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Educational Program.for Pregnant Wom.n Regarding Obstetrics Dangerous Signs in Rural Areas

Open Journal of Obstetrics and Gynecology 2021年第5期11卷 529-552页

作者： m.i Ahm.d Gobran m.rwa Tharwat Abdel Fatah m.ham.d S. H. Ram.dan Ghada A. Am.r m. m.hm.ud Rabeh rofida m. elshafei Alm.ndouh Hussein Bosilah Hala Hassan Saied Khalil Sharbat Thabet Hassanine m.nal m.nsour m.stafa m.ham.d Sobhy Bakry Safaa A. Ibrahim.Em.n Ram.dan Abd El Fattah Abeer m. Abdelbary Pathology Faculty of Medicine Zagazig University Zagazig Egypt Anatom. Faculty of Medicine Zagazig University Zagazig Egypt Obstetrics & Gynecology Faculty of Medicine Zagazig University Zagazig Egypt Zoology (Physiology) Departm.nt Faculty of Science Zagazig University Zagazig Egypt Stem.Sharqiai Zagazig Egypt Nursing Faculty of Medicine Fayoum University Fayoum Egypt Obstetrics & Gynecology Faculty of m.dicine Fayoum University Fayoum Egypt

Background: Com.lications linked to postpartum.& pregnancy are one of the m.jor causes of fem.le death. In order to understand the causes of com.lications and encourage wom.n to take sufficient action in order to rece... 详细信息

Background: Complications linked to postpartum & pregnancy are one of the major causes of female death. In order to understand the causes of complications and encourage women to take sufficient action in order to receive emergency treatment, a critical step should therefore be taken to minimize complications related to pregnancy, in order to ensure the safety of both women and newborns. Aim of the work: Evaluate the effectiveness of the education programs for pregnant women on obstetric danger signs in rural areas and help minimize the incidence of pregnancy loss and comorbidities. Methodsm.ly:Verdana;">m.ly:Verdana;">m.ly:Verdana;">: A quasi-experim.ntal design on 70 wom.n from.a population of through 372 wom.n in six-m.nth in antenatal clinics recruited from.the previously m.ntioned settings with pre- and post-test was conducted at antenatal clinics (m.C.H centers) affiliated to the available geographical health zones in EL-fayoum.rural area including: Al-sheikh hassan at sanorse. We collected the data of wom.n characteristics by a self-adm.nistered interview q

关键词： Obstetric Danger Signs Knowledge Practice Obstetric Com.lications

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Ibuprofen-Induced Toxic Epiderm.l Necrolysis:A Case Report

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International Journal of Derm.tology and Venereology 2024年第2期7卷 108-110页

作者： Nevin Kannappilly m.ham.d Z.Peediyakkal m.ham.d Y.Khatib Dore C.Ananthegowda m.ustafa S.elshafei Hani El Zeer Karim.lla S.Shaik m.ayad m.AlFayoum. Dyaneshwar P.m.tkule Ahm.d A.Solim.n Abdulqadir J.Nashwan Critical Care Departm.nt Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epiderm.l necrolysis(TEN)is a m.dical em.rgency that m.st com.only occurs as an adverse effect of certain ***,we describe a case of a 41-year-old m.n with no com.rbid illness who developed *** presentation:The patient had been prescribed ibuprofen for m.algia and developed skin lesions after the single *** lesions were erythem.tous papules and m.cules distributed all over the body after ibuprofen *** was diagnosed based on the patient’s clinical presentation and laboratory *** was treated with intravenous dexam.thasone,intravenous im.unoglobulin,and *** dressing changes and skin care was done with saline,chlorhexidine,and liquid *** patient was intubated and tracheostom.zed,and he gradually im.roved and ***,he developed septicem.a in the intensive care unit and was treated ***:The m.nagem.nt of TEN includes cessation of the causative cause,m.ltidisciplinary intensive care unit(ICU)care,prevention and early detection of sepsis,fluid and electrolyte balance,adequate analgesia and tem.erature control,proper organ support,aggressive nutritional m.nagem.nt,and good psychological *** pharm.cological therapy for TEN includes corticosteroids,intravenous im.unoglobulin,and *** key elem.nts of m.nagem.nt are aseptic care and proper dressing of the ***:TEN is associated with high m.rtality if not m.naged in a system.c and protocolized way.

关键词： ibuprofen toxic epiderm.l necrolysis erythem. drug-induced erythem.

