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Genes & Diseases 2024年第2期11卷 1082-1083页

作者： Giovanna Forte Filomena Cariola Katia de marco Andrea Manghisi Filomena Anna Guglielmi Raffaele Armentano Giuseppe Lippolis Pietro Giorgio Cristiano Simone Vittoria Disciglio Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Histopathology Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy department of General Surgery National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Gastroenterology and Digestive Endoscopy Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy department of Biomedical Sciences and Human Oncology (DIMO) Medical Genetics University of Bari Aldo Moro Piazza Umberto I Bari 70124 Italy

Evolutionary fingerprint, phylogenetic and forest structure of tropical montane Atlantic cloud forests along an elevation gradient

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Journal of Mountain Science 2024年第4期21卷 1259-1271页

作者： Ravi Fernandes MARIANO Vanessa Leite REZENde Cléber Rodrigo de SOUZA Patrícia Vieira POMPEU Rubens Manoel dos SANTOS Carolina Njaime MENdeS Aloysio Souza de MOURA Felipe Santana MACHADO Warley Augusto Caldas CARVALHO marco Aurélio Leite FONTES department of Forest Sciences Federal University of LavrasLavras 37200-900Brazil 2Environmental defence Association of Minas Gerais Belo Horizonte 30360-110Brazil department of Ecology and Conservation Federal University of LavrasLavras 37200-900Brazil department of Forest Sciences State University of Mato Grosso do SulAquidauana 79200-000Brazil Agência Zetta Federal University of LavrasLavras 37200-900Brazil. department of Natural Sciences Federal University of São João del-ReiSão João del-Rei 36307-352Brazil.

Environmental conditions can change markedly over geographical distances along elevation gradients,making them natural laboratories to study the processes that structure *** work aimed to assess the influences of elevation on Tropical Montane Cloud Forest plant communities in the Brazilian Atlantic Forest,a historically neglected *** evaluated the phylogenetic structure,forest structure(tree basal area and tree density)and species richness along an elevation gradient,as well as the evolutionary fingerprints of elevation-success on phylogenetic lineages from the tree *** do so,we assessed nine communities along an elevation gradient from 1210 to 2310 m *** large elevation *** relationships between elevation and phylogenetic structure,forest structure and species richness were investigated through Linear *** occurrence of evolutionary fingerprint on phylogenetic lineages was investigated by quantifying the extent of phylogenetic signal of elevation-success using a genus-level molecular *** results showed decreased species richness at higher elevations and independence between forest structure,phylogenetic structure and *** also verified that there is a phylogenetic signal associated with elevation-success by *** concluded that the elevation is associated with species richness and the occurrence of phylogenetic lineages in the tree communities evaluated in Mantiqueira *** the other hand,elevation is not associated with forest structure or phylogenetic ***,closely related taxa tend to have their higher ecological success in similar ***,we highlight the fragility of the tropical montane cloud forests in the Mantiqueira Range in face of environmental changes(*** warming)due to the occurrence of exclusive phylogenetic lineages evolutionarily adapted to environmental conditions(*** temperature)associated with each elevation range.

关键词： Atlantic Forest Cloud forest Conservation Community ecology Montane forests Phylogenetic diversity Phylogenetic signal

Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments

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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro Tel marco Maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

Tetrachloroethane(TeCA)removal through sequential graphite-mixed metal oxide electrodes in a bioelectrochemical reactor

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Environmental Science and Ecotechnology 2024年第1期17卷 59-67页

作者： marco Zeppilli Hafsa Yaqoubi Edoardo dell’Armi Agnese Lai Mustapha Belfaquir Laura Lorini marco Petrangeli Papini department of Chemistry University of Rome SapienzaPiazzale Aldo Moro 5Rome00185Italy department of Chemistry Ibn Tofail UniversityLaboratory of Advanced Material and Process EngineeringCampus UniversitaireBP.242KenitraMorocco

