检索结果-南通市图书馆

Differential Anti-Inflammatory Effects of Three purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

引用

Modern Research in Inflammation 2016年第3期5卷 31-44页

作者： pamela Izaret pérez-Martínez Víctor Gabriel Hernández Oscar Rodríguez-Espinosa patricia Arce-paredes Oscar rojas-Espinosa Departamentos de Inmunología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Ciudad de México México Departamentos de Morfología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Ciudad de México México

Background: The Mediterranean Diet (MD) has been linked to a reduced risk of developing degenerative diseases, including atherosclerosis, heart stroke, diabetes, arthritis and cancer. However, only a few scientific investigations have attempted to validate this impression. The ingredients of the MD include significant amounts of omega (ω3, ω6, and ω9) unsaturated fatty acids (UFAs). A few studies of these UFAs in the prevention or treatment of arthritis have yielded controversial results, but a general belief regarding their beneficial effects has prevailed. Objective: To investigate the effects of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid (AA), and Oleic Acid (OA) (ω3, ω6, and ω9, respectively), in the development of arthritis using a murine model of Collagen-Induced Arthritis (CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII) and were subsequently treated with ω-UFAs for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory agent. The effect of the treatments was evaluated through several parameters: inflammation indices, antibody levels, cell prolifera- tion, and histopathological findings. Results and Conclusion: The anti-inflammatory effect of the tested substances was inversely correlated with the histopathological findings: a greater anti- inflammatory effect was associated with less articular damage. Oleic acid (ω9) was the most efficient anti-inflammatory UFA, followed by DHA and then AA. DEXA completely inhibited the development of arthritis, whereas the untreated CII-immunized mice developed the most severe articular damage. DBA-1 mice with CII-induced arthritis constitute an adequate model for the study of arthritis and its treatment.

关键词： Collagen CIA DBA-1 Mice Omega-UFAs Dexamethasone Anti-Inflammatory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

引用

Journal of Animal Science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago Martins Guilherme pugliesi Mariana Sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-rojas Frederich D.Rodriguez Roney S.Ramos Andrea C.Basso Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of Animal Sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMpBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(p > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients

引用

World Journal of Gastroenterology 2021年第48期27卷 8343-8356页

作者： Antonio Gil-Gómez Ángela rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Muñoz-Hernandez Giorgio Fassina patrizia pontisso Javier Ampuero Manuel Romero-Gómez SeLiver Group Institute of Biomedicine of SevilleSeville 41013Spain CIBERehd Instituto de Salud Carlos IIIMadrid 28029Spain Mucosal Immunity Lab IRCCS Humanitas Research HospitalMilan 20089Italy Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610017Sichuan ProvinceChina State Key Laboratory of Biotherapy and Center of Infectious Diseases West China HospitalChengdu 610017Sichuan ProvinceChina Life Biotechnology Padua UniversityVenice 30175Italy Department of Clinical and Experimental Medicine University of PadovaPadova 35123Italy UCM Digestive Diseases Virgen del Rocío University HospitalSeville 41014Spain

BACKGROUND The combination of alpha-fetoprotein(AFp)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine *** To determine the role of the combination of SCCA-IgM and AFp in predicting mid-and long-term appearance of *** Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFp according to European Association for the Study of the Liver *** estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFp levels at *** were followed-up for 60 mo,being censored at the time of the appearance of *** There were 10.8%and 23.1%of HCC development at two-and five-years *** with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,p=0.009)during the fiveyear *** multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;p=0.003],AFp(HR=1.028,95%CI:1.009-1.046;p=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;p=0.004).The log-rank test of the combination resulted in 7.488(p=0.024)in estimation cohort and 11.061(p=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year *** We have constructed a predictive model based on the combination of SCCA-IgM and AFp that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,esp

关键词： Squamous cell carcinoma antigen Hepatocellular carcinoma prediction precision medicine Stratification of cirrhotic patient

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

断奶仔猪饲喂鸡肉粉、禽副产品、肠膜、全鸡粉豆粕复合物和常规豆粕的消化代谢能浓度和氨基酸消化率

引用

中国饲料 2016年第7期 35-41页

作者： O.J.rojas H.H.Stein 伊利诺伊大学动物科学系 61801

利用2个试验评估鸡肉粉、禽副产品、肠膜、全鸡粉豆粕复合物和常规豆粕分别喂养断奶仔猪的消化能和代谢能浓度以及氨基酸标准回肠消化率（SID）。试验1中，48头阉公猪，初始体重为（14．6±2．2）kg，被放置在代谢笼中，根据完全随机区... 详细信息

