检索结果-南通市图书馆

Genotype frequency of gelatinase B C-1562 T polymorphism in coronary heart disease and myocardial infarction

Journal of Geriatric Cardiology 2004年第2期1卷 114-118页

作者： Dieter Niederacher roger marx Thomas Scheffold Rolf Michael Klein Molecular Genetics Laboratory of the Gynecology Division Henrich-Heine University DuesseldorfGermany Heart Center Wuppertal University of Witten-HerdeckeWuppertalGermany

Background One of the characteristics of atherosclerosis is a change in the content of extracellular matrix in the arterial wall. Gelatinase B, a member of the family of matrix metalloproteinase, can regulate extracellular matrix metabolismand play a role in the pathogenesis of atherosclerosis, coronary heart disease (CHD) and myocardial infarction (MI). Gelatinase B is polymorphic due to a C to T change at the position -1562 bp in the promoter *** relationship with gene product concentration in serum and its role in mediating the risk of CHD and MI in Germans is still unknown. Methods We enrolled 102 controls and 322 patients with angiographically documented CHD,including a sub-group of 173 patients with acute or chronic MI and 80 patients with acute coronary syndrome (ACS).All patients and controls were Germans and genotyped by polymerase chain reaction and digestion with SphI. Results We found that several classical risk factors for CHD and MI, including hypercholesterolemia and cigarette smoking,were significantly increased in CHD and MI patients compared with controls. Serum levels of gelatinase B and tissue inhibitor of metalloproteinase-1 were increased in the peripheral blood of patients with acute coronary syndrome. No significant differences in genotype or allelic frequencies between CHD, MI and control subjects of either men or women were found. Our search for a possible association of the polymorphisms with CHD and MI by logistic regression analysis was also negative. The serum concentrations of gelatinase B showed no differences between genotypes. Conclusions Our data showed that gelatinase B might provide an index of plaque activity in ACS, but gelatinase B protein was not affected by genotypes. Also, the T variant of gelatinase B was not associated with CHD or MI in Germans. (J Geriatr Cardiol 2004;1(2):114-118.)

关键词： gelatinase B gene polymorphism coronary heart disease myocardial infarction gelatinase B protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functions of nuclear factor Y in nervous system development,function and health

引用

Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

严重室性心律失常患者的心肌肠病毒RNA检测

引用

中国心脏起搏与心电生理杂志 2004年第Z1期18卷 183-页

作者：姜红饶丹 roger marx Dieter Niederac her Frauke Picard Mic hael Bre hm Rolf Mic hael Klein 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032 上海复旦大学中山医院心内科上海200032

　　肠病毒是成人病毒性心肌炎最常见的病因,已证实心肌的炎症可增加发生室性心动过速和心室颤动的危险性.本研究旨在探讨肠病毒感染的心肌是否为不明原因严重室性心律失常的病因之一.……

关键词：严重室性心律失常患者病毒性心肌炎室性心动过速肠病毒感染心室颤动病因危险性炎症成人

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone cement adhesion on ceramic surfaces—Surface activation of retention surfaces of knee endoprostheses by atmospheric pressure plasma *** surface treatment

引用

Journal of Advanced Ceramics 2016年第2期5卷 137-144页

作者： B.marx C.marx R.marx U.REISGEN D.C.WIRTZ ISF Welding and Joining Institute RWTH Aachen University Pontstrasse 49 52062 Aachen GermanyCC&A Medical Components Ltd. Center for Biomedical Engineering Pauwelsstrasse 17 52074 Aachen Germany CC&A Medical Components Ltd. Center for Biomedical Engineering Pauwelsstrasse 17 52074 Aachen Germany ISF Welding and Joining Institute RWTH Aachen University Pontstrasse 49 52062 Aachen Germany Orthopaedics and Traumatology Clinic University Hospital Bonn Sigmund-Freud-Strasse 25 53127 Bonn Germany

CoCrMo alloys are contraindicated for allergy sufferers. For these patients, uncemented and cemented prostheses made of titanium alloy are indicated. Knee prostheses machined from that alloy, however, may have poor tribological behavior. Therefore, for allergy sufferers, knee replacements in form of cemented high-strength oxide ceramic prostheses which reveal excellent tribological behavior are suitable. In addition, the rate of particle induced aseptic loosening may be reduced. For adhesion of bone cement, the smooth ceramic surface, however, exposes inefficient mechanical retention spots as compared with a textured metal surface. Undercuts generated by corundum blasting, which in the short and intermediate term are highly efficient on a CoCrMo surface, are not appropriate on a ceramic surface due to the brittleness of ceramics. The corresponding textures may initiate cracks which will weaken the strength of a ceramic prosthesis. Due to the lack of textures, mechanical retention is poor or even not existent. Micromotions are facilitated and early aseptic loosening is predictable. Instead silicoating of the ceramic surface will allow specific adhesion and result in better hydrolytic stability of bonding, thereby preventing early aseptic loosening. Silicoating, however, presupposes a clean and chemically active surface which may be achieved by atmospheric plasma or thermal surface treatment. In order to evaluate the effectiveness of silicoating, the bond strengths of atmospheric plasma versus thermal surface treated and silicoated ZPTA (zirconia platelets toughened alumina) surfaces were compared with “as-fired” surfaces by utilizing TiAlV probes (diameter: 6 mm) for traction-adhesive strength test. After preparing samples for traction-adhesive strength test (sequence: ceramic substrate, silicate layer and penetrated silane, protective lacquer (PolyMA), bone cement, TiAlV probe), they were aged up to 150 days at 37°C in Ringer’s solution. The bond strengths observed

