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Antitumor efficacy of anti-CTLA4 antibody is dependant on gut microbiota.

2020年

作者： (法)罗曼·罗兰(romain Rolland)

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Antitumor efficacy of anti-CTLA4 antibody is dependant on gu...

Determination of Lethal Concentrations Using an R Software Function Integrating the Abbott Correction

第十届全国免疫学学术大会

作者： Marie Vetizou Jonathan M. Pitt romain Daillère Laurence Zitvogel Gustave Roussy Cancer Campus INSERM U1015

The cytotoxic T lymphocyte antigen-4(CTLA-4)-blocking antibody ipilimumab is an FDA and EMEA-approved treatment for metastatic melanoma,which induces immune-mediated long-term control in 15%of ***,ipilimumab also results in substantial immune related side effects including grade III-IV *** uncouple efficacy and toxicity we analyzed the mode of action of anti-CTLA4 therapy in preclinical mouse ***,the gut microbiota was

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Journal of Agricultural Science and Technology(A) 2017年第1期7卷 25-30页

作者： Merveille Koissi Savi Essomanda Tchandao Mangamana Jean Marcel Deguenon Castro Gbememali Hounmenou romain Glele Kakai Laboratoire de Biomathematiques et d'Estimations Forestieres Faculty of Agronomic Sciences University of Abomey-Calavi 04BP 1525 Cotonou Benin Department of Entomology and Plant Pathology North Carolina State University Campus Box 7616 Raleigh USA

Several thousands of chemical substances are registered every year for different purposes, and sometimes many of them are claimed to play the same role. To establish and compare their toxicities, the determination of the lethal concentrations is usually necessary and should account for natural mortality. However, many of the statistical software packages used for that purpose do not readily integrate control mortality or adjust the best link function to the data during the process. This manuscript proposes an ＂lc＂ function in the R open source that aims at the effective determination of lethal concentrations. Furthermore, it performs the procedure with the appropriate link function. The ＂lc＂ application on the example provided revealed that the complementary log link function is adequate.

关键词： Toxicity lethal concentration Abbott correction binomial family links generalized linear models pesticides.

Calibration and Validation of the GR2M Hydrologic Model in the Kouilou-Niari Basin in Southwestern Congo-Brazzaville

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Open Journal of Modern Hydrology 2022年第3期12卷 109-124页

作者： Christian Ngoma Mvoundou Christian Tathy Harmel Obami-Ondon Guy Blanchard Matété Moukoko Richard romain Niere Laboratory of Mechanics Energy and Engineering Higher National Polytechnic School Marien Ngouabi University Brazzaville Congo Laboratory of Mechanics Energy and Engineering Higher National Polytechnic School Marien Ngouabi University Brazza-ville Congo Department of Exact Sciences Higher Teacher’s Training School Marien Ngouabi University Brazzaville Congo

The hydrologic simulation of a catchment area, described as the transformation of rainfall into runoff, generally uses hydrologic model. This work opts for the global conceptual hydrologic model GR2M, a monthly time step model, to study the Kouilou-Niari basin, the second most important ones of the Republic of Congo. This includes two parameters to model the hydrologic behavior of a catchment area. The choice of the conceptual model GR2M is justified by the reduced number of parameters and the monthly time scale. The objective of this study is to determine the characteristic parameters of the GR2M model, by a calibrating and a validating procedure. The use of these parameters enables to follow the evolution of the water resources from the climatic variables. It has been first carried out a characterization of some physical, geological and climatic factors governing the flow, by dealing with the main climatic variables which constitute the inputs of the hydrologic model. Then, a hydrologic rainfall-runoff modeling allows to calibrate and validate the model at monthly time scale. Taking into account the number of parameters involved in hydrologic processes and the complexity of the cathment area, this model gives acceptable results throughout the Kouilou-Niari basin. The values of the Nash-Sutcliffe criterion and those of the correlation coefficient obtained are greater than 80% in validation, which explains the performance and robustness of the GR2M model on this basin.

关键词： Kouilou-Niari Catchment Area Rainfall-Runoff Modeling GR2M Model Nash-Sutcliffe Criterion Calibration Phase Validation Phase

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细菌电池

新发现 2021年第4期 72-74页

作者： romain Raffegeau 葛皓(编译) 不详

细菌可以发电!虽然目前细菌电池应用场景极其有限,但研究人员希望,这一生物能源能很快走出实验室,全面运用于现实生活。生物会发电并不是什么新鲜事。大家都知道某些动物,如电鳗,一次可以释放几百伏特的电。如今,科学家能将某些发电生... 详细信息

