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From the Poles to the Tropics:Novel chemistry in the atmosphere probed using field measurements of OH and HO2 radicals

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From the Poles to the Tropics:Novel chemistry in the atmosph...

Post-COVID recovery and renewal through whole-of-society resilience in cities

中国化学会第27届学术年会

作者： Dwayne Heard roisin commane Peter Edwards Mathew Evans Kate Furneaux Andrew Goddard Trevor Ingham Daniel Stone Stewart Vaughan Lisa Whalley School of Chemistry University of Leeds

＜正＞Atmospheric oxidation processes are largely controlled by the OH radical. Field measurements of OH, and the closely related radical HO2, are essential to understanding the rapid photochemical processes involved

关键词： Hydroxyl radical field measurements atmospheric chemistry

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Journal of Safety Science and Resilience 2022年第3期3卷 222-228页

作者： Andrew G.McClelland roisin Jordan Szymon Parzniewski Duncan Shaw Nat O’Grady David Powell Alliance Manchester Business School University of ManchesterManchester M139PLUK Alliance Manchester Business School Humanitarian&Conflict Response InstituteUniversity of ManchesterManchester M139PLUK Humanitarian&Conflict Response Institute University of ManchesterManchester M139PLUK

This paper explores and extends understanding of the role and significance of whole-of-society resilience pro-grammes that support cities when dealing with complex crises,like the COVID-19 *** the complexity of whole-of-society resilience as different actors locally shape it,we ask the question:How can collab-oration between formal and informal resilience practices help to enhance resilience across the‘whole-of-society’?We answer this question by reviewing the importance of whole-of-society resilience and its complexity in a city’s governance of the COVID-19 *** argue that the necessity of renewing approaches to building lo-cal resilience capabilities across the whole-of-society requires synchronisation across and between formal and informal approaches-that is,“bottom-up”and governmental initiatives-to meet the diverse needs of ***,we detail two recent practice-orientated initiatives that have taken a renewal approach to building resilience through the involvement of whole-of-society in planning recovery from COVID-19 using in-ternational standard ISO/TS 22393;and a new initiative called the National Consortium for Societal Resilience[UK+].Finally,we signpost a set of critical questions for whole-of-society resilience practice.

关键词： Whole-of-society resilience Crisis Recovery Renewal Cities,COVID-19

Use of androgen deprivation therapy in prostate cancer： indications and prevalence

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Asian Journal of Andrology 2012年第2期14卷 177-186页

作者： roisin M Connolly Michael A Carducci Emmanuel S Antonarakis Prostate Cancer Research Program Department of Medical Oncology Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore MD 21231-1000 USA

Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer, This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

关键词： androgen deprivation therapy androgen synthesis anti-androgen prostate cancer

Moving From Traditional Software Engineering to Componentware

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Journal of Software Engineering and Applications 2011年第5期4卷 283-292页

作者： Faisal Nabi roisin Mullins 不详

The field of software engineering and software technology is developing very fast. Perhaps as a consequence, there is seldom enough interest or opportunity for systematic investigation of how the underlying technology will actually perform. That is, we introduce new concepts, methods, techniques and tools – or change existing ones and emphasize their value. A major turn in software engineering leading to Componentware has dramatically changed the shape of software development and introduced interesting methods for the design and rapid development of systems which may provide cost-effective benefits. In this paper we will discuss Componentware, process model, architecture, principles and the drivers, advantages, disadvantage and reveal profound changes from the traditional software engineering approaches.

关键词： Software Component Componentware Component Infrastructure Software Pattern Software Architecture Component-Based-Development

Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy

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Protein & Cell 2018年第1期9卷 47-62页

作者： Yusuke Mimura Toshihiko Katoh Radka Saldova roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd Department of Clinical Research NHO Yamaguchi-Ube Medical Center 685 Higashi-Kiwa Ube 755-0241 Japan Laboratory of Molecular Biology and Bioresponse Division of Integrated Life Science Graduate School of Biostudies KyotoUniversity Kitashirakawa Oiwake-Cho Sakyo-Ku Kyoto 606-8502 Japan NIBRT GlycoScience Group National Institute for Bioprocessing Research and Training Mount Merrion Blackrock Dublin 4Ireland Center for Regenerative Medicine Yamaguchi University Graduate School of Medicine 1-1-1 Minami Kogushi Ube 755-8505 Japan Center for Gene Research Yamaguchi University 1-1-1 Minami-Kogushi Ube 755-8505 Japan Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University 1-308 Suematsu Nonoichi Ishikawa 921-8836 Japan

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary *** oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.

