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Clinicopathologic diagnosis of dVIN related vulvar squamous cell carcinoma:An extended appraisal from a tertiary women's hospital

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 30-37页

作者： Tiannan Wang Vandana Baloda Lakshmi Harinath Terrell Jones Huina Zhang rohit bhargava Chengquan Zhao Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033USA Department of Pathology University of Rochester Medical CenterRochesterNY14642USA

Background:Differentiated vulvar intraepithelial neoplasia(dVIN)is a non-human papilloma virus(HPV)-related high-grade precursor lesion to vulvar squamous cell carcinoma(vSCCa).Although TP53 gene mutations have been identified in 80%of dVIN,its role in dVIN pathogenesis as well as malignant transformation is still being poorly *** reproducible diagnostic criteria and ambiguous p53 immunostaining patterns,along with morphologic discordance still pose a diagnostic ***:A series of 60 cases of dVIN-related vSCCa along with adjacent dVIN were *** features as well as immunohistochemical results were recorded on the resection-confirmed dVIN-related ***:The average age of the patients was 71 ***-five cases(58.4%)of dVIN-related vSCCa were moderately differentiated,fourteen cases(23.3%)were poorly differentiated,and the remaining eleven cases(18.3%)were ***-nine cases(48.3%)were found to have lichen sclerosus adjacent to *** terms of p53 and p16 expression in dVIN-related vSCCa and the adjacent dVIN,fifty-five(91.7%)dVIN showed mutant p53 immunostaining pattern with strong positive expression in 80%cases(basal/para-basal expression)and null pattern expression in 11.7%***(8.3%)dVIN showed p53 wild-type staining *** wild-type pattern were seen in 5%of vSCCa and p53 null pattern were seen in 13.3%*** cases demonstrated atypical staining patterns:two cases showed p53 null expression in dVIN but p53 overexpression in invasive carcinoma;three cases exhibited p53 null expression in invasive carcinoma,with the adjacent dVIN showing basal and para-basal mutant(2 cases)and wild-type(1 case)p53 expression patterns.A single case demonstrated p53 wild-type pattern in dVIN and overexpression in invasive *** addition,65%dVIN were p16 negative and 31.7%dVIN had patchy p16 ***:Clinical and prognostic value of the ambiguous/inconsistent patterns are u

关键词： Differentiated vulvar intraepithelial neoplasia Vulvar squamous cell carcinoma Clinicopathologic features Immunostaining patterns

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Understanding poromechanical response of a biogenic coalbed methane reservoir

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International Journal of Coal Science & Technology 2024年第3期11卷 32-50页

作者： rohit Pandey Satya Harpalani Virginia Tech BlacksburgUSA Southern Illinois University CarbondaleUSA

Biogenic coalbed methane(BCBM)reservoirs aim to produce methane from in situ coal deposits following microbial conversion of *** of BCBM reservoirs requires economic methane production within an acceptable *** work reported here quantifies the findings of previously published qualitative work,where it was found that bioconversion induces strains in the pore,matrix and bulk *** imaging and dynamic strain monitoring techniques,the bioconversion induced strain is quantified *** understand the effect of these strains from a reservoir geomechanics perspective,a corresponding poromechanical model is ***,findings of imaging experiments are validated using core-flooding flow ***,expected field-scale behavior of the permeability response of a BCBM operation is modeled and *** results of the study indicated that,for Illinois coals,bioconversion induced strains result in a decrease in fracture porosity,resulting in a detrimental permeability drop in excess of 60%during bioconversion,which festers itself exponentially throughout its producing *** indicate that reservoirs with high initial permeability that will support higher Darcian flowrates,would be better suited for coal bioconversion,thereby providing a site-selection criteria for BCBM operations.

关键词： Coal bioconversion Poromechanical model Reservoir response Bioconversion induced strain

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Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI rohit SHUKLA Archana SHARMA Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

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Influence of BPPV and Meniere's Disease on Cognitive Abilities: A Questionnaire-Based Study

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Journal of Otology 2024年第1期19卷 10-18页

作者： rohit Bhattacharyya Animesh Barman Freddy Antony All India Institute of Speech and Hearing MysoreMysuruIndia

The vestibular system connects the inner ear to the midbrain and subcortical structures and can affect cognition. Patients with vertigo often experience cognitive symptoms such as attention deficits, memory problems, and spatial perception difficulties. This study aimed to explore the cognitive impairments associated with Benign paroxysmal positional vertigo(BPPV) and Meniere's Disease(MD). A non-experimental group comparison design was used with 107 participants divided into three groups: Group I(clinically normal), Group II(BPPV), and Group III(MD). Participants completed a questionnaire with 10 cognition-related questions, and their responses were scored. The data were found to be non-normally distributed. The analysis revealed a significant difference in scores between Group I and both Group II and Group III. Chi-square tests showed that the responses to cognition-related questions varied among the groups, with Group II exhibiting more cognitive problems. Associated conditions like hypertension, diabetes, and hearing loss did not significantly influence the responses within each group. This study suggests a significant relationship between cognitive problems and patients with BPPV and MD. However, there was no association found between the cognitive problems experienced in BPPV and MD patients. These findings align with previous research indicating that vestibular disorders can lead to deficits in spatial memory, attention, and other cognitive functions. By understanding the link between cognition and vestibular disorders, we can improve diagnosis and rehabilitation services to enhance the quality of life for these patients.

