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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Analytical model of IoT CoAP traffic

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Digital Communications and Networks 2019年第2期5卷 63-68页

作者： rolando Herrero College of Engineering Northeastern University02115BostonMAUSA

The Constrained Application Protocol (CoAP) is a mechanism that enables the efficient transmission of information in the context of Wireless Sensor Networks (WSNs) characteristic of the Internet of Things (IoT). CoAP is specifically intended to work well with low complexity sensors that have lim让ed access to computational resources. And because it lacks the overhead of other more sophisticated transport protocols,让 is suitable for high packet loss wireless networks. Relying on the User Datagram Protocol (UDP), CoAP introduces, among other things, confirmable and non-confirmable message types, depending on the nature of the source data. This paper presents a novel analytical model that can relate the application to network packet loss and be used to estimate the effect of lossy wireless channels in CoAP scenarios. Moreover, the model is ultimately validated by an experimental framework in which theoretical and experimental results are compared.

关键词： CoAP UDP WSN IoT Wireless

AIdeal:Sentience and Ideology

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Journal of Social Computing 2023年第4期4卷 275-325页

作者： Daniel estrada the Department of Humanities and Social Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA

This paper addresses a set of ideological tensions involving the classification of agential kinds,which I see as the methodological and conceptual core of the sentience ***,I consider ideals involved in the classification of biological and artifactual kinds,and ideals related to agency,identity,and *** ideals frame the background against which sentience in Artificial Intelligence(AI)is theorized and debated,a framework I call the *** make this framework explicit,I review the historical discourse on sentience as it appears in ancient,early modern,and the 20th century philosophy,paying special attention to how these ideals are projected onto artificial agents.I argue that tensions among these ideals create conditions where artificial sentience is both necessary and impossible,resulting in a crisis of *** past this crisis does not require a satisfying resolution among competing ideals,but instead requires a shift in focus to the material conditions and actual practices in which these ideals *** Charles Mills,I sketch a nonideal approach to AI and artificial sentience that seeks to loosen the grip of ideology on the ***,I propose a notion of participation that deflates the sentience discourse in AI and shifts focus to the material conditions in which sociotechnical networks operate.

关键词： sentience agency artifacts artificial intelligence ideology nonideal theory natural kinds participation

Hydrocarbon distribution along the Soapaga thrust(Eastern Cordillera, Colombia) based on new strategic geochemistry samples

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Acta Geochimica 2022年第3期41卷 335-350页

作者： Eduardo A.Rossello rolando Di Primio Departamento de Ciencias Geologicas Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaCONICET-IGEBAPabellon II1428 Buenos AiresArgentina Lundin Energy Norway LysakerNorway

The Colombian Eastern Cordillera constitutes a region with potential for finding hydrocarbon reserves that are still under-explored, despite the existence of oil and tar sand production. The intense tectonic deformation affects the petroleum systems and increases exploration challenges due to the different generation, maturation, and entrapment conditions that they produce. Diverse geochemical analysis conducted on strategic samples determines that these are likely generated by the same anoxic marine source rock type. Two source rock samples we investigated are characterized by very different biomarker signals as compared to the tar sands and oil samples. Both samples are dominated by hopanes as compared to tri-and tetracyclic terpanes, with very low(Tibasosa Formation) to no(Chipaque Formation) extended tricyclic terpanes. The Soapaga Thrust, along which the analyzed samples are located, has exercised first-rate regional structural control of the distribution of hydrocarbons in the studied area. The uplift of their Mesozoic hanging wall produces intense erosion with sediment transport towards the eastern footwall forming the present infill of the Arcabuco basin. The kitchen areas were connected with the shallower entrapment sectors where excellent reservoir levels such as the Picacho Formation before the Soapaga Thrust movement. The high degree of biodegradation observed in the Picacho Fm. tar sands support early charge before the Soapaga thrust movement, and severe biodegradation following the thrust movement when hydrocarbon supply from the kitchen was interrupted. This work aims to contribute to a better understanding of the geochemical characteristics of the petroleum systems due to the action of the Soapaga Thrust.