利用2个试验评估鸡肉粉、禽副产品、肠膜、全鸡粉豆粕复合物和常规豆粕分别喂养断奶仔猪的消化能和代谢能浓度以及氨基酸标准回肠消化率（SID）。试验1中，48头阉公猪，初始体重为（14．6±2．2）kg，被放置在代谢笼中，根据完全随机区组设计分配至6个日粮处理组，每个处理8个重复。基础对照组含有98．1％的玉米（饲喂基础），其他5组日粮分别包含玉米以及11％～16％不等的鸡肉粉、禽副产品、肠膜、全鸡粉豆粕复合物或者豆粕。以等蛋白原则配制各处理日粮。收集断奶仔猪5d的粪便和尿液。玉米、鸡肉粉、禽副产品、肠膜和全鸡粉豆粕复合物和豆粕干物质的代谢能分别为3957、3816、4586、4298、4255、4091kcal／kgn禽副产品的代谢能极显著高于玉米、鸡肉粉、全鸡粉豆粕复合物和豆粕（p〈0．01），肠膜和全鸡粉豆粕复合物的代谢能极显著高于玉米和鸡肉粉（p〈0．01），但是肠膜、全鸡粉豆粕复合物和豆粕之间无显著差异。试验2中，12头回肠中装有T型套管的阉公猪，初始体重为（12．2±1．5）kg，采用6×6拉丁方试验设计进行试验。配制无氮日粮和玉米淀粉一豆粕型基础日粮。另外4种日粮以玉米淀粉、蔗糖、豆粕为基础分别添加鸡肉粉、禽副产品、肠膜或者全鸡粉豆粕复合物。豆粕的蛋白质标准回肠消化率以及除了色氨酸、脯氨酸之外的所有氨基酸标准回肠消化率均高于其他处理日粮（p〈0．01）。全鸡粉豆粕复合物的蛋白质和必需氨基酸标准回肠消化率显著高于鸡肉粉和肠膜（p〈0．01）：此外，除了精氨酸和缬氨之外，其他必需氨基酸标准回肠消化率均高于禽副产品。然而，除了缬氨酸和赖氨酸外，其他氨基酸标准回肠消化率鸡肉粉和禽副产品间无明显差异。总之，肠膜和全鸡粉豆粕复合物的代谢能高于鸡肉粉，但与豆粕无显著差异。禽副产品较豆粕、鸡肉粉、全鸡粉豆粕复合物可提供更多的代谢能。全鸡粉豆粕复合物的大部分必需氨基酸标准回肠消化率均高于鸡肉粉、禽副产品和肠膜，但却低于豆粕。

关键词：氨基酸消化率动物蛋白鸡肉粉能量猪禽副产品

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients

引用

World Journal of Gastroenterology 2014年第37期20卷 13530-13537页

作者： Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira Unidad de Investigacion Medica en Enfermedades Infecciosas y parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexicano del Seguro Social Clinica de Hepatitis Hospital de Infectologia Centro Médico Nacional La Raza Hospital General Regional No.72 IMSS Unidad de Investigacion Medica en Enfermedades Infecciosas y parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexi-cano del Seguro Social Hospital Infantil de Mexico "Federico Gomez"

AIM: To determine the frequency of occult hepatitis B infection (OHBI) in a group of human immunodeficiency virus (HIV)-1+/ hepatitis B surface antigen negative (HBsAg)- patients from Mexico.

关键词： Hepatitis B virus Occult hepatitis B virus infection Human immunodeficiency virus Hepatitis B surface antigen negative Risk factors Molecular diagnostics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nutritional Status of patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

引用

Food and Nutrition Sciences 2013年第10期4卷 49-60页

作者： Claudia E. Lazarte Claudia Alegre Ernesto rojas Yvonne Granfeldt Biomedical Research Institute San Simon University Cochabamba Bolivia Department of Food Technology Engineering and Nutrition Lund University Lund Sweden Department of Food Technology Engineering and Nutrition Lund University Lund Sweden Food and Natural products Center San Simon University Cochabamba Bolivia Department of Nutrition San Simon University Cochabamba Bolivia

Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of healthy controls and reference values. Results showed no significant differences in most nutrient intake or anthropometrics between patients and controls. However, serum zinc level of patients (80 μg/dl) was significantly lower (p 0.001) than in controls (85 μg/dl), likely explained by the presence of leishmaniasis. The median serum zinc level in both groups was below the reference values, even though their median zinc intake met the zinc recommendations from WHO. Consequently, besides the presence of leishmaniasis, serum zinc levels may be compromised by inhibitory components in their diet, such as phytates, as it is shown by the molar ratio phytate:zinc (phy:Zn) that was between 11 and 19, while 15 is the level said to compromise zinc status. There were significant (p 0.05) negative correlations between serum zinc and phy:Zn, for patients (r = - 0.413) and controls (r = - 0.410). In conclusion this study shows that patients with CL in Chapare, Bolivia had low serum zinc levels due to the leishmaniasis per se and the decreased zinc bioavailability in their diet. CL infection was not in direct association with the nutritional status indicated by the anthropometric or dietary assessments. However, dietary intake showed 5 essential nutrients below the nutrient recommendation in both groups.

关键词： Nutritional Status Leishmaniasis Dietary Intake Anthropometrics Zinc Bioavailability phytates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

猪饲喂动物蛋白的营养价值

引用

饲料工业 2014年第12期35卷 57-64页

作者： Oscar J.rojas Hans H.Stein 美国伊利诺斯州立大学动物科学系美国乌尔班纳61801

在猪饲料中最广泛使用的动物蛋白是肉骨粉和鱼粉,它们都含有相对含量较高的氨基酸,也是可消化钙、磷的良好来源。在鱼粉和肉骨粉中,磷的消化率和产品中灰分含量是呈负相关的。家禽产业的副产物包括鸡肉粉、家禽副产物和AV-E Digest都广... 详细信息

在猪饲料中最广泛使用的动物蛋白是肉骨粉和鱼粉,它们都含有相对含量较高的氨基酸,也是可消化钙、磷的良好来源。在鱼粉和肉骨粉中,磷的消化率和产品中灰分含量是呈负相关的。家禽产业的副产物包括鸡肉粉、家禽副产物和AV-E Digest都广泛用于饲喂断奶仔猪,因为这些产品有助于提高断奶仔猪的生长性能。水解羽毛粉是另一个家禽产业的副产物,可以用于生长育肥猪的饲料。水解小肠蛋白在近年来也已经允许用于断奶仔猪饲料的氨基酸来源。血液制品,无论是通过环形干燥、滚筒干燥或喷雾干燥的,都是有价值的氨基酸和磷的来源,喷雾干燥的血液制品具有非常好的氨基酸消化率。乳制品工业的副产品包括乳清粉和低蛋白乳清粉,不像其他动物源性饲料原料一样,乳清粉和低蛋白乳清粉氨基酸含量不丰富,主要是作为乳糖的来源饲喂断奶仔猪,并且乳清粉和低蛋白乳清粉的磷都具有很高的消化率。

关键词：动物蛋白鱼粉乳制品家禽副产品水解小肠蛋白血液制品

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quality of Life in Congenital Heart Disease patients according to Their Anatomical and physiological Classification

引用

Congenital Heart Disease 2023年第2期18卷 197-206页

作者： Efrén Martínez-Quintana Hiurma Estupiñán-León Ana Beatriz rojas-Brito Liuva Déniz-Déniz Alejandro Barreto-Martín Fayna Rodríguez-González Cardiology Service Complejo Hospitalario Universitario Insular-Materno InfantilLas Palmas de Gran Canaria35016Spain Department of Medical and Surgical Sciences Faculty of Health SciencesUniversidad de Las Palmas de Gran CanariaLas Palmas de Gran Canaria35016Spain Ophthalmology Service Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran Canaria35012Spain

Background:Living well is as important as living *** objective of this study is to assess quality of life(QoL)in congenital heart disease(CHD)according to current AHA/ACC anatomical and physiological ***:Cross-sectional study examining the World Health Organization QoL Bref questionnaire(WHOQoL-Bref)in consecutive outpatient CHD patients from a single ***:191 CHD patients were *** age was 28±13 years and 59%were male.44(23%),115(60%)and 33(17%)CHD patients showed mild,moderate and great anatomical defects respectively while 69(36%)patients were in physiological Stage A,27(14%)in Stage B,84(44%)in Stage C and 11(6%)in Stage *** significant differences were seen in relation the anatomical classification and the different sections of the WHOQoL-Bref *** patients in Stages C and D had significant lower physical domain scores than patients in the Stage A(ppsychological,social relationships and environmental *** binary logistic regression analysis showed that having a higher educational level was a protective factor[OR 0.32(95%CI,0.12-0.87),p=0.026]while being married or cohabit was a risk factor[OR 3.46(95%CI,1.13-10.63),p=0.030]for having a worse rated ***,having a worse functional class(NYHA≥2)[OR 3.44(95%CI,1.20-9.81),p=0.021]was associated with dissatisfaction with ***:patients with advanced physiological stages scored lower on the physiological *** statistical significance was seen,according to the anatomical and physiological classification,in the psychological,social relationship and environmental domains.

