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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

On-line non-intrusive particle size measurement of pulverised fuel through digital imaging

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仪器仪表学报 2007年第11期28卷 1942-1946页

作者： carter Robert M Department of Electronics University of Kent

This paper presents the basic principles of particle size measurement and latest industrial results recorded using an innovative optical instrumentation system designed to measure the size distribution of particles in a pneumatic *** system is non-intrusive and cost-effective.A low-cost CCD camera is used to capture images of the particulate flow field,which is illuminated by a low-cost pulsed laser sheet *** particle size distribution is then determined by processing the particle images through the use of novel processing *** results obtained in the past on a small scale particle flow test rig have demonstrated that the system is capable of measuring the size distribution of pneumatically conveyed particles with an accuracy of a few *** the present paper results obtained when testing the system at a 4 MW industrial test facility are *** are made with both off-line reference data achieved through sieving and on-line laser diffraction data recorded using an intrusive,extractive,Malvern Instruments *** general there is good agreement between results when considering the characteristics and limitations of the individual *** novel imaging system shows itself to be rugged,practical and useful under genuine industrial conditions.

关键词：粒子测量方法数字成像数码

Differentiation of lethal and non lethal prostate cancer： PSA and PSA isoforms and kinetics

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Asian Journal of Andrology 2012年第3期14卷 355-360,I0004页

作者： H Ballentine carter Department of Urology Johns Hopkins University School of Medicine Johns Hopkins Hospital Baltimore MD 21287-2101 USA

Prostate-specific antigen （PSA） testing for the early diagnosis of prostate cancer has led to a decrease in cancer mortality. However, the high prevalence of low-grade prostate cancer and its long natural history, competing causes of death in older men and treatment patterns of prostate cancer, have led to dramatic overtreatment of the disease. Improved markers of prostate cancer lethality are needed to reduce the overtreatment of prostate cancer that leads to a reduced quality of life without extending life for a high proportion of men. The PSA level prior to treatment is routinely used in multivariable models to predict prostate cancer aggressiveness. PSA isoforms and PSA kinetics have been associated with more aggressive phenotypes, but are not routinely employed as part of prediction tools prior to treatment. PSA kinetics is a valuable marker of lethality post treatment and routinely used in determininE the need for salva=e theraov.

关键词： benign PSA human kallikrein 2 precursor form of PSA prostate specific antigen PSA kinetics unbound or free PSA

Evaluating COVID-19’s impacts on Puerto Rican’s travel behaviors

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Geo-Spatial Information Science 2023年第4期26卷 616-626页

作者： Lauren C.carter Ran Tao School of Geosciences University of South FloridaTampaFLUSA

The COVID-19 pandemic has completely disrupted and possibly permanently changed the way humans *** Puerto Rico,major travel restrictions to the island have persisted at different levels since March 2020,which heavily influenced residents’travel ***,it remains unclear about how big the impact is and how inequitable it might *** goal of this study is to evaluate COVID-19’s impacts on Puerto Rican’s travel behaviors by analyzing travel flows from Puerto Rico to the contiguous US with a modified gravity *** roles of socioeconomic factors regarding the Puerto Rican travelers and COVID-19 factors regarding the destination US states have been ***-19 was a strong deterring factor of travel at the beginning of the pandemic and also in the winter of 2020,but it did not keep Puerto Ricans from traveling during the summer 2020 when most travel restrictions were *** found that the elderly population of Puerto Rico,despite being more vulnerable to COVID-19,were much more likely to travel during the *** also found that,during the holiday season in 2020,some socioeconomically disadvantaged populations were more likely to be traveling,a direct contradiction to their travel flows the year *** findings shed light on about how disproportionately affected populations behavior changed from pre-pandemic to after the pandemic *** the continuance of the pandemic,this information is extremely valuable for future planning with respect to emergency management,travel regulation,and social benefit.

关键词： COVID-19 Puerto Rico travel behavior social vulnerability human mobility

Occurrence and formation of disinfection by-products in the swimming pool environment： A critical review

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Journal of Environmental Sciences 2017年第8期29卷 19-50页

作者： Rhys A.A.carter Cynthia A.Joll Curtin Water Quality Research Centre Department of Chemistry Curtin Uniuersity Perth Western Australia 6102 Australia

Disinfection of water for human use is essential to protect against microbial disease;however, disinfection also leads to formation of disinfection by-products（DBPs）, some of which are of health concern. From a chemical perspective, swimming pools are a complex matrix, with continual addition of a wide range of natural and anthropogenic chemicals via filling waters, disinfectant addition, pharmaceuticals and personal care products and human body excretions. Natural organic matter, trace amounts of DBPs and chlorine or chloramines may be introduced by the filling water, which is commonly disinfected distributed drinking water. Chlorine and/or bromine is continually introduced via the addition of chemical disinfectants to the pool. Human body excretions（sweat, urine and saliva） and pharmaceuticals and personal care products（sunscreens, cosmetics, hair products and lotions） are introduced by swimmers. High addition of disinfectant leads to a high formation of DBPs from reaction of some of the chemicals with the *** pool air is also of concern as volatile DBPs partition into the air above the *** presence of bromine leads to the formation of a wide range of bromo-and bromo/chloro-DBPs, and Br-DBPs are more toxic than their chlorinated analogues. This is particularly important for seawater-filled pools or pools using a bromine-based *** review summarises chemical contaminants and DBPs in swimming pool waters, as well as in the air above pools. Factors that have been found to affect DBP formation in pools are discussed. The impact of the swimming pool environment on human health is reviewed.

