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Role of IL-10 and tGF-β1 in local immunosuppression in HPV-associated cervical neoplasia

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World Journal of Clinical Oncology 2014年第4期5卷 753-763页

作者： Kirvis torres-Poveda Margarita Bahena-román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina Chronic Infection and Cancer Division Research Center on Infectious Diseases Instituto Nacional de Salud Pública 62100 Cuernavaca Morelos Mexico

Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(tGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. the effects of immunosuppressive cytokines on innate immune response, t-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and tGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. this review provides a comprehensive picture of the immunological functions of IL-10 and tGF-β1 in response to HPV in humans.

关键词： Cervical cancer Immunosuppression Interleukin-10 transforming growth factor-β1 Human Papillomavirus

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60个新观点带你另眼看世界

新发现 2020年第9期 24-66页

作者： Marie Atteia Kheira Bettayeb Coline Buanic thomas Cavaillé-Fol Anne Debroise Olivier Donnars Stéphane Fay Lise Gougis Coralie Hancok román Ikonicoff Hugo Leroux Vincent Nouyrigat Alexandra Pihen Benoît Rey Yves Sciama Jean Baptiste Veyrieras 王隽(编译) 缪伶超(编译) 不详

它们中既有仍处于研究阶段的假设,也有尚未察觉的关联,还有已存在事实支撑但还未进行论证的主张……毕竟从灵光一现到范式形成的过程非常漫长;观点的建立与科研工作的开花结果都需要时间。植物会说话吗?雨水会引发火山喷发吗?

关键词：火山喷发科研工作另眼看开花结果观点

Fundamentals of applied electromagnetics 6

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2010年

作者： Ulaby Fawwaz t. (Fawwaz tayssir) 1943-

xii, 498 p. : ill. (chiefly col.) ; 25 cm. + 1 CD-rom (4 3/4 in.)

ISBN: (纸本)9780132139311

xii, 498 p. : ill. (chiefly col.) ; 25 cm. + 1 CD-rom (4 3/4 in.)

关键词： Electromagnetism. Electromagnetism Industrial applications.

tEStS ON StRUCtURALLY DEFICIENt RC SLABS StRENGtHENED WItH FIBRE REINFORCED POLYMER (FRP) COMPOSItES

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工业建筑 2004年第Z1期34卷 -页

作者： S.t. Smith Centre for Built Infrastructure Research Faculty of Engineering University of technology Sydney PO Box 123 Broadway NSW 2007 Australia

［1］Arduini, M., Nanni, A. and romagnolo, M. (2004) "Performance of one-way reinforced concrete slabs with externally bonded fiber-reinforced polymer strengthening", ACI Structural Journal, Vol.101, No. 2, pp. 193-201.［2］AS 1012 Methods of testing Concrete, Standards Australia, Sydney, Australia.［3］AS1391 (1991)Methods for tensile testing of Metals, Standards Australia, Sydney, Australia.［4］AS3600 (2001) Concrete Structures, Standards Australia, Sydney, Australia.［5］AS/NZS4671 (2001) Steel Reinforcing Materials, Standards Australia, Sydney, Australia.［6］Lam, L. and teng, J.G. (2001) “Strength of RC cantilever slabs bonded with GFRP strips”,Journal of Composites for Construction, ASCE, Vol. 5, No. 4, pp. 221-227.［7］Seim, W., Horman, M. Karbhari, V. and Seible, F. (2001) “External FRP poststrengthening of scaled concrete slabs”, Journal of Composites for Construction, ASCE, Vol. 5, No. 2, pp. 67-75.［8］Smith, S.t. and Gilbert, R.I. (2003) “tests on RC slabs reinforced with 500 MPa welded wire fabric”, Proceedings (CD-rom), Concrete in the 3rd Millennium, CIA 2003, 21st Biennial Conference, Concrete Institute of Australia (CIA), Brisbane, Australia, 17-19 July.［9］teng, J.G., Lam, L, Chan, W. and Wang, J. (2000) “Retrofitting of deficient RC cantilever slabs using GFRP strips”, Journal of Composites for Construction, ASCE, Vol. 4, No. 2, pp. 75-84.［10］teng, J.G., Chen, J.F., Smith, S.t. and Lam, L. (2002) FRP-Strengthened RC Structures, John Wiley & Sons, Chichester, West Sussex, U.K., 245 pp.［11］teng, J.G., Smith, S.t., Yao, J. and Chen, J.F. (2003) “Intermediate crack induced debonding in RC beams and slabs”, Construction and Building Materials, Vol. 17, No. 6-7, pp.

关键词： steel reinforcement reinforced concrete reinforced polymer

上颌前牙区种植体脱落再种植-能否获得良好的美学效果

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中国口腔种植学杂志 2011年第1期16卷 32-32页

作者： Germán Gómez-román Head of Implantology in the Dept.of Prosthodontics University of TübingenGermany

尽管长期效果研究显示种植体有极高的成功率。种植体脱落时有发生。手术创伤、愈合能力受损、过早负重、感染、骨结合丧失、种植体折断、过度负重等原因能造成种植体脱落。可以采用常规修复方式重新修复。也有患者要求在原区域重新种植... 详细信息

尽管长期效果研究显示种植体有极高的成功率。种植体脱落时有发生。手术创伤、愈合能力受损、过早负重、感染、骨结合丧失、种植体折断、过度负重等原因能造成种植体脱落。可以采用常规修复方式重新修复。也有患者要求在原区域重新种植修复。如果条件允许，很多病例适宜重新种植。

关键词：种植体折断上颌前牙区美学效果修复方式长期效果手术创伤种植修复骨结合

textbook of Hepatology: From Basic Science to Clinical Practice, third Edition 3

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2007年

作者： Juan Rodés MD Jean‐Pierre Benhamou MD Andres t. Blei MD Jürg Reichen MD Mario Rizzetto MD

ISBN: (数字)9780470691861

ISBN: (纸本)9781405127417

tHE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford textbook of Clinical Hepatology , this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver the effects of diseases of other systems on the liver the effects of liver diseases on other systems It's bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD rom of the entire content. Click here to view a sample chapter on the liver and coagulation

关键词： LiverDiseases.

Demographic Methods and Concepts - CD rom CD ROM

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Demographic Methods and Concepts - CD ROM

2003年

作者： Donald t. Rowland

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睡魔 1

丛书名：外教社德语分级注释读物系列

2005年

作者：（德）E.t.A.Hoffmann 李晶浩注释

本套丛书不仅包括一些脍炙人口的大作，而且还包括一些简单易懂，语言地道，贴近生活的人生故事和故事。

ISBN: (纸本)7810952455

本套丛书不仅包括一些脍炙人口的大作，而且还包括一些简单易懂，语言地道，贴近生活的人生故事和故事。

关键词：中篇小说近代德国德语

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荒凉屋

丛书名：外教社德语分级注释读物系列

2005年

作者：（德）E.t.A.Hoffmann 李晶浩注释

本书通过对世界文学作品的某些词语和语法现象作了删节或改写，降低了阅读和理解的难度，使学生在初学伊始就能阅读原版文学名著。另外每一章后附有形式多样的词语练习和文字游戏。

ISBN: (纸本)7810952447

关键词：德语