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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

Neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda Martínez-Coria Isabel Arrieta-cruz María-Esther cruz Héctor E.López-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Laboratorio Experimental de Enfermedades Neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico Departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de Neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

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Root and leaf functional trait relations in Poaceae species: implications of differing resource- acquisition strategies

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Journal of Plant Ecology 2013年第3期6卷 211-219页

作者： Florian Fort Claire Jouany Pablo cruz INRA UMR 1248 AGIRCentre de recherche de ToulouseCS 5262731326 Castanet-TolosanCedexFrance

Aims root systems play an essential role in grassland functioning in both acquisition and storage of ***,root functional traits have not received as much attention as those measured on above-ground organs,and little is known about their *** objec-tives were to test whether morphological and root system traits allowed identification of grass species’functional strategies and to determine whether a relation exists between above-and below-ground *** Functional traits of root tissues(specific root length,diameter,tissue density and nitrogen concentration),whole root systems(root mass,root length density,root mass percentage below a depth of 20 cm and fine root%)and two major leaf traits(specific leaf area and leaf dry matter content)were determined under field conditions and their rela-tions were analysed in eleven perennial temperate Poaceae *** Findings Canonical correspondence analysis along axis 1 revealed a gra-dient of species,from those with deep,dense and coarse root systems with a large root mass to those with shallow root sys-tems,thin roots and high specific root length;this suggests strong correlations among root *** between specific root length and specific leaf area reveal two groups of species,which probably indicates different drought-tolerance *** trait syndromes enable ranking grasses along a gradient from conservative-strategy species(from stressful habitats),which display a deep and coarse root system,to acquisitive species(from rich and moist meadows),which display a shallow and thin root *** both types display similar above-ground strategies,drought-tolerant species have lower specific root lengths than drought-sensitive species,revealing more conservative root strategies.

关键词： root functional trait functional group grasses root ecology below-ground strategy

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Construction of Dulac functions for mathematical models in population biology

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International Journal of Biomathematics 2015年第3期8卷 135-154页

作者： Osvaldo Osuna cruz Vargas-De-Leon Instituto de Fisica y Matematicas Universidad MichoacanaEdif. C-3 Cd. Universitaria CP 58040 Morelia Michoacan Mexico Unidad de Medicina Experimental Hospital General de Mexico "Dr. Eduardo Liceaga" DF 06726 Mdxieo

In this paper, we present a method for constructing a Dulac function for mathematical models in population biology, in the form of systems of ordinary differential equations in the plane.

关键词： Population models epidemic models chemostat models Dulac function nonexistence of periodic orbits.

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Extracts from Marine Macroalgae and Opuntia ficus-indica Cladodes Enhance Halotolerance and Enzymatic Potential of Diazotrophic Rhizobacteria and Their Impact on Wheat Germination Under Salt Stress

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Pedosphere 2018年第2期28卷 241-254页

作者： Abdelwahab RAI Ameur CHERIF Cristina cruz Elhafid NABTI Département de Microbiologie Faculté des Sciences de la Nature et de la Vie Université Ferhat Abbas Sdtif-1 19000 (Algdrie) Universitg de Béjaia FSNV Laboratoire de Maitrise des Energies Renouvelables (LMER) Equipe de Biomasse et Environnement Targa Ouzemmour Béaia 06000 (Algérie) LR Biotechnology and Bio-Geo Resources Valorization Higher Institute for Biotechnology University of Manouba Sidi Thabet Biotechpole 2020 Sidi Thabet Ariana 2080 (Tunisia) cE3c-Centre for Ecology Evolution and Environmental Changes Campo Grande Bloco C-2 Piso 5 Sala 03 Lisboa 1749-016 CPor- tugal)

