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Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

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Asian Journal of Andrology 2012年第4期14卷 584-590页

作者： Cendrine Geoffroy-Siraudin Anderson Dieudone Loundou Fanny romain Vincent Achard Blandine Courbibre Marie-He1ene Perrard Philippe Durand Marie-Roberte Guichaoua Reproduction Biology Laboratory Conception Hospital AP-HM Marseille 13005 France Aix-Marseille University UMR CNRS IMBE 7263 Faculty of medicine of Marseille Marseille 13005 France Department of medical information Conception Hospital AP-HM Marseille 147 Bd Baille Marseille 13005 France Health Laboratory Faculty of Medicine of Marseille Marseille 13005 France Centre of Assisted Reproductive Technique (CPMA) Conception Hospital AP-HM Marseille 13005 France Functional Genomic Institute of Lyon CNRS INRA ENS of Lyon Lyon 69007 France

Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille （France） between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration （〉~ 40 million per ejaculate）. The whole population demonstrated declining trends in sperm concentration （1.5% per year）, total sperm count （1.6% per year）, total motility （0.4% per year）, rapid motility （5.5% per year） and normal morphology （2.2% per year）. In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the auality of semen decreased in this population over the study period.

关键词： environment male infertility regional differences semen quality sperm parameters

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面向环境辅助生活的动态即插即用服务

面向环境辅助生活的动态即插即用服务

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作者： romain Endelin 哈尔滨工业大学

学位级别：硕士

在新加坡，正如世界上其他许多国家，人口年纪越来越大。这种演变在我们的社会中产生了重大变化。在这些变化中，我们观察到越来越多的人有轻度痴呆，不能完全独立。这些人需要照顾者，来帮助他们解决麻烦，向他们提供基本的服务。然而... 详细信息

在新加坡，正如世界上其他许多国家，人口年纪越来越大。这种演变在我们的社会中产生了重大变化。在这些变化中，我们观察到越来越多的人有轻度痴呆，不能完全独立。这些人需要照顾者，来帮助他们解决麻烦，向他们提供基本的服务。然而，照顾者的数量不是无限的，甚至只要可能，老年人宁愿住在自己的房子，而不是去养老院。一个解决办法是提供一个环境来辅助他们的日常生活。同时，技术的发展使得笔记本电脑和台式机的简单分类不再明确。电脑越来越普遍。这意味着随着互联网与无线通信的快速发展，计算机系统不再局限于一台机器。我们看到越来越多的传感器集成到我们的环境中。输出设备，电视，平板电脑，智能手机，话筒逐渐取代单一的屏幕。现在计算机系统集成到我们的环境中，通信方式趋向于机器到机器，终端是用户的方式，而不是人到机器的方式。普适计算是一个真正的机会。它成为一个通过环境辅助生活以帮助轻度痴呆的老年人的可靠的解决方案。IPAL实验室对于进行环境辅助生活的研究，以进一步大规模部署来提供无缝的稳定的解决方案。由于每座房子都是不同的，每个人都有不同的生活习惯，不可能到处部署一个硬代码的解决方案。研究的目的是要找到替代方案，以确保合理地安装和执行上的可扩展性。在此背景下，本文档介绍的过程的贡献是重新设计和实现一个稳定的可扩展的架构。第一个目标是提供一个概念的证明，将动态传感器管理合并到一个推理平台上。一旦完成这个概念证明，就有必要利用IPAL团队在过去几年间获得的经验重新设计整个架构。当前，原型平台与推理系统已经完成并进行了测试。但是，测试结果显示推理结果并不稳定，且实现的效率不佳。我们认为，主要的原因不在于如何使程序运行起来，而是提高系统的扩展性与可靠性。环境辅助生活是计算机的一个新兴的应用领域。为了提供可靠的环境辅助生活，三个主要的特色需要被重点关注：架构的成熟度，推理的可靠性以及通信协议的标准化。

关键词：环境辅助生活 Web语义面向服务的架构物联网普适计算

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Shooting Hong Kong's Unique Vertical Cityscape

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城市漫步（上海版、英文） 2017年第9期 12-14页

作者： Dominic Ngai romain Jacquet-Lagreze 不详

Located within the'humid cub-tropical'*** Kong's cummers are perfectly defined by its climate classification-long,hot and sticky,with frequent appearances by thunderstorms,showers and *** its heat level is the way that the city was planned and developed over the last *** skyscrapers shoot off into the sky across its central areas-mainly along the iconic coastline of Victoria Harbour on Hong Kong Island and in Kowloon,as well as in pockets of the New Territories unaffected by its hilly and mountainous terrain.