关键词： Quality of life congenital heart disease complexity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

performance Quality Testing under Combined Loading of polyethylene pipes Reinforced with Aramid Fiber

引用

Journal of Mechanics Engineering and Automation 2014年第8期4卷 639-647页

作者： Hilario Hemamdez-Moreno Erik Vargas-rojas Victor Manuel Sauce-Rangel Ivan Mortera-Bravo Jorge LuisGonzhlez-Velazquez Maarten p. Kruijer Margarita Navarrete-Montesinos ESIME (Escuela Superior de Ingenieria Mecanica y Electrica) Unidad Ticoman lnstituto Politecnico Nacional Distrito Federal07340 Mexico ESIQIE (Escuela Superior de Ingenieria Quimica e lndustrias Extractivas) Instituto Politecnico Nacional Distrito Federal 07300Mexico Department of Research & Development Pipelife Netherlands B. K Enkhuizen P.O. Box 380 1600 A J The Netherlands Instituto de lngenieria Universidad Nacional Autonoma de Mexico Distrito Federal 04510 Mexico

This paper presents the results of the performance quality testing of polyethylene pipes reinforced with aramid fibers, intended for applications such as discharging and gathering oil pipelines, and describes the test rig specifically designed for this purpose. The pipe specimens are submitted to impact with a device that simulates the collision of a pickaxe, and of a backhoe loader. After the impact, the pipes are tested under combined loading comprising internal pressure, and transverse loading; some pipe specimens without previous impact are tested as well. The results show that the reinforced thermoplastic pipes can fully withstand maximal operating pressure levels in the presence of damage and additional transverse loading.

关键词： Combined pressure-bending testing oil industry reinforced thermoplastic pipe composite materials.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electric,magnetic and microstructural features of the La_(2)CoFeO_(6) lanthanide ferrocobaltite obtained by the modified pechini route

引用

Journal of Advanced Dielectrics 2021年第3期11卷 16-25页

作者： J.A.Jaramillo palacio K.A.Munoz pulido J.Arbey Rodríguez D.A.Landínez Téllez J.Roa-rojas Grupo de Física de Nuevos Materiales Departamento de Física Universidad Nacional de ColombiaBogotáDCColombia Laboratório de Magnetismo e Materiais Magnéticos Departamento de Física Universidade Federal de Santa Maria Rio Grande do Sul Brazil Grupo de Estudios de Materiales Departamento de Física Universidad Nacional de ColombiaBogotáDCColombia

In the search for new materials with applicable magnetic properties in spintronic devices,the aim of this work is to report the synthesis of the lanthanide ferrocobaltite La_(2)CoFeO_(6) using the modified pechini route;the experimental study of structural,morphological and magnetic properties,and the analysis of the electronic structure and bands are obtained in the framework of the Density Functional *** refinement of experimental X-ray diffraction patterns revealed the crystallization of this oxide material in a perovskite-like monoclinic structure,space group p2_(1)/n(#14).Scanning electron microscopy and atomic force microscopy images revealed that the surface morphology is essentially polycrystalline,with mean grain sizes between 177 and 188 *** dispersive X-ray spectroscopy suggests that the material obtained contains La,Fe,Co and O in the stoichiometric proportions expected by up to 98%.The magnetic susceptibility curves as a function of temperature indicated that the material is ordered ferromagnetically,showing strong irreversibility effects due to the disorder of the Fe and Co cations in the three crystallographic directions of the structure and to the strong distortions in the FeO_(6) and CoO_(6) *** hysteresis curves confirmed the ferromagnetic character of the material for all temperatures evaluated,up to room temperature.I-V response curves revealed a semiconductor-like behavior with a figure of merit exponent 1.53 of the varistor *** ferromagnetic semiconductor behavior suggests the potential applicability of the material in spintronic technological devices.

关键词： Double perovskite pechini method crystalline structure ferromagnetic response semiconductor behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：