关键词： Disinfection by-products Disinfection Swimming pool Spa Water quality Health effects

Investigation on modeling parameters of concrete beams reinforced with basalt FRP bars

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Frontiers of Structural and Civil Engineering 2019年第6期13卷 1520-1530页

作者： Jordan carter Aikaterini S.GENIKOMSOU Civil Engineering Department Queen s UniversityKingstonON K7N 3N6Canada

Fiber-reinforced polymer(FRP)bars are widely used as internal reinforcement replacing the conventional steel bars to prevent from *** the different types of FRP bars,basalt FRP(BFRP)bars have been used in different structural applications and,herein,three already tested concrete beams reinforced with BFRP bars are analyzed using three-dimensional(3-D)finite element analysis(FEA).The beams were tested in four-point *** the FEA the behavior of concrete is simulated using the^Concrete-Damaged Plasticity^^model offered in ABAQUS *** research presented here presents a calibrated model for nonlinear FEA of BFRP concrete beams to predict their response considering both the accuracy and the computational *** calibration process showed that the concrete model should be regularized using a mesh-dependent characteristic length and material-dependent post-yield fracture and crushing energies to provide accurate mesh-size independent *** results were compared to the test results with regard to failure load and crack *** the test results and the numerical results were compared to the design predictions of ACI 440.1R-15 and CSA S806-12,where CSA S806-12 seems to overestimate the shear strength for two beams.

关键词： basalt Fiber-reinforced polymer bars reinforced concrete beams finite element analysis damaged plasticity model design codes

Long-Time Turbulence Model Deduced from the Navier-Stokes Equations

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： roger LEWANDOWSKI IRMAR and Fluminance Team University of Rennes 1 and INRIA Campus Beaulieu

The author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions Turbulence modeling Reynolds stress

Linear viscoelastic behavior of asphalt binders and mixtures containing very high percentages of reclaimed asphalt pavement

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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1211-1227页

作者： Reza IMANINASAB Luis LORIA-SALAZAR Alan carter Construction Engineering Department École de Technologie Supérieure(ÉTS)University of QuebecMontreal H3C 1K3Canada Civil Engineering Department Universidad Isaac NewtonSan José10108Costa Rica

The primary aim of this study is to correlate the impact of aggregates,if any,on the viscoelastic behavior of rejuvenated asphalt mixtures containing very high amounts of reclaimed asphalt pavement(RAP)(>50%).First,gradation of 100%RAP was rectified,using a modified Bailey method by adding virgin aggregates to achieve two coarse dense-graded and one fine dense-graded *** modulus test was then performed from−35 to+35℃and 0.01–10 *** addition to performance grade(PG)testing,extracted and recovered binders from different asphalt mixtures underwent shear complex modulus test within−8℃to high temperature PG and frequencies from 0.001 to 30 ***−Cole,Black space,complex modulus and phase angle master curves were constructed and ShiftHomothety-Shift in time-Shift(SHStS)transformation was used to compare the linear viscoelastic behavior of asphalt binders and *** influence of aggregates on the viscoelastic behavior of asphalt mixtures depends on temperature and/or *** role of asphalt binders in the behavior of asphalt mixtures is more pronounced at high temperatures and the effect of the aggregate structure increases as the temperature *** maximum difference(60%to 70%)in the viscoelastic behavior of the binder and mixture based on SHStS transformed Cole−Cole curves is within the phase angle of 15°–20°.

关键词： RAP complex modulus SHStS transformation rejuvenation behavior of asphalt binder and mixture

Breath-based meditation: A mechanism to restore the physiological and cognitive reserves for optimal human performance

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World Journal of Clinical Cases 2016年第4期4卷 99-102页

作者： Kirtigandha Salwe carter Robert carter III Department of Integrative Physiology University of North Texas Health Science Center Tactical Combat Casualty Care Research Program United States Army Institute of Surgical Research Joint Base San Antonio-Fort Sam

Stress can be associated with many physiologicalchanges resulting in significant decrements in human *** to growing interests in alternative and complementary medicine by Westerners,many of the traditions and holistic yogic breathing practices today are being utilized as a measure for healthier *** state-of-the-art practices can have a significant impact on common mental health conditions such as depression and generalized anxiety ***,the potential of yogic breathing on optimizing human performance and overall well-being is not well *** techniques such as alternate nostril,Sudarshan Kriya and bhastrika utilizes rhythmic breathing to guide practitioners into a deep meditative state of relaxation and promote ***,yogic breathing is physiologically stimulating and can be described as a natural"technological"solution to optimize human performance which can be categorized into:(1)cognitive function(i.e.,mind,vigilance);and(2)physical performance(i.e.,cardiorespiratory,metabolism,exercise,whole body).Based on previous studies,we postulate that daily practice of breathing meditation techniques play a significant role in preserving the compensatory mechanisms available to sustain physiological *** preservation of physiological function may help to offset the time associated with reaching a threshold for clinical expression of chronic state(i.e.,hypertension,depression,dementia)or acute state(i.e.,massive hemorrhage,panic attic)of medical ***,additional rigorous biomedical research is needed to evaluate the physiological mechanisms of various forms of meditation(i.e.,breath-based,mantra,mindfulness)on human *** efforts will help to define how compensatory reserve mechanisms of cardiovascular and immune systems are modulated by breath-based *** it has been suggested that breath-based meditation is easier for beginning practitioners when compared to other

关键词： Meditation Breathing technique Cognitive reserve Neurophysiology Stress Human performance Emotional regulation