关键词： Vertical hilly mountainous

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Audio Search for Spoken Documents Content-Based Retrieval

Audio Search for Spoken Documents Content-Based Retrieval

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第八届全国人机语音通讯学术会议

作者： romain Le Tellier Signal and Image Processing department GET-ENST ParisFrance

The amount of digital audio and video documents being shot and stored in large archives is growing faster than ever before. However, lack of effective content searching methods is a major barrier that prevents people from operating audio and video databases pervasively and intelligently. This paper reviews the state-of-the-art in audio information retrieval and presents an audio searching solution that uses statistical pattern matching techniques. The two-tier speech retrieval solution proposed in this paper, named Audio Search, is composed of a fast searching component followed by an ends-free Viterbi keyword spotter combined with a histogram-based phoneme duration model. Its performances have been evaluated on the 1997 HUB4 database for Chinese broadcast news. In comparison with the results of large vocabulary automatic speech recognition based systems, the results we obtained with the Audio Search system show significant improvements for both long queries (typically 5 to 7 syllables) and out-of-vocabulary (OOV) queries.

关键词： ASR Ends-free Viterbi algorithm

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名人传

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2017年

作者： (法) 罗曼·罗兰

来源：南通市图书馆图书评论

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基于多光混频的方法产生平坦毫米波噪声

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中国激光 2022年第7期49卷 163-170页

作者：陈永祥刘文杰孙粤辉 romain Zinsou 王云才广东工业大学信息工程学院广东省信息光子技术重点实验室广东广州510006

提出了一种基于多光混频产生平坦毫米波噪声的方法。通过宽带放大自发辐射(ASE)光源,滤出多个具有不同中心波长的高斯型噪声光谱,利用宽带光电探测器,对多个具有不同中心波长的噪声光谱进行了混频以产生平坦毫米波噪声。仿真结果表明,... 详细信息

提出了一种基于多光混频产生平坦毫米波噪声的方法。通过宽带放大自发辐射(ASE)光源,滤出多个具有不同中心波长的高斯型噪声光谱,利用宽带光电探测器,对多个具有不同中心波长的噪声光谱进行了混频以产生平坦毫米波噪声。仿真结果表明,所提方案能够在大频率范围内产生平坦的毫米波噪声,如F波段(90~140 GHz)和G波段(140~220 GHz)。为了定量地比较毫米波噪声的质量,定义了相对平坦度为某个频率范围内产生噪声功率的起伏与其平均功率之比。实验结果表明,产生的毫米波噪声的相对平坦度低至0.46[@(35±15)GHz]。

关键词：光学仪器平坦度毫米波噪声多光混频光电转换

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Effect of alcohol consumption on liver stiffness measured by transient elastography

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World Journal of Gastroenterology 2013年第4期19卷 516-522页

作者： Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader romain Moirand Hepatology and Addictology Department University Hospital PontchaillouF35000 RennesFrance Institut National de la Santé et de la Recherche Médicale U991 Institut Fédératif de Recherche 140University of Rennes 1F35000 RennesFrance

AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or ***:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver *** was performed at least one week apart by senior *** examinations with less than ten successful measures or with an interquartile range above 30% were *** retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was *** biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were *** fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis *** and final putative fibrosis score were compared according to alcohol consumption during ***:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two ***-seven patients met our criteria with a median follow-up of 32.5 *** the end of the study,13(35%) were abstinent,and 24(65%) *** patients had liver biopsy during *** decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off *** relapsers TE increased in 45% and decreased in 54% of *** was no statistical difference between initial and final TE in *** the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final ***

关键词： Alcohol Transient elastography Cirrhosis Fibrosis Liver biopsy Liver stiffness

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Neonatal sepsis: within and beyond China

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Chinese Medical Journal 2020年第18期133卷 2219-2228页

作者： Ying Dong romain Basmaci Luigi Titomanlio Bo Sun Jean-Christophe Mercier Department of Neonatology Children’s Hospital of Fudan UniversityShanghai 201102China Universitéde Paris IAMEINSERM75018 ParisFrance Service de Pédiatrie-Urgences AP-HPHôpital Louis-Mourier92700 ColombesFrance Pediatric Emergency Department Robert Debre University Hospital75019 ParisFrance Departments of Pediatrics and Neonatology Children’s Hospital of Fudan UniversityShanghai 201102China Medical University of Paris 75018 ParisFrance

Sepsis remains a significant cause of neonatal morbidity and mortality in China.A better understanding of neonatal sepsis in China as compared with other industrialized and non-industrialized countries may help optimize neonatal health care both regionally and *** cited in this review was retrieved from PubMed using the keywords"neonatal sepsis,""early-onset(EOS)"and"late-onset(LOS)"in English,with the focus set on population-based *** review provides an updated summary regarding the epidemiology,pathogen profile,infectious work-up,and empirical treatment of neonatal sepsis within and beyond *** incidence of neonatal EOS and the proportion of Group B Streptococcus(GBS)within pathogens causing EOS in China seem to differ from those in developed countries,possibly due to different population characteristics and intrapartum/postnatal health care *** to adopt GBS screening and intrapartum antibiotic prophylaxis in China remains highly *** pathogen profile of LOS in China was shown to be similar to other ***,viruses as potential pathogens of neonatal LOS have been *** antimicrobial resistance in China reflects limitations in adapting antibiotic regimen to local microbial profile and timely cessation of treatment in non-proven bacterial *** review stresses that the local epidemiology of neonatal sepsis should be closely monitored in each institution.A prompt and adequate infectious work-up is critically important in diagnosing neonatal *** and appropriate antibiotic strategies must be overemphasized to prevent the emergence of multi-resistant bacteria in China.

