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Prostate cancer temporal and regional trends in Brazil

Oncology research 2024年第10期32卷 1565-1573页

作者： Jalalizadeh m. roesch h.r.m. Korkes F. Dien-Trinh Q. reis L.O. UroScience School of Medical Sciences State University of Campinas Campinas 13083-872 Brazil Division of Urology Faculdade de Medicina do ABC São Paulo 09051-040 Brazil Division of Urological Surgery and Center for Surgery and Public health Brigham and Women’s Hospital Harvard Medical School Boston 02115 MA United States ImmunOncology Pontifical Catholic University of Campinas PUC-Campinas Campinas 13087-571 Brazil

Objectives: The Brazilian Unified health System (Sistema Único de Saúde−SUS) is the universal public healthcare system of Brazil that maintains a nationwide database of its patients. Our primary objective was to analyze regional and temporal trends, while our secondary goal was to establish correlations between states’ health economy status and their prostate cancer (PCa) epidemiology. methods: We analyzed Brazil’s nationwide data on prostate cancer (PCa) incidence, mortality, and care gathered between 2013 and 2021 by the Information Technology Department of SUS (DATA-SUS), updated monthly using the International Classification of Diseases (ICD-10) code. results: In the period, 273,933 new cases of PCa and 135,336 PCa deaths were reported in men aged 50 years or over in Brazil. The median annual PCa-specific incidence rate (PCSIr) ranged from 14.7 in the Southeast to 6.9 in the North region and the median annual PCa-specific mortality rate (PCSmr) ranged from 7.7 in the Northeast to 6.0 in the South region (per 10,000 men >50). The median annual mortality to incidence ratio (mIr) was highest in the North (0.88) and lowest in the Southeast region (0.44). There were significant regional differences in PCa treatment rates (per new cases); the midwest region had the highest median annual surgery rate (0.63) while the North region had the highest median annual systemic therapy rate (0.75) and the lowest radiation therapy rate (0.06). Temporal analysis of the data showed significant change in annual rate trends after the year 2018 for PCSIr (coefficient [β] = +3.66, p reatment (β = −0.06, p = 0.016), surgery ([Sr] β = +0.05, p = 0.017) radiation therapy ([rTr] β = −0.06, p = 0.005) and systemic therapy ([STr] β = −0.10, p = 0.002). After the 2020 pandemic, annual PCSIr decreased (β = −2.15, p = 0.002) but annual PCSmr, mIr, and treatment rates remained stable. Correlation studies showed that the PCSIr was strongly negatively correlated with STr (p < 0.001)

关键词： COVID-19 pandemic Prostate cancer (PCa) epidemiology regional disparities Screening Temporal trends

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凝固条件和镁对Al-Si11.0合金组织的影响

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材料工程 1999年第1期27卷 3-6页

作者：徐才录 h.m.TEBSI r.roesch 清华大学机械工程系慕尼黑工业大学

研究了定向凝固时冷却条件和镁元素对Ａｌ－Ｓｉ１１．０合金树枝晶结构和共晶组织的影响。试验结果表明，随着冷却速度的增加，Ａｌ－Ｓｉ１１．０合金的一次枝晶和二次分枝间距都显著减小；在较小的冷却速度时，加入镁元素后合金的二... 详细信息

研究了定向凝固时冷却条件和镁元素对Ａｌ－Ｓｉ１１．０合金树枝晶结构和共晶组织的影响。试验结果表明，随着冷却速度的增加，Ａｌ－Ｓｉ１１．０合金的一次枝晶和二次分枝间距都显著减小；在较小的冷却速度时，加入镁元素后合金的二次分枝间距明显增大，而在冷却速度大于１６０Ｋ／ｍｉｎ时，则没有影响。试验还发现，加入镁元素后，冷却速度对共晶成分的影响显著减小。提高冷却速度使得合金的共晶组织变细。在试验范围内，Ａｌ－Ｓｉ１１．０合金中加入０．１５％镁时，共晶组织变得较粗；而当镁的加入量增加到０．３％时，其共晶组织比Ａｌ－Ｓｉ１１．０合金细得多，分析了出现这一结果的原因。

