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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Nanosecond mid-infrared pulse generation via modulated thermal emissivity

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Light(Science & Applications) 2019年第1期8卷 724-731页

作者： Yuzhe Xiao Nicholas A.Charipar Jad Salman Alberto pique Mikhail A.Kats Department of Electrical and Computer Engineering University of Wisconsin-MadisonMadisonWI 53706USA Naval Research Laboratory 4555 Overlook Ave.SWWashingtonDC 20375USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Department of Physics University of Wisconsin-MadisonMadisonWI 53706USA

We demonstrate the generation of nanosecond mid-infrared pulses via fast modulation of thermal emissivity enabled by the absorption of visible pump pulses in unpatterned silicon and gallium *** free-carrier dynamics in these materials result in nanosecond-scale modulation of thermal emissivity,which leads to nanosecond pulsed thermal *** our knowledge,the nanosecond thermal-emissivity modulation in this work is three orders of magnitude faster than what has been previously *** also indirectly observed subnanosecond thermal pulses from hot carriers in *** experiments are well described by our multiphysics *** method of converting visible pulses into the mid infrared using modulated emissivity obeys different scaling laws and can have significant wavelength tunability compared to approaches based on conventional nonlinearities.

关键词： pump emissivity thermal

Product Fingerprints for the Evaluation of Tool/Polymer Replication Quality in Injection Molding at the Micro/Nano Scale

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Nanomanufacturing and Metrology 2021年第4期4卷 278-288页

作者： Dario Loaldi Francesco regi Dongya Li Nikolaos Giannekas Matteo Calaon Yang Zhang Guido Tosello Department of Mechanical Engineering Technical University of Denmark(DTU)2800 Kongens LyngbyDenmark

Replication processes for the manufacturing of micro/nano-structured components are characterized by a certain degree of precision and *** transcription loss,or replication fidelity,defines the geometrical and dimensional correspondence of micro/nano-structure from metal tool inserts into plastic patterned *** employment of a vast spectrum of micro/nano-structured geometries calls for methodologies that can be used for the estimation of replication *** study presents a number of product fingerprints,which propose multiple ways to characterize micro/nano structures in replication *** fidelity yielded values above 80%and up to 96%depending on the considered product fingerprints and their ***,a correlation of the product fingerprint with the process parameters was found to optimize the replication *** uncertainty accompanies the analysis of the product fingerprints,enabling a standardized,robust,and quantitative methodology for process learning,modeling,and optimization.

关键词： Micro/nano replication Product fingerprinting Metrology Micro injection molding

Assessing business incubation:A review on benchmarking

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International Journal of Innovation Studies 2018年第3期2卷 91-100页

作者： Mustafa Torun Laura Peconick Vinicius Sobreiro Herbert Kimura Josep pique Department of Management Universidade de BrasiliaCampus Darcy RibeiroAsa NorteBrasiliaDF70910-900Brazil Universitat Ramon Llull La SalledUniversitat Ramon LlullBarcelonaCatalunya08022Spain

This paper studies benchmarking on Business Incubators(BIs),aggregating the state of knowledge about benchmarks for BI *** on 136 papers that evaluate BI performance,this study first investigates all Key Performance Indicators(KPIs)provided by 42 BI assessment studies and the relevant benchmarks for each *** final benchmark list is created by taking seven of the most prominent benchmarking studies as a *** this framework,this research contributes to the literature on BI assessment by providing comprehensive and aggregated benchmarks for these important innovation habitats.A final list of 33 benchmarks is provided so that BI assessment,for which no common framework exists,becomes *** study suggests that with the difficulty of creating a common assessment framework for BIs,it is more reasonable to create a common benchmarking framework that accounts for regional and industrial *** results could be subject to a multiple criteria decision *** paper is the first to aggregate the diverse information on benchmarking and provide researchers and BI managers with a base list of benchmarks.

关键词： Business incubation Performance evaluation Benchmarks

Long-Time Turbulence Model Deduced from the Navier-Stokes Equations

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： roger LEWANDOWSKI IRMAR and Fluminance Team University of Rennes 1 and INRIA Campus Beaulieu

The author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions Turbulence modeling Reynolds stress

Avian succession along ecological gradients： Insight from species-poor and species-rich communities of Sylvia warblers

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Current Zoology 2011年第3期57卷 307-317页

作者： Alban GUILLAUMET roger PRODON EPHE CEFE-CNRS UMR 5175 1919 route de Mende 34293 Montpellier cedex 5 France Department of Wildlife Fisheries & Aquaculture Mail Stop 9690 Mississippi State University Mississippi MS 39762 USA

