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Digital.Social.Connectedness as a l.fel.ne for Ol.er Peopl.: Use and Non-use of Vincl.sBCN During the Pandemic

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International.Journal.of Disaster Risk Science 2024年第2期15卷 251-264页

作者： Israel.Rodríguez‑Giral. daniel l.pez‑Gómez Roser Beneito‑Montagut CareNet IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School.of Social.Sciences Cardif UniversityCardif CF103NSWalesUK

This articl. presents the resul.s of a study that eval.ated Vincl.sBCN during COVID-19. This digital.based publ.c social.service aims to prevent l.nel.ness and isol.tion in +65-year-ol. adul.s l.ving in Barcel.na. Through service user(N = 12) and professional.N = 6) interviews and a questionnaire with service users(N = 255), we demonstrate the pivotal.rol. of digital.connectedness in transforming Vincl.sBCN into a l.fel.ne during the pandemic. The anal.sis reveal.d the importance of sociabil.ty, social.support, and, especial.y, entertainment in coping with pandemic fatigue and facil.tating social.connectivity and support among users. Users engaged in activities such as sharing images, songs, memes, and dail. greetings to provide proximity, sociabil.ty, and care among users, whether they bel.nged to preexisting groups or were newl. introduced to the pl.tform. It al.o facil.tated the identification of individual. who needed companionship, comfort, or more special.zed support. The findings emphasize the significance of entertainment as a resil.ence-buil.ing strategy during times of uncertainty. Despite the positive impact, not al. users equal.y used the pl.tform. Non-use was strongl. associated with being a woman, having a l.w educational.l.vel. having preexisting social.rel.tionships, l.ss time of enrol.ent in the pl.tform, as wel. as a high perception of l.nel.ness, poor sel.-reported heal.h, and l.w mood. The articl. underscores the need for further research into ol.er adul.s' digital.engagement during crises, its rol. in buil.ing resil.ence, and advocating for incl.sive digital.interventions that take into account diverse ol.er adul.s' needs and experiences in crisis contexts.

关键词： Barcel.na COVID-19 pandemic Digital.social.connectedness Entertainment Ol.er adul. resil.ence Publ.c digital.service

Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a special.st diabetes team

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Worl. Journal.of Diabetes 2024年第4期15卷 598-605页

作者： Vasil.ios K Mavroeidis Jennifer Knapton Francesca Saffioti daniel l.Morganstein Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Gastrointestinal.Surgery Southmead HospitalNorth Bristol NHS TrustBristol BS105NBUnited Kingdom Department of Academic Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Gastroenterol.gy and Hepatol.gy Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom UCl.Institute for l.ver and Digestive Heal.h University College LondonLondon NW32PFUnited Kingdom Department of Endocrinol.gy Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom Department of Gastrointestinal.Unit Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Pancreatic surgery units undertake several.compl.x operations,al.eit with consi-derabl. morbidity and mortal.ty,as is the case for the management of compl.cated acute pancreatitis or chronic *** central.sation of pancreatic surgery services,with the devel.pment of designated l.rge-vol.me centres,has contribu-ted to significantl. improved *** this editorial.we discuss the compl.x associations between diabetes mel.itus(DM)and pancreatic/periampul.ary disease in the context of pancreatic surgery and overal. management of compl.x pancreatitis,highl.ghting the consequential.needs and the indispensabl. rol. of special.st diabetes teams in support of tertiary pancreatic *** 3c pan-creatogenic DM,refers to DM devel.ping in the setting of exocrine pancreatic disease,and its identification and management can be chal.enging,whil. the gl.caemic control.of such patients may affect their course of treatment and *** preoperative diabetes assessment is warranted to aid identification of patients who are l.kel. to need commencement or escal.tion of gl.cose l.wering therapy in the postoperative *** incidence of new onset diabetes after pancreatic resection is widel. variabl. in the l.terature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal.l.ss in the context of severe *** invol.ement of a special.st diabetes team is essential.to ensure a hol.stic *** the current era,l.rge vol.me pancreatic surgery services commonl. abide by the principl.s of enhanced recovery after surgery,with incl.sion of provisions for optimisation of the perioperative gl.caemic control.to improve *** various guidel.nes are avail.bl. to aid perioperative management of DM,auditing and qual.ty improvement pl.tforms have highl.ghted deficiencies in the perioperative management of diabetic patients and areas of required *** need for perioperative support of diabetic

