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What Tool for Diagnosis of Latent Tuberculosis Infection in Developing Country with Tuberculosis High Burden: Interferon.gamma Release Assays versus Tuberculin Skin Test in Burkina Faso

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Advances in Infectious Diseases 2022年第4期12卷 668-684页

作者： Diakourga Arthur Djibougou gloria Ivy Mensah Tibila Kientega Leon Tinnoaga Sawadogo Hervé Hien Clément Ziemlé meda Adrien Marie-gaston Belem Roch Konbobr Dabiré Bassirou Bonfoh Kennedy Kwasi Addo Potiandi Serge Diagbouga Université nazi BOnI Bobo-Dioulasso Burkina Faso Centre MURAZ/Institut national de Santé Publique Bobo-Dioulasso Burkina Faso Centre national de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Department of Bacteriology Noguchi Memorial Institute for Medical Research College of Health Sciences University of Ghana Legon Accra Ghana Université de Montréal Centre de recherche du Centre hospitalier de l’universitaire de Montréal (CRCHUM) Montréal Canada Programme national Tuberculose Ministry of Health Ouagadougou Burkina Faso Centre Suisse de Recherches Scientifique de Cô te d’Ivoire Abidjan C&#244 te d’Ivoire Etudes Formation et Recherches Développement en Santé (EFORDS) Ouagadougou Burkina Faso

Background: The diagnosis and treatment of active tuberculosis and the detection/man.gement of latent tuberculosis infection (LTBI) cases are the two main strategies for the TB control, particularly in endemic countries. Tuberculin skin test (TST) and Interferon.gamma Release Assays (IgRAs) are tools for detection of LTBI. The objective of this study was to evaluate the performance of the TST and QuantiFEROn-TB gold Plus® (QTF-Plus) and to identify a threshold for TST in best agreement with QTF-Plus for LTBI detection in a high TB burden setting. Methods: In July 2020, a cross-sectional analytical study was performed for QFT-Plus using blood samples and TST in 101 individuals with a high risk of TB living in Bobo-Dioulasso, Burkina Faso. A crude comparison between both tests was done and receiver operating characteristic curve was generated to determine TST’s threshold. TST sensitivity, specificity, predictive values and accuracy were calculated. Adjusted agreement between TST and QFT-Plus was evaluated. Results: With the minimum threshold of positivity set at 5 mm for TST, the overall agreement between the latter and QFT-Plus was poor with a Kappa coefficient (κ) rated at 0.319 (95% CI: 0.131 - 0.508). This cut-off yielded a sensitivity of 94.12% (95% CI: 88.53 - 99.71), and very poor specificity of 36.4% (95% IC: 25.0 - 47.80). However, an adjusted cut-off set at 11 mm gave a better specificity of 72.73% (95% CI: 62.1 - 83.30) of TST and improved the PPV (86%). Moreover, concordance between both tests was improved with κ at 0.56 (95% CI: 0.385 - 0.728) and 80.20% of accuracy. Factors associated with discordance between TST (11 mm) and QFT-Plus results were BCg vaccination, OR = 7.53 (95% CI: 1.43 - 139.25), p = 0.05 and chronic cough, OR = 5.07 (95% CI: 1.27 - 20.43), p = 0.01. Conclusions: This study showed that using a minimal cut-off of 11mm for TST significantly improved the concordance between QTF-Plus (IgRA) and TST. Using the cut-off TST of

关键词： LTBI Diagnosis IgRA TST Threshold Concordance Burkina Faso

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Socio-Environmental Impact of Water Pollution on the Mid-canal (<i>meda Ela</i>), Sri Lanka

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Journal of Water Resource and Protection 2012年第7期4卷 451-459页

作者： K. B. S. n. Jinadasa S. K. I. Wijewardena Dong Qing Zhang Richard M. gersberg C. S. Kalpage Soon Keat Tan Jing Yuan Wang Wun Jern ng Department of Chemical and Process Engineering University of Peradeniya Peradeniya Sri Lanka Department of Civil Engineering University of Peradeniya Peradeniya Sri Lanka graduate School of Public Health San Diego State University Hardy Tower Campanile San Diego USA nanyang Environment & Water Research Institute (nEWRI) Nanyang Technological University Singapore City Singapore nanyang Environment & Water Research Institute (nEWRI) Nanyang Technological University Singapore Singapore Works Department Kandy Municipal Council Kandy Sri Lanka

Unplanned urban population.growth in developing countries such as Sri Lanka exert pressures on the sectors of water supply, sewage disposal, waste man.gement, and surface drain.ge in the cities as well as their surrounding areas. The Mid-canal is considered the most polluted surface water body in the Kandy district of Sri Lanka and contributes significantly to pollution of the Mahaweli River. Health problems in the nearby population may well be associated with environmental degradation and related to deteriorated water quality. The overall objectives of this study were to identify the socio-economic status of the community settled along the meda Ela banks, and to examine the current water quality status of the meda Ela and possible impacts of the nearby residents on water quality. Additionally, we propose remedial measures concerning wastewater and solid waste disposal to improve environmental conditions in this area.

