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Mitochondrial transport of catalytic RNAs and targeting of the organellar transcriptome in human cells

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Journal of Molecular Cell Biology 2023年第8期15卷 40-53页

作者： PawełGłodowicz Konrad Kuczynski romain Val AndréDietrich Katarzyna Rolle Department of Molecular Neurooncology Institute of Bioorganic ChemistryPolish Academy of Sciencesul.Z.Noskowskiego 12/1461-704 PoznanPoland institute of Plant Molecular Biology French National Center for Scientific Research(CNRS)and University of Strasbourg12 rue du Général Zimmer67084 StrasbourgFrance

Mutations in the small genome present in mitochondria often result in severe *** genetic strategies have been explored,aiming to rescue such mutations.A number of these strategies were based on the capacity of human mitochondria to import RNAs from the cytosol and designed to repress the replication of the mutated genomes or to provide the organelles with wild-type versions of mutant ***,the mutant RNAs present in mitochondria turned out to be an obstacle to therapy and little attention has been devoted so far to their ***,we present the development of a strategy to knockdown mitochondrial RNAs in human cells using the transfer RNA-like structure of Brome mosaic virus or Tobacco mosaic virus as a shuttle to drive trans-cleaving ribozymes into the organelles in human cell *** obtained a specific knockdown of the targeted mitochondrial ATP6 mRNA,followed by a deep drop in ATP6 protein and a functional impairment of the oxidative phosphorylation *** strategy provides a powerful approach to eliminate mutant organellar transcripts and to analyse the control and communication of the human organellar genetic system.

关键词： human cells mitochondria ribozyme RNA trafficking transcriptome manipulation tRNA-like structure

Nankai Trough Velocity Structure Reconstruction using FWi of Wide-angle OBS Data with Graph-space Optimal Transport Misfit Function

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 11-14页

作者： Andrzej GóRSZCZYK romain BROSSiER Ludovic MéTiViER iSTerre Université Grenoble AlpesGrenobleFrance institute of Geophysics Polish Academy of SciencesWarsawPoland Université Grenoble Alpes CNRSLJKGrenobleFrance

Technical development oriented on the detailed seismic imaging and velocity model building coupled with rapid increase of the computing power available nowadays make it possible to process large volumes of seismic dat... 详细信息

关键词： time-domain full-waveform inversion alternative misfit function high-resolution crustal-scale imaging

Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy

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World Journal of Gastroenterology 2017年第5期23卷 853-858页

作者： Gaetan-romain Joliat ismail Labgaa Nicolas Demartines Nermin Halkic Department of Visceral Surgery University Hospital CHUV1011 LausanneSwitzerland

AiM To identify a preoperative blood marker predictive of alveolar echinococcosis(AE) recurrence after *** All consecutive patients who underwent operation for liver AE at the Lausanne University Hospital(CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume(MCV), red blood cell distribution width(RDW), thrombocytes, C-reactive protein(CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic(ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrencefree survival curves were calculated using the KaplanMeier *** The cohort included 68 adult patients(37 females) with median age of 61 years [interquartile range(iQR): 46-71]. Eight of the patients(12%) presented a recurrence over a median follow-up time of 76 mo(iQR: 34-128). Median time to recurrence was 10 mo(iQR: 6-11). Median preoperative leukocyte, MCV, RDW,thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/L(iQR: 41-45) for nonrecurrent cases and 36 g/L(iQR: 33-42) for recurrent cases(P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840(95%Ci: 0.642-1, P = 0.002). The cutoff albumin level value was 37.5 g/L for sensitivity of 94.5% and specificity of 75%. in multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence(HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively).CONCLUSiON Low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up.