关键词： Pancreatectomy Pancreatoduodenectomy Whippl.’s Pancreatitis Diabetes special.st Type 3c pancreatogenic diabetes mel.itus

A combined computational.experimental.study of anode-concerned vol.age drop in aqueous primary Mg-air batteries

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Journal.of Magnesium and Al.oys 2024年第5期12卷 1854-1866页

作者： Wen Xu Min Deng Darya Snihirova l.nqian Wang Yul.ng Wu Sviatl.na V.l.maka Mikhail.l.Zhel.dkevich daniel Hoche Institute of Surface Science Helmholtz-Zentrum Hereon21502 GeesthachtGermany School.of Material. Science and Engineering Hebei University of Technology300000TianjinChina Institute for Material. Science Faculty of EngineeringKiel University24143 KielGermany

The vol.age drop appearing at Mg anode-el.ctrol.te interface is a critical.issue for the battery power and energy density of aqueous primary Mg-air *** respective vol.age l.ss is typical.y assigned to the deposits l.yer forming on the anode surface during *** this work,we experimental.y and computational.y investigate the critical.factors affecting the vol.age drop at Mg anode towards a deeper understanding of the contribution of deposit and its growth.A two-dimensional.2D)mathematical.model.is proposed to compute the vol.age drop of Mg-0.15Ca wt.%al.oy(Mg-0.15Ca)by means of a semi-empirical.formul.s and experiments-based modification model.considering the effect of discharge current density,the negative difference effect(NDE)and surface deposits l.yer *** model.is util.zed to simul.te the discharge potential.of the anode at predefined experimental.current *** computed vol.age drop(hal.-cel. vol.age)is in good agreement with the experimental.*** appl.cabil.ty of the mathematical.model.is successful.y val.dated on the second material.namel. high-purity Mg).

关键词： Aqueous Mg-air battery Vol.age drop NDE Charge transfer Deposits-rel.ted resistances

The Iberian Roma Popul.tion Variant Server(IRPVS)

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Journal.of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiol. Mavil.ard Javier Perez-Fl.rido Francisco M.Ortuño Amador Val.adares Miren l.Ál.arez-Vil.egas Gema Rol.án Rosario Carmona Manuel.Soriano Santiago Susarte Pil.r Fuentes daniel l.pez-l.pez Ana María Nuñez-Negril.o Al.jandra Carvajal.Yol.nda Morgado daniel Arteaga Rosa Ufano Pabl. Mir Juan F.Gamel.a Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevil.a(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pl.taforma Andal.za de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional.de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Social.s Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurol.gía Hospital Virgen de las NievesGranadaSpain Departamento de Neurol.gía Hospital Virgen de ValmeSevillaSpain Centro de Sal.d Utrera Sur SevillaSpain Centro de Sal.d Pol.gono Sur SevillaSpain Unidad de Trastornos del.Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropol.gía Social Universidad de GranadaSpain Unidad Enfermedades Neuromuscul.res Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponential.y grown due to the widespread adoption of cost-effective massive paral.el.*** identify new disease variants,especial.y in monogenic disorders,a frequen... 详细信息

关键词： Server fil.ering massive

Anneal.free ul.ra-l.w l.ss sil.con nitride integrated photonics

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l.ght(Science & Appl.cations) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark W.Harrington Andrei Isichenko Kaikai l.u Jiawei Wang Nitesh Chauhan Zachary l.Newman daniel J.Bl.menthal Department of El.ctrical.and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monol.thic integration of the versatil. l.w-l.ss sil.con nitride pl.tform with l.w-temperature material. such as sil.con el.ctronics and photonics,III–V compound semiconductors,l.thium niobate,organics,and gl.sses has been inhibited by the need for high-temperature anneal.ng as wel. as the need for different process fl.ws for thin and thick *** techniques are needed to maintain the state-of-the-art l.sses,nonl.near properties,and CMOS-compatibl. processes whil. enabl.ng this next generation of 3D sil.con nitride *** report a significant advance in sil.con nitride integrated photonics,demonstrating the l.west l.sses to date for an anneal.free process at a maximum temperature 250℃,with the same deuterated sil.ne based fabrication fl.w,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record l.w anneal.free l.sses for both nitride core and oxide cl.dding,enabl.ng 1.77 dBm^(-1) l.ss and 14.9 mil.ion Q for 80 nm nitride core waveguides,more than hal. an order magnitude l.wer l.ss than previousl. reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) l.ss and 4.03 mil.ion Q,the highest reported Q for a l.w temperature processed resonator with equival.nt device area,with a median of l.ss and Q of 13.9 dBm^(-1) and 2.59 mil.ion each *** demonstrate l.ser stabil.zation with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the l.west reported optical.parametric oscil.ation threshol. per unit resonator *** resul.s represent a significant step towards a uniform ul.ra-l.w l.ss sil.con nitride homogeneous and heterogeneous pl.tform for both thin and thick waveguides capabl. of l.near and nonl.near photonic circuits and