关键词： Hydrocarbon geochemistry Soapaga thrust Eastern Cordillera Colombia

Gorenstein injective sheaves

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Frontiers of Mathematics in China 2017年第1期12卷 87-95页

作者： Sergio estrada Alina IACOB Departamento de Matem~ticas Universidad de Murcia Murcia 30100 Spain Department of Mathematical Sciences Georgia Southern University Statesboro GA 3O460 USA

We define Gorenstein injective quasi-coherent sheaves, and prove that the notion is local in case the scheme is Gorenstein. We also give a new characterization of a Gorenstein scheme in terms of the total acyclicity o... 详细信息

关键词： Gorenstein injective Noetherian scheme

Estimating the Lost Economic Production Caused by Internal Displacement Because of Disasters

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International Journal of Disaster Risk Science 2018年第4期9卷 496-506页

作者： Mario A.salgado-Gálvez Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) 08034 BarcelonaSpain

Disasters are a large cause of internal displacement at the global level, in 2017 alone affecting more than19 million people. This dimension of disaster risk is usually overlooked in many disaster risk management strategies and assessments. It is only very recently that efforts to quantify displacement risk and integrate that dimension into existing physical risk models have been made. A key component of internal displacement assessment is the quantification of its economic impacts, both direct and indirect, not only to make a figure available but to raise awareness and increase accountability among governments, stakeholders, policymakers, and decision *** article presents a novel and peril-agnostic methodology with which to estimate, using a scenario-based approach, the economic production lost because of internal population displacement. The methodology is applied by using as a triggering event the April 2015 Gorkha, Nepal M7.8 earthquake. The method quantifies the indirect cost caused by internal population displacement because of that event in terms of lost economic production and estimates the loss to be between USD 400 and 850 million.

关键词： Disability adjusted life years Disaster risk Internally displaced people Lost economic production Disaster risk assessment

Study of Branes with Variable Tension

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Communications in Theoretical Physics 2017年第11期67卷 595-599页

作者： Rodrigo Aros Milko estrada Departamento de Ciencias Fisicas Universidad Andres Bello Department of Physics Universidad de Antofagasta Instituto de Matematica Fisica y Estadistica Universidad de las Americas

In this work we study a brane world model with variable tension, which gives rise to four-dimensional cosmologies. The brane worlds obtained correspond to E?tv?s branes whose(internal) geometry can be casted as either a four-dimensional(A)dS_4 or a standard radiation period cosmology. The matter dominated period is discussed as well.

关键词： Randall–Sundrum brane world de Sitter hierarchy problem brane tension

Arthropods associated with medicinal plants in coastal South Carolina

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Insect Science 2007年第6期14卷 519-524页

作者： rolando LOPEZ B. MERLE SHEPARD Clemson University Department of Entomology Soils and Plant Sciences and Coastal Research and Education CenterCharleston South Carolina USA

Arthropods were sampled from feverfew [Tanacetum parthenium （L.） Schultz- Bip], Echinacea purpurea （L.） Moench, Echinacea pallida （Nutt.） Nutt., Valeriana officinalis L., and St. John＇s wort （Hypericum perforatum L.） during 1998-2001. In addition, arthropods were sampled on tansy （Tanacetum vulgare L.） from 2001-2004. In general, 50-60 arthropod species where collected and identified among all of the medicinal plant species. Among the predators, Orius insidiosus （Say）（Hemiptera： Anthocoridae）, Geocoris punctipes （Say）（Hemiptera： Lygaeidae） and spiders were most abundant from 1998-2004. The three-cornered alfalfa hopper, Spissistilus festinus （Say）, was the most abundant herbivore found from 1998 to 2001. Orius insidiosus and G. punctipes were 3-4 times more abundant on T. parthenium than on any other medicinal plant species. Based on the numbers of predatory arthropods found on T. parthenium, this crop could be suitable as a companion or ＂banker＂ plant to attract and maintain populations of predators, especially O. insidiosus and G. punctipes. Whitefly nymphs attacked by predators with piercing/sucking mouthparts are easily identified using a microscope because of the general appearance of the carcass left by the predators. Thus, populations of predators on T. parthenium suppressed Bemisia tabaci populations on E. purpurea when these crops were planted as companion crops.

关键词： companion plants Geocoris punctipes medicinal plants Orius insidiosus,predators