关键词： chemoenzymatic glycoengineering crysta structure endoglycosidase fucose glycosylation,intravenous immunoglobulin sialic acid transglycosylation,ultra performance liquid chromatography

Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： roisin Mary Heaney Conor Shields Jurgen Mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal carcinoma Peritoneal metastases Carcino

慢性阻塞性肺疾病全球创议（2011年修订版）概述

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中华医学杂志 2012年第14期92卷 937-938页

作者： Jcrgen Vestbo Suzanne S Hurd Roberto Rodriguez-roisin 申永春（译校）文富强（译校）贺蓓（译校）代表慢性阻塞性肺疾病全球创议科学委员会不详

自10年前第一份慢性阻塞性肺疾病（COPD）全球创议（GOLD）报告——全球COPD诊断、治疗和预防策略发表后，该创议已进行了多次修订，有相当多的内容得到了更新。本次修订的内容主要基于COPD的新研究成果和相关新知识。

关键词：慢性阻塞性肺疾病修订病全 COPD 预防策略新知识

海表面动力和热力过程耦合的重要性:大尺度、海洋观点

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气象科技 1988年第3期 45-51页

作者： B. Cushman-roisin 闵伟

海表面动力和热力过程(切应力和浮力通量)的结合会导致重要的结果,这些结果用任何单一的过程是不可能解释的。本工作着重于中纬度大尺度、平均海洋环流。经典的斜温层理论的新发展表明,风驱动的和浮力引起的洋流可能存在相互作用并以某... 详细信息

海表面动力和热力过程(切应力和浮力通量)的结合会导致重要的结果,这些结果用任何单一的过程是不可能解释的。本工作着重于中纬度大尺度、平均海洋环流。经典的斜温层理论的新发展表明,风驱动的和浮力引起的洋流可能存在相互作用并以某种方式结合而导致锋面形成。北太平洋上的副热带锋可解释为是这种相互作用的结果,而不是Ekman辐合引起的。最后要强调的是,在全球气候模式中,锋生过程的模式敏感度要求有精确的海表面过程的参数化和细的空间分辨率。

关键词：副热带锋热力强迫风应力海洋锋面辐合锋生西北太平洋热力

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中黄须白蚁中性品级的发育路径及其行为多型

城市害虫防治 2010年第3期 40-43页

作者： Toru Miura Yves roisin Tadao Matsumoto 东京大学生物系东京153--8902日本布鲁塞尔自由大学细胞和动物生物学实验室布鲁塞尔比利时

中黄须白蚁（Hospitalitermes medioflavus）是露天觅食、呈队列行进的象白蚁，它具有一型兵蚁和三型工蚁。本实验检验了该白蚁中性品级的发育路径。须白蚁属是象白蚁亚科中呈队列行进、露天觅食的属之一，其觅食队列由兵蚁、小工蚁、... 详细信息

中黄须白蚁（Hospitalitermes medioflavus）是露天觅食、呈队列行进的象白蚁，它具有一型兵蚁和三型工蚁。本实验检验了该白蚁中性品级的发育路径。须白蚁属是象白蚁亚科中呈队列行进、露天觅食的属之一，其觅食队列由兵蚁、小工蚁、中工蚁和大工蚁组成。通过解剖和组织染色发现，兵蚁和小工蚁是雄性的，中工蚁和大工蚁是雌性的。对幼蚁的头宽进行测量，发现有三个头宽高峰。最小的高峰由一龄幼蚁的雄蚁和雌蚁组成；中间的高峰仅由二龄幼蚁的雄蚁组成，最大的高峰仅由二龄幼蚁的雌蚁组成。通过对蜕皮的个体和上颚的观察，进一步确定了品级间的发育关系。我们得出了中黄须白蚁中性品级的发育路径与象白蚁属（Nasutitermes）中性品级的发育路径相等的结论。雄性白蚁的任务可以从“咬食”（作为小工蚁）转变为“防卫”（作为兵蚁）；雌性白蚁在觅食中进行了专门分工（“咬食”和“运食”）。这种白蚁在觅食过程中的劳动分工主要依赖于于性别和中性品级的发育阶段，因此呈现出既有时间的行为多型，又有雌雄性别的行为多型（polyethism）。

关键词：发育阶段白蚁品级中性路径行为劳动分工实验检验