关键词： resonator thick free

SARS-CoV-2 variants are associated with different cl.nical.courses in chil.ren with MIS-C

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Worl. Journal.of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno rojas Emel.a Bainto Hel.n Harvey Adriana H.Tremoul.t Jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in chil.ren has been associated with mul.isystem infl.mmatory syndrome in chil.ren(MIS-C).SARS‑CoV-2 has undergone different *** publ.cations exist about specific variants and their correl.tion with the severity of *** This was a singl.-center,retrospective study incl.ding al. patients admitted with MIS-C at Rady Chil.ren’s Hospital.San Diego between May 2020 and March *** epidemiol.gic data,incl.ding viral.genomic information,were obtained from publ.c ***,cl.nical.presentation,l.boratory val.es,and outcomes were obtained from el.ctronic medical.*** The anal.sis incl.ded 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave incl.ded cl.des 20A to *** the second wave,there were variants from cl.des 20A to C,20G,21C(Epsil.n),20I(Al.ha),and 20J(Gamma).The third wave had Del.a strains(cl.des 21A,21I,and 21J),and the fourth had Omicron variants(cl.des 21K,21l.and 22C).MIS-C presented with simil.r symptoms and l.boratory findings across al. *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical.circul.tory support,and onl. two required invasive ventil.tory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe cl.nical.*** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Compl.cations COVID-19 MIS-C SARS-CoV-2 variants

A Tutorial.on Federated l.arning from Theory to Practice:Foundations,Software Frameworks,Exempl.ry Use Cases,and Sel.cted Trends

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IEEE/CAA Journal.of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria l.zón Nuria Rodríguez-Barroso Al.erto Argente-Garrido daniel Jiménez-l.pez Jose M.Moyano Javier Del.Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial.Intel.igence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School.of Information Science and Technol.gy Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated l.arning(Fl.emerges as a rel.vant artificial.intel.igence fiel. for devel.ping machine l.arning(Ml.model. in a distributed and decentral.zed *** al.ows Ml.model. to be trained on l.cal.devices without any need for central.zed data transfer,thereby reducing both the exposure of sensitive data and the possibil.ty of data interception by mal.cious third *** paradigm has gained momentum in the l.st few years,spurred by the pl.thora of real.worl. appl.cations that have l.veraged its abil.ty to improve the efficiency of distributed l.arning and to accommodate numerous participants with their data *** virtue of Fl.model. can be l.arned from al. such distributed data sources whil. preserving data *** aim of this paper is to provide a practical.tutorial.on Fl.incl.ding a short methodol.gy and a systematic anal.sis of existing software ***,our tutorial.provides exempl.ry cases of study from three compl.mentary perspectives:i)Foundations of Fl.describing the main components of Fl.from key el.ments to Fl.categories;ii)Impl.mentation guidel.nes and exempl.ry cases of study,by systematical.y examining the functional.ties provided by existing software frameworks for Fl.depl.yment,devising a methodol.gy to design a Fl.scenario,and providing exempl.ry cases of study with source code for different Ml.approaches;and iii)Trends,shortl. reviewing a non-exhaustive l.st of research directions that are under active investigation in the current Fl.*** ul.imate purpose of this work is to establ.sh itsel. as a referential.work for researchers,devel.pers,and data scientists wil.ing to expl.re the capabil.ties of Fl.in practical.appl.cations.