关键词： Liver surgery Alveolar echinococcosis Albumin Predictive marker Recurrence

Evidence for the effect of brief exposure to food,but not learning interference,on maze solving in desert ants

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integrative Zoology 2022年第5期17卷 704-714页

作者： Tomer GiLAD Arik DORFMAN Aziz SUBACH romain LiBBRECHT Susanne FOiTZiK inon SCHARF School of Zoology The George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael institute of Organismic and Molecular Evolution Johannes Gutenberg University MainzMainzGermany

Theories of forgetting highlight 2 active mechanisms through which animals forget prior knowledge by recipro-cal disruption of *** to“proactive interference,”information learned previously interferes with the acquisition of new information,whereas“retroactive interference”suggests that newly gathered information interferes with already existing *** goal was to examine the possible effect of both mechanisms in the desert ant Cataglyphis niger,which does not use pheromone recruitment,when learning spatial information while searching for food in a *** experiment indicated that neither proactive nor retroactive interference took place in this system although this awaits conﬁrmation with individual-level learning ***,the ants’persistence or readiness to search for food grew with successive runs in the *** persistence led to more ant workers arriving at the food when retested a day later,even if the maze was shifted between *** support thisﬁnding in a second experiment,where ant workers reached the food reward at the maze end in higher numbers after encountering food in the maze entry compared to a treatment,in which food was present only at the maze *** result suggests that spatial learning and search persistence are 2 parallel behavioral mechanisms,both assisting foraging *** suggest that their relative contribution should depend on habitat complexity.

关键词： binary-tree maze desert ants forgetting memory motivation

Mating behavior of Psammotettix alienus （Hemiptera： Cicadellidae）

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insect Science 2018年第1期25卷 148-160页

作者： Maja Derlink isabelle Abt romain Mabon Charlotte Julian Meta Virant-Doberleti Emmanuel Jacquot Department of Organisms and Ecosystems Research National Institute of Biology Vecna pot 111 1000 Ljubljana Slovenia iNRA- Cirad-Montpellier SupAgro UMR 385 BGPI Cirad TA A-54K 34398 Montpellier France Bayer CropScience 16 rue Jean Marie Leclair - CS 90106 69266 Lyon Cedex 09 France

The Wheat dwarf virus, the causal agent of the wheat dwarf disease, is trans- mitted by leafhoppers from the genus Psammotettix and currently the main protection strategy is based on the use of insecticide treatments. Sustainable management strategies for insect vectors should include methods that are targeted to disrupt reproductive behavior and here we investigated the mating behavior of Psammotettix alineus （Dahlbom 1850） in order to determine the role of vibrational signals in intra-specific communication and pair formation. Both genders spontaneously emit species- and sex-specific calling songs that consisted of regularly repeated pulse trains and differ primarily in pulse train duration and pulse repetition time. Females preferred the conspecific male calling song. After a coordinated exchange of pulse trains, the male approached the stationary female. During the close range courtship and also immediately prior to copulatory attempts distinct male vibrational signals associated with wing flapping and wing vibrations were recorded from the substrate. in the presence of a receptive female, competing males emitted vibrational signals most likely aimed to interfere with male-female interaction. Mated females re- gained sexual receptivity after they laid eggs. Although results suggest that the viruliferous status of insects may have an effect on vibrational songs, our current results did not reveal a significant effect of virus on leafhopper performance in mating behavior. However, this study also suggests, that detailed understanding ofplant-vecto^virus interactions relevant for vector mating behavior is essential for trying new approaches in developing future control practices against plant viruses transmitted by insect vectors.

关键词： mating behavior Psammotettix alienus vibrational communication wheat dwarf virus

in silico screening for As/Se-free ovonic threshold switching materials

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npj Computational Materials 2023年第1期9卷 1359-1366页

作者： Sergiu Clima Daisuke Matsubayashi Taras Ravsher Daniele Garbin romain Delhougne Gouri Sankar Kar Geoffrey Pourtois imec Kapeldreef 75B-3001 LeuvenBelgium Device Technology Research&Development Center Future Memory Development DepartmentKIOXIA CorporationShin-sugita-cho 8Isogo-kuYokohamaJapan KU Leuven Celestijnenlaan 200DB-3001 LeuvenBelgium

Restricted use of hazardous environmental chemicals is one important challenge that the semiconductor industry needs to face to improve its *** threshold switching(OTS)ternary compound materials used in memory selector devices contain As and *** these elements out of these materials requires significant research *** facilitate this process,we performed systematic material screening for As/Se-free ternary materials,based on ab-initio *** limit the large amount of possible chemical compositions to fewer promising candidates,we used physics-based material parameter filters like material stability,electronic properties,or change in *** OTS gauge concept is introduced as a computed parameter to estimate the probability of a material to show an OTS *** a result,we identified 35 As/Se-free ternary alloy compositions for stand-alone OTS memory applications,as well as 12 compositions for RRAM selector *** work aims seeding the development of As/Se-free OTS materials.

