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Impact of Beijing’s“Coal to Electricity”program on ambient PM_(2.5) and the associated reactive oxygen species(ROS)

journal of Environmental Sciences 2023年第11期133卷 93-106页

作者： Kaining Zhao Yuanxun Zhang jing Shang james jschauer Wei Huang jingyu Tian Shujian Yang Dongqing Fang Dong Zhang College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China CAS Center for Excellence in Regional Atmospheric Environment Chinese Academy of SciencesXiamen 361021China Institute of Eco-Environmental Forensics Shandong UniversityQingdao 266237China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China Wisconsin State Laboratory of Hygiene University of Wisconsin-MadisonMadisonWI53718USA Institute of Environmental Reference Materials of Environmental Development Center of Ministry of Ecology and Environment Beijing 100029China Meteorological Observation Center of China Meteorological Administration Beijing 100081China

The Beijing“Coal to Electricity”program provides a unique opportunity to explore air quality impacts by replacing residential coal burning with electrical *** this study,the atmospheric ROS(Gas-phase ROS and Particle-phase ROS,abbreviated to G-ROS and P-ROS)were measured by an online instrument in parallel with concurrent PM_(2.5) sample collections analyzed for chemical composition and cellular ROS in a baseline year(Coal Use Year-CUY)and the first year following implementation of the“Coal to Electricity”program(Coal Ban Year-CBY).The results showed PM_(2.5) concentrations had no significant difference between the two sampling periods,but the activities of G-ROS,P-ROS,and cellular ROS in CBY were 8.72 nmol H_(2)O_(2)/m^(3),9.82 nmol H 2 O 2/m 3,and 2045.75μg UD/mg PM higher than in *** sources were identified by factor-analysis from the chemical components of PM_(2.5).Secondary sources(SECs)were the dominant source of PM_(2.5) in the two periods,with 15.90%higher contribution in CBY than in *** Emission&Coal Combustion sources(Ind.&CCs),mainly from regional transport,also increased significantly in *** contributions of Aged Sea Salt&Residential Burning sources to PM_(2.5) decreased 5.31% from CUY to *** correlation results illustrated that Ind.&CCs had significant positive correlations with atmospheric ROS,and SECs significantly associated with cellular ROS,especially nitrates(r=0.626,p=0.000).Therefore,the implementation of the“Coal to Electricity”program reduced PM_(2.5) contributions from coal and biomass combustion,but had little effect on the improvement of atmospheric and cellular ROS.

关键词： PM_(2.5) Reactive oxygen species(ROS) Factor analysis(FA) Correlation Principal component regression(PCR)

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卡波西肉瘤广泛肺间质弥漫浸润一例

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中华病理学杂志 2002年第6期31卷 563-564页

作者：谭光明 rolf F.Barth Cynthia M.Magro Gerard j Nuovo DepartmentofPathology OhioStateUniversityMedicalCenter

患者男，46岁。15年前发现HIV阳性。1年前左颊部出现红色斑疹，活检示卡波西肉瘤。偶有室上性心动过速，因咳嗽、气促、痰中带血一周而于2002年1月16日就诊。无发热、寒颤及恶心、呕吐等症状。X光片示右侧胸腔积液及下肺叶实变（图1）... 详细信息

患者男，46岁。15年前发现HIV阳性。1年前左颊部出现红色斑疹，活检示卡波西肉瘤。偶有室上性心动过速，因咳嗽、气促、痰中带血一周而于2002年1月16日就诊。无发热、寒颤及恶心、呕吐等症状。X光片示右侧胸腔积液及下肺叶实变（图1）。体检：一般情况尚可，体温37℃，血压131/83 mm Hg，脉搏85次／min，呼吸24次／min。双侧瞳孔等大等圆，对光反射好。口腔黏膜有少量干血迹。心律齐，无杂音。右肺呼吸音减弱，可闻及干性及湿性啰音。腹平软，肠鸣音正常。四肢无异常。一周后患者因病情恶化，出现呼吸循环衰竭，治疗无效而死亡。

