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B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

中国化学会2014年大分子体系理论、模拟与计算研讨会

作者：纪仕辰张晓佳 roland g.winkler gerhard gompper Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Chemical EngineeringGuangxi Normal University Theoretical Soft Matter and Biophysics Institute of Complex Systems and Institute for Advanced SimulationForschungszentrum JülichD-52425 JülichGermany

以高分子等黏弹性溶剂为分散介质的胶体体系在新型功能材料研发等领域有着广泛的应用。实验表明,外加流场可以诱导黏弹性溶剂中的胶体自组装形成链状、层状等有序结构1,2,然而其机理及动力学过程仍不清晰。多粒子碰撞动力学模拟(MPC)是... 详细信息

以高分子等黏弹性溶剂为分散介质的胶体体系在新型功能材料研发等领域有着广泛的应用。实验表明,外加流场可以诱导黏弹性溶剂中的胶体自组装形成链状、层状等有序结构1,2,然而其机理及动力学过程仍不清晰。多粒子碰撞动力学模拟(MPC)是一种新兴的模拟方法,同时考虑了流体力学相互作用和热涨落,具有模拟效率高的优点,被广泛用来研究软物质体系3。我们将MPC模拟的溶剂粒子连接为dumbbell,研究表明dumbbell是一种高效的黏弹性溶剂4。进而我们考察了单个胶体粒子以及两个胶体粒子在流场下的运动。发现黏弹性溶剂中,单个胶体粒子的转动速率要慢于牛顿流体中。两个胶体的相对运动轨迹与单个胶体周围的流线相近。胶体的两体作用是多体作用的基础,我们的模拟有助于更好的理解胶体在黏弹性溶剂中的组装行为。

关键词：多粒子碰撞动力学黏弹性流变行为

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente Thomas H.winkler Matthias Tenbusch Institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines Igg4

Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39

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Marine Life Science & Technology 2024年第3期6卷 198-211页

作者： Wanyue Jiang Tongtong Lin Jiao Pan Caitlyn ERivera Clayton Tincher Yaohai Wang Yu Zhang Xiang gao Yan Wang Ho‑Ching T.Tsui Malcolm E.winkler Michael Lynch Hongan Long Institute of Evolution and Marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China Department of Biology Indiana UniversityBloomingtonIN 47405USA School of Mathematics Science Ocean University of ChinaQingdao 266000China State Key Laboratory of Microbial Technology Microbial Technology InstituteSchool of Life ScienceShandong UniversityQingdao 266237China Biodesign Center for Mechanisms of Evolution Arizona State UniversityTempeAZ 85281USA

Bacteria with functional DNA repair systems are expected to have low mutation rates due to strong natural selection for genomic ***,our study of the wild-type Streptococcus pneumoniae D39,a pathogen responsible for many common diseases,revealed a high spontaneous mutation rate of 0.02 per genome per cell division in mutation-accumulation(MA)*** rate is orders of magnitude higher than that of other non-mutator bacteria and is characterized by a high mutation bias in the A/T *** high mutation rate may have resulted from a reduction in the overall efficiency of selection,conferred by the tiny effective population size in *** line with this,*** D39 also exhibited the lowest DNA mismatch-repair(MMR)efficiency among *** with the antibiotic penicillin did not elevate the mutation rate,as penicillin did not induce DNA damage and *** lacks a stress response *** findings suggested that the MA results are applicable to within-host scenarios and provide insights into pathogen evolution.

关键词： Neutral evolution Mutation spectrum Antibiotics DNA mismatch repair Oxidative damage repair

阿尔卑斯古近纪火山活动的沉积记录及其地质意义

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地球科学 2024年

作者：芦刚高亮王长城陈兴聪卢喜和 Wilfried winkler 成都理工大学能源学院山东石油化工学院石油工程学院瑞士苏黎世联邦理工大学

在始新世中期至渐新世早期，欧洲板块和亚得里亚板块发生碰撞，导致了阿尔卑斯造山带的大规模岩浆活动，由于后期隆升剥蚀无法保存，而弧后盆地中同时期的沉积火山碎屑岩记录了这一构造事件。本文针对该套沉积火山碎屑岩，开展了地质年... 详细信息

在始新世中期至渐新世早期，欧洲板块和亚得里亚板块发生碰撞，导致了阿尔卑斯造山带的大规模岩浆活动，由于后期隆升剥蚀无法保存，而弧后盆地中同时期的沉积火山碎屑岩记录了这一构造事件。本文针对该套沉积火山碎屑岩，开展了地质年代学与地球化学等方面的研究，揭示了阿尔卑斯造山带的火山活动和构造演化特征。本次研究表明：火山碎屑岩中的锆石年龄峰值主要集中在～47Ma、40Ma和37Ma，并且锆石的Hf同位素呈现负值，说明其主要形成于板块俯冲过程中部分地壳熔融的岩浆中。此外，通过对岩浆锆石同位素计算地壳厚度的变化，说明了阿尔卑斯造山带不仅存在由于板块俯冲碰撞引起的地壳垂直挤压增厚，还存在俯冲板片拉伸引起的地壳伸展变薄。

关键词：火山碎屑岩岩浆锆石 U-Pb年龄 Eu值地壳厚度

The Algebro-geometric Method for Solving Algebraic Differential Equations——A Survey

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Journal of Systems Science & Complexity 2019年第1期32卷 256-270页

作者： winkler Franz Research Institute for Symbolic Computation J.Kepler University

This paper presents the algebro-geometric method for computing explicit formula solutions for algebraic differential equations(ADEs). An algebraic differential equation is a polynomial relation between a function, some of its partial derivatives, and the variables in which the function is de?*** all these quantities as unrelated variables, the polynomial relation leads to an algebraic relation de?ning a hypersurface on which the solution is to be found. A solution in a certain class of functions, such as rational or algebraic functions, determines a parametrization of the hypersurface in this class. So in the algebro-geometric method the author ?rst decides whether a given ADE can be parametrized with functions from a given class; and in the second step the author tries to transform a parametrization into one respecting also the differential conditions. This approach is relatively well understood for rational and algebraic solutions of single algebraic ordinary differential equations(AODEs). First steps are taken in a generalization to systems and to partial differential equations.