The mechanisms responsible for species replacement during ecological successions is a long-standing and open debate. In this study, we examined the distribution of the Sardinian warbler Sylvia melanocephala along two grassland-to-forest gradients, one in a high-diversity area （Albera-Aspres chain in Catalonia： eight Sylvia warbler species） and one in a low-diversity area （Mount Hymittos in Greece： four species）. In Catalonia, distribution models suggested that the apparent exclusion of S. melanocephala from the open and forest ends of the gradient may be explained entirely by the preference of S. melanocephala for mid-successional shrublands. However, a joint analysis of both data sets revealed that： 1） S. melanocephala was more evenly dis- tributed along the vegetation gradient in Greece, suggesting ecological release in the low-diversity area; and 2） a distribution model assuming interspecific competition （based on the distribution of Sylvia species showing a negative co-occurrence pattern with S. melanocephala） had a significantly higher predictive ability than a distribution model based on habitat variables alone. Our study supports the view that species turnover along ecological gradients generally results from a combination of intrinsic preferences and interspecific competition [Current Zoology 57 （3）： 307-317, 2011].

关键词： Avian succession Cross-validation Diffuse competition Ecological release GLM Habitat selection Nichewidening Species distribution model

Endoscopic mucosal resection of colorectal polyps in typical UK hospitals

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World Journal of Gastroenterology 2010年第42期16卷 5324-5328页

作者： Teegan R Lim Venkat Mahesh Salil Singh Benjamin HL Tan Mohamed Elsadig Nerukav Radhakrishnan Phil Conlong Chris Babbs regi George Department of Gastroenterology and Medicine Rochdale InfirmaryRochdaleOL12 0NBUnited Kingdom Department of Gastroenterology and Medicine Royal Oldham HospitalOldhamOL1 2JHUnited Kingdom Department of Gastroenterology and Medicine Salford Royal HospitalStott LaneSalfordM6 8HDUnited Kingdom Division of Gastrointestinal Surgery Nottingham Digestive Diseases Centre NIHR Biomedical Research UnitNottingham University HospitalsQueen's Medical CentreNottinghamNG7 2 UHUnited Kingdom

AIM:To evaluate the outcomes of endoscopic mucosal resection(EMR) for colorectal polyps,with particular regard to procedural complications and recurrence rate,in typical United Kingdom(UK) hospitals that perform an average of about 25 colonic EMRs per ***:A total of 239 colorectal polyps(≥ 10 mm) resected from 199 patients referred to Rochdale Infirmary,Salford Royal Hospital and Royal Oldham Hospital for EMR between January 2003 and January 2009 were ***:The mean size of polyps resected was 19.6 ± 12.4 mm(range 10-80 mm).The overall major complication rate was 2.1%.Complications were less frequent with non-adenomas compared with the other groups(Pearson's χ 2 test,P < 0.0001).Resections of largersized polyps were more likely to result in complications(unpaired t-test,P = 0.021).Recurrence was associated with histology,with carcinoma-in-situ more likely to recur compared with low-grade dysplasia [hazard ratio(HR) 186.7,95% confidence interval(95% CI):8.81-3953.02,P = 0.001].Distal lesions were also more likely to recur compared with right-sided and transverse colon lesions(HR 5.93,95% CI:1.35-26.18,P = 0.019).CONCLUSION:EMR for colorectal polyps can be performed safely and effectively in typical UK *** follow-up is required for histologically advanced lesions due to increased recurrence risk.

关键词： Endoscopic mucosal resection Polyps Endoscopic Resection

A Relative Theory for Leibniz n-Algebras

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Algebra Colloquium 2016年第2期23卷 219-226页

作者： Guy roger Biyogmam Department of Mathematics Southwestern Oklahoma State University 100 Campus Drive Weatherford OK 73096 USA

In this paper we show that for an n-Filippov algebra g, the tensor power g ^n-1 is endowed with a structure of anti-symmetric co-representation over the Leibniz algebra g ^n-1. This co-representation is used to define some relative theories for Leibniz n-algebras with n 〉 2 and obtain exact sequences relating them. As a result, we construct a spectral sequence for the Leibniz homology of Filippov algebras.

关键词： Leibniz n-algebras Filippov algebras Leibniz homology

Correction of disturbed pathophysiology of hepatic failure by albumin dialysis

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 19-24页

作者： roger Williams Institute of Hepatology University College London Medical School 69-75 Chenies MewsLondonWC1E 6HXUK

Introduction In my presentation to the 4th International Symposium on Hepatic Failure and Artificial Liver Support in Chongqing on which this paper is based, I was specifically asked to address the question of whether albumin dialysis, as in the Molecular Adsorbents Recirculating System (MARS) did correct known abnormalities of the disturbed pathophysiology in liver failure. Before doing this

关键词： albumin dialysis