检索结果-南通市图书馆

Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

World Journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： John J Miklavcic Glen K Shoemaker Vera c Mazurak M Tom clandinin Tasha DL hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. content and composition of phospholipid classes phosphatidylcholine(Pc) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P control intestine exhibited 3-fold higher(P content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of Pc containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P content of HEXA in IBD intestine was increased 1.7-fold(P creased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国华北、华南陆块碰撞时代的钐-钕同位素年龄证据

引用

中国科学（B辑） 1989年第3期 312-319页

作者：李曙光 S. R. hart 郑双根郭安林刘德良张国伟中国科学技术大学地球与空间科学系美国麻省理工学院地球大气行星科学系安徽省地质矿产局313地质队西北大学地质系

本文报道了秦岭-大别山造山带的c型榴辉岩Sm-Nd同位素年龄(243.9±5.6Ma),和镁铁-超镁铁岩Sm-Nd同位素年龄(230.6±30.7Ma和40.62±17.4Ma)。这些年龄表明中国华北、华南地块在三叠纪初期就沿秦岭-大别山碰撞带连接在一起了。在两地块... 详细信息

本文报道了秦岭-大别山造山带的c型榴辉岩Sm-Nd同位素年龄(243.9±5.6Ma),和镁铁-超镁铁岩Sm-Nd同位素年龄(230.6±30.7Ma和40.62±17.4Ma)。这些年龄表明中国华北、华南地块在三叠纪初期就沿秦岭-大别山碰撞带连接在一起了。在两地块最后碰撞以前,在古生代,有一系列蛇绿岩套仰冲事件沿华北地块南缘向外逐次发生。

关键词：华南陆块钐-钕同位素同位素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

克罗恩病及结肠癌中大肠埃希菌的黏附性和侵袭性增加

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 27-28页

作者： Martin H.M. campbell B.J. hart c.A. J.M. Rhodes 翟惠虹 Department of Medicine Henry Wellcome Lab. Molec.Cell. G. Univ. of Liverpool United Kingdom Liverp oolUnited Kingdom

Background &Aims: Altered mucosal glycosylation in inflammatory bowel disease and colon cancer could affect mucosal bacterial adherence. This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria,particula rly Escherichia coli, in these conditions. Methods:Mucosa-associated bacteria w ere isolated, after dithiothreitol mucolysis, from biopsy samples obtained at co lonoscopy(crohn’s disease, n = 14 patients; ulcerative colitis, n = 21;noninfla med controls, n = 24) and at surgical resection (colon cancer, n = 21). Intramuc osal bacteria were grown after gentamicin treatment followed by hypotonic lysis. Results:Mucosa-associated and intramucosal bacteria were cultured more commonl y in crohn’s disease (79%, P = 0.03; and 71%,P ctively), but not ulcerative colitis (38%and48%), than in noninflamed controls (42%and 29%) a nd were commonly cultured from colon cancers (71%and 57%). Mucosa-associated E. coli, which accounted for 53%of isolates,were more common in crohn’s diseas e (6/14; 43%) than in noninflamed controls (4/24, 17%), as also were intramuco sal E. coli: crohn’s disease, 29%; controls, 9%. E. coli expressed hemaggluti nins in 39%of crohn’s cases and 38%of cancers but only 4%of controls, and th is correlated (P = 0.01) with adherence to the I407 and HT29 cell lines. Invasio n was cell-line dependent. E. coli, including nonadherent isolates, induced int erleukin-8 release from the cell lines. E. coli adhesins showed no blood group specificity, excepting 1 cancer isolate (HM44)with specificity for the Thomsen- Friedenreich antigen, but they could be blocked by soluble plantain fiber. concl usions: These studies support a central role for mucosally adherent bacteria in the pathogenesis of crohn’s disease and colon cancer. Soluble plant fibers that inhibit their adherence have therapeutic potential.

关键词：克罗恩病大肠埃希菌侵袭性结肠癌黏附性溃疡性结肠炎炎症性肠病非炎症性结肠镜检红细胞凝集素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acute Fornix Deep Brain Stimulation Improves Hippocampal Glucose Metabolism in Aged Mice

引用

chinese Medical Journal 2018年第5期131卷 594-599页

作者： Xiu Wang Wen-hart HU Kai Zhang Jun-Jian Zhou De-Feng Liu Mei-Yu Zhang Jian-Guo Zhang Department of Neurosurgery Beijing Tian Tan Hospital Capital Medical University Beijing 100050 China Stereotactic and Functional Neurosurgery Laboratory Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Beijing Key Laboratory of Neurostimulation Beijing 100050 China Experimental Research center China Academy of Traditional Chinese Medicine Beijing 100700 China