关键词：铝合金定向凝固显微组织镁元素

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凝固条件和热处理及微量锶对一种Al-Si合金组织和性能的影响

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金属热处理 1998年第2期23卷 1-5页

作者：徐才录 hmTensi rroesch SSpaic 梁吉魏秉庆吴德海清华大学机械系慕尼黑工业大学洛勃里亚纳大学

研究了凝固条件和热处理及微量锶对Ａ３５６合金组织与性能的影响。试验结果表明，锶的加入不仅对显微组织而且对合金中αＡｌ固溶体的弥散析出行为也有较大的改变，加入锶后的合金在冷却过程中（“隐形热处理”）的一次弥散相和随后热... 详细信息

研究了凝固条件和热处理及微量锶对Ａ３５６合金组织与性能的影响。试验结果表明，锶的加入不仅对显微组织而且对合金中αＡｌ固溶体的弥散析出行为也有较大的改变，加入锶后的合金在冷却过程中（“隐形热处理”）的一次弥散相和随后热处理的二次弥散相都要比Ａ３５６合金细得多。这种细化作用较普通光学显微组织对力学性能的影响还要大。即使通过长时间的热处理，锶和冷却速度对显微组织的影响仍没有实质的变化。同时比较了定向凝固的Ａ３５６合金在铸态与热处理态下的质量指数，结果显示其明显高于普通条件下的Ａ３５６合金的质量指数。

关键词：铝合金力学性能热处理弥散强化凝固条件

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德国煤矿充填技术现状

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矿业译丛 1992年第1期 34-36页

作者： m．roesch 周国才

近年来，德国煤矿巷旁充填技术发展很快，主要使用集中供料充填设备和风力充填方法，混凝土仍是目前巷旁充填的主要材料。为了保证高效的巷道充填作业，现有二分之一的部分断面掘进机均装备有充填设备。众所周知，巷旁充填的目的在于... 详细信息

近年来，德国煤矿巷旁充填技术发展很快，主要使用集中供料充填设备和风力充填方法，混凝土仍是目前巷旁充填的主要材料。为了保证高效的巷道充填作业，现有二分之一的部分断面掘进机均装备有充填设备。众所周知，巷旁充填的目的在于减少巷道掘进、维护费用和巷道复用时所需的追加费用，以及全面地改善巷道状况，提高其稳定性。因此，要想提高采掘进度、支架回收率及其复用次数，就须采用最佳的巷旁充填技术。对于使用钻爆法掘进的巷道和使用部分断面掘进机开掘的巷道而言，使用不同的充填方法对提高巷道的稳定性具有十分重要的意义。

关键词：巷道掘进巷旁充填煤矿充填设备采掘进度充填技术掘进机德国现状状况

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满足未来排放法规的先进三元催化器技术

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汽车与新动力 2016年第5期48卷 49-55页

作者： J.Schoenhaber J.m.richter J.Despres m.Schmidt S.Spiess m.roesch 陈佳

欧洲的新排放法规欧6要求在更多实际行驶工况下达到更严格的碳氢化物（hC）、一氧化碳（CO）、氮氧化物（NOx）和颗粒物排放。该法规还将引入测量CO2排放的全球统一的轻型车试验规程（WLTP）行驶循环和新的实际行驶排放（rDE）要求。rD... 详细信息