关键词： meda Ela Sri Lanka Environment Pollution Water Quality

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Factors Associated with Antigen HBs Seroconversion among Blood Donors in Ouagadougou from 2008 to 2017

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Advances in Infectious Diseases 2021年第3期11卷 278-289页

作者： Abdoul-guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed Kabore Dahourou Honorine Arzouma Paul Yooda Bia Emile Drabo Jean-Etienne Koanda Alain Konseybo Eléonore Kafando nicolas meda Léon Blaise Savadogo Centre national de Transfusion Sanguine (CnTS) Ouagadougou Burkina Faso Ong Terre des hommes Lausanne Ouagadougou Burkina Faso Centre MURAZ Bobo-Dioulasso Burkina Faso Université nazi BOnI Bobo-Dioulasso Burkina Faso Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université norbert ZOngO Koudougou Burkina Faso

Introduction: The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and fact... 详细信息

ng>Introduction: ng>The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors at the Regional Blood Transfusion Centre of Ouagadougou. ng>Methods:ng> A retrospective cohort study of voluntary non-remunerated blood donors (VnRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. ng>Results:ng> Of 23,494 donors, 559 had HBsAg seroconversion. The number of donor years was 58,637.50 and the HBV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p n among donors under 21 years old. Female donors were 1.11 times more likely to seroconvert than male donors (p = 0.33). Donor residence was not significantly associated with HBsAg seroconversion (Hazard ratio = 1.12;p = 0.36). The risk of seroconversion decreased significantly with the number of blood donations (Hazard ratio = 0.58;p = 0.006). ng>Conclusion: ng>The incidence of HBsAg remains high among blood donors, which could have a n.gative impact on transfusion safety. The age of the blood donor was significantly associated to AgHBs seroconversion.

关键词： Time to Onset Viral Hepatitis B Blood Donors Seroconversion

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家具的“小骨感”

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现代装饰 2018年第5期 112-118页

作者： Liu Yaxi Max Voytenko Fraricesco meda Mario Alessiani Yonoh Estudio Creativo Republic of Fritz Hansen Puck Dieben Christian Meiz Bower giuseooe Bavuso 李薇 Wanghe Studio Luisa+Lilian Parrado Studio nienke Hoogvliet

环肥燕瘦皆是美,家具产品也是如此。那些搭配了厚厚的软垫、或大量采用棉绒等物料填充的沙发和休闲椅,大都属于＂环肥＂这一类型,身体软软的,看起来稍显丰满,但同时也拥有舒适柔软的触感与就坐体验,带着些温柔的暖意,有着一种柔和之美... 详细信息

环肥燕瘦皆是美,家具产品也是如此。那些搭配了厚厚的软垫、或大量采用棉绒等物料填充的沙发和休闲椅,大都属于＂环肥＂这一类型,身体软软的,看起来稍显丰满,但同时也拥有舒适柔软的触感与就坐体验,带着些温柔的暖意,有着一种柔和之美。而也有一些家具产品,它们多以木材和金属为主要材料,利用材质本身的特质大胆地呈现出线条与骨架,并使其成为设计的亮点,给人以一种＂瘦＂的小骨感之美。

关键词：家具产品休闲椅木材沙发触感柔软木质颜色

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肾素生成细胞中缝隙连接蛋白40表达恢复可减少缝隙连接蛋白40缺失小鼠高血压的发生

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中华高血压杂志 2014年第5期22卷 474-474页

作者：刘莉叶鹏 Le gal L Alonso F Wagner C germain S Haefliger Dn meda P Haefliger JA

缝隙连接蛋白（connexin，Cx）40在肾脏肾素生成细胞（renin—producingcells，RSC）和血管内皮细胞中表达。Cx40缺失小鼠（Cx40-/-）以肾素合成和分泌较多为特点，可导致慢性高血压发生，还可使内皮型一氧化氮合酶（endothelialnitrico... 详细信息

缝隙连接蛋白（connexin，Cx）40在肾脏肾素生成细胞（renin—producingcells，RSC）和血管内皮细胞中表达。Cx40缺失小鼠（Cx40-/-）以肾素合成和分泌较多为特点，可导致慢性高血压发生，还可使内皮型一氧化氮合酶（endothelialnitricoxidesynthase，enOS）和一氧化氮生成减少，导致主动脉内皮依赖性舒张功能发生改变。为了区别Cx40在肾素分泌和血管信号传递情况的作用，

