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Thermal hypersensitivity in a subset of irritable bowel syndrome patients

World Journal of Gastroenterology 2009年第26期15卷 3254-3260页

作者： QiQi Zhou roger b fillingim Joseph L Riley Ⅲ G Nicholas Verne Department of Medicine OhioState University Columbus Ohio 43210 United States College of Dentistry University of Florida Gainesville Florida 32610 United States North Florida/South Georgia Veteran Health System Gainesville Florida 32610 United States Research Service Cincinnati VAMCCincinnati Ohio 45220 United States

AIM： To characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome （IbS）. METHODS： Thermal pain sensitivity was tested among patients with diarrhea-predominant IbS （D-IbS） and constipation-predominant IbS （C-IbS） compared to healthy subjects. A total of 42 patients （29 female and 13 male; mean age 27.0 ＋ 6.4 years） with D-IbS; 24 patients （16 female and eight male; mean age 32.5 ：1：8.8 years） with C-IbS; and 52 control subjects （34 female and 18 male; mean age 27.3 ± 8.0 years） participated in the study. Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area. Heat pain threshold （HPTh） and heat pain tolerance （HPTo） were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional bowel Disease Severity Index （FbDSI） was also obtained for all subjects. RESULTS： Controls were less sensitive than C-IbS and D-IbS （both at P 〈 0.001） with no differences between C-IbS and D-IbS for HPTh and HPTo. Thermal hyperalgesia was present in both groups of IbS patients relative to controls, with IbS patients reporting significantly lower pain threshold and pain tolerance at both test sites. Cluster analysis revealed the presence of subgroups of IbS patients based on thermal hyperalgesia. One cluster （17% of the sample） showed a profile of heat pain sensitivity very similar to that of healthy controls; a second cluster （47% of the sample） showed moderate heat pain sensitivity; and a third cluster （36% of the sample） showed a very high degree of thermal hyperalgesia. CONCLUSION： A subset of IbS patients had thermal hypersensitivity compared to controls, who reported significantly lower HPTh and HPTo. All IbS patients had a higher score on the FbDSI than controls. Interestingly, the subset of IbS patients with high thermal sensitivity （36%） had the highest FbDSI score compared to the other two groups of IbS patients.

关键词： Irritable bowel syndrome Visceral pain thermal hypersensitivity Heat pain threshold Heat pain tolerance

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