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World Journal of Gastrointestinal Surgery 2013年第1期5卷 9-11页

作者： roland fernandes Irshad Shaikh Samer Doughan Deparment of Colorectal Surgery Queen Elizabeth The Queen Mother HospitalMargate CT9 4ANUnited Kingdom

AIM:To assess the outcomes of laparoscopic colorectal cancer resection in the octogenarian population at our ***:Retrospective analysis of registry data accumulated prospectively were used in conjunction with the data obtained from patient notes to identify outcome data for octogenarians who had undergone elective laparoscopic colorectal cancer ***:Laparoscopic colorectal cancer resections were performed in 68 octogenarians between 2003 and 2011 at our *** operations(6%) were converted to an open *** were twelve cases of morbidity(18%) and two cases of mortality(3%).The overall median hospital stay was 8 *** median time for a patient to be deemed surgically fit for discharge was 5 d reflecting a delay in provision of social care or stoma ***:Our results support the view that laparoscopic surgery in octogenarians is safe,feasible and with a reduced length of *** is well reflected in our results which are compatible with United Kingdom national figures.

关键词： Laparoscopic surgery Colorectal disease Octogenarian Mortality Morbidity

Emergency laparotomy in octogenarians: A 5-year study of morbidity and mortality

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World Journal of Gastrointestinal Surgery 2013年第7期5卷 216-221页

作者： Gemma Green Irshad Shaikh roland fernandes Henk Wegstapel Department of Colorectal Surgery Medway Maritime HospitalGillingham ME7 5NY United Kingdom

AIM: To determine the morbidity and mortality associated with emergency laparotomy for a clinically acute abdomen in patients aged ≥ 80 years. METHODS: In this retrospective audit, octogenarians undergoing emergency laparotomy between 1st January 2005 and 1 st January 2010 were identified using the Galaxy Theatre System. Patients undergoing abdominal surgery through groin crease incisions or Lanz or Gridiron incisions were excluded. Also simple appendectomies were excluded. All patients were aged 80 years or more at the time of their surgery. Data were obtained using casenote review with a standardised proforma to determine patient age, American Society of Anesthesiologists (ASA) grade, indications for surgery, early (within 30 d) and late (after 30 d) complications, mortality and length of stay. Data were inserted into a Microsoft Excel spreadsheet and analysed. RESULTS: One hundred patients were identified from the database (Galaxy) as having undergone emergency laparotomy. Of those, 55 underwent the procedure for intestinal procedures and 37 for secondary *** was a 2:1 female predominance; average age 85 and ASA grade 3. Bowel resection was required in 51 out of the 100 patients and 22 (43%) died. Other procedures included appendicectomy, adhesiolysis, repair of AAA graft leak and colostomies for the pathological process resulting in an acute abdomen. Twelve of 100 patients (12%) suffered intra-operative complications, including splenic and bowel-serosal tears. Seventy patients (70%) had postoperative complications including myocardial infarction, wound infection, haematoma and sepsis. Overall mortality was 45/100 patients (45%). The major causes of death were sepsis (19/45 patients, 42%), underlying cancer (13/45 patients, 29%); with others including bowel obstruction (2/45 patients, 4%), myocardial and intestinal ischaemia and dementia. CONCLUSION: Emergency laparotomy in octogenarians carries a significant morbidity and mortality. In particular,

关键词： Laparotomy Perioperative care Aged Mortality Morbidity

Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<*** 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

Phenomenological model for torsional galloping of an elastic flat plate due to hydrodynamic loads

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Journal of Hydrodynamics 2014年第1期26卷 57-65页

作者： fernandes Antonio Carlos ARMANDEI Mohammadmehdi Department of Naval and Ocean Engineering COPPE/UFRJ

This study investigates the torsional galloping phenomenon, an instability type flow-induced oscillation, in an elastic stru-cture due to hydrodynamic loads into the water current. The structure applied here is a rectangular flat plate with an elastic axis in its mid-chord length. The elasticity is provided by torsion spring. The flat plate has only one degree of freedom which is rotation in pure yaw about its axis. It is observed that as the current speed is higher than a critical velocity, the flat plate becomes unstable. The instability leads to torsional galloping occurrence, as a result of which the flat plate begins to yaw about the elastic axis. By testing two different chord lengths each with several torsion spring rates, the flat plate behavior is investigated and three different responses are recognized. Then, a phenomenological model is developed with the original kernel in the form of the van der Pol-Duffing equa-tion. The model explains these three responses observed experimentally.

