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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Long-Time Turbulence Model Deduced from the Navier-Stokes Equations

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： roger LEWANDOWSKI IRMAR and Fluminance Team University of Rennes 1 and INRIA Campus Beaulieu

The author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions Turbulence modeling Reynolds stress

A Relative Theory for Leibniz n-Algebras

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Algebra Colloquium 2016年第2期23卷 219-226页

作者： Guy roger Biyogmam Department of Mathematics Southwestern Oklahoma State University 100 Campus Drive Weatherford OK 73096 USA

In this paper we show that for an n-Filippov algebra g, the tensor power g ^n-1 is endowed with a structure of anti-symmetric co-representation over the Leibniz algebra g ^n-1. This co-representation is used to define some relative theories for Leibniz n-algebras with n 〉 2 and obtain exact sequences relating them. As a result, we construct a spectral sequence for the Leibniz homology of Filippov algebras.

关键词： Leibniz n-algebras Filippov algebras Leibniz homology

Correction of disturbed pathophysiology of hepatic failure by albumin dialysis

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 19-24页

作者： roger Williams Institute of Hepatology University College London Medical School 69-75 Chenies MewsLondonWC1E 6HXUK

Introduction In my presentation to the 4th International Symposium on Hepatic Failure and Artificial Liver Support in Chongqing on which this paper is based, I was specifically asked to address the question of whether albumin dialysis, as in the Molecular Adsorbents Recirculating System (MARS) did correct known abnormalities of the disturbed pathophysiology in liver failure. Before doing this

关键词： albumin dialysis

Archaeal viruses-novel,diverse and enigmatic

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Science China(Life Sciences) 2012年第5期55卷 422-433页

作者： GARRETT roger A Archaea Centre Department of BiologyCopenhagen UniversityOle Maal esVej 5DK2200 Copenhagen NDenmark

Recent research has revealed a remarkable diversity of viruses in archaeal-rich environments where spindles, spheres, fila- ments and rods are common, together with other exceptional morphotypes never recorded previously. Moreover, their dou- ble-stranded DNA genomes carry very few genes exhibiting homology to those of bacterial and eukaryal viruses. Studies on viral life cycles are still at a preliminary stage but important insights are being gained especially from microarray analyses of viral transcripts for a few model virus-host systems. Recently, evidence has been presented for some exceptional archaeal- nspecific mechanisms for extra-cellular morphological development of virions and for their cellular extrusion. Here we sum- marise some of the recent developments in this rapidly developing and exciting research area.

关键词： virus morphotypes diversity and evolution life cycle temporal regulation cellular extrusion mechanism

SOME REMARKS ON HYDROFOIL CAVITATION

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Journal of Hydrodynamics 2012年第3期24卷 305-314页

作者： ARNDT roger E. A. Saint Anthony Falls Laboratory University of Minnesota MinneapolisMN 55414 USA

This paper reviews numerical and experimental investigations of sheet/cloud cavitation carried out at the St. Anthony Falls Laboratory and at two collaborating facilities （Versuchsanstalt Ftir Wasserbau, Obernach, Germany and Osaka University, Japan） for more than a decade. Although significant advances have been made in the analysis of this flow several issues are still unresolved. The purpose of this paper is to examine the overall features of the problem, review the progress made to date and suggest avenues for new investigation.

关键词： cavitation hydrofoil numerical simulations

Multi-agent Control of High Redundancy Actuation

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International Journal of Automation and computing 2014年第1期11卷 1-9页

作者： Jessica Davies roger Dixon roger M.Goodall Thomas Stefen Lancaster Environment Centre Lancaster University School of Electrical Electronic & Systems EngineeringLoughborough University Department of Aeronautical and Automotive Engineering Loughborough University

The high redundancy actuator(HRA)concept is a novel approach to fault tolerant actuation that uses a high number of small actuation elements,assembled in series and parallel in order to form a single actuator which has intrinsic fault *** this structure afords resilience under passive control methods alone,active control approaches are likely to provide higher levels of performance.A multiple-model control scheme for an HRA applied through the framework of multi-agent control is presented *** application of this approach to a 10×10 HRA is discussed and consideration of reconfguration delays and fault detection errors are *** example shows that multi-agent control can provide tangible performance improvements and increase fault tolerance in comparison to a passive fault tolerant *** delays are shown to be tolerable,and a strategy for handling false fault detections is detailed.

关键词： Fault tolerance actuators intelligent control redundancy intelligent actuators cooperative systems

Flow near a model spur dike with a fixed scoured bed

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International Journal of Sediment Research 2013年第3期28卷 349-357页

作者： roger KUHNLE Carlos ALONSO National Sedimentation Laboratory U.S.Department of AgricultureAgricultural Research Service

Three-dimensional flow velocities were measured using an acoustic Doppler velocimeter at a closely spaced grid over a fixed scoured bed with a submerged spur ***-dimensional flow velocities were measured at 3,484 positions around the trapezoidal shaped submerged model spur *** velocity distributions and detailed near field flow structures were revealed by the *** differences were revealed between flow over fixed flat and scoured *** lateral flows were the dominant cause of the observed local *** stresses were higher for the scoured bed than in the flat bed *** rates of scour as the scour hole developed were attributed to increases in critical shear stress in the scour holes caused by the increase in the length and magnitude of adverse slopes associated with the two main scour holes.

关键词： Submerged spur dike 3-dimensional flow Velocity measurements Free surface flow Hydraulic structure

A sphingolipid message promotes neuronal health across generations

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Neural Regeneration Research 2024年第11期19卷 2325-2326页

作者： Wenyue Wang roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient *** the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across ***,the molecular mechanisms of regulating such intergenerational effects remain largely unknown.

关键词： mother intestine transferred