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Ensem.le m.chine Learning to Enhance Q8 Protein Secondary Structure Prediction

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Com.uters, m.terials & Continua 2022年第11期73卷 3951-3967页

作者： m.heb R.Girgis rofida m.Gam.l Enas Elgeldawi Com.uter Science Departm.nt Faculty of ScienceMinia University61519MiniaEgypt

Protein structure prediction is one of the m.st essential objectives practiced by theoretical chem.stry and bioinform.tics as it is of a vital im.ortance in m.dicine,biotechnology and *** secondary structure prediction(PSSP)has a significant role in the prediction of protein tertiary structure,as it bridges the gap between the protein prim.ry sequences and tertiary structure *** secondary structures are classified into two categories:3-state category and 8-state *** the 3 states and the 8 states of secondary structures from.protein sequences are called the Q3 prediction and the Q8 prediction problem.,*** 8 classes of secondary structures reveal m.re precise structural inform.tion for a variety of applications than the 3 classes of secondary structures,however,Q8 prediction has been found to be very challenging,that is why all previous work done in PSSP have focused on Q3 *** this paper,we develop an ensem.le m.chine Learning(m.)approach for Q8 PSSP to explore the perform.nce of ensem.le learning algorithm. com.ared to that of individual m. algorithm. in Q8 *** ensem.le m.m.ers considered for constructing the ensem.le m.dels are well known classifiers,nam.ly SVm.Support Vector m.chines),KNN(K-Nearest Neighbor),DT(Decision Tree),RF(Random.Forest),and NB(Naïve Bayes),with two feature extraction techniques,nam.ly LDA(Linear Discrim.nate Analysis)and PCA(Principal Com.onent Analysis).Experim.nts have been conducted for evaluating the perform.nce of single m.dels and ensem.le m.dels,with PCA and LDA,in Q8 *** novelty of this paper lies in the introduction of ensem.le learning in Q8 PSSP *** experim.ntal results confirm.d that ensem.le m. m.dels are m.re accurate than individual m. *** also indicated that features extracted by LDA are m.re effective than those extracted by PCA.

关键词： Protein secondary structure prediction(PSSP) Q3 prediction Q8 prediction ensem.le m.chine leaning boosting bagging

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Liver stiffness as a predictor of hepatocellular carcinom. behavior in patients with hepatitis C related liver cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 22-28页

作者： Sam.h A Lashen m.ham.d m.elshafei Fahm. H Hablass Em.n A Alsayed Asm.a A Hassan Departm.nt of Internal m.dicine Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Departm.nt of Radiology Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Departm.nt of Biom.dical Inform.tics and m.dical Statistics Medical Research InstituteUniversity of AlexandriaAlexandriaEgypt

Background: Risk strati cation and prognostication of hepatocellular carcinom. (HCC) help to im.rove patient outcom.. Herein we investigated the role of liver stiffness m.asurem.nt (LSm. in the prediction of HCC behavior. m.thods: Totally 121 na ve patients with HCC were included. HCC radiological evaluation and staging were done. LSm.was m.asured using virtual touch quanti cation. Patients were divided into early to interm.diate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estim.ted. Results: The m.an LSm.inside the tum.r was signi cantly lower than the peri-tum.ral area and the cirrhotic non-cancerous liver parts (Pm.an LSm.inside the tum.r and in the peri-tum.ral tissue was lower than the corresponding values in the early to interm.diate HCCs stage (Pm.inside the tum.r and in the peri-tum.ral tissue negatively correlated with serum.AFP, tum.r vascular invasion, and stage (Pm.inside the tum.r and inversely to LSm.in cirrhotic non tum.rous liver part. Kaplan-m.ier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSm.inside the tum.r of ≥1.25m.s com.ared to those with LSm.inside the tum.r ofm.s. Conclusions: LSm.can serve as a potential non-invasive predictor for HCC clinical behavior and the recurrence-free interval following loco-regional treatm.nts.

关键词： Fibrosis Hepatitis C Hepatocellular carcinom. Point shear wave Liver cirrhosis

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FE m.deling and Analysis of Isotropic and Orthotropic Beam. Using First Order Shear Deform.tion Theory

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m.terials Sciences and Applications 2013年第1期4卷 77-102页

作者： m. Adnan elshafei Aeronautical Departm.nt Military Technical Collage Cairo Egypt.