关键词：卡波西肉瘤肺间质弥漫浸润肺肿瘤诊断 X线诊断治疗病例报告

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PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival

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Advances in Lung Cancer 2015年第3期4卷 37-51页

作者： Kaia K. Hampton Rachel Stewart Dana Napier Pier Paolo Claudio rolf j. Craven Department of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA Department of Pathology and Laboratory Medicine University of Kentucky Lexington KY USA Markey Cancer Center University of Kentucky Lexington KY USA Department of Biomolecular Sciences and National Center for Natural Products Research School of Pharmacy University of Mississippi Oxford MS USA Department of Radiation Oncology University of Mississippi Medical Center Jackson MS USA

Cancer is one of the leading causes of death in America, and there is an urgent need for new therapeutic approaches. The progesterone receptor membrane component 1 (PGRMC1) is a cytochrome b5 related protein that binds heme and is associated with signaling, apoptotic suppression and autophagy. PGRMC1 is essential for tumor formation, invasion and metastasis, and is upregulated in breast, colon, lung and thyroid tumors. In the present study, we have analyzed PGRMC1 levels in over 600 tumor sections, including a larger cohort of lung tumors than in previous studies, and report the first clinical analysis of PGRMC1 levels in human oral cavity and ovarian tumors compared to corresponding nonmalignant tissues. PGRMC1 was highly expressed in lung and ovarian cancers and correlated with patient survival. PGRMC1 has been previously associated with drug resistance, a characteristic of cancer stem cells. The stem cell theory proposes that a subset of cancerous stem cells contribute to drug resistance and tumor maintenance, and PGRMC1 was detected in lung-tumor derived stem cells. Drug treatment with a PGRMC1 inhibitor, AG-205, triggered stem cell death whereas treatment with erlotinib and the ERK inhibitor, PD98059, did not, suggesting a specific role for PGRMC1 in cancer stem cell viability. Together, our data demonstrate PGRMC1 as a potential tumor biomarker across a variety of tumors, as well as a therapeutic target for cancer stem cells.

关键词： Lung Cancer Oral Cancer Head and Neck Cancer Stem Cells PGRMC1

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First report of a de novo germline mutation in the MLH1 gene

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World journal of Gastroenterology 2006年第5期12卷 809-811页

作者： Rein P Stulp Yvonne j Vos Bart Mol Arend Karrenbeld Monique de Raad Huub jC van der Mijle rolf H Sijmons Department of Clmical Genetics University Medical Center GroningenPO Box 300019700 RB GroningenThe Netherlands Department of Pathology University Medical Center GroningenPO Box 300019700 RB GroningenThe Netherlands Department of Surgery Nij Smellinghe HospitalPO Box 202009200 DA DrachtenThe Netherlands

Hereditary non-polyposis colorectal carcinoma （HNPCC） is an autosomal dominant disorder associated with colorectal and endometrial cancer and a range of other tumor types. Germline mutations in the DNA mismatch repair （MMR） genes, particularly MLH1, MEH2, and MEH5, underlie this disorder. The vast majority of these HNPCC-associated mutations have been proven, or assumed, given the family history of cancer, to be transmitted through several generations. To the best of our knowledge, only a single case of a de novo germline MMR gene mutation （in MEH2） has been reported till now. Here, we report a patient with a de novo mutation in MLH1. We identified a MLH1 Q701X truncating mutation in the blood lymphocytes of a male who had been diagnosed with rectal cancer at the age of 35. His family history of cancer was negative for the first- and second-degree relatives. The mutation could not be detected in the patient＇s parents and sibling and paternity was confirmed with a set of highly polymorphic markers. Non-penetrance and small family size is the common explanation of verified negative family histories of cancer in patients with a germline MMR gene mutation. However, in addition to some cases explained by non-paternity, de novo germline mutations should be considered as a possible explanation as well. As guidelines that stress not to restrict MMR gene mutation testing to patients with a positive family history are more widely introduced, more cases of de novo MMR gene germline mutations may be revealed.

