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Resilience deficit index for quantification of resilience

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Resilient Cities and Structures 2022年第2期1卷 1-9页

作者： rohit Ranjan singh Michel Bruneau Andreas Stavridis Kallol Sett Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNY 14260United States

After a brief overview of how the dimensionless resilience index has been calculated in the past for buildings,and some of the shortcomings of that approach,the use of a resilience deficit index is advocated to overcome some of these *** example is provided and the pros and cons of each approach are discussed,with broad recommendations applicable to the quantification of building resilience.

关键词： Resilience Buildings Deficit Functionality Occupancy

Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model

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World Journal of Clinical Oncology 2018年第8期9卷 188-199页

作者： Himani Garg rohit singh Hada Jagdish C Gupta G P Talwar Shweta Dubey Talwar Research Foundation Neb Sarai Amity Institute of Virology and Immunology Amity University Uttar Pradesh

AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast *** Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer *** Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen *** Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.

关键词： Immunotherapy Survivin Luteinizing hormone-releasing hormone fusion protein Combination immunotherapy Breast cancer

Ankle Fractures: A Literature Review of Current Treatment Methods

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Open Journal of Orthopedics 2014年第11期4卷 292-303页

作者： rohit singh Tamer Kamal Nick Roulohamin Gopikanthan Maoharan Bessam Ahmed Peter Theobald Robert Jones and Agnes Hunt Oswestry UK Orthopaedic Department Cairo University Giza Egypt Cardiff school of Engineering Cardiff University Cardiff UK

Ankle fracture is one of the most common lower limb fractures for they account for 9% of all fractures representing a significant portion of the trauma workload. Ankle fractures usually affect young men and older women, however, below the age of 50;ankle fractures are the commonest in men. Two commonly used classification systems for ankle fractures include the danis weber AO classification and the Lauge-Hansen classification. There is biomechanical evidence that posterior non-locking plates are superior in stability than laterally placed plates;however there is little clinical evidence. There are several different methods of ankle fracture fixation, however the goal of treatment remains a stable anatomic reduction of talus in the ankle mortise and correction of the fibula length as a 1 mm lateral shift of the talus in the ankle mortise reduces the contact area by 42%, and displacement (or shortening) of the fibula more than 2 mm will lead to significant increases in joint contact pressures. Further research both biomechanically and clinically needs to be undertaken in order to clarify a preferable choice of fixation.

关键词： Ankle Fracture Review Current Treatment Classification Management

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim rohit singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

4-1BB-4-1BBL cis-interaction contributes to the survival of selfreactive CD8^(+)T cell

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Cellular & Molecular Immunology 2023年第9期20卷 1077-1080页

作者： Eunjung Cho rohit singh Chungyong Han Seon-Hee Kim Kwang H.Kim Bo-Mi Park Dong Hoon Shin Seongeun Han Young H.Kim Byoung S.Kwon Ki Taek Nam Beom K.Choi Immuno-oncology Branch Division of Rare and Refractory CancerNational Cancer CenterGoyang 10408Republic of Korea Severance Biomedical Science Institute Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulRepublic of Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408Republic of Korea Department of Biomedical Laboratory Science Catholic Kwandong UniversityGangneung 25601Republic of Korea Biomedicine Production Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea Anticancer Resistance Branch Division of Rare and Refractory CancerResearch InstituteNational Cancer CenterGoyang 10408Republic of Korea Eutilex Co. Ltd.Geumcheon-guSeoul 08594Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA Innobationbio Co. Ltd.Mapo-guSeoul 03929Republic of Korea

4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of... 详细信息

关键词： interaction activation knowledge

Hoarseness Due to Right Vocal Cord Paralysis Associated with Aortic Diverticulum from Right Aortic Arch—A Rare and Unusual Vascular Etiology of Right Vocal Cord Paralysis

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 99-103页

作者： Produl Hazarika Seema E. Punnoose Sanjay Arora Ramagowdanapura Sadashivan Diesh Raghavendra K. Itgampalli rohit singh Department of ENT NMC Specialty Hospital Abu Dhabi UAE Department of Cardiothoracic Surgery NMC Specialty Hospital Abu Dhabi UAE Department of Radiology NMC Specialty Hospital Abu Dhabi UAE Department of ENT & Head-Neck Surgery Kasturba Medical College Manipal India

Right vocal cord paralysis in our present case was diagnosed on clinical and radiological examination which is precipitated by an anomalous right aortic arch with diverticulum. This is a very uncommon vascular etiology of hoarseness and is extremely rare. Because of this rarity, the practicing otolaryngologist may miss this finding while evaluating a case of idiopathic right vocal cord paralysis. Thus, the authors feel that idiopathic or unexplained right vocal cord paralysis should be routinely investigated with a CT or MRI of neck and chest with or without contrast to avoid such shortcomings. There is only one such case of right vocal cord paralysis by right aortic which has been reported earlier in literature.