Electro-bioremediation offers a promising approach for eliminating persistent pollutants from groundwater since allows the stimulation of biological dechlorinating activity,utilizing renewable electricity for process operation and avoiding the injection of chemicals into *** this study,a two-chamber microbial electrolysis cell has been utilized to achieve both reductive and oxidative degradation of tetrachloroethane(TeCA).By polarizing the graphite granules cathodic chamber at650 mV vs the standard hydrogen electrode and employing a mixed metal oxide(MMO)counter electrode for oxygen production,the reductive and oxidative environment necessary for TeCA removal has been *** experiments were conducted using two feeding solutions:an optimized mineral medium for dechlorinating microorganisms,and synthetic groundwater containing sulphate and nitrate anions to investigate potential side *** bioelectrochemical process efficiently reduced TeCA to a mixture of trans-dichloroethylene,vinyl chloride,and ethylene,which were subsequently oxidized in the anodic chamber with removal efficiencies of 37±2%,100±4%,and 100±5%,*** introduction of synthetic groundwater with nitrate and sulphate stimulated reductions in these ions in the cathodic chamber,leading to a 17%decrease in the reductive dechlorination rate and the appearance of other chlorinated by-products,including cis-dichloroethylene and 1,2-dichloroethane(1,2-DCA),in the cathode ***,despite the lower reductive dechlorination rate during synthetic groundwater operation,aerobic dechlorinating microorganisms within the anodic chamber completely removed VC and 1,*** study represents the first demonstration of a sequential reductive and oxidative bioelectrochemical process for TeCA mineralization in a synthetic solution simulating contaminated groundwater.

关键词： Chlorinated aliphatic hydrocarbons Microbial electrolysis cells Oxidative dechlorination Reductive dechlorination Sulphate reduction Nitrate reduction

Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

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Food Science and Human Wellness 2024年

作者： Mirco Vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco Maria Calabrese marco Gobbetti Maria de Angelis Faculty of Science and Technology， Free University of Bozen Evonik Operations GmbH department of Soil Plant and Food Sciences， University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide MASSOCCHI Nora LECIS marco LATTUADA Davide SCAGLIA Steven CHATTERTON Paolo PENNACCHI department of Mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDM).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

A quantitative analysis of the US materials flow methodology and comparison to the EU methodology for MSW statistics

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Waste Disposal and Sustainable Energy 2024年第1期6卷 85-94页

作者： demetra Tsiamis Fabio Poretti Stefano Consonni marco J.Castaldi Earth Engineering Center Department of Chemical EngineeringThe City College of New YorkNew YorkNYUSA Dipartimento Di Energetica Politecnico Di MilanoPiazza Leonardo da Vinci 3220133MilanItaly

The European Union(EU)and the United States(US)determine municipal solid waste(MSW)statistics *** EU applies a site-specific methodology that directly measures waste whereas the US employs a materials flow methodology that estimates MSW statistics indirectly based on production and recovery data from *** study dissects the materials flow methodology and presents quantitative materials flow Sankey diagrams for the primary MSW materials to highlight data gaps that can be addressed to improve the methodology’s *** industry plastics data were applied to the materials flow methodology,and the results were within 10%of the plastics statistics reported by the US Environmental Protection Agency(US EPA).Drawbacks to the methodologies include EU measurement inaccuracies due to double-counting and not accounting for residual waste in the *** latter may partially explain why landfilling tonnages reported by the US EPA were approximately 60%less than the tonnages reported by the Waste to Energy Research and Technology Council(WTERT)in its national MSW survey that applied the EU methodology in the *** the EU,there is no US national policy that requires states to measure and report state-level waste data to the US *** improvements in US MSW statistics rely heavily on the implementation of national policies to homogenize the measurement and collection of waste data from states.

关键词： Materials flow methodology Site-specific methodology United States European Union Municipal solid waste Discrepancy

Hybrid Modular Smart Transformer for Asymmetrically Bidirectional Power Flow Operation

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1384-1398页

作者： Kangan Wang Youngjong Ko Rongwu Zhu Siyu Wu Weimin Wu marco Liserre Shanghai Maritime University Shanghai 201306China Pukyong National University Busan 48513South Korea Harbin Institute of Technology(Shenzhen) Shenzhen 518000China Kiel University Kiel 24118Germany