关键词： MLH1 de novo HNPCC Germline mutation

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Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 1592-1600页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph j.Brabec rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore 138602Singapore Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Massachusetts Institute of Technology CambridgeMA 02139USA Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz Institute HI-ErN Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany National University of Singapore Singapore 119077Singapore

Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global ***,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box *** Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical *** the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the *** a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods.

关键词： knowledge network enable

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电子购物与电子商务对物流管理的影响

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机电信息（北京） 2002年第1期 44-47页

作者： rolf jansen jrg Schmidt

谁想在因特网上的采购和销售活动中占有一席之地,谁就必须具备比普通销售企业更加强大的能力,满足不同客户的各种需求。而这种更加强大的能力对企业的物流管理体系有着十分重要的意义。在电子的市场领域内,电子的商务手段对物流管理和... 详细信息

谁想在因特网上的采购和销售活动中占有一席之地,谁就必须具备比普通销售企业更加强大的能力,满足不同客户的各种需求。而这种更加强大的能力对企业的物流管理体系有着十分重要的意义。在电子的市场领域内,电子的商务手段对物流管理和存储管理的各个方面都有着重要的影响。它赋予物流管理人员和存储管理人员新的工作职责和新的工作领域。

关键词：电子购物电子商务物流管理互联网

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Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

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Synthetic and Systems Biotechnology 2016年第1期1卷 39-46页

作者： Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu rolf Muller David T.Weaver Lixin Zhang Buchang Zhang Institute of Health Sciences School of Life SciencesAnhui UniversityHefei 230601China CAS Key Laboratory of Pathogenic Microbiology&Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Helmholtz Institute for Pharmaceutical Research Helmholtz Centre for Infection Research and Department of Pharmaceutical BiotechnologySaarland UniversityP.O.Box 1511566041 SaarbruckenGermany

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of ***,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in *** A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin *** and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their ***,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin *** demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial *** *** with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and *** cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to *** strategy reported here will be useful to improve antibiotics production in other industrial actinomycete.

关键词： Saccharopolyspora erythraea Erythromycin TetR family SACE_3446 Regulatory network

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Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

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Cellular & Molecular Immunology 2023年第6期20卷 666-679页

作者： Elien Grajchen Melanie Loix Paulien Baeten Beatriz F.Côrte-Real Ibrahim Hamad Sam Vanherle Mansour Haidar jonas Dehairs jelle Y.Broos james M.Ntambi Robert Zimmermann rolf Breinbauer Piet Stinissen Niels Hellings Sanne G.S.Verberk Gijs Kooij Martin Giera johannes V.Swinnen Bieke Broux Markus Kleinewietfeld jerome j.A.Hendriks jeroen F.j.Bogie Department of Immunology and Infection Biomedical Research InstituteHasselt UniversityDiepenbeekBelgium University MS Center Hasselt PeltBelgium Neuro-Immune Connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium VIB Laboratory of Translational Immunomodulation VIB Center for Inflammation ResearchHasselt UniversityDiepenbeekBelgium Department of Oncology Laboratory of Lipid Metabolism and CancerLKI–Leuven Cancer InstituteKU Leuven-University of LeuvenLeuvenBelgium Department of Molecular Cell Biology and Immunology Amsterdam University Medical CenterVrije Universiteit AmsterdamAmsterdam NeuroscienceMS Center AmsterdamAmsterdamThe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biochemistry Department of Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA Institute of Molecular Biosciences University of GrazGrazAustria BioTechMed-Graz GrazAustria Institute of Organic Chemistry Graz University of TechnologyGrazAustria Cardiovascular Research Institute Maastricht Department of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis(MS).Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a major impact on both T cell fate and *** date,however,the molecular mechanisms that underlie the impact of fatty acid metabolism on T cell physiology and autoimmunity remain poorly ***,we report that stearoyl-CoA desaturase-1(SCD1),an enzyme essential for the desaturation of fatty acids and highly regulated by dietary factors,acts as an endogenous brake on regulatory T-cell(Treg)differentiation and augments autoimmunity in an animal model of MS in a T cell-dependent *** by RNA sequencing and lipidomics analysis,we found that the absence of Scd1 in T cells promotes the hydrolysis of triglycerides and phosphatidylcholine through adipose triglyceride lipase(ATGL).ATGL-dependent release of docosahexaenoic acid enhanced Treg differentiation by activating the nuclear receptor peroxisome proliferator-activated receptor *** findings identify fatty acid desaturation by SCD1 as an essential determinant of Treg differentiation and autoimmunity,with potentially broad implications for the development of novel therapeutic strategies and dietary interventions for autoimmune disorders such as MS.