关键词： torsional galloping flow-induced oscillation phenomenological model van der Pol-Duffing equation

Modeling of Fischer-Tropsch Synthesis in a Slurry Reactor with Water Permeable Membrane

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Journal of Natural Gas Chemistry 2007年第2期16卷 107-114页

作者： Fabiano A. N. fernandes Universidade Federal do Ceara Departamento de Engenharia QuimicaCampus Universitario do PiciBloco 70960455-760 Fortaleza-CEBrazil

Fischer-Tropsch synthesis is an important chemical process for the production of liquid fuels and olefins. In recent years, the abundant availability of natural gas and the increasing demand of olefins, diesel, and waxes have led to a high interest to further develop this process. A mathematical model of a slurry membrane reactor used for syngas polymerization was developed to simulate and compare the maximum yields and operating conditions in the reactor with that in a conventional slurry reactor. The carbon polymerization was studied from a modeling point of view in a slurry reactor with a water permeable membrane and a conventional slurry reactor. Simulation results show that different parameters affect syngas conversion and carbon product distribution, such as the hydrogen to carbon monoxide ratio, and the membrane parameters such as membrane permeance.

关键词： slurry reactor membrane reactor Fischer-Tropsch modeling

Stability analysis of the fluttering and autorotation of flow-induced rotation of a hinged flat plate

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Journal of Hydrodynamics 2013年第5期25卷 755-762页

作者： MIRZAEISEFAT Sina fernandes Antonio Carlos Department of Naval Architecture and Marine Engineering University of Michigan COPPE/UFRJ Federal University of Rio de Janeiro

This work describes investigations performed on the interaction of uniform current and freely rotating plate about a fixed vertical axis. Fluttering and autorotation are two different motions that may occur during the flow induced rotation. The dimensional analysis proves that the motion in flow induced rotation motion is governed essentially by the dimensionless moment of inertia and Reynolds number. Certain combinations define the stability boundaries between fluttering and autorotation. Fluttering is oscillation of body about a vertical axis and the autorotation is a name given to the case when the body turns continuously about the vertical axis First, the loads and moment coefficients are calculated by experiments and streamline theory for different angles of attack for a fixed fiat plate. Then for dynamic case, a bifurcation diagram is presented based on experiments to classify different motion states of flow induced rotation. Finally, a dynamical model is proposed for stability analysis of flow induced rotation of a flat plate.

关键词： flow-induced rotation autorotation fluttering stability analysis

Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering

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Bone Research 2016年第4期4卷 185-205页

作者： Gabriela fernandes Shuying Yang Department of Oral Biology School of Dental Medicine University at Buffalo The State University of New York Developmental Genomics Group New York State Center of Excellence in Bioinformatics and Life Sciences University at Buffalo The State University of New York Department of Anatomy & Cell Biology School of Dental Medicine University of Pennsylvania

Presently, there is a high paucity of bone grafts in the United States and worldwide. Regenerating bone is of prime concern due to the current demand of bone grafts and the increasing number of diseases causing bone loss. Autogenous bone is the present gold standard of bone regeneration. However, disadvantages like donor site morbidity and its decreased availability limit its use. Even allografts and synthetic grafting materials have their own limitations. As certain specific stem cells can be directed to differentiate into an osteoblastic lineage in the presence of growth factors(GFs), it makes stem cells the ideal agents for bone ***, platelet-rich plasma(PRP), which can be easily isolated from whole blood, is often used for bone regeneration, wound healing and bone defect repair. When stem cells are combined with PRP in the presence of GFs, they are able to promote osteogenesis. This review provides in-depth knowledge regarding the use of stem cells and PRP in vitro, in vivo and their application in clinical studies in the future.

