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chasing Sequencing Perfection:Marching Toward Higher Accuracy and Lower costs

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 1-12页

作者： Hangxing Jia Shengjun tan Yong e.Zhang cAS Key Laboratory of Zoological Systematics and evolution&State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of chinese Academy of Sciences Beijing 100049China cAS center for excellence in Animal evolution and Genetics Chinese Academy of SciencesKunming 650223China

Next-generation sequencing(NGS),represented by Illumina platforms,has been an essential cornerstone of basic and applied ***,the sequencing error rate of 1 per 1000 bp(10^(−3))represents a serious hurdle for research areas focusing on rare mutations,such as somatic mosaicism or microbe *** examining the high-fidelity sequencing methods developed in the past decade,we summarized three major factors underlying errors and the corresponding 12 strategies mitigating these *** then proposed a novel framework to classify 11 preexisting representative methods according to the corresponding combinatory strategies and identified three trends that emerged during methodological *** further extended this analysis to eight long-read sequencing methods,emphasizing error reduction ***,we suggest two promising future directions that could achieve comparable or even higher accuracy with lower costs in both NGS and long-read sequencing.

关键词： Sequencing error High-fidelity sequencing consensus sequencing Single-molecule sequencing Rare mutation

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On B(5,20)2-Groups

Algebra colloquium 2024年第3期31卷 429-440页

作者： e.A.Alhassan Y.L.tan Y.Li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by several *** this paper,we give a complete characterization of B(5,20)2-groups by showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

Synchronization of Drive-Response Networks With Delays on Time Scales

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Ieee/cAA Journal of Automatica Sinica 2024年第4期11卷 1063-1065页

作者： Yanxia tan Zhenkun Huang the School of Science Jimei UniversityXiamen 361021China

Dear editor,This letter deals with the synchronization in drive-response networks with discrete and distributed delays on time *** on the theory of calculus on time scales,Lyapunov functional method and inequality technique,we obtain new sufficient conditions to ensure synchronization criteria which are dependent on boundedness of grainness but independent of the types of *** simulations are given to illustrate the effectiveness of our new results.

关键词： inequality letter boundedness

Influence of ambient temperature on the cO_(2)emitted of light-duty vehicle

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Journal of environmental Sciences 2024年第6期140卷 59-68页

作者： Dan tan Yachao Wang Jianwei tan Jiachen Li changyu Wang Yunshan Ge School of Mechanical engineering Beijing Institute of TechnologyBeijing 100081China

Because of global warming,people have paid more attention to greenhouse gas emitted by *** quantify the impact of temperature on vehicle cO_(2)emissions,this study was conducted using the world light vehicle test cycle on two light-duty e10 gasoline vehicles a ambient temperatures of-10,0,23,and 40℃,and found that cO_(2)emission factors of Vehicle1 in the low-speed phase were 22.07%and 20.22%higher than those of Vehicle 2 at cold star and hot start under-10℃.The reason was vehicle 1 had a larger displacement and more friction pairs than vehicle *** was the highest cO_(2)emission at the low-speed phase due to low average speed,frequent acceleration,and *** cO_(2)temperature factor and the ambient temperature had a strong linear correlation(R2=0.99).According to cO_(2)temperature factors and their relationships,cO_(2)emission factors of other ambien temperatures could be calculated when the cO_(2)emission factor of 23℃was obtained,and the method also could be used to obtain the cO_(2)temperature factors of different *** separate the effect of load setting and temperature variation on cO_(2)emission quantitatively a method was *** results showed that the load setting was dominant for the cO_(2)emission *** with 23℃,the cO_(2)emission for vehicle 1 caused by load setting variation were 62.83 and 47.42 g/km,respectively at-10 and 0℃,while those fo vehicle 2 were 45.01 and 35.63 g/km,respectively.

关键词： cO_(2)emission Ambient temperature e10 gasoline Light-duty vehicle WLTc

exploring the functional roles of small-molecule metabolites in disease research:Recent advancements in metabolomics

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chinese chemical Letters 2024年第8期35卷 93-100页

作者： Aolei tan Xiaoxiao Ma Department of Precision Instrument Tsinghua UniversityBeijing 100084China

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in ***,an essential scientific discipline,is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during *** the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and *** comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic *** scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

关键词： Metabolites Small molecules Biological functions Physiological processes Diseases

Best Paper Award 2022

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Building Simulation 2024年第1期17卷 1-2页

作者： Gang tan college of civil engineering and Architecture Zhejiang University HangzhouZhejiang 310058China

I am pleased to announce that the following paper has been awarded the Best Review Paper 2022,which stands out from the 24 review papers published by Building Simulation from 2018(Volume 11)to 2022(Volume 15):Yuejing Zhao&Bin Zhao."emissions of air pollutants from chinese cooking:A literature review."Building Simulation,2018,11(5):977-995.