Soil salinity, which affects more than 6% of the earth’s land surface and more than 20% of its irrigated areas, is a major threat to agriculture. Diazotrophic bacteria are among the functional groups of soil microbiota that are threatened by this abiotic stress, as their activity is mostly inhibited by salt stress. Seventy bacterial strains with distinct characteristics were isolated from soils by using N-free Jensen’s selective medium. Based on their ability to produce metabolites of agricultural interest, four strains were selected and identified as Flavobacterium johnsoniae, Pseudomonas putida, Achromobacter xylosoxidans, and Azotobacter chroococcum. The selected strains were grown at different NaCl concentrations (0–600 mmol L^(-1) in N-free broth and 0–2 000 mmol L^(-1) in Luria-Bertani medium) in the presence and absence of glycine betaine (GB), aqueous and hydro-alcoholic extracts from marine macroalgae, Ulva lactuca and Enteromorpha intestinalis, and Opuntia ficus-indica cladodes. The selected bacterial strains, GB, and the aforementioned extracts were tested for their ability to promote the germination of wheat (Triticum durum) seeds at 0–300 mmol L^(-1) NaCl. Compared with the results obtained with the synthetic osmoprotectant GB, the extracts from O. ficus-indica, U. lactuca, and E. intestinalis significantly promoted bacterial growth and seed germination under salt stress.

关键词： glycine betaine Ulva lactuca Enteromorpha intestinalis plant growth-promoting rhizobacteria (PGPR) seed germi-nation Triticum durum

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Output Second-order Sliding-mode Control for a Gecko Biomimetic Climbing Robot

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Journal of Bionic Engineering 2019年第4期16卷 633-646页

作者： David cruz-Ortiz Mariana Ballesteros-Escamilla Isaac Chairez Alberto Luviano SEPl UPIITAInstitute Politecnico NationalAv.Institute Politecnico National 258007340Mexico Bioprocesses Department UPIBIInstitute Politecnico NationalAv.Acueducto 55007340Mexico

The aim of this study is to propose the output controller to solve the execution of the gait sequence for Gecko Bio-inspired Robotic Devices (GBRDs).The Twisting Controller (TC) serves as basis of the tracking trajectory designed *** TC uses both the tracking error and its estimated derivative,which is calculated by a set of distributed Super-Twisting Algorithms (STAs).Each STA is implemented as a robust and exact *** output-based controller structure corresponds to a sort of decentralized form for robotic ***,each articulation is controlled by an independent TC.A set of proposed references trajectories reproduce the gait cycle of a Real Gecko-Lizard (RG-L).The reference trajectories are proposed as the superposition of sigmoid functions ful-filling the conditions of the Bezzier *** simulations evaluate the GBRD movement enforced by the suggested controller in the horizontal as well as the vertical *** own 3D printed GBRD is the experimental platform aimed to test the distributed *** controlled vacuum pumps are used to adhere the GBRD to the wall surfaces.A set of experimental validations confirm the robustness and the reliability of the proposed controller when its performance is compared with classical output feedback controllers.

关键词： gecko robot biomimetic output-based controller twisting controller Super-Twisting Algorithm(STA)

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Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio Jose Goncalves cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

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An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros Lima Wu Hong Kwong Antonio José Goncalves cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

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Google timeline accuracy assessment and error prediction

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Forensic Sciences Research 2018年第3期3卷 240-255页

作者： Andrea Macarulla Rodriguez Christian Tiberius roel van Bree Zeno Geradts Netherlands Forensic Institute Den HaagThe Netherlands Delft University of Technology DelftThe Netherlands

Google Location Timeline,once activated,allows to track devices and save their *** feature might be useful in the future as available data for evidence in *** that,the court would be interested in the reliability of these *** position is presented in the form of a pair of coordinates and a radius,hence the estimated area for tracked device is enclosed by a *** research focuses on the assessment of the accuracy of the locations given by Google Location History Timeline,which variables affect this accuracy and the initial steps to develop a linear multivariate model that can potentially predict the actual error with respect to the true location considering environmental *** determination of the potential influential variables(configuration of mobile device connectivity,speed of movement and environment)was set through a series of experiments in which the true position of the device was recorded with a reference Global Positioning System(GPS)device with a superior order of *** accuracy was assessed measuring the distance between the Google provided position and the de facto one,later referred to as Google *** this Google error distance is less than the radius provided,we define it as a *** configuration that has the largest hit rate is when the mobile device has GPS available,with a 52%*** the use of 3G and 2G connection go with 38%and 33%*** Wi-Fi connection only has a hit rate of 7%.Regarding the means of transport,when the connection is 2G or 3G,the worst results are in Still with a hit rate of 9%and the best in Car with 57%.Regarding the prediction model,the distances and angles from the position of the device to the three nearest cell towers,and the categorical(nonnumerical)variables of Environment and means of transport were taking as input variables in this initial *** evaluate the usability of a model,a Model hit is defined when the actual observation is within the 95%