关键词： bone cell Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering BMSCs stem

On the Ranks of Semigroups of Transformations on a Finite Set with Restricted Range

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Algebra Colloquium 2014年第3期21卷 497-510页

作者： Vitor H. fernandes Departamento de Matematica Faculdade de Ciencias e Tebcnologia Universidade Nova de Lisboa Monte da Caparica 2829-516 Caparica Portugal Centro de Algebra da Universidade de Lisboa Av. Prof. Gama Pinto 2 1649-003 Lisboa Portugal Department of Mathematics Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Material Science Research Center Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand

Let ΡΥ（X） be the semigroup of all partial transformations on X, Υ（X） and Ι（X） be the subsemigroups of ΡΥ（X） of all full transformations on X and of all injective partial transformations on X, respectively. Given a non-empty subset Y of X, let ΡΥ（X, Y） = {α∈ ΡΥ（X）： Xα Y}, Υ（X, Y） = ΡΥ（X, Y） ∩Υ（X） and Ι（X, Y） = ΡΥ（X, Y） ∩ Ι（X）. In 2008, Sanwong and Sommanee described the largest regular subsemigroup and determined Green＇s relations of Υ（X,Y）. In this paper, we present analogous results for bothΡ Υ（X, Y） and Ι（X, Y）. For a finite set X with ｜x｜≥ 3, the ranks of ΡΥ（X） = ΡΥ（X, X）, Υ（X） = Υ（X, X） and.Ι（X） = Ι（X, X） are well known to be 4, 3 and 3, respectively. In this paper, we also compute the ranks of ΡΥ（X,Y）, Υ（X, Y） and Ι（X, Y） for any proper non-empty subset Y of X.

关键词： transformations restricted range regular elements Green's relations rank

Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

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World Journal of Gastroenterology 2010年第17期16卷 2094-2099页

作者： roland Andersson Department of Surgery Clinical Sciences LundLund University Lund University Hospital SE-221 85 LundSweden

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem,with a mortality rate in the range of 30%-40%.The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical *** mediators and pathophysiological pathways are involved during the different phases of ALI and *** initial exudative phase is characterized by diffuse alveolar damage,microvascular injury and influx of inflammatory *** phase is followed by a fibro-proliferative phase with lung repair,type Ⅱ pneumocyte hypoplasia and proliferation of *** derived from polymorphonuclear neutrophils,various pro-inflammatory mediators,and phospholipases are all involved,among *** factors that promote pancreatitis-associated ALI may be found in the gut and mesenteric *** is a lack of complete understanding of the underlying mechanisms,and by improving our knowledge,novel tools for prevention and intervention may be developed,thus contributing to improved outcome.

关键词： Acute lung injury Acute respiratory distress syndrome Acute pancreatitis Etiology Pathophysiology

Long-term monitoring of PCDD/PCDF and other unintentionally produced POPs-Concepts and case studies from Europe

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Science China Chemistry 2010年第5期53卷 1017-1024页

作者： REINMANN Jürgen WEBER roland HAAG roland Environnement S.A Deutschland Benzstrasse 1161352 Bad HomburgGermany POPs Environmental Consulting Ulmenstraβe 373035 GppingenGermany TüV Süd Industrie Service GmbH Grabenwiesenstraβe 473072 DonzdorfGermany

During the start-up and unstable combustion periods,even the state-of-the-art incinerators emit polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/PCDF) in stack gases at concentrations that are up to 1000 times higher than normal operation. Therefore,incinerators and other sources with variation of PCDD/PCDF release into air cannot be reliably monitored by the conventional short-term sampling that covers only 0.1%to 0.2%of the yearly operating time.A more comprehensive monitoring regime is *** paper describes different applications of continuous PCDD/PCDF sampling in some European *** cases demonstrate that flexible regimes for continuous sampling can be crafted and applied by governments or regional/local *** regimes range from a countrywide,continuous requirement for selected facility types(e.g.,waste incinerators) to a facility-specific regime that applies,for example,to new facilities for a defined time period until the facility has demonstrated continuous compliance with regulatory limits. Countries implementing the Stockholm Convention are suggested to evaluate in their Best available technology/Best environmental practice(BAT/BEP) activities the usefulness of long-term sampling by,for example,designating institutes related to the environmental ministry or regional authorities to supervise long-term sampling regimes at relevant facilities in their country/areas,beginning with priority sources(e.g.,facilities used for destruction of persistent organic pollutants(POPs) or hazardous waste processing) . This paper presents and discusses the results of the AMESA long-term monitoring system having demonstrated that in addition to PCDD/PCDF all other unintentionally produced POPs listed in the Stockholm Convention could be supervised.

关键词： PCDD/PCDF PCB continuous sampling unintentionally produced POPs Stockholm Convention BAT/BEP