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Clinical significance of granuloma in Crohn's disease

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World Journal of Gastroenterology 2005年第20期11卷 3118-3121页

作者： Tamás Molnár László Tiszlavicz Csaba gyulai Ferenc Nagy János Lonovics First Department of Medicine Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8. Hungary Department of Pathology Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8. Hungary Department of Radiology Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8. Hungary

AIM: Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this study was to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or without granuloma exhibit a different clinical course. METHODS: Fifty-six patients with newly diagnosed CD were included in the study. Jejunoscopy, enteroclysis and ileo-colonoscopy were performed in all patients. At least two biopsy specimens from each examined gastrointestinal segment were examined microscopically searching granuloma. The clinical course was followed in all patients, and extraintestinal manifestations as well as details of any immunosuppressive therapy and surgical intervention were noted. RESULTS: Granuloma was found in 44.6% of the cases (25 patients). Patients with granuloma had higher activity parameters at the time of the biopsies. Extraintestinal manifestations were observed and surgical interventions were performed more often in the granuloma group. The need of immunosuppressive therapy was significantly more frequent in the patients with granuloma. Granuloma formation is mote often seen in younger patients, and mainly in the severe, active penetrating disease. CONCLUSION: The significantly higher frequency of surgical interventions and immunosuppressive therapy suggests that granuloma formation is associated with a more severe disease course during the first years of CD.

关键词： Crohn's disease Granuloma Activity Complication

Damage Enhancement Effect in Silicon Implanted With Molecular Ions

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Science China Mathematics 1993年第2期36卷 235-242页

作者：林成鲁杨根庆方子韦李晓勤邹世昌 J.gyulai R.G.Elliman Shanghai Institute of Metallurgy Academia Sinica Shanghai 200050 PRC Central Research Institute for Physics H-1525 Budapest P.O. Box 49 Hungary Microelectronics and Materials Technology Center Royal Melbourne Institute of Technology GPO Box 2476V Melbourne 3001 Australia

This paper reports a comparison between the two kinds of damage behavior in silicon implanted with P_2^+ molecular ions and P^+ atomic ions. The dependence of damage enhancement effect of P_2^+ implanted silicon on ion doses, energies and target temperatures, and their annealing behavior in subsequent thermal anneal process are investigated systematically. A multiple collision model has been developed to elucidate the mechanism of the damage enhancement effect.

关键词： silicon molecular ion implantation damage enhancement.

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Severity of gastroesophageal reflux disease influences daytime somnolence: A clinical study of 134 patients underwent upper panendoscopy

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World Journal of Gastroenterology 2004年第12期10卷 1798-1801页

作者： Pái Demeter Katalin Várdi Visy Nóra gyulai Róbert Sike Tamás G Tóth János Novák Pál Magyar Outpatient Clinic of Gastroenterology St.John's HospitalBudapestHungary Department of Pulmonology Semmelweis Medical UniversityBudapestHungary Dept.of

AIM: To asses the relationship between severity of gastroesophageal refluxe disease and Epworth sleepiness scale as an indicator of daytime somnolence. METHODS: One hundred and thirty-four patients underwent an upper panendoscopy as indicated by the typical reflux symptoms and were also investigated with regard to somnolence. Sleepiness was evaluated by Epworth Sleepiness Scale, which was compared to the severity of endoscopic findings (Savary-Miller/modified by Siewert). Patients with psychiatric disorders or being on sedato-hypnotics as well as shift workers were excluded from the study. The relationship between the severity of the reflux disease and daytime somnolence was analyzed with the help of multivariate regression analysis. RESULTS: A positive tendency was found between the severity of the reflux disease and the corresponding Epworth Sleepiness Scale. In the case of the more severe type-Savary-Miller Ⅲ- at least a mild hypersomnia was found. For this group daytime somnolence was significantly higher than in the case of the non-erosive type of Gastroesophageal Reflux Disease representing the mildest stage of reflux disease. CONCLUSION: The severity of Gastroesophageal Reflux Disease influences daytime somnolence.

关键词： Severity of Illness Index Adult Aged Disorders of Excessive Somnolence Endoscopy, Digestive System Female Gastroesophageal Reflux Humans Linear Models Male Middle Aged Predictive Value of Tests

The Application of Joint Inversion in Geophysical Exploration

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International Journal of Geosciences 2013年第2期4卷 283-289页

作者： ákos gyulai Mátyás Krisztián Baracza éva Eszter Tolnai Department of Geophysics Faculty of Earth Science and Engineering University of Miskolc Miskolc Hungary

The paper presents a short overview about the application of joint inversion in geophysics. It gives also an alternative explanation for the term of “different data sets” and discusses what types of inversion procedures can be considered as joint inversion. Nowadays there are no standard standpoints using the appellation joint inversion. What is joint inversion? Based on the information matrix an answer could be given for this question what could be regarded as various types of data sets that are inverted simultaneously. We would like to expand the explanation—that is professed by many researchers—of the method that regards only the simultaneous inversion of data sets based on different physical parameters as joint inversion.

