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Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

Acta Pharmaceutica Sinica B 2020年第6期10卷 1061-1072页

作者： Yishan Ye Laure Ricard Lama Siblany Nicolas stocker Frédéric De Vassoigne Eolia Brissot Baptiste Lamarthée Arsène Mekinian Mohamad Mohty Béatrice Gaugler Florent Malard Sorbonne Université INSERMCentre de Recherche Saint-Antoine(CRSA)Paris F-75012France Bone Marrow Transplantation Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China AP-HP Hôpital Saint-AntoineService d’Hématologie Clinique et Thérapie CellulaireParis F-75012France AP-HP Hôpital Saint-AntoineService de Médecine Interne et de l'Inflammation-(DHU i2B)Paris F-75012France

Arsenic trioxide(As2O3)is recently found to have therapeutic potential in systemic sclerosis(SSc),a life-threatening multi-system fibrosing autoimmune disease with type I interferon(IFN-I)*** activated plasmacytoid dendritic cells(pDCs)are responsible for IFN-I secretion and are closely related with fibrosis establishment in *** this study,we showed that high concentrations of As2O3 induced apoptosis of pDCs via mitochondrial pathway with increased BAX/BCL-2 ratio,while independent of reactive oxygen species ***,at clinical relevant concentrations,As2O3 preferentially inhibited IFN-αsecretion as compared to other cytokines such as TNF-α,probably due to potent down-regulation of the total protein and mRNA expression,as well as phosphorylation of the interferon regulatory factor7(IRF7).In addition,As2O3 induced a suppressive phenotype,and in combination with cytokine inhibition,it down-regulated pDCs’capacity to induce CD4+T cell proliferation,Thl/Th22 polarization,and B cell differentiation towards ***,chronically activated pDCs from SSc patients were not resistant to the selective IFN-αinhibition,and regulatory phenotype induced by ***,our data suggest that As2O3 could target pDCs and exert its treatment efficacy in SSc,and more autoimmune disorders with IFN-I signature.

关键词： Arsenic trioxide Plasmacytoid dendritic cell Immunotherapy Systemic sclerosis IFN-I

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MR弹性成像对临床显著性门静脉高压症的诊断效能优于剪切波弹性成像

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国际医学放射学杂志 2023年第1期46卷 121-122页

作者： P.Kennedy D.stocker G.Carbonell D.Said O.Bane S.Hectors 朱雪琳

摘要目的门静脉高压症(PH)与腹水和食管静脉曲张等并发症有关,传统检测方法为有创性肝静脉压力梯度(HVPG)测量,但该方法应用受限。本研究旨在以HVPG测量

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MRI动态增强灌注技术定量评估肝细胞癌：钆塞酸二钠和钆贝酸葡甲胺的比较

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国际医学放射学杂志 2022年第1期 123-124页

作者： D.stocker S.Hectors O.Bane N.Vietti-Violi D.Said P.Kennedy 李文菲

摘要目的定量评估肝脏动态增强（DCE）MRI动脉输入函数（AIF）；注射钆塞酸二钠和钆贝酸葡甲胺（GdBOPTA）对比剂3 min内，定量不同病人群体中的肝细胞癌

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FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources

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Data Intelligence 2020年第1期2卷 158-170,313页

作者： Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg Annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes GO FAIR International Support and Coordination Office LeidenThe Netherlands Centre for Digital Scholarship Leiden University LibrariesLeidenThe Netherlands Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany Leiden University Medical Center Leiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK Environment Agency Austria A-1090 ViennaAustria TIB Leibniz Information Centre for Science and Technology HannoverGermany SURF Utrecht 3511 EPThe Netherlands Corporation for National Research Initiatives(CNRI) RestonVirginia 20191USA Stanford Center for Biomedical Informatics Research StanfordCA 94305USA

The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by *** by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR *** different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global *** an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence *** Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and *** Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services.

关键词： FAIR Implementation Choices and Challenges Convergence FAIR Communities

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