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Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes

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Animal Nutrition 2020年第1期6卷 98-106页

作者： Hao Xiao cuifang Zha Fangyuan Shao Li Wang Bi’e tan State Key Laboratory of Livestock and Poultry Breeding Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South ChinaGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou510640China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China Faculty of Health Sciences University of MacaoMacaoChina college of Animal Science and Technology Hunan Agricultural UniversityChangsha410128China

As major fuels for the small intestinal mucosa,dietary amino acids(AA)are catabolized in the mitochondria and serve as sources of energy *** present study was conducted to investigate AA metabolism that supply cell energy and the underlying signaling pathways in porcine *** porcine epithelial cells(IPec-J2)were treated with different concentrations of AA,inhibitor,or agonist of mammalian target of rapamycin complex 1(mTORcl)and adenosine monophosphate activated protein kinase(AMPK),and mitochondrial respiration was *** results showed that AA treatments resulted in enhanced mitochondrial respiration,increased intracellular content of pyruvic acid and lactic acid,and increased hormone-sensitive lipase mRNA ***,decreased citrate synthase,isocitrate dehydrogenase alpha,and carnitine palmitoyltransferase 1 mRNA expression were also *** found that AA treatments increased the protein levels of phosphorylated mammalian target of rapamycin(p-mTOR),phosphorylated-p70 ribosomal protein S6 kinase,and phosphorylated-4 e-binding protein *** is more,the protein levels of phosphorylated AMPKα(pAMPKa)and nicotinamide adenine dinucleotide(NAD)-dependent protein deacetylase sirtuin-1(SIRT1)were decreased by AA treatments in a time depending *** bioenergetics and the production of tricarboxylic acid cycle intermediates were decreased upon inhibition of mTORcl or ***,AMPK activation could up-regulate the mRNA expressions of inhibitor of nuclear factor kappa-B kinase subunit beta(Ikbk(3),integrin-linked protein kinase(ILK),unconventional myosin-Ic(Myolc),ribosomal protein S6 kinase beta-2(RPS6 Kβ2),and vascular endothelial growth factor(VeGF)-β,which are downstream effectors of mammalian target of rapamycin(mTOR).The mRNA expressions of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(PIK3 cD)and5’-AMP-activated protein kinase subunit gamma-1(PRKAG1),which are upst

关键词： Amino acids Mammalian target of rapamycin Adenosine monophosphate activated protein kinase Mitochondrial respiration energy utilization

SeLF-ORGANIZING ASSeMBLY MODeLING BASeD ON ReLATIONAL cONSTRAINTS

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chinese Journal of Mechanical engineering 2000年第2期13卷 145-152页

作者： tan Jianrong 浙江大学计算机辅助设计与图形学国家重点实验室浙江杭州抚顺石油学院辽宁抚顺

On the research of assembly modeling of mechanical products,current cAD systems can only support the design Process of component-to-assembly. It is difficult to realize the design process of assembly-to -*** theory of self-organizing assembly modeling based on relational constraints is proposed, which implements the product design of assembly-to-component commencing with conceptual design and supporting abstract design and step-nice refinement design.

关键词： Assembly modeling Assembly constraint Self-organizing assembly

Assessment of Timoshenko Beam Models for Vibrational Behavior of Single-Walled carbon Nanotubes using Molecular Dynamics

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Advances in Applied Mathematics and Mechanics 2009年第1期1卷 89-106页

作者： Y.Y.Zhang c.M.Wang V.B.c.tan Department of Mechanical engineering National University of SingaporeKent RidgeSingapore 119260 engineering Science Programme and Department of civil engineering National University of SingaporeKent RidgeSingapore 117574

In this paper,we study the flexural vibration behavior of single-walled carbon nanotubes(SWcNTs)for the assessment of Timoshenko beam ***tensive molecular dynamics(MD)simulations based on second-generation reactive empirical bond-order(ReBO)potential and Timoshenko beam modeling are performed to determine the vibration frequencies for SWcNTs with various length-todiameter ratios,boundary conditions,chiral angles and initial *** effectiveness of the local and nonlocal Timoshenko beam models in the vibration analysis is assessed using the vibration frequencies of MD simulations as the *** is shown herein that the Timoshenko beam models with properly chosen parameters are applicable for the vibration analysis of *** simulation results show that the fundamental frequencies are independent of the chiral angles,but the chirality has an appreciable effect on higher vibration *** SWcNTs is very sensitive to the initial strain even if the strain is extremely small.

关键词： Vibration carbon nanotubes molecular dynamics Timoshenko beam models

An Implementation ofMAc Grid-Based IIM-Stokes Solver for Incompressible Two-Phase Flows

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communications in computational Physics 2011年第10期10卷 1333-1362页

作者： Zhijun tan K.M.Lim B.c.Khoo Guangdong Province Key Laboratory of computational Science and School of Mathematics and computational Science Sun Yat-sen UniversityGuangzhou 510275China Singapore-MIT Alliance 4 Engineering Drive 3National University of SingaporeSingapore 117576Singapore Department ofMechanical engineering National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore

*** this paper,a novel implementation of immersed interface method combined with Stokes solver on a MAc staggered grid for solving the steady two-fluid Stokes equations with *** velocity components along the interface are introduced as two augmented variables and the resulting augmented equation is then solved by the GMReS *** augmented variables and/or the forces are related to the jumps in pressure and the jumps in the derivatives of both pressure and velocity,and are interpolated using cubic splines and are then applied to the fluid through the jump *** Stokes equations are discretized on a staggered cartesian grid via a second order finite difference method and solved by the conjugate gradient *** numerical results show that the overall scheme is second order *** major advantages of the present IIM-Stokes solver are the efficiency and flexibility in terms of types of fluid flow and different boundary *** proposed method avoids solution of the pressure Poisson equation,and comparisons are made to show the advantages of time savings by the present *** generalized two-phase Stokes solver with correction terms has also been applied to incompressible two-phase Navier-Stokes flow.