欧洲的新排放法规欧6要求在更多实际行驶工况下达到更严格的碳氢化物（hC）、一氧化碳（CO）、氮氧化物（NOx）和颗粒物排放。该法规还将引入测量CO2排放的全球统一的轻型车试验规程（WLTP）行驶循环和新的实际行驶排放（rDE）要求。rDE法规要求确保现代车辆在所有常态行驶工况下都符合排放法规。这就需要有更可靠的排气后处理措施来满足这些新要求。介绍1种为应对新法规而改进的汽油机用三元催化器。在稳态和动态工况下,在若干发动机和车辆上按各种行驶循环对这种催化器进行了试验。这种催化器与之前几代催化器相比具有更好的热稳定性和更低的排气背压。这种新三元催化器具有能降低30%NOx排放的潜力,更重要的是,它能在高动态工况下提高CO/NOx的转化效率。最后,诊断显示,新三元催化器的储氧能力得到了优化。

关键词：催化剂配方排放三元催化器

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Antarctic macroalgae Palmaria decipiens (rhodophyta, Palmariales) Extracts Present Antioxidant and Antitumor Activity against Colorectal Cancer

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Advances in Biological Chemistry 2022年第6期12卷 274-291页

作者： marina Della Giustina rafaele Frassini Sidnei moura Fernando Joel Scariot Sérgio Echeverrigaray Vanessa Sayuri Osaki Franciane m. Pellizari Pio Colepicolo João Antonio Pêgas henriques Janaina da Silva Crespo mariana roesch-Ely Laboratory of Applied Toxicology and Bioproducts University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Biosynthetic and Natural Products University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Applied microbiology Biotechnology Institute University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Phytology and Quality of marine Water Paraná State University Paranaguá Campus PR Brazil Laboratory of Biochemistry and molecular Biology of Algae University of S&#227 o Paulo S&#227 o Paulo SP Brazil Exact Sciences and Engineering Area University of Caxias do Sul Rio Grande do Sul RS Brazil

Despite therapeutic advances in recent decades, colorectal cancer is still the third most frequent neoplasm worldwide, with significant morbidity and mortality in young and middle-aged adults. Therefore, advance in treatment options for patients who are afflicted with tumor subtypes without effective therapies is needed. Antarctica macroalgae are substances-producing organisms with important biological activities, in which antitumor properties are investigated, showing promising cytotoxic results. There are no reports so far showing antitumor activity of macroalgae Palmaria decipiens extracts against colorectal tumors. This study aims to evaluate the effect of macroalgae P. decipiens extract from Antarctic on tumor cell hCT-116 and non-tumor cell haCaT lines. The phenolic compounds present were identified by high performance liquid chromatography. The antioxidant activity of the extracts was determined by the DPPh radical inhibition method and cytotoxicity was evaluated through mTT assay. Cell death events were identified using dual staining with acridine orange/ethidium bromide and flow cytometry. The quantification of phenolic compounds present in the extracts identified the presence of three main compounds among them is kaempferol. The metanolic extract showed inhibition within 72 h of treatment in hCT-116 and potential antioxidant activity. The results presented in this study point out an imbalance in the redox metabolism and also a loss of mitochondrial membrane potential integrity, most likely inducing cell death mechanisms after 72 h exposure to treatment with metanolic extract. These events could be observed by penetration of propidium iodide through membrane damage. The results indicate that the extract of the Antarctic macroalgae P. decipiens interferes in the mechanisms of action of colorectal cancer tumor cells, acting as a potential antitumor and antioxidant agent.

关键词： Antarctic Seaweeds Antitumor Activity Colorectal Cancer Antioxidant Activity

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Brown Algae <i>himantothallus grandifolius</i>(Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-mediated Cell Death in Tumor Cells

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Advances in Biological Chemistry 2014年第2期4卷 98-108页