关键词： Joint Inversion Simultaneous Inversion Geophysical Serious Expansion

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地电法测定煤层的构造变化和煤质变化

国外地质勘探技术 1989年第2期 28-31页

作者： J.CSO’KA’S M’.DOBRO’KA A’.gyulai 王杰

引言为确保煤矿生产的效率和安全,需要查明煤层的构造和地层特征。地而地球物理勘探往往不能很准确地获得煤层的构造信息。如果在煤层回采期间遇到了断层、煤层尖灭或夹石层,那么不仅可能会影响煤炭产量,

关键词：地电法测深水深测量视电阻率地层煤层

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硅中分子离子注入的损伤增强效应

中国科学（A辑） 1992年第7期23卷 713-718页

作者：林成鲁杨根庆方子韦李晓勤邹世昌 J.gyulai R.G.Elliman 中国科学院上海冶金研究所上海200050 匈牙利科学院中央物理研究所澳大利亚墨尔本皇家理工学院微电子中心

本文研究了单晶硅中磷分子离子(P_2^+)注入相对于磷原子离子(P^+)注入的损伤增强效应,系统分析了这种损伤增强效应与注入剂量、能量、靶温的关系以及注入后退火的特征,利用我们提出的离子注入时分子离子与靶原子的多体碰撞模型对其物理... 详细信息

本文研究了单晶硅中磷分子离子(P_2^+)注入相对于磷原子离子(P^+)注入的损伤增强效应,系统分析了这种损伤增强效应与注入剂量、能量、靶温的关系以及注入后退火的特征,利用我们提出的离子注入时分子离子与靶原子的多体碰撞模型对其物理机制进行了讨论.

关键词：硅分子离子注入损伤增强效应

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Utility of serum TNF-a,infliximab trough level,and antibody titers in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 5031-5035页

作者： va Pallagi-Kunstár Klaudia Farkas Zoltán Szepes Ferenc Nagy Mónika Szucs Róbert Kui Rolland gyulai Anita Bálint Tibor Wittmann Tamás Molnár First Department of Medicine University of SzegedH6720 SzegedHungary Department of Medical Physics and Informatics University of SzegedH6720 SzegedHungary Department of Dermatology and Allergology University of SzegedH6720 SzegedHungary

AIM:To assess tumor necrosis factor-a(TNF-a),infliximab(IFX)concentrations,and antibodies against IFX molecules in patients with inflammatory bowel disease(IBD)who develop loss of response,side effects,or allergic reaction during anti TNF-a ***:Blood samples of 36 patients with response loss,side effects,or hypersensitivity to IFX therapy(Group?Ⅰ)and 31 patients in complete clinical remission(GroupⅡ)selected as a control group were collected to measure trough serum TNF-a level,IFX,and anti-IFX antibody(ATI)*** examined the correlation between loss of response,the development of side effects or hypersensitivity,and serum TNF-a,IFX trough levels,and ATI ***:The serum TNF-a level was shown to be correlated with the presence of ATI;ATI positivity was significantly correlated with low trough levels of *** were detected in 25%of IBD patients with loss of response,side effects,or hypersensitivity,however no association was revealed between these patients and antibody positivity or lower serum IFX *** use of IFX correlated with the development of ATI,although concomitant immunosuppression did not have any impact on ***:On the basis of the present study,we suggest that the simultaneous measurement of serum TNF-a level,serum anti TNF-a concentration,and antibodies against anti TNF-a may further help to optimize the therapy in critical situations.

关键词： Tumor necrosis factor-a Infliximab Antibody Inflammatory bowel disease

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用水量减少的水灌肠CT检查直肠癌

放射学实践 2001年第4期16卷 235-235页

作者：关键 A.Palk Cs.gyulai N.Fedinecz 华中科技大学同济医学院附属同济医院

***ó，***，***，et al 目的：在水灌肠CT（WE-CT）作直肠癌局部分期检查时，确定是否可减少水的用量，而不影响检查的诊断价值。材料与方法：对29例直肠癌患者行术前WE-CT检查。静脉注射平滑肌松驰剂并向直肠内灌注400～500ml微温热... 详细信息

***ó，***，***，et al 目的：在水灌肠CT（WE-CT）作直肠癌局部分期检查时，确定是否可减少水的用量，而不影响检查的诊断价值。材料与方法：对29例直肠癌患者行术前WE-CT检查。静脉注射平滑肌松驰剂并向直肠内灌注400～500ml微温热水之后，行对比增强CT（平衡期）检测。评价取得的扫描图质量，并分析图像以了解肿瘤的浸润深度。将CT检查的结果与手术发现相对比。结果：尽管水灌肠时减少了水的用量，29例接受检查的患者中有19例效果极佳；6例效果良好；4例效果差，但是仍能诊断。鉴别肿瘤是局限在肠壁内还是超出肠壁范围，所取得的敏感性为90%，特异性为70.1%，准确性为86.2%。结论：行直肠CT检查时用大量的水灌肠，会引起不适且增加并发症的危险。本研究结果证明，较少的用水量不会影响检查的质量和直肠癌局部分期的准确性。华中科技大学同济医学院附属同济医院关键译郭俊渊校摘自：Fortschr Rntgenstr 2000，172∶901

关键词：直肠癌 CT 诊断水灌肠

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