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Flow near a model spur dike with a fixed scoured bed

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International Journal of Sediment Research 2013年第3期28卷 349-357页

作者： roger KUHNLE Carlos ALONSO National Sedimentation Laboratory U.S.Department of AgricultureAgricultural Research Service

Three-dimensional flow velocities were measured using an acoustic Doppler velocimeter at a closely spaced grid over a fixed scoured bed with a submerged spur ***-dimensional flow velocities were measured at 3,484 positions around the trapezoidal shaped submerged model spur *** velocity distributions and detailed near field flow structures were revealed by the *** differences were revealed between flow over fixed flat and scoured *** lateral flows were the dominant cause of the observed local *** stresses were higher for the scoured bed than in the flat bed *** rates of scour as the scour hole developed were attributed to increases in critical shear stress in the scour holes caused by the increase in the length and magnitude of adverse slopes associated with the two main scour holes.

关键词： Submerged spur dike 3-dimensional flow Velocity measurements Free surface flow Hydraulic structure

A sphingolipid message promotes neuronal health across generations

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Neural Regeneration Research 2024年第11期19卷 2325-2326页

作者： Wenyue Wang roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient *** the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across ***,the molecular mechanisms of regulating such intergenerational effects remain largely unknown.

关键词： mother intestine transferred

Treatment of tunnel wash waters-experiments with organic sorbent materials. PartⅡ: Removal of toxic metals

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Journal of Environmental Sciences 2008年第8期20卷 1042-1045页

作者： PARUCH Adam M ROSETH roger Bioforsk-the Norwegian Institute for Agricultural and Environmental Research Soil and Environment Division

In the first part of the article, the column and the bag experiments concerning removal of polycyclic aromatic hydrocarbons (PAHs) and nonpolar oil (NPO) from tunnel wash waters using organic sorbent materials have been described. This part presents the results of removal of toxic metals. The metals of concern (Al, As, Cd, Cr, Cu, Fe, Pb, Mo, Ni, and Zn) were selected based on the priority toxicant pollutants defined in surface water quality criteria. Concentrations of these metals in the collected effluent...

关键词： electrostatic filters reduction level sorbents tunnel toxic metals treatment efficiency wash water

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Water Security:Why We Need Global Solutions

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Engineering 2022年第9期16卷 13-15页

作者： roger A.Falconer Hydro-environmental Research Centre School of EngineeringCardiff UniversityCardiff CF243AAUK Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210024China

*** to the challenges of water security Over the past two to three decades,international concern about global water security has been increasing,along with a need for a more holistic approach to deliver sustainable solutions that address the growing challenges of water *** a series of high-profile reports have been published on global water security during this period(e.g.,Ref.[1]),the challenges remain and—if anything—are becoming more *** planet has limited freshwater resources:The total global volume of water is 1.4 billion km^(3),but only 35 million km^(3) of this resource is freshwater,and much of it is locked in the form of ***,only 105000 km^(3) of fresh water is accessible for use as water supply,and 70% of all withdrawals of freshwater are currently used for agriculture,primarily for food production[2].

关键词： planet extreme freshwater

Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung cells: An indispensable part in nanoparticle-based intracellular drug delivery

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Asian Journal of Pharmaceutical Sciences 2018年第3期13卷 197-211页

作者： roger Salvacion Tan Department of Chemistry College of Science De La Salle University Department of Chemistry College of Science and Mathematics Mindanao State University-Iligan Institute of Technology

Difference in sub-cellular trafficking of glycosylated and naked peptides, between normal and lung cancer cells, was established. Normal lung tissue discriminately sorted glycosylated from non-glycosylated peptides by allowing golgi localization of the glycosylated peptides while restricting golgi entry of the naked peptides. This mechanism was surprisingly not observed in its cancer cell counterpart. Lung cancer cells tend to allow unrestricted localization of both glycosylated and naked peptides in the golgi apparatus. This newly discovered difference in sub-cellular trafficking between normal and lung cancer cells could potentially be used as an effective strategy in targeted intracellular delivery, especially targeting golgi-resident enzymes for possible treatment of diseases associated with glycans and glycoproteins, such as, congenital disease of glycosylation(CDG). This very important detail in intracellular trafficking inside normal and cancer cells is an indispensable part in nanoparticle-based intracellular drug delivery.

