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Differential signaling of Flt3 activating mutations in acute myeloid leukemia:a working model

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Protein & Cell 2011年第2期2卷 108-115页

作者： perry M.Chan Neuroscience Research Partnership Biomedical Sciences Instituteaffiliated with Institute of Molecular and Cell BiologyASTARSingapore 138673Singapore

Receptor tyrosine kinases couple a wide variety of extracellular cues to cellular *** class III subfamily comprises the platelet-derived growth factor receptor,c-Kit,Flt3 and c-Fms,all of which relay cell proliferation signals upon ligand ***,mutations in these proteins that confer ligand-independent activation are found in a subset of *** mutations cluster in the juxtamembrane(JM)and catalytic tyrosine kinase domain(TKD)*** the case of acute myeloid leukemia(AML),the juxtamembrane(named ITD for internal tandem duplication)and TKD Flt3 mutants differ in their spectra of clinical *** the mechanism of aberrant activation has been largely elucidated by biochemical and structural analyses of mutant kinases,the differences in disease presentation cannot be attributed to a change in substrate specificity or signaling strength of the catalytic *** review discusses the latest literature and presents a working model of differential Flt3 signaling based on mis-localized juxtamembrane autophosphorylation,to account for the disease *** will have bearing on therapeutic approaches in a complex disease such as AML,for which no efficacious drug yet exists.

关键词： acute myeloid leukemia receptor tyrosine kinase oncogenic mutation autoinhibition intracellular traf-ficking

A review of geometry-confined perovskite morphologies:From synthesis to efficient optoelectronic applications

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Nano Research 2022年第8期15卷 7402-7431页

作者： Jinshuai Zhang perry Ping Shum Lei Su School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUK College of Engineering Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China

With the continuous study of metal halide perovskite,geometry-confined technologies have been widely applied to reduce the material dimensionality and to produce pre-designed structures,which can tune optical reflectance,scattering,and absorption,thereby optimizing the performance of perovskite-based optoelectronic devices and improving their commercial *** morphologies of perovskite active layer play a pivotal role in optoelectronic properties and the resulting device *** this review,we systematically summarized recent progress in the preparation and manufacture of various perovskite geometry-confined morphologies,as well as their promising advances in different optoelectronic applications,including photodetectors,solar cells(SCs),lasers,and light-emitting diodes(LEDs).In addition,the remaining challenges and further improvements of preparation unique geometry-confined perovskite morphologies for next-generation high quality optoelectronic devices are discussed.

关键词： geometry confinement metal halide perovskite controllable morphology optoelectronics

Understanding the connection between blasting and highwall stability

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International Journal of Mining Science and Technology 2019年第1期29卷 99-103页

作者： R.Quentin Eades Kyle perry Department of Mining and Nuclear Engineering Missouri University of Science and Technology

Surface mines continue to implement highwalls for several reasons, such as increasing recovery, improving margins, and justifying higher stripping ratios. Highwall stability is a complex issue that is dependent upon a variety of mining and geologic factors, and a safe design is necessary for a successful surface operation. To improve highwall stability, it is important to understand the connection between local geology and blasting. Explosives are employed throughout the mining industry for primary rock breakage. There are a number of controlled blasting techniques that can be implemented to improve highwall *** include line drilling, smooth wall blasting, trim blasting, buffer blasting, air decking, and presplitting. Each of these techniques have associated advantages and disadvantages. Understanding local geology is necessary for selecting the appropriate controlled blasting technique. Furthermore, understanding the limitations and conditions for successful implementation of each technique is necessary. A discussion of the impact of geologic conditions on highwall stability is provided. Additionally, discussion is provided for the successful incorporation of the controlled blasting techniques listed above, and the associated mining and geologic factors that influence the selection and design of controlled blasting ***, a new methodology is proposed.

