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Functional assessment of liver regeneration after major hepatectomy

Hepatobiliary Surgery and Nutrition 2022年第4期11卷 530-538页

作者： Fadi Rassam Pim B.Olthof Bart Takkenberg Marc G.Besselink Olivier R.Busch joris I.Erdmann Rutger-jan Swijnenburg Krijn Pvan Lienden Ulrich H.Beuers roelof j.bennink Thomas Mvan Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of Gastroenterology&Hepatology Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Departments of Radiology and Nuclear Medicine Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background: Liver regeneration is crucial to restore the functional liver mass after liver resection. The aim of this study was to evaluate the early postoperative changes in remnant liver function, volume and liver stiffness after major liver resection and their correlation with postoperative outcomes. Methods: Patients undergoing major liver resection (≥3 segments) between February and November 2018 underwent both functional assessment using technetium-99m mebrofenin hepatobiliary scintigraphy (HBS) and CT-volumetry of the (future) remnant liver on preoperative day 1, the 5th postoperative day, and 4-6 weeks after resection. At the same time points, patients underwent transient elastography (TE) for the assessment of liver stiffness. Severe postoperative complications (Clavien-Dindo ≥ 3A) and mortality were correlated with the functional and volumetric increases of the remnant liver. Liver failure was graded according to the International Study Group of Liver Surgery (ISGLS) criteria. Results: A total of 18 patients were included of whom 10 (56%) had severe complications and one patient (5%) developed liver failure. Function and volume of the remnant liver had increased by the 5th postoperative day from 6.9 (5.4-10.9) to 9.6 (6.7-13.8) %/min/m2, P=0.004 and from 795.5 (538.3-1,037.5) to 1,080.0 (854.0-1,283.3) mL, P<0.001, respectively. After 4-6 weeks, remnant liver volume had further increased [from 1,080.0 (854.0-1,283.3) to 1,222.0 (1,016.0-1,380.5) mL, P=0.035], however, liver function did not show any significant, further increase [from 9.6 (6.7-13.8) to 10.9 (8.8-13.6) %/min/m2, P=0.177]. Liver elasticity of the future remnant liver (FRL) increased [from 10.8 (5.7-18.7) to 17.5 (12.4-22.6) kPa, P=0.018] and gradually recovered after 4-6 weeks to a median of 10.9 (5.7-18.8) kPa (T3 vs. T4, P=0.079). Patients who had severe postoperative complications did not show a significant increase in liver function on the 5th postoperative day (P=0.203), despite increas

关键词： Hepatobiliary scintigraphy(HBS) liver resection liver regeneration posthepatectomy liver failure liver function test

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Discovering Mathematics with Maple: An interactive exploration for mathematicians, engineers and econometricians 1

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1999年

作者： roelof j. Stroeker johan F. Kaashoek (auth.)

ISBN: (纸本)9783764360917;9783034887267

From the Publisher: This book introduces Maple in a rather special way, namely, it shows how a computer algebra system most naturally fits into a mathematically oriented work environment.. "The intended audience is the mixed group of mathematicians, econometricians, engineers and other scientists, principally those who in their chosen discipline need to work with mathematical ideas and techniques.

关键词： Mathematics

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动态肝细胞特异性增强MRI和99Tcm-Mebrofenin肝胆显像结合SPECT在定量评估肝功能中的比较研究

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国际医学放射学杂志 2019年第6期 747-748页

作者： F.Rassam T.Zhang K.P.Cieslak C.Lavini j.Stoker R.j.bennink 李相文 Department of Surgery Cancer Center AmsterdamAmsterdam UMC University of Amsterdam

摘要目的比较Gd-EOB-DTPA动态肝细胞特异性增强MRI（DHCE-MRI）和99TcmMEBROFENIN肝胆显像（HBS）对肝切除术病人术前评估肝功能的价值。方法采用99Tcm-美

关键词： MRI 定量评估 Tc~m-Mebrofenin 肝胆显像细胞特异性 SPECT 肝功能比较研究

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制约深度估计精度的诸因素

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国外油气勘探 1997年第4期9卷 514-517页

作者： roelof j.Versteeg 徐广民于志龙石油地球物理勘探局第二地质调查处

由偏移地震剖面确定深度的误差(errorbars)有两部分。第一部分是由于模型估计方案的失败,这一部分误差可以通过改善模型设计方案来降低。第二部分是由地震数据性质、地层特性和野外观测系统所产生,对于给定的数据集这部分是常量,可以定... 详细信息

由偏移地震剖面确定深度的误差(errorbars)有两部分。第一部分是由于模型估计方案的失败,这一部分误差可以通过改善模型设计方案来降低。第二部分是由地震数据性质、地层特性和野外观测系统所产生,对于给定的数据集这部分是常量,可以定量地表示为偏移距、速度、反射面深度、于波频率、Q值和拾取精度的函数。该量值对任何方法获得的深度估计提供一种估计"最佳情况"误差(errorbar)的快速方法。如果对偏移深度剖面提供一个固有的深度误差表,这将是对解释数据库的一个非常有用的补充,因为它量化了限制地震深度估计的各种因素。

关键词：地震勘探偏移成像深度估计精度

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FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer

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World journal of Gastroenterology 2016年第31期22卷 6987-7005页

作者： Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus j Peters Enrico Vasile Elisa Giovannetti University Hospital of Pisa 56124 Pisa Italy Department of Medical Oncology VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Surgery VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Experimental Diagnostic and Speciality Medicine University of Bologna Sant'Orsola-Malpighi Hospital Via Massarenti 9 40138 Bologna Italy Cancer Pharmacology Lab AIRC Start-Up Unit University of Pisa 56124 Pisa Italy CNR-Nano Institute of Nanoscience and Nanotechnology University of Pisa 56124 Pisa Italy

Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers.

关键词： FOLFIRINOX Personalized therapy New treatments MicroR NA Pancreatic cancer

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Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma

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World journal of Gastrointestinal Oncology 2020年第3期12卷 347-357页

作者： Laura L Meijer Marin Strijker jacob K de Bakker jurgen Gj Toennaer Barbara M Zonderhuis Hans j van der Vliet Hanneke Wilmink joanne Verheij Freek Daams Olivier R Busch Nicole CT van Grieken Marc G Besselink Geert Kazemier Department of Surgery Cancer Center AmsterdamAmsterdam UMCVU University AmsterdamAmsterdamNoord-Holland 1081HVThe Netherlands Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamNoord-Holland 1105AZThe Netherlands Department of Medical Oncology Cancer Center AmsterdamAmsterdam UMCVU University AmsterdamAmsterdamNoord-Holland 1081HVThe Netherlands Department of Medical Oncology Cancer Center AmsterdamAmsterdam UMCUniversity of Amsterdam AmsterdamNoord-Holland 1105AZThe Netherlands Department of Pathology Cancer Center AmsterdamAmsterdam UMCUniversity of Amsterdam AmsterdamNoord-Holland 1105AZThe Netherlands Department of Pathology Cancer Center AmsterdamAmsterdam UMCVU University Amsterdam Noord-Holland 1081HVThe Netherlands

BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal *** therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological *** To retrospectively investigate the clinical outcome of patients with DA and *** All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the *** patients with histopathologically-confirmed DA or it-PVA were eligible for *** outcome was compared between DA and it-PVA per disease *** the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive *** In total,155 patients with DA and it-PVA were *** with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative *** median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease ***(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of *** treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,*** Survival of patients with DA and it-PVA is comparable per disease *** results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed.

关键词： Duodenal adenocarcinoma Papilla of Vater adenocarcinoma Clinical outcomes Local treatment Metastases Survival

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