关键词： Algebraic differential equation exact solution parametrization of curves

general Solutions of First-Order Algebraic ODEs in Simple Constant Extensions

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系统科学与复杂性学报:英文版 2023年第4期36卷 1769-1788页

作者： MITTERAMSKOgLER Johann Josef winkler Franz Research Institute for Symbolic Computation(RISC) Johannes Kepler Universität LinzA-4040 LinzAustria

If a first-order algebraic ODE is defined over a certain differential field,then the most elementary solution class,in which one can hope to find a general solution,is given by the adjunction of a single arbitrary constant to this *** of this type give rise to a particular kind of generic point—a rational parametrization—of an algebraic curve which is associated in a natural way to the ODE’s defining *** for the opposite direction,we show that a suitable rational parametrization of the associated curve can be extended to a general solution of the ODE if and only if one can find a certain automorphism of the solution *** automorphisms are determined by linear rational functions,i.e.,Möbius *** properties of rational parametrizations,in combination with the particular shape of such automorphisms,lead to a number of necessary conditions on the existence of general solutions in this solution ***,the desired linear rational function can be determined by solving a comparatively simple differential system over the ODE’s field of *** results hold for arbitrary differential fields of characteristic zero.

关键词： Algebraic curve algebraic differential equation general solution Möbius transformation rational parametrization

Stochastic Runge-Kutta–Munthe-Kaas Methods in the Modelling of Perturbed Rigid Bodies

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Advances in Applied Mathematics and Mechanics 2022年第2期14卷 528-538页

作者： Michelle Muniz Matthias Ehrhardt Michael günther Renate winkler Institute of Mathematical Modelling Analysis and Computational Mathematics(IMACM)Applied Mathematics and Numerical AnalysisBergische Universität WuppertalGaußstraße 2042119 WuppertalGermany

In this paper we present how nonlinear stochastic Itˆo differential equations arising in the modelling of perturbed rigid bodies can be solved numerically in such a way that the solution evolves on the correct *** this end,we formulate an approach based on Runge-Kutta–Munthe-Kaas(RKMK)schemes for ordinary differ-ential equations on ***,we provide a proof of the mean-square convergence of this stochastic version of the RKMK schemes applied to the rigid body problem and illustrate the effectiveness of our proposed schemes by demonstrating the structure preservation of the stochastic RKMK schemes in contrast to the stochastic Runge-Kutta methods.

关键词： Stochastic Runge-Kutta method Runge-Kutta–Munthe-Kaas scheme nonlinear Itˆo SDEs rigid body problem

Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary

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Journal of Forestry Research 2022年第1期33卷 343-355页

作者： gáborÓnodi Zoltán Botta‑Dukát Dániel winkler Tamás Rédei Institute of Ecology and Botany Centre for Ecological ResearchVácrátótHungary Department of Botany and Biodiversity Research University of ViennaViennaAustria Institute of Wildlife Management and Wildlife Biology University of SopronSopronHungary

The biodiversity of natural or semi-natural native,old oak woodlands have high conservation importance,especially in landscapes of monocultural forest plantations and arable *** a wider variety of microhabitats and foraging sources,such old oak forests can provide essential habitat for native forest bird *** conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak(Quercus robur)remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields,settlements,and monocultural *** surveys were carried out in old oak forest remnants,middle-aged oak,white poplar(Populus alba),hybrid poplar(Populus×euramericana),black locust(Robinia pseudoacacia),and pine(Pinus spp.)*** has been carried out in nine study sites,where all six habitat types were represented(with a few exceptions),to determine total abundance,species richness,Shannon–Wiener diversity,species evenness,dominant and indicator species,and guild *** found that old oak forest remnants were the most diverse habitats among the studied forest types,while hybrid poplar and pine plantations exhibited the lowest avian *** avian guilds most sensitive to the loss of old oak forest remnants were ground foragers,bark foragers,cavity-nesters,residents,and Mediterranean migratory *** habitats were more diverse than non-native *** results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations,longer rotation lengths,or retention forestry.

关键词： Forest bird community Bird conservation Old oak forest-steppe remnant Plantation forestry Forest conservation Non-native plantation

Immediate regularization of measure-type population densities in a two-dimensional chemotaxis systemwith signal consumption

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Science China Mathematics 2021年第4期64卷 725-746页

作者： Yulan Wang Michael winkler Zhaoyin Xiang School of Science Xihua UniversityChengdu 610039China Institut für Mathematik Universität PaderbornPaderbom 33098Germany School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731China

This paper deals with the Neumann initial-boundary value problem for a classical chemotaxis system with signal consumption in a *** contrast to previous studies which have established a comprehensive theory of global classical solutions for suitably regular nonnegative initial data,the focus in the present work is on the question to which extent initially prescribed singularities can be regularized despite the presence of the nonlinear cross-diffusive *** main result in this paper asserts that at least in the framework of radial solutions immediate regularization occurs under an essentially optimal condition on the initial distribution of the population *** precisely,it will turn out that for any radially symmetric initial data belonging to the space of regular signed Borel measures for the population density and to L^(2) for the signal density,there exists a classical solution to the Neumann initial-boundary value problem,which is smooth and approaches the given initial data in an appropriate trace sense.

关键词： chemotaxis measure valued initial data instantaneous smoothing global existence