关键词： Controlled blasting Highwall stability Presplitting Surface mining

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 4-18页

作者： Grant perry Fernando Cortezon-Tamarit Sofia I.Pascu Department of Chemistry University of BathClaverton DownBath BA27AYUK

Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer *** the development of the disease is greatly correlated to age,the identification of novel detection methods reliable,efficient,and cost effective is a matter of significant importance in the ageing population of western *** detection of the prostate specific antigen(PSA)in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past *** the indications against its use in massive population screening,PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate *** latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed *** incorporation of gold nanoparticles,silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity,stability and *** electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

关键词： biosensing immunosensor PSA prostate cancer fluorescence

Evaluation of the 20 L dust explosibility testing chamber and comparison to a modified 38 L vessel for underground coal

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International Journal of Mining Science and Technology 2018年第6期28卷 885-890页

作者： Robert Eades Kyle perry Catherine Johnson Jacob Miller Department of Mining and Nuclear Engineering Missouri University of Science and Technology

The phenomenon of combustible dust explosions is present within many industries. Tests for explosibility of dust clouds per ASTM E1226 use a 20 L explosive chamber that places the combustible dust directly below the dispersion nozzle which generates a thorough mixture for testing purposes. However, in the underground coal mining industry, there are a number of geologic, mining, and regulatory factors that change the deposition scheme of combustible coal dust. This causes the atmosphere of a coal mine to have a variable rock dust-coal dust mixture at the time of ignition. To investigate the impact of this variable atmosphere, a series of lean explosibility tests were conducted on a sample of Pittsburgh Pulverized coal dust. These explosibility tests were conducted in a 38 L chamber with a 5 kJ Sobbe igniter. The 38 L chamber generates a variable air-dust mixture prior to ignition. The test results indicate that the 38 L chamber experiences reduced explosive pressures, and lower explosibility index values when compared to the 20 L chamber.

关键词： Dust explosion Coal mining Coal dust Explosibility testing

“Of Rare Compatibility”:Jen Bervin’s Silk Poems and Making Kin in the Sericene

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Journal of Foreign Languages and Cultures 2019年第2期3卷 1-18页

作者： David perry New York University Shanghai

Scripting what may be read as a“string figure”companion to Donna Haraway’s Chthulucene,Jen Bervin’s 2017 Silk Poems project becomes entangled with the damage of the Anthropocene—and with projects of recuperation in the face of that damage—via a proposed Sericene:an ecopoetic weaving of human-worm-moth symbiosis in silk,a human voicing articulated through the nonhuman persona of Bombyx mori,the domestic silkworm(家蚕jiācán).This larval Sericene,like Haraway’s critical reinscription of the Anthropocene as the“tentacular”Chthulucene,underscores the necessity of thinking and acting in what Haraway terms“sympoiesis—making-with and becoming-with”in a time of accelerating planetary ecological crisis,insisting that we read ourselves in coproductive kinship with other species not merely as a strategy for poetry,art,and critical intervention,but for long-term multispecies *** is important to keep things light,we learn:the silkworm is never a hectoring lecturer,but rather often quite the comedian,good-natured in the face of individual and collective ***’s Chthulucene and Bervin’s Silk Poems converge in unsettling self into selves,species-being into multispecies being,and suggest sites of refuge,recuperation,and future-oriented sympoiesis within the ongoing crisis of crises which“the Anthropocene”attempts to name,and in which critical memetic neologisms(Capitalocene,Plantationocene,Chthulucene)seek to intervene,renaming and reframing in coproductive critique.

