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Anti-Toxocara *** in an adult healthy population:serosurvey and risk factors in Southeast Brazil

Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 211-216页

作者： Elaine Cristina Negri Vamilton Alvares Santarem Guita Rubinsky-Elefant rogerio giuffrida Pro-Reitoria de Pesquisa e Pos-GraduacaoRod.Raposo Tavares km 572Bairro Limoeiro19067-175 Presidente PrudenteSao PauloBrazil Laboratory of Preventive Veterinary Medicine Veterinary Teaching-Hospital-Unoeste-Rod.Raposo Tavares km 572Bairro Linmeiro19067-175 Presidente PrudenteSao Paulo.Brazil Laboratory of Seroepidemiology and Immunobiology-Instituto de Medicina Tropical de Sao Paulo-University of Sao Paulo Av Dr Eneas deCarralho Aguiar 47005403-000 Sao PauloSPBrazil Laboratory of Preventive Veterinary Medicine Veterinary Teaching-Hospital-Unoeste-Rod.Raposo Tavares km 572Bairro Linmeiro19067-175Presidente PrudenteSao Paulo.Brazil

Objective:To evaluate the frequency of anti-Toxocara *** in an adult healthy ***:The study was performed by interviewing 253 blood donors,from 19 to65 years of age,in a hematological centre in Presidente Prudente,S(?)o Paulo,southeast Brazil.A survey was applied to blood donors in order to evaluate the possible factors associated to the presence of antibodies,including individual(gender and age),socioeconomic(scholarship,familial income and sanitary facilities)and habit information(contact with soil,geophagy,onycophagy and intake of raw/undercooked meat)as well as the presence of dogs or cats in the *** test was run for detection of the anti-Toxocara *** *** analysis followed by logistic regression was performed to evaluate the potential risk factors associated to ***:The overall prevalence observed in this study was 8.7%(22/253).Contact with soil was the unique risk factor associated with the presence of antibodies(P=0.0178;0R=3.52;95%CI=1.244-9.995).Conclusions:The results of this study reinforce the necessity in promoting preventive public health measures,even for healthy adult individual,particularly those related to the deworming of pets to avoid the soil contamination,and hygiene education of the population.

关键词： Toxocariasis Larva migrans Seroprevalence Diagnostic Epidemiology

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Radioisotope production using lasers:From basic science to applications

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Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.L.Andreoli M.Huault H.Larreur D.Singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.La Cognata S.Palmerini T.Carriere M.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone L.giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal M.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

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ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells

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World Journal of Stem Cells 2021年第11期13卷 1783-1796页

作者： Giuliana Mannino Martina Cristaldi Giovanni Giurdanella Rosario Emanuele Perrotta Debora Lo Furno Rosario giuffrida Dario Rusciano Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123CTItaly Research Center SOOFT-Italia S.p.A.Catania 95123CTItaly Department of General Surgery and Medical-Surgery Specialties University of CataniaCatania 95100CTItaly

BACKGROUND Adipose-derived stem cells(ASCs)have been increasingly explored for cell-based medicine because of their numerous advantages in terms of easy availability,high proliferation rate,multipotent differentiation ability and low *** this respect,they have been widely investigated in the last two decades to develop therapeutic strategies for a variety of human pathologies including eye *** ocular diseases involving the retina,various cell types may be affected,such as Müller cells,astrocytes,photoreceptors and retinal pigment epithelium(RPE),which plays a fundamental role in the homeostasis of retinal tissue,by secreting a variety of growth factors that support retinal *** To test ASC neural differentiation using conditioned medium(CM)from an RPE cell line(ARPE-19).METHODS ASCs were isolated from adipose tissue,harvested from the subcutaneous region of healthy donors undergoing liposuction *** ASC culture conditions were investigated:ASCs cultured in basal Dulbecco's Modified Eagle Medium(DMEM);ASCs cultured in serum-free DMEM;ASCs cultured in serumfree DMEM/F12;and ASCs cultured in a CM from ARPE-19,a spontaneously arising cell line with a normal karyotype derived from a human *** proliferation rate and viability were assessed by crystal violet and MTT assays at 1,4and 8 d of *** the same time points,ASC neural differentiation was evaluated by immunocytochemistry and western blot analysis for typical neuronal and glial markers:Nestin,neuronal specific enolase(NSE),protein gene product(PGP)9.5,and glial fibrillary acidic protein(GFAP).RESULTS Depending on the culture medium,ASC proliferation rate and viability showed some significant ***,less dense populations were observed in serum-free cultures,except for ASCs cultured in ARPE-19 serum-free ***,a different cell morphology was seen in these cultures after 8 d of treatment,with more elongated cells,often showing cytoplasmic ramifications.