关键词： Antibiotic resistance Blood culture Early-onset sepsis Late-onset sepsis Neonatal sepsis Nosocomial neonatal sepsis

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SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging

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World Journal of Gastroenterology 2017年第2期23卷 216-223页

作者： Rachel Marion-Letellier Pierre Bohn romain Modzelewski Pierre Vera Moutaz Aziz Charlène Guérin Guillaume Savoye Céline Savoye-Collet INSERM Unit UMR1073 Rouen University and Rouen University Hospital QUANTIF LITIS EA 4108 Rouen University and Rouen University Hospital Service d’Anatomo-pathologie Rouen University Hospital Gastroenterology department Rouen University Hospital Radiology department Rouen University Hospital

AIMTo assess the feasibility of SPECT-computed tomography (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory *** was induced in Sprague-Dawley rats by intrarectal injection of TNBS (n = 10) while controls received vehicle (n = 10). SPECT-CT with intravenous injection of 10 MBq of 67Ga-Citrate was performed at day 2. SPECT-CT criteria were colon wall thickness and maximal wall signal intensity. Laboratory parameters were assessed: colon weight:length ratio, colon cyclooxygenase-2 expression by western blot and histological inflammatory *** weight/length ratio, colon COX-2 expression and histological inflammatory score were significantly higher in the TNBS group than in the control group (P = 0.0296, P < 0.0001, P = 0.0007 respectively). Pixel max tend to be higher in the TNBS group than in the control group but did not reach statistical significance (P = 0.0662). Maximal thickness is significantly increased in the TNBS group compared to the control group (P = 0.0016) while colon diameter is not (P = 0.1904). Maximal thickness and colon diameter were correlated to colon COX-2 expression (P = 0.0093, P = 0.009 respectively) while pixel max was not (P = 0.22). Maximal thickness was significantly increased when inflammation was histologically observed (P = 0.0043) while pixel max and colon diameter did not (P = 0.2452, P = 0.3541, respectively).CONCLUSIONSPECT-CT is feasible and easily distinguished control from colitic rats.

关键词： Crohn’ s disease Colitis Colitis imaging Cyclooxygenase-2 SPECT-computed tomography

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汝拉葡萄酒在中国的市场研究

汝拉葡萄酒在中国的市场研究

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作者： romain Angevelle（罗曼）华东理工大学

学位级别：硕士

本论文的研究目的在于评估法国汝拉地区葡萄酒的生产现状,及在尊重当前中国进出口的实际操作流程的同时,该地区葡萄酒生产者如何将其产品出口至中国的可能性。目前,葡萄酒生产者在其所在地占有较高的市场份额,拥有其所处领域卓越的专业... 详细信息

本论文的研究目的在于评估法国汝拉地区葡萄酒的生产现状,及在尊重当前中国进出口的实际操作流程的同时,该地区葡萄酒生产者如何将其产品出口至中国的可能性。目前,葡萄酒生产者在其所在地占有较高的市场份额,拥有其所处领域卓越的专业知识,良好的财务状况和出口至各国的有利条件。由此可见,他们已具备将其葡萄酒业务扩展至中国的理想前提。在初步定义产品可出口后,本文将确定目标市场选定的关键因素。鉴于当前欧洲和世界其它国家葡萄酒业的现状,世界上大多数葡萄酒生产者及汝拉葡萄酒的生产者都已决定将其产品的一部分出口至中国市场。事实上,中国市场的确具备诸多吸引葡萄酒生产者的优势。中国葡萄酒消费和进口量的逐年递增,种类繁多的法国葡萄酒在中国市场成功进驻的先例,都充分显示出汝拉葡萄酒具备在中国成功的潜力。同时,中国人也越来越希望能够不仅了解葡萄酒本身,而且了解其富含的文化底蕴。此外,中国大城市的西化进程也促进了葡萄酒消费的大众化。为了提高在中国市场的占有率和减少实施困难,本文分析和了解中国市场特征是十分必要的。须针对中国现状,瞄准其潜在的庞大消费群制定相应的销售及市场策略,最终实现向大型连锁超市或小型葡萄酒商,甚至餐厅或酒店直接销售的目标。明确在进口环节和分销渠道上的职能分配同样也是扩展中国市场根本因素。找到良好的合作伙伴及如何找到他们是一个公司在中国开展业务面临的主要挑战之一。除此之外,一项重要的任务即是分析出口产品至中国市场所涉及物流的不同环节(海关、运输、物流、保险、食品标准和包装)。

关键词： Market Study Jura's Wines China

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