：碱性成纤维细胞生长因子小鼠胚胎成纤维细胞人胚胎干细胞条件培养基分化抑制

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蓝胡子城堡的嗜血主人

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环球人文地理 2012年第23期 118-125页

作者：汪海 romain Kormin 不详

读过法国作家夏尔·佩罗作品《蓝胡子》的人,大都不会忘记故事中那个阴森的城堡和那间鲜血淋淋的密室。惊悚之余,不少人抱怨作者的描绘太过逼真,以至于阅读后在心理上留下阴影。事实上,这些令人恐怖的场景并非作者虚构,就连故事中那个... 详细信息

读过法国作家夏尔·佩罗作品《蓝胡子》的人,大都不会忘记故事中那个阴森的城堡和那间鲜血淋淋的密室。惊悚之余,不少人抱怨作者的描绘太过逼真,以至于阅读后在心理上留下阴影。事实上,这些令人恐怖的场景并非作者虚构,就连故事中那个凶狠残暴的男爵也确有其人——他曾追随圣女贞德在战场上杀敌无数,后半生却沉迷于炼金术,以荒淫放荡、虐杀儿童而臭名昭著……

关键词：蓝胡子圣女贞德

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摩天奇迹

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新发现 2016年第6期 88-97页

作者： romain Raffegoau 苏迪

王国塔将会成为人类第一座高于1000米的建筑。该如何建造这样的钢筋混凝土庞然大物？待在里面安全呢？摩天大厦的高度竞赛何日才会终结？

关键词：钢筋混凝土王国塔安全高度竞赛摩天大厦

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视觉化桌游

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新发现 2017年第3期 56-59页

作者： romain Raffegeau

“准备好接招了么？对你的暴食巨魔发动火球术!”加布里埃尔刚把他的卡牌放在游戏桌上，桌中央就出现了一头栩栩如生的飞龙，背生一对巨大的翅膀。只听它发出低沉的叫声，用后肢立起身，向对手喷出一发火球弹。那只手举大钉锤的巨魔应... 详细信息

“准备好接招了么？对你的暴食巨魔发动火球术!”加布里埃尔刚把他的卡牌放在游戏桌上，桌中央就出现了一头栩栩如生的飞龙，背生一对巨大的翅膀。只听它发出低沉的叫声，用后肢立起身，向对手喷出一发火球弹。那只手举大钉锤的巨魔应声倒地，直接K．O．出局。

关键词：视觉化人体知识游戏桌游戏

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Comparative Study of the Widal Test against Stool Culture in the Diagnosis of Suspected Cases of Typhoid Fever in Some Low Income Communities in the Adamawa Region of Cameroon

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Journal of Biosciences and Medicines 2024年第6期12卷 178-190页

作者： Mariane Lucie Ngueguim Bernard Viban Tangwa Victor Ngu Ngwa Jules romain Ngueguim Abdoulmoumini Mamoudou School of Veterinary Medicine and Sciences University of Ngaoundere Ngaoundere Cameroon Department of Veterinary Medicine University of Buea Buea Cameroon Institute de Recherhe Agricole pour le Development (IRAD) Ngaoundere Cameroun