关键词： Adipose-derived mesenchymal stem cells Retinal pigment epithelium Neural markers Neural differentiation Retina damage Cell-based medicine

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Activity of Tagetes minuta Linnaeus(Asteraceae)essential oil against L3 Anisakis larvae type 1

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 440-444页

作者： Filippo Giarratana Daniele Muscolino Graziella Ziino Alessandro giuffrida Stefania Maria Marotta Vittorio Lo Presti Vincenzo Chiofalo Antonio Panebianco Department of Veterinary Sciences University of MessinaPolo Universitario dell’Annunziata98168 MessinaItaly

Objective:To evaluate in vitro effects of Tagetes minuta L. essential oil(TEO) on L3 Anisakis larvae type 1. Methods:In order to evaluate the potential use of Tagetes minuta essential oil against L3 Anisakis larvae three different media were tested:1) a saline solution(SS); 2) an industrial marinating solution; 3) sunflower seeds oil(SO). For each media and concentrations of TEO(0.1%,0.5%,1.0% and 5.0% v/v),20 parasites were introduced into plastic Petri dishes(diameter 90 mm) and maintained at room temperature. As controls,larvae were maintained without TEO under identical experimental conditions in SS,MS and SO. A total of 900 larvae were tested. The normalized mean viability,LT100,LT50 and the percentage of inactivation at 24 hours were calculated. Results:In vitro tests revealed a complete inactivation of parasites in saline solution after 2 hours with 5% and 1% of TEO. In marinating solution,a complete inactivation of parasites was observed after 4 hours at all concentrations used. A slower activity for all TEO concentration was reported in SO. Conclusions:The results obtained,showing a strong activity against Anisakis larvae,confirm TEO as a larvicidal agent in the treatment of human anisakidosis and in the industrial marinating process.

关键词： Anisakis Essential oil Tagetes minuta Biocidal activity Parasites

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Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

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Pericyte-like differentiation of human adipose-derived mesenchymal stem cells:An in vitro study

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World Journal of Stem Cells 2020年第10期12卷 1152-1170页

作者： Giuliana Mannino Florinda Gennuso Giovanni Giurdanella Federica Conti Filippo Drago Salvatore Salomone Debora Lo Furno Claudio Bucolo Rosario giuffrida Physiology Section Department of Biomedical and Biotechnological SciencesUniversity of CataniaCatania 95123Italy Pharmacology Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy Biochemistry Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy

BACKGROUND Adipose-derived mesenchymal stem cells(ASCs)are characterized by long-term self-renewal and a high proliferation *** adequate conditions,they may differentiate into cells belonging to mesodermal,endodermal or ectodermal *** support endothelial cells and play an important role in stabilizing the vessel wall at the microcirculation *** loss of pericytes,as occurs in diabetic retinopathy,results in a breakdown of the blood-retina barrier(BRB)and infiltration of inflammatory *** this context,the use of pericytelike differentiated ASCs may represent a valuable therapeutic strategy for restoring BRB *** To test in vitro strategies to obtain pericyte-like differentiation of human ASCs(hASCs).METHODS Different culture conditions were tested:hASCs cultured in a basal medium supplemented with transforming growth factorβ1;and hASCs cultured in a specific pericyte medium(PM-hASCs).In a further sample,pericyte growth supplement was omitted from the *** addition,cultures of human retinal pericytes(hRPCs)were used for ***-like differentiation of hASCs was tested by immunocytochemical staining and western blotting to evaluate the expression ofα-smooth muscle actin(α-SMA)and neural/glial antigen 2(NG2).Interactions between human retinal endothelial cells(hRECs)and different groups of hASCs were investigated in co-culture *** these cases,the expression of typical junctional proteins such as vascular endothelial-Cadherin,zonula occludens-1 and Occludin were assessed in *** an in vitro model of the BRB,values of trans-endothelial electrical resistance were measured when hRECs were co-cultured with various groups of pretreated *** values observed were compared with co-cultures of hRECs and hRPCs as well as with cultures of hRECs ***-dimensional co-cultures of hRECs and hRPCs or pericyte-like hASCs in Matrigel were designed to assess their reciprocal *** After 3-6 d of cult