关键词： BPPV Meniere's disease Cognition Questionnaire

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Photocatalytic application of magnesium spinel ferrite in wastewater remediation:A review

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Journal of Magnesium and Alloys 2024年第2期12卷 490-505页

作者： rohit Jasrotia Nikhil Jaswal Jyoti Prakash Chan Choon Kit Jagpreet Singh Abhishek Kandwal School of Physics and Materials Science Shoolini UniversityBajholSolanH.P.India Himalayan Centre of Excellence in Nanotechnology Shoolini UniversityBajholH.P.India INTI International University Putra NilaiNegeri SembilanMalaysia Department of Chemistry University Centre for Research&Development Chandigarh UniversityMohali140413PunjabIndia Shenzhen Institute of Advanced Technology Chinese Academy of SciencesChina

This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these *** analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the *** to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being *** in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater *** concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.

关键词： Magnesium ferrite Wastewater Dyes Antibiotics Photocatalytic degradation

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Progress in metal oxide-based electrocatalysts for sustainable water splitting

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Materials Reports(Energy) 2024年第3期4卷 19-34页

作者： Aasiya S.Jamadar rohit Sutar Susmita Patil Reshma Khandekar Jyotiprakash B.Yadav Vacuum Techniques and Thin Film Laboratory USICShivaji UniversityKolhapur416004MaharashtraIndia

Metal oxide-based electrocatalysts are promising alternatives to platinum group metals for water splitting due to their low cost,abundant raw materials,and impressive *** review covers recent progress in various metal oxides tailored for hydrogen and oxygen evolution reactions,discussing their crystal structure,composition,and surface modification influence on *** like surface engineering,doping,and nanostructuring are evaluated for enhancing catalytic activity and *** key considerations for commercialization are highlighted,emphasizing ongoing research,innovation,and future scope to drive widespread adoption of water-splitting technology for a cleaner and sustainable future.

关键词： Metal oxide HER OER Electrocatalyst Overall water spilling

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必须向Google学习的五个品牌建设秘诀

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新营销 2011年第6期13卷 14-15页

作者： rohit bhargava

你可以问任何一个设计师，他们可能都会认为谷歌（Google）的品牌标志是所有品牌标志中最丑的。现在很多企业，一旦新的CEO上任，很可能会改变品牌标志或是改变企业定位。然而，谷歌不仅一直坚持使用自己“丑陋”的品牌商标，同时还让... 详细信息

你可以问任何一个设计师，他们可能都会认为谷歌（Google）的品牌标志是所有品牌标志中最丑的。现在很多企业，一旦新的CEO上任，很可能会改变品牌标志或是改变企业定位。然而，谷歌不仅一直坚持使用自己“丑陋”的品牌商标，同时还让它成为世界上最知名的企业标志之一，同时也是世界上最有价值的品牌。

关键词：品牌建设 Google 学习品牌标志企业标志品牌商标设计师 CEO

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PACK-CXL *** therapy for bacterial,fungal,and mixed infectious keratitis:a prospective randomized phase 3 trial

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Eye and Vision 2024年第1期10卷 10-20页

作者： Farhad Hafezi Mohammed Hosny rohit Shetty Boris Knyazer Shihao Chen Qinmei Wang Hassan Hashemi Emilio A.Torres‑Netto 无 Center for Applied Biotechnology and Molecular Medicine(CABMM) University of ZurichZurichSwitzerland ELZA Institute DietikonSwitzerland. Faculty of Medicine University of GenevaGenevaSwitzerland Department of Ophthalmology Medical University of WenzhouWenzhouChina USC Roski Eye Institute University of Southern California Los AngelesLos AngelesUSA Department of Ophthalmology University of CairoCairoEgypt Narayana Nethralaya Eye Hospital and the Postgraduate Institute of Ophthal‑mology BangaloreIndia Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael Noor Ophthalmology Research Center Noor Eye HospitalTehranIran University Hospital Zurich ZurichSwitzerland. the PACK-CXL Working Group