Background： A beneficial memory effect of acute formix deep brain stimulation （DBS） has been reported in clinical studies. The aim of this study was to investigate the acute changes in glucose metabolism induced by fornix DBS. Methods： First, the Morris water maze test and novel object recognition memory test were used to confirm declined memory in aged mice （c57BL/6, 20-22 months old）. Then, four groups of mice were used as follows： aged mice with stimulation （n = 12）, aged mice with sham-stimulation （n = 8）, adult mice （3-4 months old） with stimulation （n = 12）, and adult mice with sham-stimulation （n = 8）. lpsilateral hippocampal glucose metabolism and glutamate levels were measured in vivo by microdialysis before, during, and after fornix DBS treatment. Histological staining was used to verify the localization of electrodes and mice with inaccurate placement were excluded from subsequent analyses. The effects of fornix DBS on extracellular glucose, lactate, pyruvate, and glutamate levels over time were analyzed by repeated-measures analysis of variance followed by Fisher＇s least significant difference post hoc test. Results： The aged mice had a higher basal lactate/pyruvate ratio （LPR） and lactate/glucose ratio （LGR） than the adult mice （LPR： 0.34 ± 0.04 vs. 0.13 ± 0.02, t = 4.626, P 〈 0.0001 ; LGR： 6.06± 0.59 vs. 4.14 ± 0.36, t = 2.823, P 〈 0.01 ）. Fomix DBS decreased the ipsilateral hippocampal pyruvate and lactate levels （P 〈 0.05）, but the glucose levels were not obviously changed in aged mice. Similarly, the LGR and LPR also decreased in aged mice after fornix DBS treatment （P 〈 0.05）. Glucose metabolism in adult mice was not significantly influenced by tbrnix DBS. In addition, fornix DBS significantly decreased the ipsilateral hippocampal extracellular levels of glutamate in aged mice （P 〈 0.05）, while significant alterations were not found in the adult mice. conclusions： The present study provides experimental evidence that fornix DBS could significantly

关键词： Deep Brain Stimulation Fornix Glucose Metabolism Memory Decline

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

领导力开发的50种活动

引用

2017年

作者： (美)哈特·B·哈特，(美)夏洛特·S·威斯曼

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

口服抗凝治疗安全地预防老年人心房颤动患者发生脑卒中

引用

英国医学杂志中文版 2010年第2期13卷 113-114页

作者： van Walraven c.hart RG connolly S 赵振燕(译) 李崇剑(校) 吴永健(校) 不详北京阜外心血管病医院心内科

研究设计设计：对12项随机对照试验中个体的资料进行汇总分析。6项随机对照试验是安慰剂对照试验，8项是比较口服抗凝药与抗血小板药物的随机对照试验。

关键词：心房颤动患者口服抗凝治疗随机对照试验脑卒中老年人预防安全抗血小板药物

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关于Rose心绞痛远期结果的人群研究:Renfrew-Paisley研究的20年随访结果

引用

世界核心医学期刊文摘(心脏病学分册) 2007年第5期 31-32页

作者： Murphy N.F. Stewart S. hart c.L. J.J.V. McMurray 奚群英 Department of cardiology Western InfirmaryGlasgow G11 6NT United Kingdom

目的:通过大型的流行病学研究调查心绞痛的远期心血管结果。设计:在1972—1976年间进行的前瞻性队列研究,随访期为20年(Renfrew-Paisley研究)。地点:位于英国苏格兰西部的Renfrew和Paisley。研究对象:7048例男性和8354例女性,年龄在45... 详细信息

目的:通过大型的流行病学研究调查心绞痛的远期心血管结果。设计:在1972—1976年间进行的前瞻性队列研究,随访期为20年(Renfrew-Paisley研究)。地点:位于英国苏格兰西部的Renfrew和Paisley。研究对象:7048例男性和8354例女性,年龄在45～64岁之间,基

关键词：心绞痛 Rose 男性女性基线冠心病 Renfrew-Paisley 全因死亡

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

领导力开发的50种活动

引用

作者： (美)洛伊丝·B·哈特(Lois B. hart)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

A study on the relationships between c-reactive protein and coronary heart disease

A study on the relationships between C-reactive protein and ...

引用

湖北省暨武汉生物化学与分子生物学学会第八届会员代表大会和第十五次学术年会

作者： ZHENG Fang, XIA Yong, ZHOU Kin Zhong Nan Hospital of Wu hart University Department of Laboratory Medicine, School of Medicine Wuhan University

Introduction: (1) To investigate the relationships between the Taq polymorphism of

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Applicability of Near Infrared Reflectance Spectroscopy for Analysis of Wheat Straw

Applicability of Near Infrared Reflectance Spectroscopy for ...

引用

第三十五届国际光谱会议

作者： c.J.Huang L.J.hart~* Z.L.Yang X.Liu college of Engineering china Agricultural University Beijing 100083 china Key laboratory of Modern Precision Agriculture System Integration Ministry of Education Beijing 100083 china

＜正＞china yields more than 120 million tons of wheat straw annually and the use of wheat straw for energy production is catching increasing interest for the sustainable development of china’s *** about the characte...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：