细菌可以发电!虽然目前细菌电池应用场景极其有限,但研究人员希望,这一生物能源能很快走出实验室,全面运用于现实生活。生物会发电并不是什么新鲜事。大家都知道某些动物,如电鳗,一次可以释放几百伏特的电。如今,科学家能将某些发电生物放进电池里来生产电流。

关键词：生物能源应用场景实验室现实生活发电电池电流科学家

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勒索软件的威胁

新发现 2021年第10期 84-88页

作者： romain Raffegeau 竹叶(编译) 不详

恶意软件通过挟持并控制计算机来勒索赎金。一次针对医院或配电站等公共服务场所的网络攻击可能将整个社会置于险境。上午10点,刚刚结束第堂课的物理学教授德路易(Deslouis)一走出教室就收到了部门主任发来的邮件:“你能否尽快在学校网... 详细信息

恶意软件通过挟持并控制计算机来勒索赎金。一次针对医院或配电站等公共服务场所的网络攻击可能将整个社会置于险境。上午10点,刚刚结束第堂课的物理学教授德路易(Deslouis)一走出教室就收到了部门主任发来的邮件:“你能否尽快在学校网站上录入学生的成绩?我们准备今晚统计该学期的成绩单。这是网站链接。”

关键词：恶意软件网络攻击网站链接勒索软件物理学教授配电站成绩单计算机

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失败的“瓦萨”号

新发现 2021年第7期 86-89页

作者： romain Raffegeau 葛皓(编译) 不详

1628年8月10日,瑞典海军最强战舰“瓦萨”号(Vasa)起航了。它即将离开皇宫边的码头,前往斯德哥尔摩港列队接受人们欢送。整艘战舰令人叹为观止:这是瑞典历史上第一艘双层炮舰,底舱之上有两层炮甲板,装载有48门重炮!

关键词：斯德哥尔摩瓦萨令人

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约翰·克利斯朵夫

约翰·克利斯朵夫

作者： (法)罗曼·罗兰(romain Rolland)

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在肝脏病理学研究中的蛋白质组学（下）

传染病网络动态 2005年第9期 39-41页

作者： romain Parent 杨月（编译）

1．3肝炎的病毒性感染世界范围约有4亿人感染HBV，1．7亿人感染了HCV。利用蛋白质组学技术来探讨这两种病毒致病机理的研究很少。通过比较HBV阴性和HBV阳性的血清标本，He等报告了7种蛋白质的变化，不仅表现在数量上而且表现在类型上... 详细信息

1．3肝炎的病毒性感染世界范围约有4亿人感染HBV，1．7亿人感染了HCV。利用蛋白质组学技术来探讨这两种病毒致病机理的研究很少。通过比较HBV阴性和HBV阳性的血清标本，He等报告了7种蛋白质的变化，不仅表现在数量上而且表现在类型上，且与坏死性炎症反应的计分有关。本小组采用2D凝胶电泳和MS来识别亚细胞区域的蛋白质含量，

关键词：蛋白质组学技术病理学研究病毒性感染 HBV阳性肝脏 HBV阴性蛋白质含量世界范围致病机理

Hydrophilic solvent recovery from switched‐on microdroplet dissolution

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Droplet 2023年第4期2卷 91-102页

作者： romain Billet Binglin Zeng Hongyan Wu James Lockhart Mike Gattrell Hongying Zhao Xuehua Zhang Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaCanada BC Research Inc. RichmondBritish ColumbiaCanada

Switchable hydrophilicity solvents(SHSs)are a unique class of chemical compounds that can be switched between their hydrophobic and hydrophilic *** switchable characteristics allow SHSs to be used as emerging,green solvents for sustainable extraction and separation *** the production of polymeric microparticles from recycled plastics,SHSs are used to dissolve the polymer and then are switched to the hydrophilic form for separation from the generated polymeric ***,it is extremely difficult to fully recover the SHS residue from the *** this work,we will identify the key parameters that determine the level of the solvent residue during the switched‐on dissolution of emulsion *** SHS N,N‐dimethylcyclohexylamine from solvent–polymer binary emulsion droplets was switched to the hydrophilic,water‐soluble form,triggered by addition of an acid in the surrounding aqueous *** applying a sensitive detection method developed in this work,we compared the levels of SHS residue in polymer microparticles obtained under 30 different dynamical and chemical conditions for the switching *** quantitative analysis revealed that residue levels remained constant at varied addition rates and concentration of the trigger solution,but decreased with the increase in organic phase fractions or the decrease in the emulsion *** water in the drops during switched‐on dissolution may have contributed to the high level of solvent *** understanding of the new possible mechanism for residual solvent reported in this work may help develop effective approaches for the recovery of switchable solvents in environmentally friendly separation processes.

关键词： switched residue separation