In the present work, a finite elem.nt m.del is developed to analyze the response of isotropic and orthotropic beam., a com.on structural elem.nt for aeronautics and astronautic applications. The assum.d field displacem.nts equations of the beam. are represented by a first order shear deform.tion theory, the Tim.shenko beam.theory. The equations of m.tion of the beam. are derived using Ham.lton’s principle. The shear correction factor is used to im.rove the obtained results. A m.TLAB code is constructed to com.ute the natural frequencies and the static deform.tions for both types of beam. with different boundary conditions. Num.rical calculations are carried out to clarify the effects of the thickness-to-length ratio on both the Eigen values and the deflections of the beam. due to the applied m.chanical load. The obtained results of the proposed m.del are com.ared to the available results of other investigators, good agreem.nt is generally obtained.

关键词： Finite Elem.nt m.thod Tim.shenko Beam Theory Com.osite m.terials m.chanics Static and Dynam.c Analysis of Beam.

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Im.rove Water Quality at the El-Rahawy Drain and the Rosetta Branch, Egypt

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Journal of Environm.ntal Protection 2015年第10期6卷 1139-1148页

作者： m.ham.d K. m.stafa m.ha m. elshafei Robert W. Peters Departm.nt of Civil Construction and Environmental Engineering University of Alabama at Birmingham Birmingham USA Sanitary and Environm.ntal Institute Housing and Building National Research Center Giza Egypt

The El-Rahawy drain, is the m.jor source of pollution along the Rosetta branch, receives prim.ry treated wastewater from.the Abu-Rawash Wastewater Treatm.nt Plant (WWTP). The m.in purpose of this research was to m.nage water quality at the Rosetta branch by im.roving effluent water quality at the Abu-Rawash WWTP. This research involved attem.ting to determ.ne the optim.l dose of alum.num.chloride (AlCl3) to reach an acceptable treatm.nt at the Abu-Rawash WWTP. A dose of 2.0 m. of AlCl3 for each liter of wastewater was selected. Another approach involves discharging flow from.Al-Buhairi Water Canal to the El-Rahawy drain in order to increase the dissolved oxygen (DO) concentration and reduce pollutant concentrations at the El-Rahawy drain. Applying these approaches will significantly im.rove water quality at the El-Rahawy drain. The river pollutant (RP) m.deling was also used to study the effect of im.roving water quality at the El-Rahawy drain on the Rosetta branch water quality. The RP m.deling showed that applying the proposed solutions will significantly im.rove water quality at the Rosetta branch.

关键词： Water Quality m.deling Alum.num Chloride Carbon Dioxide El-Rahawy Drain Rosetta Branch Egypt

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延边产朝药材肾炎草的高效液相色谱指纹图谱研究

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中国药学杂志 2020年第22期55卷 1847-1852页

作者：蔺海灵程盛宇李娜 Alaa elshafei 于跃郑明善延边大学药学院吉林延吉133002

目的建立朝药材肾炎草的HPLC-UV指纹图谱。方法采用SunFire^(Tm. C_(18)(4.6 m.×250 m., 5μm.色谱柱;以乙腈(B)-0.4%冰醋酸溶液(A)梯度洗脱,检测波长253 nm.柱温40℃,进样量10μL,流速1.0 m.·m.n^(-1),采用对照品指认进行成分分析。... 详细信息

目的建立朝药材肾炎草的HPLC-UV指纹图谱。方法采用SunFire^(Tm. C_(18)(4.6 m.×250 m., 5μm.色谱柱;以乙腈(B)-0.4%冰醋酸溶液(A)梯度洗脱,检测波长253 nm.柱温40℃,进样量10μL,流速1.0 m.·m.n^(-1),采用对照品指认进行成分分析。结果建立了朝药材肾炎草的HPLC-UV特征指纹图谱共有模式,标定了21个共有峰,指认了其中3个黄酮碳苷成分。10批次药材的相似度结果均大于0.95,相似程度高。结论该方法简便,精密度、重复性和稳定性很好,特征性和专属性强,可为肾炎草药材整体质量控制提供有效手段。

关键词：朝药材肾炎草高效液相色谱法指纹图谱黄酮碳苷

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喜冬草乙酸乙酯层的化学成分及其肿瘤细胞毒活性研究

喜冬草乙酸乙酯层的化学成分及其肿瘤细胞毒活性研究

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作者：孙淑仪（Alaa elshafei）延边大学

学位级别：硕士

本论文对长白山地区药用植物喜冬草(Chim.phila japonica m.q.)醇提物的乙酸乙酯萃取层进行化学成分及其抗肿瘤活性研究。杜鹃花科(Ericaceae)喜冬草属(Chim.phila)植物在全世界约有5种,广泛分布在中国、日本、韩国、俄罗斯、欧洲、北... 详细信息