Background:Infectious keratitis is a major cause of global *** tested whether standalone photoactivated chromophore corneal cross-linking(PACK-CXL)may be an efective frst-line treatment in early to moderate infectious keratitis,compared with standard antimicrobial ***:This is a randomized,controlled,multinational phase 3 clinical *** in fve centers in Egypt,India,Iran,Israel,and China,aged≥18 years,with infectious keratitis of presumed bacterial,fungal,or mixed origin,were randomly assigned(1:1)to PACK-CXL,or antimicrobial *** measures included healing,defned as time to re-epithelialization of the corneal epithelial defect in the absence of infammatory activity in the anterior chamber and clearance of stromal *** success was defned as the complete resolution of signs of ***:Between July 21,2016,and March 4,2020,participants were randomly assigned to receive PACK-CXL(n=18)or antimicrobial therapy per American Academy of Ophthalmology(AAO)guidelines(n=21).No participants were lost to *** eyes were excluded from the epithelialization time analysis due to treatment failure:two in the antimicrobial therapy group,and two in the PACK-CXL *** rates were 88.9%(16/18 patients)in the PACK-CXL group and 90.5%(19/21 patients)in the medication *** was no signifcant diference in time to complete corneal re-epithelialization(P=0.828)between both treatment ***:PACK-CXL may be an alternative to antimicrobial drugs for frst-line and standalone treatment of early to moderate infectious keratitis of bacterial or fungal origin.

关键词： Photoactivated chromophore Corneal cross-linking Infectious keratitis Corneal melting PACK-CXL

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Clinical outcomes of triceps reflecting anconeus pedicle and olecranon osteotomy approach for distal humerus intercondylar fractures

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World Journal of Orthopedics 2024年第6期15卷 570-577页

作者： rohit Ailani Sanjeev Kumar Bhuyan Brejesh Kumar Prasad Amit Kumar Namrata Dawani Department of Orthopaedics Lovee Shubh HospitalLucknowUttar Pradesh 226002India Department of Orthopaedics Gauhati Medical CollegeGuahati 781032India Department of Orthopaedics ESIC Medical College and HospitalFaridabadHaryana 121001India Department of Orthopaedics All India Institute of Medical SciencesKalyaniWest Bengal 741245India Department of Obstetric and Gynecology Kannauj Medical CollegeKannaujUttar Pradesh 209732India

BACKGROUND The preferred treatment for distal humeral intercondylar fractures is open reduction and internal *** there is consensus about the posterior approach,several posterior approaches have been *** is debatable as to which approach is *** To compare triceps reflecting anconeus pedicle(TRAP)and olecranon osteotomy approaches for internal fixation of distal humeral intercondylar *** In total,40 cases of Arbeitsgemeinschaft für Osteosynthesefragen/Association of the Study of Internal Fixation type C,closed,and Gustilo type I intercondylar humeral fractures were *** ranged in age from 18 years to 70 *** patients were randomized into two groups:TRAP group and olecranon osteotomy group,with 20 cases in *** were followed up at 6 wk,3 months,6 months,and 12 *** outcomes were measured in terms of flexion-extension arc,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance *** The mean age was 43.2 years in the TRAP group and 37.5 years in the olecranon osteotomy *** mean operative time and mean duration of hospital stay in the TRAP group were significantly higher than in the olecranon osteotomy group(119.5 vs 111.5 min and 9.85 vs 5.45 d,respectively).The mean arc of flexion-extension,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance Score were comparable without any significant difference in the groups at the 12-month follow-up(107.0 vs 106.2,18.3 vs 15.7,and 84.2 vs 86.2,respectively).Ulnar paresthesia and superficial infections were comparable in both groups(2 cases vs 3 cases and 3 cases vs 2 cases,respectively).Hardware prominence was significantly higher in the olecranon osteotomy group,mostly due to tension band *** Both approaches were equivalent,but there is a need for further study including higher numbers of subjects and longer study duration to prove the benefits of one approach over the other.

关键词： Elbow joint Humeral fracture Osteotomy Internal Fracture fixation

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Steroids in acute respiratory distress syndrome:A panacea or still a puzzle?

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World Journal of Critical Care Medicine 2024年第2期13卷 93-105页

作者： Sharmili Sinha rohit Patnaik Srikant Behera Department of Critical Care Medicine Apollo HospitalsBhubaneswar 751005OdishaIndia Department of Critical Care Medicine Medeor 24x7 HospitalAl Danah 40330Abu DhabiUnited Arab Emirates Department of Internal Medicine and Critical Care All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia

Acute respiratory distress syndrome(ARDS)is a unique entity marked by various etiologies and heterogenous *** remain concerns regarding the efficacy of particular medications for each severity level apart from respiratory *** several pharmacotherapies which have been examined in the treatment of ARDS,corticosteroids,in particular,have demonstrated potential for improving the resolution of ***,it is imperative to consider the potential adverse effects of hyperglycemia,susceptibility to hospital-acquired infections,and the development of intensive care unit acquired weakness when administering *** far,a multitude of trials spanning several decades have investigated the role of corticosteroids in *** stringent trials are necessary to identify particular subgroups before implementing corticosteroids more widely in the treatment of *** review article provides a concise overview of the most recent evidence regarding the role and impact of corticosteroids in the management of ARDS.

关键词： Acute respiratory distress syndrome Corticosteroids Septic shock Community acquired pneumonia COVID-19 Randomized controlled trials

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