关键词：血管内皮细胞慢性高血压连接蛋白40 肾素小鼠内皮型一氧化氮合酶内皮依赖性舒张功能缝隙连接蛋白

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年轻发病2型糖尿病对中青年比马印第安人终末期肾病发病率和死亡率的影响

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美国医学会杂志（中文版） 2007年第3期26卷 147-151页

作者： meda E. Pavkov, MD, PhD Peter H. Bennett, MB, FRCP William C. Knowler, MD, DrPH Jonathan Krakoff, MD Maurice L Sievers, MD Robert g. nelson, MD, PhD 蔡润策（译）贾伟平（校） Phoenix Epidemiology and Clinical Research Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Phoenix Adz. 不详

背景：年轻发病2型糖尿病患者的长期结局尚未被阐明。目的：在年轻与年长发生糖尿病的比马印第安人中比较糖尿病性终末期肾病（end-stagerenal disease，ESRD）的发病率和死亡率。设计、地点及参试者：于1965～2002年在Arizona比马印第... 详细信息

背景：年轻发病2型糖尿病患者的长期结局尚未被阐明。目的：在年轻与年长发生糖尿病的比马印第安人中比较糖尿病性终末期肾病（end-stagerenal disease，ESRD）的发病率和死亡率。设计、地点及参试者：于1965～2002年在Arizona比马印第安人中进行人群纵向研究。参试者分为两组：年轻发病2型糖尿病（发病年龄〈20岁）和年长发病2型糖尿病（发病年龄20～55岁）。随访事件和人年按时间依赖方式以每10岁进行分层。终末期肾病的定义为因糖尿病肾病而接受透析治疗或者死于糖尿病肾病。主要观测指标：根据2型糖尿病的发病年龄，计算25至55岁之间糖尿病ESRD的发病率和死亡率。结果：在1856例糖尿病参试者中，96例为年轻发病。校正年龄及性别后，年轻发病2型糖尿病者ESRD的发生率为每1000人年25．0例（95％可信区间[confidence interval，CI]，6．7～43．1），年长发病者ESRD的发病率为每10130人年5．4例（95％CI，4．4～6．4）（发病率比，4．6；95％CI，2．2～9．8）。在所有年龄段中，年轻发病参试者的年龄别ESRD发生率均较高。在校正年龄及性别后，年轻发病2型糖尿病参试者的自然原因死亡率为每10130人年15．4例（95％CI，0．2～30．5），年长发病2型糖尿病个体为每10130人年7．3例（95％CI，5．9～8．7）（死亡率比，2．1；95％CI，0．8～5．7）。与无糖尿病的参试者相比，年轻发病2型糖尿病个体的死亡率为前者的3倍（95％CI，1．1～1．8），年长发病2型糖尿病个体的死亡率是其1．4倍（95％CI，1．1～1．8）。在1386例具有所有协变量完整数据的亚组中（从糖尿病发病开始即进行观察），在校正性别、平均动脉压、体重指数（kg／m^2）、血浆葡萄糖浓度、吸烟、降糖药以及降压药后，Cox比例风险模型显示糖尿病发病年龄与ESRD发病率并不相关（风险比，1．0；95％CI，0．9～1．2）。结论：2型糖尿病较早发病与中年时ESRD发病率和死亡率显著升高相关。其主要原因是20岁以下诊断糖尿病的个体在中年时已有较长的糖尿病病程。

关键词： 2型糖尿病发病率比终末期肾病印第安人死亡率年轻 Cox比例风险模型发病年龄

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帕金森运动障碍中丘脑底核-苍白球同步化发生改变

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 29-29页

作者： Foffani g. Ardolino g. meda B. A. Priori 赵睿 Dipartimentodi Scienze neurologiche Clinica NeurologicaOspedale Maggiore Policlinico Via F. Sforza 35 Milano20122 Italy Prof.

The aim of this work was to study the role of subthalamo-pallidal synchronisa tion in the pathophysiology of *** recorded local field potentials (L FPs) in a patient with Parkinson’s disease and left surgery induced dyskinesias with double, bilateral deep brain stimulation electrode implants inthe subthala mic nucleus (STn) and the globus pallidus internus(gPi). Synchronisation was stu died through coherence *** the nuclei contralateral to the dyskinetic si de of the body there was decreased STn.gPi coherence in the high beta range (20 -30 Hz) and an enhanced coherence at low frequencies(ns arising fromsin.gle-case observations, our findings suggest tha t parkinsonian dyskinesias are related to altered synchronisation between differ ent structures of the basal ganglia. Firing abnormalities within individual basa l ganglia nuclei are probably not enough to account for the complex balance betw een hypokinetic and hyperkinetic symptoms in human parkinsonian dyskinesias and altered interactions between nuclei should also be considered.