关键词： Regulatory T cells Autoimmunity Fatty acid metabolism Stearoyl-CoA desaturase-1 Multiple sclerosis

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波罗的海斯德哥尔摩群岛不同类型海底和水体深度沉积物中PCB的分布

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AMBIO－人类环境杂志 2000年第4期29卷 276-281页

作者： Anders jnsson rolf Carman 于云江 Dept.of Geology and Geochemistru Stockholm University SE-10691 Stockholm。 Dept. of Geology and Geochemistry Stockholm University SE-10691 Stockholm

水生环境中的多氯联苯(PCB)与有机物密切相关。在不同水体深度和不同海底类型中,其沉积物的有机质性质不同。不同的海底类型可以表现为或者是需氧/生物扰动条件,或者是缺氧/纹层状条件,这取决于水体深度。为了调查这些不同环境是否影响... 详细信息

水生环境中的多氯联苯(PCB)与有机物密切相关。在不同水体深度和不同海底类型中,其沉积物的有机质性质不同。不同的海底类型可以表现为或者是需氧/生物扰动条件,或者是缺氧/纹层状条件,这取决于水体深度。为了调查这些不同环境是否影响沉积物中PCB的分布,在波罗的海斯德哥尔摩群岛的两个区域选择了不同海底类型和不同水深的沉积物。根据含水量将海底分成不同的类型。结果表明,在两个区域以有机碳为基准的PCB浓度在不同的海底类型中是相同的。不同沉积物中有机物性质可能存在的差异可能没有重要的作用,好像生物扰动和氧化还原条件的影响那样。相反,正是PCB同类物的性质决定着PCB在沉积物中的分布。

关键词：海底类型水体深度沉积物 PCB 海洋监测群岛

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痴呆患者行为障碍的神经解剖学联系

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 29-30页

作者： Rosen H.j. Allison S.C. schauer G.F. 赵天智 UCSF Department of Neurology Memory and Aging Center Box 1207 350 Parnassus Avenue San Francisco CA 94143- 1207 United States

Neurodegenerative diseases are associated with profound changes in social and emotional function. The emergence of increasingly sophisticated methods for measuring brain volume has facilitated correlation of local changes in tissue content with cognitive and behavioural changes in neurodegenerative disease. The current study examined neuroanatomical correlates of behavioural abnormalities, as measured by the Neuropsychiatric Inventory, in 148 patients with dementia using voxel-based morphometry. Of 12 behaviours examined, 4 correlated with tissue loss: apathy, disinhibition, eating disorders and aberrant motor behaviour. Increasing severity across these four behaviours was associated with tissue loss in the ventral portion of the right anterior cingulate cortex (vACC) and adjacent ventromedial superior frontal gyrus (vmSFG), the right ventromedial prefrontal cortex (VMPC) more posteriorly, the right lateral middle frontal gyrus, the right caudate head, the right orbitofrontal cortex and the right anterior insula. In addition, apathy was independently associated with tissue loss in the right vmSFG, disinhibition with tissue loss in the right subgenual cingulate gyrus in the VMPC, and aberrant motor behaviour with tissue loss in the right dorsal ACC and left premotor cortex. These data strongly support the involvement of the right hemisphere in mediating social and emotional behaviour and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours. Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions.

关键词：神经解剖学痴呆患者情感淡漠

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