关键词： Incompressible two-phase Stokes equations two-phaseNavier-Stokes equations discontinuous viscosity singular force immersed interface method Uzawa method front tracking method.

On mapping degrees between 1-connected 5-manifolds

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Science china Mathematics 2006年第12期49卷 1855-1863页

作者： tan Liang LMAM Department of MathematicsPeking UniversityBeijing 100871China

We study the set of the mapping degrees between simply connected closed manifolds in this paper.

关键词： mapping degree simply connected manifolds Moore space eilenberg-Maclane space.

Design of Perfect Reconstruction cosine Modulated Filter Bank with Linear Phase

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Journal of Systems engineering and electronics 1998年第1期9卷 24-30页

作者： tan, Ying Univ of Science and Technology of China Hefei China

We propose the quadratic constrained formulas for the design of linear phase cosine modulated paraunitary filter banks given in references . Using these formulae, we can, directly, optimize the prototype filter coeff... 详细信息

关键词： Quadratic constrained formula Linear phase Perfect reconstruction cosine modulated FB.

Application and reliability analysis of DPM system in site investigation of HK weathered granite

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Journal of University of Science and Technology Beijing 2005年第6期12卷 481-488页

作者： Zhuoying tan Meifeng cai Zhongqi Yue L.G. Tham c.F. Lee State Key Laboratory of High-efficient Mining and Safety of Metal Mines （University of Science and Technology Beijing） Ministry of Education Beijing 100083 China Department of civil engineering University of Hong Kong Pokfulam Road Hong Kong China

A drilling process monitor （DPM） for ground characterization of weathered granite is presented. The monitor is portable and can be mounted on a hydraulic rotary drilling rig to record various drilling parameters in real time during normal subsurface investigation. The identification method for dominative and subsidiary interfaces has been established. The study reveals that the monitored drilling parameters are dependent on geotechnical materials and can be further applied to characterize ground interfaces. The t-test between manual logging and DPM logging has been carried out. The results show that the DPM has high accuracy in interfaces detection and well agreement with the manual logging. The findings show that the device and data analysis method are of potential application in subsurface drilling exploration in weathered granites. It also seems to have prospective uses in the determination of orebody boundary as well as in the detection of geohazards.

关键词： drilling process monitoring hydraulic rotary drill instrumented borehole drilling geotechnical engineering weathered granite

eventual Positivity of Hermitian Polynomials and Integral Operators

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chinese Annals of Mathematics,Series B 2016年第1期37卷 83-94页

作者： colin tan Department of Mathematics National University of Singapore Block S17 10 Lower Kent Ridge Road Singapore 119076.

Quillen proved that if a Hermitian bihomogeneous polynomial is strictly positive on the unit sphere, then repeated multiplication of the standard sesquilinear form to this polynomial eventually results in a sum of Hermitian squares. catlin-D'Angelo and Varolin deduced this positivstellensatz of Quillen from the eventual positive-definiteness of an associated integral operator. Their arguments involve asymptotic expansions of the Bergman kernel. The goal of this article is to give an elementary proof of the positive-definiteness of this integral operator.

关键词： Asymptotics Polynomial Positivity

Development of Oryza rufipogon and O. sativa Introgression Lines and Assessment for Yield-related Quantitative Trait Loci

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Journal of Integrative Plant Biology 2007年第6期49卷 871-884页

作者： Lubin tan Department of Plant Genetics and Breeding and State Key Laboratory of Agro-biotechnology China Agricultural University Beijing 100094 China Key Laboratory of crop Heterosis and Utilization of Ministry of education Beijing 100094 China Key Laboratory of crop Genetic Improvement and Genome of Ministry of Agriculture China Agricultural University Beijing 100094 China Beijing Key Laboratory of crop Genetic Improvement China Agricultural University Beijing 100094 China

Introgression lines population was effectively used in mapping quantitative trait loci （QTLs）, identifying favorable genes, discovering hidden genetic variation, evaluating the action or interaction of QTLs in multiple conditions and providing the favorable experimental materials for plant breeding and genetic research. In this study, an advanced backcross and consecutive selfing strategy was used to develop introgression lines （ILs）, which derived from an accession of Oryza rufipogon Griff. collected from Yuanjiang county, Yunnan Province of china, as the donor, and an elite indica cultivar Teqing （O. sativa L.）, as the recipient. Introgression segments from O. rufipogon were screened using 179 polymorphic simple sequence repeats （SSR） markers in the genome of each IL. Introgressed segments carried by the introgression lines population contained 120 ILs covering the whole O. rufipogon genome. The mean number of homozygous O. rufipogon segments per introgression line was about 3.88. The average length of introgressed segments was approximate 25.5 cM, and about 20.8% of these segments had sizes less than 10 cM. The genome of each IL harbored the chromosomal fragments of O. rufipogon ranging from 0.54% to 23.7%, with an overall average of 5.79%. At each locus, the ratio of substitution of O. rufipogon alleles had a range of 1.67-9.33, with an average of 5.50. A wide range of alterations in morphological and yield-related traits were also found in the introgression lines population. Using single-point analysis, a total of 37 putative QTLs for yield and yield components were detected at two sites with 7%-20% explaining the phenotypic variance. Nineteen QTLs （51.4%） were detected at both sites, and the alleles from O. rufipogon at fifteen loci （40.5%） improved the yield and yield components in the Teqing background. These O. rufipogon-O, sativa introgression lines will serve as genetic materials for identifying and using favorable genes from common wild rice.

关键词： common wild rice cultivated rice introgression lines quantitative trait locus yield-related trait.