关键词： total knee replacement out of oxide ceramics aseptic loosening allergenic potential atmospheric plasma treatment silicoating hydrolytic stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-Time Turbulence Model Deduced from the Navier-Stokes Equations

引用

Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： roger LEWANDOWSKI IRMAR and Fluminance Team University of Rennes 1 and INRIA Campus Beaulieu

The author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions Turbulence modeling Reynolds stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Relative Theory for Leibniz n-Algebras

引用

Algebra Colloquium 2016年第2期23卷 219-226页

作者： Guy roger Biyogmam Department of Mathematics Southwestern Oklahoma State University 100 Campus Drive Weatherford OK 73096 USA

In this paper we show that for an n-Filippov algebra g, the tensor power g ^n-1 is endowed with a structure of anti-symmetric co-representation over the Leibniz algebra g ^n-1. This co-representation is used to define some relative theories for Leibniz n-algebras with n 〉 2 and obtain exact sequences relating them. As a result, we construct a spectral sequence for the Leibniz homology of Filippov algebras.

关键词： Leibniz n-algebras Filippov algebras Leibniz homology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correction of disturbed pathophysiology of hepatic failure by albumin dialysis

引用

Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 19-24页

作者： roger Williams Institute of Hepatology University College London Medical School 69-75 Chenies MewsLondonWC1E 6HXUK

Introduction In my presentation to the 4th International Symposium on Hepatic Failure and Artificial Liver Support in Chongqing on which this paper is based, I was specifically asked to address the question of whether albumin dialysis, as in the Molecular Adsorbents Recirculating System (MARS) did correct known abnormalities of the disturbed pathophysiology in liver failure. Before doing this

关键词： albumin dialysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Archaeal viruses-novel,diverse and enigmatic

引用

Science China(Life Sciences) 2012年第5期55卷 422-433页

作者： GARRETT roger A Archaea Centre Department of BiologyCopenhagen UniversityOle Maal esVej 5DK2200 Copenhagen NDenmark

Recent research has revealed a remarkable diversity of viruses in archaeal-rich environments where spindles, spheres, fila- ments and rods are common, together with other exceptional morphotypes never recorded previously. Moreover, their dou- ble-stranded DNA genomes carry very few genes exhibiting homology to those of bacterial and eukaryal viruses. Studies on viral life cycles are still at a preliminary stage but important insights are being gained especially from microarray analyses of viral transcripts for a few model virus-host systems. Recently, evidence has been presented for some exceptional archaeal- nspecific mechanisms for extra-cellular morphological development of virions and for their cellular extrusion. Here we sum- marise some of the recent developments in this rapidly developing and exciting research area.

关键词： virus morphotypes diversity and evolution life cycle temporal regulation cellular extrusion mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SOME REMARKS ON HYDROFOIL CAVITATION

引用

Journal of Hydrodynamics 2012年第3期24卷 305-314页

作者： ARNDT roger E. A. Saint Anthony Falls Laboratory University of Minnesota MinneapolisMN 55414 USA

This paper reviews numerical and experimental investigations of sheet/cloud cavitation carried out at the St. Anthony Falls Laboratory and at two collaborating facilities （Versuchsanstalt Ftir Wasserbau, Obernach, Germany and Osaka University, Japan） for more than a decade. Although significant advances have been made in the analysis of this flow several issues are still unresolved. The purpose of this paper is to examine the overall features of the problem, review the progress made to date and suggest avenues for new investigation.

关键词： cavitation hydrofoil numerical simulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon–Mann–Whitney Test

引用

Genomics, Proteomics & Bioinformatics 2016年第1期14卷 55-61页

作者： Alexander marx Christina Backes Eckart Meese Hans-Peter Lenhof Andreas Keller Chair for Clinical Bioinformatics Medical Faculty Saarland University Department of Human Genetics Saarland University University Hospital Chair for Bioinformatics Saarland University

In many research disciplines, hypothesis tests are applied to evaluate whether findings are statistically significant or could be explained by chance. The Wilcoxon-Mann-Whitney （WMW） test is among the most popular hypothesis tests in medicine and life science to analyze if two groups of samples are equally distributed. This nonparametric statistical homogeneity test is commonly applied in molecular diagnosis. Generally, the solution of the WMW test takes a high combinatorial effort for large sample cohorts containing a significant number of ties. Hence, P value is frequently approximated by a normal distribution. We developed EDISON-WMW, a new approach to calcu- late the exact permutation of the two-tailed unpaired WMW test without any corrections required and allowing for ties. The method relies on dynamic programing to solve the combinatorial problem of the WMW test efficiently. Beyond a straightforward implementation of the algorithm, we pre- sented different optimization strategies and developed a parallel solution. Using our program, the exact P value for large cohorts containing more than 1000 samples with ties can be calculated within minutes. We demonstrate the performance of this novel approach on randomly-generated data, benchmark it against 13 other commonly-applied approaches and moreover evaluate molec- ular biomarkers for lung carcinoma and chronic obstructive pulmonary disease （COPD）. We foundthat approximated P values were generally higher than the exact solution provided by EDISON- WMW. Importantly, the algorithm can also be applied to high-throughput omics datasets, where hundreds or thousands of features are included. To provide easy access to the multi-threaded version of EDISON-WMW, a web-based solution of our algorithm is freely available at http：// ***/software/wtest/.

关键词： Wilcoxon-Mann-Whitneytest:Wilcoxon rank-sum test Dynamic programing Exact permutation Parallel optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：