关键词： cooking stands award

Preface to the Special Issue:AI Applications in Atmospheric and Oceanic Science:Pioneering the Future(Part I)

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Advances in Atmospheric Sciences 2024年第7期41卷 1279-1280页

作者： Zhemin tan Key Laboratory of Mesoscale Severe Weather Ministry of Educationand School of Atmospheric SciencesNanjing UniversityNanjing 210023China

As AI continues to establish itself as a cornerstone technology across various industries and scientific disciplines,its profound impact on atmospheric and oceanic science is becoming increasingly *** advantages of AI in surmounting obstacles within our field are undeniable,as evidenced by breakthroughs in weather forecasting(e.g.,Bi et al.,2023),climate prediction(e.g.,Ham et al.,2019),AI-based parameterization schemes(e.g.,Rasp et al.,2018;Wang and tan,2023),and *** the transformative potential of AI in atmospheric and oceanic science,this special issue endeavors to explore the extensive applications of AI in our domain.

关键词： weather forecasting prediction

A Novel extremum Seeking control to enhance convergence and Robustness in the Presence of Nonlinear Dynamic Sensors

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Journal of Systems Science & complexity 2024年第1期37卷 3-21页

作者： LIU Hengchang tan Ying OeTOMO Denny School of electrical Mechanical and Infrastructure EngineeringThe University of MelbourneParkville VIC 3010Australia

This paper focuses on optimizing an unknown cost function through extremum seeking(eS)control in the presence of a slow nonlinear dynamic sensor responsible for measuring the *** contrast to traditional perturbation-based eS control,which often suffers from sluggish convergence,the proposed method eliminates the time-scale separation between sensor dynamics and eS control by using the relative degree of the nonlinear sensor *** improve the convergence rate,the authors incorporate high-frequency dither signals and a *** enhance the robustness with the existence of rapid disturbances,an off-the-shelf linear high-gain differentiator is *** first result demonstrates that,for any desired convergence rate,with properly tuned parameters for the proposed eS algorithm,the input of the cost function can converge to an arbitrarily small neighborhood of the optimal solution,starting from any initial condition within any given compact ***,the second result shows the robustness of the proposed eS control in the presence of sufficiently fast,zero-mean periodic *** results substantiate these theoretical findings.

关键词： Averaging extremum seeking optimization singular perturbation time-scale separation

Amorphous hybrid tungsten oxide–nickel hydroxide nanosheets used as a highly efficient electrocatalyst for hydrogen evolution reaction

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Nano Research 2024年第4期17卷 2499-2508页

作者： chao Lyu chenghai Dai Yiwei tan State Key Laboratory of Materials-Oriented chemical engineering School of Chemistry and Chemical EngineeringNanjing Tech UniversityNanjing 211816China

There are more challenges for alkaline hydrogen evolution reaction(HeR)via simultaneously expediting the electron-coupled water dissociation process(Volmer step)and the following electrochemical H_(2) desorption(Heyrovsky step).Hybrid amorphous electrocatalysts are highly desirable for efficient hydrogen evolution from water-alkali electrolyzers due to the bifunctionality for the different elementary steps of HeR and optimal interactions with water molecules and the reactive hydrogen intermediates(Had).Herein,the synthesis of amorphous hybrid ultrathin(tungsten oxide/nickel hydroxide)hydrate(a-[WO_(3)/Ni(OH)_(2)]·0.2H_(2)O)nanosheets on nickel foam(NF)for efficient alkaline HeR is *** structural and composition features of a-[WO_(3)/Ni(OH)_(2)]·0.2H_(2)O are characterized in *** resulting a-[WO_(3)/Ni(OH)_(2)]·0.2H_(2)O/NF electrocatalyst with the synergistic effect of both hybrid components for the HeR elementary steps shows greatly improved the activity and durability for the HeR with a low overpotential of-41 and-163 mV at-10 and-500 mA·cm^(-2),respectively,a Tafel slope as low as-72.9 mV·dec^(-1),and long-term stability of continuous electrolysis for at least 150 h accompanying by inappreciable overpotential change in 1 M *** the hybrid a-[WO_(3)/Ni(OH)_(2)]·0.2H_(2)O,Ni(OH)_(2) and WO_(3) moieties are separately responsible for accelerating dissociative adsorption of water and weakening Had adsorption strength,which is beneficial to the improvement of the alkaline HeR activity.

关键词： amorphous nanomaterial bimetallic electrocatalyst tungsten oxide ultrathin nanosheet hydrogen evolution reaction