关键词： Forensic science accuracy error Google Timeline linear regression model smartphone location

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Liver-inclusive intestinal transplantation results in decreased alloimmune-mediated rejection but increased infection

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Gastroenterology Report 2018年第1期6卷 29-37,I0001,I0002页

作者： Guosheng Wu Ruy J.cruz Jr Department of Gastrointestinal Surgery Xijing Hospital of Digestive DiseasesThe Fourth Military Medical UniversityXi’anShannxiChina Thomas E.Starzl Transplantation Institute University of Pittsburgh Medical CenterPittsburghPAUSA

Background and aims:A co-transplanted liver allograft has been thought to protect other organs from rejection-mediated injury;however,detailed analyses of co-transplanted liver on intestinal allograft outcomes have not been conducted to *** aimof the study was to compare immune-mediated injury,causes of graft failure and clinical outcomes between recipients who underwent either a liver-inclusive intestinal transplant(LITx)or liver-exclusive intestinal transplant(LETx).Methods:Between May 2000 and May 2010,212 adult patients undergoing LITx(n¼76)and LETx(n¼136)were *** underwent either liver combined intestinal or full multivisceral *** underwent either isolated intestinal or modified multivisceral ***:During 44.9631.4 months of follow-up,death-censored intestinal graft survival was significantly higher for LITx than LETx(96.9%,93.2%and 89.9%vs 91.4%,69.3%and 60.0%at 1,3 and 5 years;p¼0.0001).Incidence of graft loss due to rejection was higher in LETx than in LITx(30.9%vs 6.6%;p<0.0001),while infection was the leading cause of graft loss due to patient death in LITx(25.0%vs 5.1%;p<0.0001).Despite similar immunosuppression,the average number(0.87 vs 1.42,p¼0.02)and severity of acute cellular rejection episode(severe grade:7.9%vs 21.3%;p¼0.01)were lower in LITx than in *** of acute antibody-mediated rejection was also significantly lower in LITx than in LETx(3.6%vs 15.2%;p¼0.03).Incidence of chronic rejection was reduced in LITx(3.9%vs 24.3%;p¼0.0002).Conclusions:Intestinal allografts with a liver component appear to decrease risk of rejection but increase risk of *** findings emphasize that LITx has characteristic immunologic and clinical *** immunosuppression may need to be considered for patients who undergo LITx to attenuate increased risk of infection.

关键词： Intestinal transplant immunosuppression rejection infection

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2020 tropical cyclones in the Philippines: A review

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Tropical Cyclone Research and Review 2021年第3期10卷 191-199页

作者： Gemma Dela cruz Santos College of Education Nueva Ecija University of Science and TechnologyPhilippines

The official website of the Philippine Atmospheric Geophysical and Astronomical Services Administration(PAG AS A)said more tropical cyclones(TCs)enter the Philippine Area of Responsibility(PAR)than anywhere else in the *** the average of 20 TCs per year,about eight(8)or nine(9)of them are crossing the *** peak of the typhoon season is July through October,when nearly 70%of all typhoons develop(http://***/climate/tropical-cyclone-information).Based on the report of the Asian Disaster Reduction Center(ADRC),five of the typhoons that visit the country are destructive and being situated in the"Pacific Ring of Fire"makes the country vulnerable to frequent earthquakes and volcanic *** geographical location and physical environment also contribute to its high susceptibility to tsunami,sea-level rise,storm surges,landslides,flash/flood/flooding,and drought(https://***/***?NationCode=608&Lang=en).For the past years,some typhoons that visited the country brought serious damages and kill many Filipinos by floods and *** researcher comes up with the idea of assessing the aftermath of 2020 typhoons that visited the *** data used by the researcher were collected from different sources,namely NDRRMC(National Disaster Risk Reduction and Management Council),PAGASA,social media and other *** result of the study reveals that the most destructive typhoon in 2020 that caused huge damage on the infrastructure and agriculture is Ulysses followed by Rolly,Quinta,Ambo,Vicky,Pepito,Ofel,and *** of the affected areas are those nearer to water bodies,surrounded by mountains with few trees to absorb a huge amount of water and situated in the low-lying areas.

关键词： ADRC NDRRMC PAGASA TC Pacific ring of fire

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