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Combined radial and median nerve injury in diaphysea fracture of humerus： a case report

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Chinese Journal of Traumatology 2013年第6期16卷 365-367页

作者： Rajesh Rohilla rohit singla Narender Kumar Magu Roop Singh Ashish Devgun Reetadyuti Mukhopadhyay Paritosh Gogna Department of Orthopaedic Surgery Paraplegia & Re-habilitation PtBD Sharma PGIMS Rohtak 124001

Radial nerve palsy is the most common neurological involvement in humeral shaft *** combined radial and median nerve injury in a closed diaphyseal fracture of the humerus is *** injury to both radial and median nerve can cause significant disability.A detailed clinical examination is therefore necessary following humeral shaft *** report a patient with closed diaphyseal humeral fracture （AO 12A-2.3） together with radial and median nerve palsy,its management and review of the *** the patient had two nerves involved,surgical exploration was *** was reduced and fixed with a 4.5 mm narrow dynamic compression pla *** was no external injury to both radial and median nerves on surgical *** recovery started at 3 weeks＇ *** recovery was seen at 12 *** clinical examination is of the utmost importance in early diagnosis of combined nerve injuries,which allows better management and rehabilitation of the patient.

关键词： Humeral fractures Radial nerve Me-dian nerve Diaphyses Paralysis

Missed ulnar nerve injury and closed forearm fracture in a child

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Chinese Journal of Traumatology 2013年第4期16卷 246-248页

作者： Batra Amit Devgan Ashish Verma Vinit Singh Raj Batra Shivan Magu Narender singla rohit Gogna ParitoshGupta Navdeep Department of Orthopedics PGIMS Rohtak HaryanaIndia

Ulnar nerve injury in closed fracture of lbrearnl in children is uncommon. Commonly, neurapraxia is the reason for this palsy but other severe injuries or nerve entrapment has been reported in some cases. The impor- tance of diagnosis concerning the types of the nerve injury lies in the fact that they have totally different management. We present a case of ulnar nerve deficit in a child following a closed fracture of the forearm bones. It is imperative to diagnose exact cause of palsy as it forms the basis for treatment. MR1 scan can help diagnosis and accordingly guide the management. Simple nelwe contusion should be treated conservatively, and exploration with fixation of the fracture should be done in lacerations and entrapments of the nerve. Surgery is not the treatment of choice in cases that could be managed conserwltively.

关键词： Ulnar nerve Peripheral nerve injuries Forearm injuries Child

Dsteosynthesis with long volar locking plates for meta- physeal-diaphyseal fractures of the distal radius

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Chinese Journal of Traumatology 2013年第6期16卷 339-343页

作者： Paritosh Gogna Harpal Singh Selhi rohit singla Mukul Mohindra Amit Batra Reetadyuti Mukhopadhyay Rajesh Rohilla Umesh Yadav Department of Orthopaedics and Rehabilitation Pt BDSharma Postgraduate Institute of Medical SciencesRohtak Haryana India Department of Orthopaedics Dayanand Medical Col-lege and Hospital Ludhiana Punjab India

Objective：Metaphyseal-diaphyseal fractures of the distal radius are a major treatment dilemma and orthopaedic surgeons have to pay due consideration to restoration of anatomy of distal radius together with rotation of the radial shaft and maintenance of radial bow and interosseous *** performed this study to evaluate the clinic-radiological outcome of metaphyseal-diaphyseal fractures of the distal radius treated with long volar locking ***：This prospective study involved 27 patients （22 males and 5 females） with metaphyseal-diaphyseal fracture of the distal *** mean age was （30.12±11.48） years （range 19-52 years） and the follow-up was 26.8 months （range 22-34 months）.All patients underwent open reduction and internal fixation with a long volar locking *** to AO/OTA classification,there were 7 type A3,13 type C2 and 7 type C3 *** assessment was done based on the disabilities of the arm,shoulder and hand （DASH） *** evaluation was done by measuring grip strength and range of motion around the wrist and the radiological determinants included radial angle,radial length,volar angle and ulnar *** final assessment was done according to Gartland and Werley scoring ***：Postoperative radiological parameters were well maintained throughout the trial,and there was significant improvement in the functional parameters from 6 weeks to final *** average DASH scores improved from 37.5 at 6 weeks to 4.2 at final *** assessment using Gartland and Werley scoring system revealed 66.67%（n=l8） excellent and 33.33% （n=9） good *** was one case of superficial infection which responded to antibiotics and another carpel tunnel syndrome which was managed ***：Volar locking plate fixation for metaphyseal-diaphyseal fractures of distal radius is associated with excellent to good functional outcome,early rehabilitation and minimal complications.

关键词： Radius fractures Fracture fixation,internal Bone plates

Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend

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World Journal of Diabetes 2015年第11期6卷 1179-1185页

作者： Baishakhi De Koushik Bhandari Nishant Chakravorty Ranjan Mukherjee rohit Gundamaraju Rajeev K singla Prakash Katakam Shanta K Adiki Biswajoy Ghosh Analava Mitra School of Medical Science and Technology IIT Kharagpur 721302 India Department of Medical Microbiology Faculty of Medicine University of Malaya Division of Biotechnology Netaji Subhas Institute of Technology Faculty of Pharmacy University of Zawiya Nirmala College of Pharmacy

Despite tremendous strides in modern medicine stringent control over insulin resistance or restoration of normoglycemia has not yet been *** the growth of molecular biology,omics technologies,docking studies,and in silico pharmacology,modulators of enzymes and receptors affecting the molecular pathogenesis of the disease are being considered as the latest targets for anti-diabetic *** molecular targets are now being developed basing on the up or down regulation of different signaling pathways affecting the *** antidiabetic therapy is in vogue both with classical and non-classical medicinal *** its chemoprofiling,structural and pharmacokinetic validation awaits providing recognition to such formulations for international *** health research with its focus on benchside product development and its sequential transition to patient bedside puts the pharma RDs to a challenge to develop bio-waiver *** simulation models and establishment of in vitro-in vivo correlation can help to replace in vivo bioavailability studies and provide means of quality control for scale up and post approval *** attempts to bring different shades highlighting phyto-synergy,molecular targeting of antidiabetic agents via different signaling pathways and bio-waiver studies under a single umbrella.

关键词： In silico pharmacology Phytosynergistic Anti-diabe