关键词：丘脑底核苍白球同步化运动障碍帕金基底神经节深部脑刺激内侧部 ganglia 神经核

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CO_2捕集过程中有机胺热降解的实验研究

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清华大学学报（自然科学版） 2012年第1期52卷 81-86页

作者：周姗王淑娟 Rochelle g T 陈昌和清华大学热能工程系热科学与动力工程教育部重点实验室中国北京100084 德克萨斯大学奥斯汀分校化学工程系美国德克萨斯州奥斯汀78712-0231

在使用有机胺捕集CO2的工艺中,胺的降解性质是评价胺的重要因素之一。该文使用不锈钢密闭反应器和强制对流烘箱,在相同CO2负荷条件下分别考察了乙二胺(EDA)、1,2-二胺基丙烷(meda)、2-哌啶乙醇(2-PE)、哌嗪/2-氨基-2-甲基-1-丙醇(PZ/AMP... 详细信息

在使用有机胺捕集CO2的工艺中,胺的降解性质是评价胺的重要因素之一。该文使用不锈钢密闭反应器和强制对流烘箱,在相同CO2负荷条件下分别考察了乙二胺(EDA)、1,2-二胺基丙烷(meda)、2-哌啶乙醇(2-PE)、哌嗪/2-氨基-2-甲基-1-丙醇(PZ/AMP)混合溶液在373～423K的热降解过程。除乙二胺外,所有实验的胺类的热降解速率都低于常用的乙醇胺(MEA)的热降解速率。在乙二胺分子上添加空间位阻有助于降低胺的热降解速率。本身具有热稳定结构的胺与其他胺类混合后,其热降解速率可能会提高。

关键词： CO2捕集有机胺热降解

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女性使用生物燃料相关的慢性阻塞性肺疾病：一项系统性回顾和meta分析

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英国医学杂志中文版 2018年第6期21卷 358-358页

作者：王臻(译) 施焕中(校) Adama Sana Serge M A Somda nicolas meda Catherine Bouland 首都医科大学附属北京朝阳医院呼吸与危重症医学科不详

目的慢性阻塞性肺疾病（COPD）是世界范围内患病率和死亡率不断增长的主要疾病。女性的COPD患病率较男性增长更快，因为女性更常暴露在生物燃料燃烧产生的室内污染物中。

关键词：慢性阻塞性肺疾病生物燃料 meta分析系统性回顾女性室内污染物世界范围 COPD

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A Review on Surface?Functionalized Cellulosic nanostructures as Biocompatible Antibacterial Materials

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nano-Micro Letters 2020年第6期12卷 90-112页

作者： Mandana Tavakolian Seid Mahdi Jafari Theo gMvan de Ven Department of Chemical Engineering McGill UniversityMontrealQC H3A 0C5Canada Pulp and Paper Research Center McGill UniversityMontrealQC H3A 0C7Canada Quebec Centre for Advanced Materials(QCAM/CQMF) MontrealCanada Department of Food Materials and Process Design Engineering Gorgan University of Agricultural Science and Natural ResourcesGorganIran Department of Chemistry McGill UniversityMontrealQC H3A 0B8Canada

As the most abundant biopolymer on the earth,cellulose has recently gained significant attention in the development of antibacterial ***,renewability,strong mechanical properties,tunable aspect ratio,and low density offer tremendous possibilities for the use of cellulose in various *** to the high number of reactive groups(i.e.,hydroxyl groups)on the cellulose surface,it can be readily functionalized with various functional groups,such as aldehydes,carboxylic acids,and amines,leading to diverse *** addition,the ease of surface modification of cellulose expands the range of compounds which can be grafted onto its structure,such as proteins,polymers,metal nanoparticles,and *** are many studies in which cellulose nano-/microfibrils and nanocrystals are used as a support for antibacterial ***,little is known about the relationship between cellulose chemical surface modification and its antibacterial activity or *** this study,we have summarized various techniques for surface modifications of cellulose nanostructures and its derivatives along with their antibacterial and biocompatibility behavior to develop non-leaching and durable antibacterial *** the high effectiveness of surface-modified cellulosic antibacterial materials,more studies on their mechanism of action,the relationship between their properties and their effectivity,and more in vivo studies are required.

关键词： Cellulose nanocellulose Surface modification Antibacterial activity Biocompatibility

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