Introduction: Infectious diseases constitute a major concern of public health in developing countries. Facilities and well trained staff have been shown to be one of the major obstacles in the rapid and quality diagnosis of these diseases. As such, we carried out an analysis to compare the Widal test and stool culture to identify febrile patients with Salmonella infection. Method: A cross sectional study was conducted to diagnose salmonella infection with out-patients who demonstrated signs of salmonella infection. Serum was harvested from blood collected from 368 (Vina = 234, Mayo Banyo 65, and Djerem = 69) patients accompanied by stool, Widal test was conducted on the spot and stool was taken to a reference laboratory for culture using standard microbiological methods, sociological set up was calculated in percentages, prevalence was calculated using excel while statistical difference was calculated using SPSS. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to compare the Widal test against stool culture. Results: A total of 368 (50.8% females and 49.2% males) participants took part in the survey. Salmonella prevalence (66.24%) in stool culture in the Vina division was significantly different (p 0.05). The sensitivity,specificity, PPV, and NPV of slide agglutination test against stool culture varied from different areas (Vina: 51.6%, 73.62%, 79.21% and 43.61%;Mayo Banyo: 60.53%, 77.78%, 79.31% and 58.33%;Djerem: 53.18%, 83.73% 73.91% and 67.39%) respectively. Slide agglutination test has a fair agreement with the stool culture (kappa, Vina = 0.202;Mayo Banyo = 0.37 and Djerem = 0.38). Conclusion: Generally, in the three areas of study, the Widal test had a fair correlation with the stool culture;This means the Widal test should not be used alone but in combination with stool culture in the detection of salmonella infections.

关键词： Salmonella Infections Stool Culture Widal Test Adamawa Region Cameroon

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作者：罗曼·罗兰( romain)

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PSP Based DCG-FGT Transistor Model Including Characterization Procedure on Dummy Cell

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Journal of Energy and Power Engineering 2012年第11期6卷 1878-1883页

作者： Abderrezak Marzaki Virginie Bidal romain Laffont Wencelas Rahajandraibe Jean-Michel Portal Rachid Bouchakour ST-Microelectronics Z de Rousset BP 2 Rousset Cedex F-13106 France Institut Matriaux et Microlectronique Nanoscience de Provence IMT Technop6le Chfiteau Gombert Marseille F-13451 France

A new DCG-FGT （dual-control-gate floating-gate transistor） transistor model for static and transient simulations is presented. The PSP MOS （metal-oxide-semiconductor） description is used as a basis for the formulation of the conduction channel behavior. The floating gate potential is implicitly computed with an added charge neutrality relation that ensures a good convergence. The model is running under electrical simulator （ELDO） and is characterized thanks to ICCAP （integrated circuit characterization and analysis program） software. It has been validated on an advanced STMicroelectronics technology. The final objective of this work is to provide an accurate and scalable model available in design framework. This device which is derived from a flash memory cell offers many possibilities for circuit design.

关键词：晶体管模型虚拟单元 PSP 程序表征 FGT 意法半导体闪速存储器

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新型短程硝化反硝化工艺处理高浓度氨氮废水

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中国给水排水 2013年第11期29卷 1-5页

作者：宫曼丽刘洋赵欣陈晓华 romain Lemaire Julien Chauzy 威立雅水务工程<北京>有限公司北京100004 天津大学环境科学与工程学院天津300072 威立雅技术与合作部

研发了一种新型短程硝化反硝化工艺——ANITATMShunt,它通过特殊的自控系统来控制N2O的释放。采用500 L的SBR中试装置处理消化污泥脱水上清液,经过18个月的稳定运行表明:通过短程硝化反硝化途径可以实现90%的脱氮率,并且释放的N2O不足... 详细信息

研发了一种新型短程硝化反硝化工艺——ANITATMShunt,它通过特殊的自控系统来控制N2O的释放。采用500 L的SBR中试装置处理消化污泥脱水上清液,经过18个月的稳定运行表明:通过短程硝化反硝化途径可以实现90%的脱氮率,并且释放的N2O不足总脱氮量的0.7%。将通过pH值、温度和在线监测的NO-2-N浓度实时计算的亚硝酸浓度与亚硝酸浓度设定值进行比对,以便对曝气过程进行调控,从而抑制了N2O的释放并实现了对SBR短程硝化反硝化工艺的自动控制。同时证实了在低溶解氧条件下,由氨氧化菌(AOB)在短程硝化反硝化过程中产生的N2O并非与高亚硝酸盐浓度有直接关系,而是与游离亚硝酸浓度有关。

关键词：生物脱氮短程硝化反硝化 SBR N2O释放游离亚硝酸

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