关键词： alloy ternary free

Capturing Near-Equilibrium Solutions: A Comparison between High-Order Discontinuous Galerkin Methods and Well-Balanced Schemes

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Communications in Computational Physics 2019年第6期26卷 1-34页

作者： Maria Han Veiga David A.Velasco-Romero Remi Abgrall romain Teyssier institute of Computational Science University of ZurichSwitzerland institute of Mathematics University of ZurichSwitzerland Universidad Autonoma del Estado de Morelos Mexico instituto de Ciencias Fisicas Universidad Nacional Aut́onoma de ḾexicoMexico

Equilibrium or stationary solutions usually proceed through the exact balance between hyperbolic transport terms and source terms. Such equilibrium solutions are affected by truncation errors that prevent any classical numerical scheme from capturing the evolution of small amplitude waves of physical significance. in order to overcome this problem, we compare two commonly adopted strategies: going to very high order and reduce drastically the truncation errors on the equilibrium solution, or design a specific scheme that preserves by construction the equilibrium exactly, the so-called well-balanced approach. We present a modern numerical implementation of these two strategies and compare them in details, using hydrostatic but also dynamical equilibrium solutions of several simple test cases. Finally, we apply our methodology to the simulation of a protoplanetary disc in centrifugal equilibrium around its star and model its interaction with an embedded planet, illustrating in a realistic application the strength of both methods.

关键词： Numerical methods benchmark well-balanced methods discontinuous Galerkin methods

indocyanine green fluoroscopy and liver transplantation:a new technique for the intraoperative assessment of bile duct vascularization

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Hepatobiliary & Pancreatic Diseases international 2017年第4期16卷 440-442页

作者： Laurent Coubeau Julie Frezin romain Dehon Jan Lerut Raymond Reding Starzl Unit Abdominal Transplantation Department of Abdominal and Transplantation SurgeryCliniques Universitaires Saint LucUniversitécatholique Louvain(UCL)BrusselsBelgium Pathology Unit Cliniques Universitaires Saint LucUniversitécatholique Louvain(UCL)BrusselsBelgium

To the Editor:Biliary tract complications remain the Achilles’heel of liver transplantation（LT）;and the transplant commu nity is exploring ways of tackling this problem.A well vascularized bile duct is a prerequisi... 详细信息

关键词： iCG by is it from of for

Low-k integration: Gas screening for cryogenic etching and plasma damage mitigation

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 511-516页

作者： romain Chanson Remi Dussart Thomas Tillocher P. Lefaucheux Christian Dussarrat Jean Francois de M arneffe iMEC v.z.w. 3001 LeuvenBelgium GREMi/University of Orleans OrleansFrance Air Liquide Laboratories TsukubaJapan

The integration of porous organo-silicate low-k materials has met a lot of technical *** of the main issues is plasma-induced damage,occurring for all plasma steps involved during interconnects *** the present paper,we focus on porous SiOCH low-k damage mitigation using cryogenic temperature so as to enable micro-capillary *** aim is to protect the porous low-k from plasma-induced damage and keep the k-value of the material unchanged,in order to limit the RC delay of interconnexion levels while shrinking the microchip *** cryogenic temperature is used to condense a gas inside the porous low-k ***,the etching process is performed at the temperature of condensation in order to keep the condensate trapped inside the material during the *** the first part of this work,the condensation properties of several gases are screened,leading to a down selection of five ***,their stability into the porous structure is evaluated at different *** of them are used for plasma damage mitigation *** mitigation is effective and shows negligible damage for one of the gases at-50℃.

关键词： low-A nanotechnology micro-electronics cryo-etching plasma processing