The presence of renewable energy resources in LV distribution networks may lead to a distribution transformer,also known as a Smart Transformer(ST),experiencing the bidirectional power ***,the ST must have the capability to operate in both ***,the reverse power is less as compared to the forward power,thus the design of ST with the same capacity in both directions increases the hardware cost and decreases the system *** paper proposes a Hybrid-modular-ST(H-ST),composed of a mixed use of single active bridge-based series resonant converter and dual active bridge instead of complete use of uni-or bi-directional converter adopted in the conventional *** on the proposed H-ST,the impacts of power imbalance among cascaded modules in reverse operation mode are analyzed and then an effective solution based on reactive power compensation combined with the characteristics of the proposed architecture is *** simulation and experimental results clearly validate the effectiveness and feasibility of the theoretical analyses.

关键词： Cascaded H-bridge dual-active bridge series resonant converter smart transformer(ST) three-stage architecture

Intelligent speed adaptation for visibility technology affects drivers’speed selection along curves with sight limitations

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 16-27页

作者： Abrar Hazoor Alberto Terrafino Leandro L.Di Stasi marco Bassani department of Environment Landand Infrastructure EngineeringPolitecnico di TorinoTorino 10129Italy Road Traffic Division Nord UniversityStjørdal 7502Norway Mind Brainand Behavior Research Centre(CIMCYC)University of GranadaGranada 18071Spain

Sight obstructions along road curves can lead to a crash if the driver is not able to stop the vehicle in *** is a particular issue along curves with limited available sight,where speed management is necessary to avoid unsafe situations(e.g.,driving off the road or invading the other traffic lane).To solve this issue,we proposed a novel intelligent speed adaptation(ISA)system for visibility,called V-ISA(intelligent speed adaptation for visibility).It estimates the real-time safe speed limits based on the prevailing sight conditions.V-ISA comes with three variants with specific feedback modalities(1)visual and(2)auditory information,and(3)direct intervention to assume control over the vehicle ***,we investigated the efficiency of each of the three V-ISA variants on driving speed choice and lateral behavioural response along road curves with limited and unsafe available sight distances,using a driving *** also considered curve road geometry(curve direction:rightward ***).Sixty active drivers were recruited for the *** half of them(experimental group)tested the three V-ISA variants(and a V-ISA off condition),the other half always drove with the V-ISA off(validation group).We used a linear mixed-effect model to evaluate the influence of V-ISA on driver *** V-ISA variants were efficient at reducing speeds at entrance points,with no discernible negative impact on driver lateral *** rightward curves,the V-ISA intervening variant appeared to be the most effective at adapting to sight *** of the current study implies that V-ISA might assist drivers to adjust their operating speed as per prevailing sight conditions and,consequently,establishes safer driving conditions.

关键词： Sight distance Intelligent speed adaptation Driver behaviour Road safety Driving simulation Advanced driver assistance systems

Lunar orbits for telecommunication and navigation services

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Astrodynamics 2024年第1期8卷 209-220页

作者： marco Cinelli Emiliano Ortore Giovanni Mengali Alessandro A.Quarta Christian Circi Istituto di Astrofisica e Planetologia Spaziali(IAPS) Istituto Nazionale di Astrofisica(INAF)Via del Fosso del Cavaliere 100Roma00133Italy School of Aerospace Engineering Sapienza University of RomeVia Salaria 881Rome00138Italy department of Civil and Industrial Engineering University of PisaPisa56122Italy department of Astronautical Electricaland Energy EngineeringSapienza University of RomeVia Salaria 851Rome00138Italy

Orbits that are frozen in an averaged model,including the effect of a disturbing body laying on the equatorial plane of the primary body and the influence of the oblateness of the primary body,have been applied to probes orbiting the *** this scenario,the main disturbing body is represented by the Earth,which is characterized by a certain obliquity with respect to the equatorial plane of the *** a consequence of this,and of the perturbing effects that are not included in the averaged model,such solutions are not perfectly ***,the orbit eccentricity,inclination,and argument of pericenter present limited variations and can be set to guarantee the fulfillment of requirements useful for lunar telecommunication missions and navigation *** advantage of this,a practical case of a Moon-based mission was investigated to propose useful solutions for potential near-future applications.

关键词： lunar orbits frozen orbits lunar telecommunications lunarnavigation services