关键词： Adipose-derived mesenchymal stem cells Pericyte-like differentiation Retinal endothelial cells Retinal pericytes Blood-retina barrier Junction proteins

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Management of patients with melanoma and non-melanoma skin cancers in the coronavirus disease 2019 era

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Chinese Medical Journal 2020年第17期133卷 2017-2019页

作者： Claudio Conforti Nicola di Meo Roberta giuffrida Iris Zalaudek Department of Dermatology and Venereology Dermatology ClinicUniversity of TriesteTriesteItaly Department of Clinical and Experimental Medicine Section of DermatologyUniversity of MessinaMessinaItaly

The recent coronavirus disease 2019(COVID-19)pandemic has completely disrupted hospital and outpatient activities.[1,2]It has been reorganized to allow a lower inflow of patients,to reduce non-urgent out-patient visits and to concentrate public health forces in the fight against the COVID-19 *** this reorganization,dermatology departments have also adapted their activities suspending routine patient visits and providing only urgent surgical removal,urgent visits,consultations,and oncological examinations.

关键词： patients routine melanoma

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Kidney transplantation from donors with hepatitis C infection

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World Journal of Gastroenterology 2014年第11期20卷 2801-2809页

作者： Massimiliano Veroux Daniela Corona Nunziata Sinagra Alessia Giaquinta Domenico Zerbo Burcin Ekser Giuseppe giuffrida Pietro Caglià Riccardo Gula Vincenzo Ardita Pierfrancesco Veroux Vascular Surgery and Organ Transplant Unit Department of SurgeryTransplantation and Advanced TechnologiesUniversity Hospital of Catania95123 CataniaItaly

The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clinical situations which previously were regarded as contraindications. Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool. When allocated to serology-matched recipients, kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list. Special care must be dedicated to the pre-transplant evaluation of potential candidates, particularly with regard to liver functionality and evidence of liver histological damage, such as cirrhosis, that could be a contraindication to transplantation. Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results, which may be affected by the progression of liver disease in the recipients. An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome.

关键词： Kidney transplantation Deceased donor Hepatitis C virus De novo glomerulonephritis Liver failure Graft survival End-stage renal disease Hemodialysis

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Modelling Bacterial Dynamics in Food Products: Role of Environmental Noise and Interspecific Competition

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Journal of Modern Physics 2013年第8期4卷 1059-1065页

作者： Davide Valenti Alessandro giuffrida Graziella, Ziino Filippo Giarratana Bernardo Spagnolo Antonio Panebianco Department of Veterinary Science Università di Messina Polo Universitario dell’Annunziata Facoltà di Medicina Veterinaria Messina Italy Dipartimento di Fisica e Chimica Group of Interdisciplinary Physics Università di Palermo and CNISM Unità di Palermo Viale delle Scienze Palermo Italy

In this paper we review some results obtained within the context of the predictive microbiology, which is a specific field of the population dynamics. In particular we discuss three models, which exploit tools of statistical mechanics, for bacterial dynamics in food of animal origin. In the first model, the random fluctuating behaviour, experimentally measured, of the temperature is considered. In the second model stochastic differential equations are introduced to take into account the influence of physical and chemical variables, such as temperature, pH and activity water, subject to deterministic and random variations. The third model, which is an extended version of the second one, neglects the environmental fluctuations, and concentrates on the role of the interspecific bacterial interactions. The comparison between expected results and observed data indicates that the presence of noise sources and interspecific bacterial interactions improves the predictive features of the models analyzed.

关键词： Statistical Mechanics Population Dynamics Noise-Induced Effects Stochastic Modeling Noise in Biological Systems

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Is it worth investigating splenic function in patients with celiac disease?

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World Journal of Gastroenterology 2013年第15期19卷 2313-2318页

作者： Antonio Di Sabatino Laura Brunetti Gabriella Carnevale Maffè Paolo giuffrida Gino Roberto Corazza Department of Internal Medicine Celiac CentreS. Matteo Hospital FoundationUniversity of Pavia27100 PaviaItaly

Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition.

关键词： Hyposplenism Memory B cell Pitted red cell Pneumococcal vaccine Splenic atrophy

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