作者： Gabriela Gambato érico G. Baroni Charlene S. C. Garcia rafaele Frassini Caroline O. S. Frozza Sidnei moura Cláudio m. P. Pereira mutue T. Fujii Pio Colepicolo Ana Paula F. Lambert Joã o A. P. henriques mariana roesch-Ely Botanical Institute SMA S&atilde o Paulo Brazil Faculty of Pharmacy University of Caxias do Sul Caxias do Sul Brazil Institute of Chemistry and Geosciences Federal University of Pelotas Pelotas Brazil Institute of Chemistry University of S&atilde o Paulo S&atilde o Paulo Brazil Laboratory of Biotechnology of Natural and Synthetic Products Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil Laboratory of Genomics Proteomics and DNA Repair Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil

marine algae have been used as food since ancient times and today are consumed as a regular part of the diet. In this study, we hypothesized that h. grandifolius phlorotannins-enriched extract exerts cytotoxic selective effects against tumor cell lines promoting cell death trough apoptosis mechanisms. The aim of the present study is to characterize chemically and investigate the selective cytotoxic effect of the h. grandifolius extract on epithelial tumour cell lines (A375, A549, hep-2, heLa) compared to non-malignant cell line (hek-293), and evaluate possible molecular mechanisms involved in the programmed cell death pathway. high-resolution directly-infusion mass spectrometry (hr-DImS) analysis with electrospray ionization (ESI) was performed in positive and negative mode. Cytotoxicity was evaluated through colorimetric assay and morphological alterations were observed in giemsa stained cells after extract treatment. Apoptosis was further evaluated by annexin V staining. Spectra showed peaks m/z between 370 and 430 and molecular formula was defined upon isotopic ratio. Extract showed selectivity to the non-tumor line with enhanced cytotoxicity in tumor cells according to the concentration and exposure time. After 72 h treatment, the heLa strain was more susceptible to the extract, followed by lines hep2, A375 and A549. morphological changes by giemsa were observed after increased doses of extracts and staining for annexin V showed majority of tumor cells at early stages of the apoptotic process. here, selective anti-tumor activity of extract taken from the alga h. grandifolius was able to suppress proliferation and promote apoptosis-mediated cell death with induction of initial stages of apoptosis in different cell lines.

关键词： Algae Cytotoxicity Apoptosis Cancer in Vitro

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higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease

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World Journal of hepatology 2022年第8期14卷 1633-1642页

作者： Giovanni Alejandro Salgado Alvarez Samanta mayanin Pinto Galvez Uriel Garcia mora Ana Delfina Cano Contreras Cristina Durán rosas Bryan Adrián Priego-Parra Arturo Triana romero mercedes Amieva Balmori Federico roesch Dietlen Sophia Eugenia martinez Vazquez Ines Osvely mendez Guerrero Luis Alberto Chi-Cervera raúl Bernal reyes Leonardo Alberto martinez roriguez maria Eugenia Icaza Chavez Jose maria remes Troche Instituto de Investigaciones médico-biologicas Universidad VeracruzanaVeracruz 91700VeracruzMexico Department of Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMéxico 14080MéxicoMexico Clínica de Especialidades Gastrointestinales y hepáticas Hospital Star MedicaMerida 97133YucatanMexico Department of Gastroenterologia Sociedad Española de BeneficenciaPachuca 42000HidalgoMexico Department of Gastroenterologia Clínica de Rehabilitación Metabólica Digestiva y HepáticaMexico 14080MexicoMexico Department of Gastroenterologia Hospital Star Médica de MéridaMerida 97133YucatanMexico

BACKGrOUND The definition of metabolic-dysfunction-associated fatty liver disease(mAFLD)allows identification of metabolically complicated *** risk scores are related to cardiovascular risk(CVr)scores and could be useful for the identification of patients at risk of systemic *** To evaluate the relationship between mAFLD and CVr using the Framingham risk score in a group of mexican *** Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with mAFLD *** risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVr was determined by the Framingham *** One hundred and twenty-five participants(21.4%)with mAFLD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~*** Framingham CVr was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVr and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased *** One of every three patients with mAFLD had a high CVr,and in those with high fibrosis risk,the CVr risk was even greater.

关键词： Fatty liver Cardiovascular risk hepatic steatosis Fibrosis Liver disease

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Antarctic macroalgae Palmaria decipiens (rhodophyta, Palmariales) Extracts Present Antioxidant and Antitumor Activity against Colorectal Cancer

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Advances in Biological Chemistry 2022年第6期

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