关键词： Hoarseness Vocal Cord Paralysis Right Aortic Arch CT Scan Neck and Chest

A Novel Hybrid Tunicate Swarm Naked Mole-Rat Algorithm for Image Segmentation and Numerical Optimization

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Computers, Materials & Continua 2022年第5期71卷 3445-3462页

作者： Supreet singh Nitin Mittal Urvinder singh rohit Salgotra Atef Zaguia Dilbag singh Department of Electronics&Communication Engineering Chandigarh UniversityMohali140413India Department of Electronics&Communication Engineering TIETPatiala147004India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju61005Korea

This paper provides a new optimization algorithm named as tunicate swarm naked mole-rat algorithm(TSNMRA)which uses hybridization concept of tunicate swarm algorithm(TSA)and naked mole-rat algorithm(NMRA).This newly developed algorithm uses the characteristics of both algorithms(TSA and NMRA)and enhance the exploration abilities of *** from the hybridization concept,important parameter of NMRA such as mating factor is made to be self-adaptive with the help of simulated annealing(sa)mutation operator and there is no need to define its value *** evaluating the working capabilities of proposed TSNMRA,it is tested for 100-digit challenge(CEC 2019)test problems and real multi-level image segmentation *** the results obtained for CEC 2019 test problems,it can be seen that proposed TSNMRA performs well as compared to original TSA and *** case of image segmentation problem,comparison of TSNMRA is performed with multi-threshold electro magnetism-like optimization(MTEMO),particle swarm optimization(PSO),genetic algorithm(GA),bacterial foraging(BF)and found superior results for TSNMRA.

关键词： Optimization NMRA TSA image segmentation thresholding

Probiotic fermentation of polyphenols: potential sources of novel functional foods

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Food Production, Processing and Nutrition 2022年第1期4卷 259-274页

作者： rohit Sharma Bhawna Diwan Brij Pal singh Saurabh Kulshrestha Faculty of Applied Sciences&Biotechnology Shoolini University of Biotechnology and Management SciencesSolan173229India Department of Microbiology Central University of HaryanaMahendragarhIndia

Fermented functional food products are among the major segments of food processing *** imparts several characteristic effects on foods including the enhancement of organoleptic characteristics,increased shelf-life,and production of novel health beneficial ***,in addition to macronutrients present in the food,secondary metabolites such as polyphenols are also emerging as suitable fermentable *** the traditional antimicrobial view of polyphenols,accumulating research shows that polyphenols exert differential effects on bacterial communities by suppressing the growth of pathogenic microbes while concomitantly promoting the proliferation and survival of probiotic ***,probiotic bacteria not only survive among polyphenols but also induce their fermentation which often leads to improved bioavailability of polyphenols,production of novel metabolic intermediates,increased polyphenolic content,and thus enhanced functional capacity of the fermented *** addition,selective fermentation of combinations of polyphenol-rich foods or fortification with polyphenols can result in novel functional *** present narrative review specifically explores the potential of polyphenols as fermentable substrates in functional *** discuss the emerging bidirectional relationship between polyphenols and probiotic bacteria with an aim at promoting the development of novel functional foods based on the amalgamation of probiotic bacteria and polyphenols.

关键词： Probiotics Polyphenols Fermented Foods Lactic acid bacteria Tea

Photocatalytic application of magnesium spinel ferrite in wastewater remediation:A review

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Journal of Magnesium and Alloys 2024年第2期12卷 490-505页

作者： rohit Jasrotia Nikhil Jaswal Jyoti Prakash Chan Choon Kit Jagpreet singh Abhishek Kandwal School of Physics and Materials Science Shoolini UniversityBajholSolanH.P.India Himalayan Centre of Excellence in Nanotechnology Shoolini UniversityBajholH.P.India INTI International University Putra NilaiNegeri SembilanMalaysia Department of Chemistry University Centre for Research&Development Chandigarh UniversityMohali140413PunjabIndia Shenzhen Institute of Advanced Technology Chinese Academy of SciencesChina

This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these *** analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the *** to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being *** in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater *** concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.

关键词： Magnesium ferrite Wastewater Dyes Antibiotics Photocatalytic degradation