关键词： Jen Bervin Silk Poems Donna Haraway Anthropocene experimental poetry

Regulatory issues for genetically modified animals

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 188-203页

作者： perry Bradbury HACKETT Center for Genome Engineering Department of GeneticsCell Biology and DevelopmentUniversity of MinnesotaMN 55455USA

Precision genetics and breeding have the potential to meet the agricultural needs and goals of the world in the 21 st *** needs include increasing the efficiency of production of animals and improving their products with minimal impact on the *** USA is the major innovator in genomic science and the acknowledged leader in formulating policies to regulate genetic applications in medicine and ***,governments worldwide have been exceedingly reluctant to support the introduction of genetically modified(GM)animals into *** policies have stagnated due to legal guidelines that could not anticipate the needs and solutions that are evident *** must change if we are to maintain planetary integrity.I propose a new,market-based regulatory model for GM livestock that has both a strong scientific foundation and has worked for 10000 *** model is similar to that for information technology in which specific algorithms drive computer and cell phone *** engineers write genetic algorithms that drive the traits in biological ***,GM products should be viewed in terms of their use and public benefit rather than by limitations to the genetic programing coming from a few highly vocal *** algorithms(Genapps)of the 21st century will include not only introduction of synthetic genes,but also complete natural and synthetic biochemical pathways to produce agricultural products that are maximally efficient,healthy to humans and animals,and sustainable in an era of changing climates while avoiding environmental degradation.

关键词： algorithms editing FDA GMO recombinant DNA USDA

THREE BAYS ESTUARY(BARNSTABLE,CAPE COD)WATERSHED RESTORATION PL AN:A GREEN INFRASTRUCTURE APPROACH

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Journal of Green Building 2016年第2期11卷 22-38页

作者： Scott Horsley Erin perry Lindsey Counsell Horsley Witten Group Inc. Cape Cod Commission Three Bays Preservation Inc

This paper presents an approach described as“non-traditional”for restoring water quality and ecosystem services that have been degraded as a result of excess *** focuses on emerging technologies often referred to as green *** technologies may provide cost effective alternatives to traditional,gray infrastructure such as sewering and is likely to provide significant co-benefits including the creation of local jobs,the preservation of real estate values,and habitat *** paper focuses on the Three Bays estuary on Cape Cod to illustrate the benefits and potential of green infrastructure *** Three Bays estuary is presented as a case study and as a representative example of implementation of the broader Cape Cod Water Quality Management Plan Update(208 Plan Update)-a nationally-recognized watershed planning project designed to provide a pathway for the fifteen towns of Cape Cod to achieve compliance with Section 208 of the Clean Water *** Three Bays estuary and embayment system is a scenic Cape Cod bay that hosts sailing,kayaking,swimming and shellfishing and is located in the Town of *** is comprised of three primary segments that include West Bay,North Bay and Cotuit ***-systems include Prince Cove that flows into North Bay,the Narrows that flows between North Bay and Cotuit Bay and Eel Pond that flows into East Bay(see Figure 1).The Massachusetts Estuaries Project(MEP)is a state-sanctioned watershedmodeling project that assesses the conditions of the state’s estuaries and required restoration *** technical report(2006)indicates that the water quality of the Three Bays system has resulted in seriously degraded to moderately degraded *** system is listed as an impaired water body on the US Environmental Protection Agency(EPA)303d list of impaired *** approved Total Maximum Daily Load(TMDL)for nitrogen has been established for the *** assessment is supported by more recent em

关键词： water quality green infrastructure ecosystem services stormwater management floating constructed wetlands nitrogen management permeable reactive barriers urine diversion technology

Mitigation of floor heave in West Kentucky Coal Mine

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International Journal of Mining Science and Technology 2016年第3期26卷 521-525页

作者： perry Kyle Bradley Joel Unrug Kot Klimek Mark Mining Engineering Department University of Kentucky Alliance Resource Partners

A West Kentucky mine operation in No. 11 seam encountered floor heave, due to the localized increase in the thickness of the fireclay mine floor. Floor heave has overridden seals installed in two mined out panels. The third seal's location was planned for isolating that area from the Mains. A plan of support has been developed to prevent repetition of the floor heave and related problems outby the seals. The applied ground control measures were successful. An attempt of a 3D numerical modeling was made; thus, it would match the observed behavior of the mine floor and could be used as a design tool in similar conditions. The paper describes sequence of events, an applied mitigation ground control system, and the first stage of numerical modeling.

关键词： Floor heave Presplit Secondary support Modeling