关键词： Intracellular trafficking Peptides and glycopeptides Lung cancer cells Normal lung tissue Golgi localization Quantum dots

Cross-industry standard test method developments：from manufacturing to wearable robots

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1447-1457页

作者： roger BOSTELMAN Elena MESSINA Sebti FOUFOU National Institute of Standards and Technology GaithersburgMD 20899USA Le2i Universite de BourgogneDijon 21078France College of Engineering Qatar UniversityDoha 2713Qatar

Manufacturing robotics is moving towards human-robot collaboration with light duty robots being used side by side with workers. Similarly, exoskeletons that are both passive(spring and counterbalance forces) and active(motor forces) are worn by humans and used to move body parts. Exoskeletons are also called ‘wearable robots' when they are actively controlled using a computer and integrated sensing. Safety standards now allow, through risk assessment, both manufacturing and wearable robots to be used. However, performance standards for both systems are still lacking. Ongoing research to develop standard test methods to assess the performance of manufacturing robots and emergency response robots can inspire similar test methods for exoskeletons. This paper describes recent research on performance standards for manufacturing robots as well as search and rescue robots. It also discusses how the performance of wearable robots could benefit from using the same test methods.

关键词： Wearable robot Exoskeleton Cross-industry Artifact Standards Grasping

The Origin of Spots in Contact Aureoles and Over-Heating of Country Rock Next to a Dyke

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Journal of Earth Science 2018年第5期29卷 1005-1009页

作者： roger Mason Rong Liu School of Earth Sciences China University of Geosciences

Petrographic comparison of andalusite in the contact aureole of the Fangshan pluton, Zhoukoudian, Beijing, China, and hornfels in the aureole of the Markfield diorite, Leicestershire, Eng- land, shows that spots characteristic of the outer zones of contact metamorphic aureoles did not form during the progressive stage of contact metamorphism, but are pseudomorphs after earlier andalusite with characteristic chiastolite microstructure. The baked margin produced by contact metamorphism of syenite against a dyke in the Houshihushan ring complex, Shanhaiguan, Hebei Province, China, is an unusual feature caused by the dyke＇s role as a feeder to a family of cone-sheets.

关键词： contact metamorphism contact aureole retrogression hornfels spots Zhoukoudian Houshihushan.

The interaction of genetics and environmental toxicants in amyotrophic lateral sclerosis:results from animal models

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Neural Regeneration Research 2017年第6期12卷 902-905页

作者： roger B.Sher Department of Neurobiology and Behavior Stony Brook University

Amyotrophic lateral sclerosis（ALS） is a devastating neurodegenerative disease that results in the progressive death of motor neurons, leading to paralysis and eventual death. There is presently no cure for ALS, and only two drugs are available, neither of which provide significant extension of life. The wide variation in onset and progression of the disease, both in sporadic and even in strongly penetrant monogenic familial forms of ALS, indicate that in addition to background genetic variation impacting the disease process, environmental exposures are likely contributors. Epidemiological evidence worldwide implicates exposures to bacterial toxins, heavy metals, pesticides, and trauma as probable environmental factors. Here, we review current advances in gene-environment interactions in ALS animal models. We report our recent discoveries in a zebrafish model of ALS in relation to exposure to the cyanobacterial toxin BMAA, and discuss several results from mouse models that show interactions with exposure to mercury and statin drugs, both leading to acceleration of the disease process. The increasing research into this combinatorial gene-environment process is just starting, but shows early promise to uncover the underlying biochemical pathways that instigate the initial motor neuron defects and lead to their rapidly progressive dysfunction.

关键词： amyotrophic genetics paralysis familial progressive progression likely pesticides biochemical devastating

Rac GTPases:domain-specific functions in neuronal development

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Neural Regeneration Research 2019年第8期14卷 1367-1368页

作者： Steffen Norgaard roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology Monash University Melbourne Victoria Australia Biotech Research and Innovation Centre University of Copenhagen Copenhagen Denmark

Understanding fundamental mechanisms governing axon outgrowth and guidance can inform the development of therapeutic strategies to restore neuronal function damaged though injury or disease. Axons navigate the extracellular environment by responding to guidance cues that bind to cell surface receptors to relay information intracellularly via Rho GTPase family members, including the Rac GTPases.

关键词： Rac GTPases domain-specific functions neuronal development