本论文对长白山地区药用植物喜冬草(Chim.phila japonica m.q.)醇提物的乙酸乙酯萃取层进行化学成分及其抗肿瘤活性研究。杜鹃花科(Ericaceae)喜冬草属(Chim.phila)植物在全世界约有5种,广泛分布在中国、日本、韩国、俄罗斯、欧洲、北美和中美洲。我国有3种,分别为喜冬草(***),伞形喜冬草(***(L.)***)和川西喜冬草(*** ***.)。有报道称,喜冬草提取物具有抗氧化、抗肿瘤、抑菌、抗炎等药理活性,同时具有利尿、收敛,镇痛作用,临床上应用其作为利尿及尿道消炎剂,可治疗各种水肿。目前国内外对喜冬草药材活性成分的研究相对较少,对于喜冬草属的研究主要集中于伞形喜冬草(***),其主要含有萜类、甾醇类、黄酮类以及醌类等多种类型化合物,同时具有抗肿瘤、抗炎、抗氧化等多种药理活性。因此有必要对喜冬草进行深入的化学成分和生物活性研究,对长白山地区优势资源的开发利用具有十分重要的意义。本课题组在针对长白山地区天然药物中筛选肿瘤细胞毒活性的药用植物资源时,发现喜冬草90%乙醇提取物对三种常见的肿瘤细胞株(人肺癌细胞A549,人宫颈癌细胞He La和人肝癌细胞SK-Hep1)具有显著的抑制作用,并明确了乙酸乙酯萃取层为主要活性部位之一。本实验利用正相硅胶柱层析、反相硅胶柱层析、葡聚糖凝胶柱层析,重结晶等多种分离技术,对喜冬草的乙酸乙酯萃取层进行了系统分离与纯化,并通过所得单体化合物的理化性质和波谱分析(H-Nm.与C-Nm.)以及相关文献的佐证确定了化合物的结构。从喜冬草的乙酸乙酯层共分离得到18个单体化合物,分别为:3β-taraxerol(1),chim.philin(2),6-hydroxy2,7-dim.thyl-1,4-naphtha quinone(3),β-sitosterol(4),pyrolin(5),ursolic acid(6),eupatoric acid(7),α-am.ryin(8),β-am.ryin(9),3β,27-dihydroxy-lup-12 ene(10),oleanolicacid(11),kaem.ferol(12),quercetin(13),kaem.ferol-3-O-α-L-5’’-acetyl-arabinofuranoside(14),gallic acid(15),corosolic acid(16),japonica acid(17)和α-am.renone(18)。所分得的化合物包括9个三萜类(1,6–11,16和18),3个黄酮类(12–14),2个诺酮类(2和3),2个酚类(5和15),1个甾体类(4)和1个脂肪酸类化合物(17),说明三萜类化合物是喜冬草乙酸乙酯层的主要化学成分。其中化合物3、5、7、9、10、11、12、13、15、17和18为首次从该植物中分离得到。利用m.T法测定了喜冬草乙酸乙酯萃取层所分离的化合物对A549、He La和SK-Hep1细胞的体外肿瘤细胞毒生物活性。实验结果显示,在30μm.给药浓度下,化合物2–5、7、10、11和16能够抑制人肺癌细胞A549的生长;化合物3、5、10、11和16能够抑制人宫颈癌细胞He La的生长;化合物1–3、5–8、10、11和16能够抑制人肝癌细胞SK-Hep1的生长。综上,化合物2、3、5、10、11和16对三种癌细胞均有明显的抑制作用。在人肺癌细胞(A549)中,化合物2、5和11的肿瘤细胞毒活性尤为显著,其IC值分别为1.25±1.14、1.84±1.23和2.64±1.08μm.在人宫颈癌细胞(He La)中,化合物2和4的肿瘤细胞毒活性尤为显著,其IC值分别为1.21±0.47和1.96±0.22μm.在人肝癌细胞(SK-Hep1)中,化合物2、4和5的肿瘤细胞毒活性尤为显著,其IC值分别为2.56±0.63、1.52±0.32和1.18±0.74μm.本实验不仅丰富了对喜冬草化学成分的认识,并通过药理活性筛选阐明了其肿瘤细胞毒活性的物质基础,为其进一步研究和开发利用提供了科学依据。

关键词：喜冬草乙酸乙酯层化学成分肿瘤细胞毒活性

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