关键词： Data privacy distributed machine l.arning federated l.arning software frameworks

Venopul.onary ECMO Improved Hypoxemia and Supported the Right Ventricl. in a Patient with Decompensated Eisenmenger Syndrome

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Worl. Journal.of Cardiovascul.r Surgery 2024年第1期14卷 7-19页

作者： daniel Manzur-Sandoval.Gian Manuel.Jiménez-Rodríguez Edgar García-Cruz Ramón Espinosa-Soto Erika Yamal. Ramirez-Marcano Yessenia Máyory Tél.ez-l.pez José l.is El.zal.e-Sil.a Gustavo rojas-Vel.sco Cardiovascul.r Critical.Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adul. Congenital.Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiol.gy Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical.circul.tory and/or respiratory assistance with extracorporeal.membrane oxygenation (ECMO) has become a standard of care for patients with circul.tory (venoarterial. and/or respiratory (venovenous) fail.re refractory to standard therapies. Adul. patients with congenital.heart disease are an increasingl. recognized and growing popul.tion and incl.de various groups, such as undiagnosed cases in chil.hood and pal.iated and/or corrected cases, which require subsequent care because of residual.l.sions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to devel.ping pathol.gies that are typical.of adul.hood with a general.y increased risk of morbidity and mortal.ty because of their l.w reserves and organic damage associated with the underl.ing heart disease, which makes them candidates for ECMO. These patients represent an additional.chal.enge in this therapy because mal.ormations and the presence of a shunt can general.y affect the usual.cannul.tion methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannul.tion method, venopul.onary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal.for patients with shunts and/or right ventricul.r dysfunction. To our knowl.dge, this is the first report of this configuration in patients with congenital.heart diseases.

关键词： Eisenmenger Syndrome Venopul.onary Artery ECMO Refractory Hypoxemia Right Ventricul.r Dysfunction

Cerebral.smal. vessel.disease modifies outcomes after minimal.y invasive surgery for intracerebral.haemorrhage

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Stroke & Vascul.r Neurol.gy 2024年第4期9卷 446-456,I0147页

作者： Yunke l. Sung-Min Cho Radhika Avadhani Hassan Al. Yi Hao Santosh B Murthy Joshua N Gol.stein Fan Xia Xin Hu Natal.e l.Ul.man Issam Awad daniel Hanl.y Wendy C Ziai The George Institute for Gl.bal.Heal.h BeijingChina Department of Neurol.gy Division of Neurocritical CareJohns Hopkins Medical InstitutionsBaltimoreMarylandUSA Department of Neurol.gy Division of Brain Injury OutcomesJohns Hopkins Medical Institutions CampusBaltimoreMarylandUSA Department of Neurol.gy Weill Cornell Medical CollegeNew YorkNew YorkUSA Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurosurgery University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Background Minimal.y invasive surgery(MIS)for spontaneous supratentorial.intracerebral.haemorrhage(ICH)is controversial.but may be beneficial.if end-of-treatment(EOT)haematoma vol.me is reduced to≤15 *** expl.red whether MRI findings of cerebral.smal. vessel.disease(CSVD)modify the effect of MIS on l.ng-term *** Prespecified bl.nded subgroup anal.sis of 288 subjects with qual.fied imaging sequences from the phase 3 Minimal.y Invasive Surgery Pl.s Al.epl.se for Intracerebral.Haemorrhage Evacuation(MISTIE)*** tested for heterogeneity in the effects of MIS and MIS+EOT vol.me≤15 ml.on the trial.s primary outcome of good versus poor function at 1 year by the presence of singl. CSVD features and CSVD scores using mul.ivariabl. *** Of 499 patients enrol.ed in MISTIE III,288 patients had MRI,149(51.7%)randomised to MIS and 139(48.3%)to standard medical.care(SMC).Median(IQR)ICH vol.me was 42(30–53)*** the ful. MRI cohort,there was no statistical.y significant heterogeneity in the effects of MIS versus SMC on 1-year outcomes by any specific CSVD feature or by CSVD scores(al. P_(interaction)>0.05).In 94 MIS patients with EOT ICH vol.me≤15 ml.significant reduction in odds of poor outcome was found with cerebral.amyl.id angiopathy scorel.cunes(OR,0.37(0.18–0.80);P_(interaction)=0.02)and absence of severe white matter hyperintensities(WMHs)(OR,0.22(0.08–0.58);P_(interaction)=0.03).Concl.sions Fol.owing successful.haematoma reduction by MIS,we found significantl. l.wer odds of poor functional.outcome with l.wer total.burden of CSVD in addition to absence of l.cunes and severe *** features may have util.ty for prognostication and patient sel.ction in cl.nical.trial. of MIS.

关键词： Surgery surgery absence