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Kinases: Understanding Their Role in HIV Infection

World Journal of AIDS 2019年第3期9卷 142-160页

作者： William De Martini roksana rahman Eduvie Ojegba Emily Jungwirth Jasmine Macias Frederick Ackerly Mia Fowler Jessica Cottrell Tinchun Chu Sulie L. Chang Department of Biological Sciences Seton Hall University South Orange NJ USA Institute of NeuroImmune Pharmacology South Orange NJ USA

Antiviral drugs currently on the market primarily target proteins encoded by specific viruses. The drawback of these drugs is that they lack antiviral mechanisms that account for resistance or viral mutation. Thus, there is a pressing need for researchers to explore and investigate new therapeutic agents with other antiviral strategies. Viruses such as the human immunodeficiency virus (HIV) alter canonical signaling pathways to create a favorable biochemical environment for infectivity. We used Qiagen Ingenuity Pathway Analysis (IPA) software to review the function of several cellular kinases and the resulting perturbed signaling pathways during HIV infection such as NF-κB signaling. These host cellular kinases such as ADK, PKR, MAP3K11 are involved during HIV infection at various stages of the life cycle. Additionally IPA analysis indicated that these modified host cellular kinases are known to have interactions with each other especially AKT1, a serine/threonine kinase involved in multiple pathways. We present a list of cellular host kinases and other proteins that interact with these kinases. This approach to understanding the relationship between HIV infection and kinase activity may introduce new drug targets to arrest HIV infectivity.

关键词： HIV AIDS Kinases IPA NF-κB

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Detection and Characterization of the Cyanobacteria and Cyanophages of Barnegat Bay, New Jersey

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Journal of Environmental Protection 2019年第11期10卷 1472-1483页

作者： roksana M. rahman Alexandra Greco Alisha Nanda Christian Rios-Ruiz Yan Wang Paul Yoon Dena J. Restaino John J. Gaynor Paul A. X. Bologna Tinchun Chu Department of Biological Sciences Seton Hall University NJ USA Department of Biology and Chemistry County College of Morris Randolph NJ USA Department of Biology Montclair State University NJ USA

Cyanobacterial harmful algal blooms (CHAB), caused by eutrophication, are known to threaten both wildlife and human health. Due to urbanization and land use changes, an increase of CHAB’s at a more frequent rate within Barnegat Bay has been observed. In order to detect possible CHAB causing cyanobacteria, water samples were collected from 12 different locations within Barnegat Bay. Each sample was filtered through a 30- and 0.4-μm polycarbonate filter sequentially. Flow cytometry was carried out for the filtrate collected between 0.4- and 30-μm. Chelex DNA extraction, polymerase chain reaction (PCR), and gel electrophoresis were then performed for all sites using four primer sets (27F/785R, PSF/UR, CYA359F/CYA781R and MSF/MSR) designed to detect cyanobacteria. Flow cytometric results indicated the water samples contained a wide range of cyanobacteria, including M. aeruginosa, Cylindrospermum spp., Anabaena spp., and Synechococcus sp. IU 625 ranges from 3.16 to 8.17 × 107 cells·L-1. PCR-based assays suggest that general cyanobacteria as well as phytospecific species were present for all sites, but no toxin-producing Microcystis aeruginosa was detected. Plaque assays demonstrated the presence of cyanophages for S. IU 625, Anabaena spp., and M. aeruginosa at all sites, up to 105 PFU·ml-1.

关键词： Cyanobacterial Harmful Algal Blooms Eutrophication Flow Cytometry Polymerase Chain Reaction Plaque Assay

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On chip chiral and plasmonic hybrid dimer or tetramer:Generic way to reverse longitudinal and lateral optical binding forces

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Chinese Physics B 2022年第5期31卷 305-316页

作者： Sudipta Biswas roksana Khanam Rumi Tasnia rahman Raima Saikat Chandra Das M R C Mahdy Department of Electrical&Computer Engineering North South UniversityBashundharaDhaka1229Bangladesh

For both the longitudinal binding force and the lateral binding force,a generic way of controlling the mutual attraction and repulsion(usually referred to as reversal of optical binding force)between chiral and plasmonic hybrid dimers or tetramers has not been reported so *** this paper,by using a simple plane wave and an onchip configuration,we propose a possible generic way to control the binding force for such hybrid objects in both the near-field region and the far-field *** also investigate different inter-particle distances while varying the wavelengths of light for each inter-particle distance throughout the *** of all,for the case of longitudinal binding force,we find that chiral-plasmonic hybrid dimer pairs do not exhibit any reversal of optical binding force in the near-field region nor in the far-field region when the wavelength of light is varied in an air ***,when the same hybrid system of nanoparticles is placed over a plasmonic substrate,a possible chip,it is possible to achieve a reversal of the longitudinal optical binding ***,for the case of lateral optical binding force,we investigate a setup where we place the chiral and plasmonic tetramers on a plasmonic substrate by using two chiral nanoparticles and two plasmonic nanoparticles,with the setup illuminated by a circularly polarized plane *** applying the left-handed and the right-handed circular polarization state of light,we also observe the near-field and the far-field reversal of lateral optical binding force for both *** far as we know,so far,no work has been reported in the literature on the generic way of reversing the longitudinal optical binding force and the lateral optical binding force of such hybrid *** a generic way of controlling optical binding forces can have important applications in different fields of science and technology in the near future.

关键词： longitudinal binding force plasmonics chirality optical force

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