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Discovering genetic biomarkers for targeted cancer therapeutics with eXplainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty elizabeth Gutierrez-Chakraborty Cristian rodriguez-Aguayo Hakan Başağaoğlu Gabriel Lopez-Berestein Paola Amero School of Civil and Environmental Engineering and Construction Management The University of Texas at San AntonioSan AntonioTexasUSA Department of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most prevalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted

Energy model based on solar potential and the production of electrical energy through living plants’photosynthesis

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Clean Energy 2024年第3期8卷 116-126页

作者： Raymond Daniel rodriguez Martinez Department of Industrial Production Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Developing a sustainable energy model is imperative considering the current trend towards decarbonizing sectors *** this purpose,Venezuela was used as a reference to propose an energy model focused on taking advantage of plant photosynthesis through microbial-vegetable fuel cells together with an agro-photovoltaic system to enhance energy and agricultural *** production from the cells was estimated using an average power density of 264 mW/m^(2) over 4%of the areas destined for crops in the entire Venezuelan region,obtaining an annual production of 19.889 GWh/*** contrast,the energy production of the agro-photovoltaic system was modelled using PVsyst software on 50%of the area used for the cells distributed throughout the states of Anzoátegui,Guárico,Monagas and Portuguesa according to their meteorological conditions,solar irradiation and agricultural activity,resulting in 3703417 GWh/*** resulting whole system proved to be able to cover>10 times the installed electricity generation capacity at a national level and,together with the tremendous scalability of the microbial fuel cells,it shows that Venezuela has a high potential for the production and distribution of clean energy.

关键词： ecosystems microbial fuel cell microorganisms renewable sustainability

Plant-microbial fuel cell for electrical generation through living plants: an internal resistance insight into the plant species used

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Clean Energy 2024年第5期8卷 45-53页

作者： Raymond Daniel rodriguez Martinez Department of Industrial Production Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Climate change is a global threat,the presence of which has encouraged the development and implementation of renewable energies,including plant–microbial fuel cells,which could generate 6629568–33147840 MWh per year due to their large-scale *** of the main challenges associated with microbial cells is internal resistance—a parameter whose magnitude is influenced by sev-eral *** the case of plant–microbial fuel cells,adding a plant positively affects the mitigation of internal ***,the species employed is expected to play an important *** the present study,the objective was to determine as a general reference the internal resistance of cells using various plant species,among which were tomato(Solanum lycopersicum),black beans(Phaseolus vulgaris),aloe vera(Aloe vera),corn(Zea mays),and moss(Dicranidae).For this purpose,an experimental procedure was carried out to compare the manual voltage measurements with a free cell concerning the voltage obtained by adding an external resistor in *** internal resistance values were determined as a function of the measured voltage,obtaining 177,179,175,324,and 233 kΩfor aloe vera,corn,tomato,black beans,and moss,*** this,it was shown that the roots of the plants represent an essen-tial addition to the internal resistance of the cell in the short *** contrast,plants with a C4 photosynthetic metabolism are more favourable,while C3 plants can also benefit from internal resistance during a more extended period of rhizodeposition.

关键词： climate change energy microorganism renewable source voltage

MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma Melissa MTorres Sheryl rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

A Survey on Model Predictive Control of DFIGs in Wind Energy Conversion Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1085-1104页

作者： Shuo Yan Junyu Chen Minghao Wang Yongheng Yang Jose M.rodriguez STEM College RMIT UniversityMelbourneAustralia Hong Kong Polytechnic University Hong KongChina State Key Laboratory of Internet of Things for Smart City(UM) Department of Electrical and Computer EngineeringUniversity of MacaoMacaoChina College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Universidad San Sebastin Campus BellavistaSantiago de ChileCLSantiago de Chile 000000Chile IEEE

This paper presents a comprehensive study on the model predictive control(MPC)of doubly fed induction generators(DFIG)in wind energy conversion systems(WECS);in particular the MPC of the rotor side *** general principle of prevalent MPC strategies is discussed to introduce the theoretical framework in the first ***,mainstream and high-performance MPC methods of DFIGs have been identified as model predictive current control(MPCC),model predictive torque control(MPTC),and model predictive power control(MPPC).Starting from analyzing dynamic models,these MPC strategies are investigated in terms of operating principles and technical *** paper further investigates implementation of MPC strategies in unbalanced *** on the quantitative and qualitative analysis of several case studies,performance of various MPC schemes is compared and their special features are *** for designing MPC strategies of DFIGs in WECS are provided.

关键词： Doubly fed induction generator(DFIG) model predictive control(MPC) wind energy

Mortality rate after total knee arthroplasty or total hip arthroplasty in patients with a history of liver transplant

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World Journal of Orthopedics 2024年第4期15卷 310-311页

作者： E Carlos rodriguez-Merchan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain

In this editorial I comment on the article by Ahmed et al published in a recent issue of the World J Orthop 2023;14:*** is well known that patients who have undergone a liver transplant(LT)may need to have a total hip arthroplasty(THA)or total knee arthroplasty(TKA)*** et al stated that the mortality rate in these patients was similar to the one of the general ***,there are three articles previously published that found higher mortality in LT patients who experienced THA/TKA than in the general population(individuals without LT).Therefore,in this Editorial I would like to point out that there is controversy in the literature regarding whether LT patients undergoing THA/TKA have higher mortality than the general ***,future research should attempt to resolve this controversy.

关键词： Liver transplant Total knee arthroplasty Total hip arthroplasty Results Mortality

Efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environmental Sciences 2024年第2期136卷 56-67页

作者： Ernesto Valadez-Renteria Christian Perez-Carrasco Dulce Yolotzin Medina-Velazquez Vicente rodriguez-Gonzalez Jorge Oliva CONACYT-División de Materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Metamizole(MZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the MZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RPE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RPE+LCCO composite was employed for the photocatalytic degradation of MZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of MZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RPE+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： Photocatalysis Metamizole Pharmaceutical contaminant UV-Vis irradiation Perovskite

Pelleting and particle size reduction of corn increase net energy and digestibility of fiber,protein,and fat in corn-soybean meal diets fed to group-housed pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.rodriguez Chad B.Paulk Hans H.Stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

Background Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable *** may also reduce particle size of grain,but it is not known if there are interactions between particle size reduction and *** objective of this experiment was to test the hypothesis that particle size reduction and pelleting,separately or in combination,increase N balance,apparent total tract digestibility(ATTD)of fiber and fat,and net energy(NE)in corn-soybean meal diets fed to group-housed *** Six corn-soybean meal-based diets were used in a 3×2 factorial design with 3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad libitum access to feed and ***-four castrated male pigs(initial weight:29.52 kg;standard diviation:1.40)were allotted to the 6 diets using a 6×6 Latin square design with 6 calorimeter chambers(i.e.,4 pigs/chamber)and 6 *** consumption and CO_(2)and CH_(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,the ATTD of gross energy(GE),N,and acid-hydrolyzed ether extract(AEE),and the concentration of NE were greater(P<0.05)in pelleted diets than in meal *** of diet form,the ATTD of GE,N,and AEE,and the concentration of NE were increased(linear;P<0.05)by reducing the particle size of corn,but the increase was greater in meal diets than in pelleted diets(interaction;P<0.05).Conclusions Both pelleting and reduction of corn particle size increased nutrient digestibility and NE,but increases were greater in meal diets than in pelleted diets.

关键词： Corn Digestibility Feed technology Net energy Particle size Pelleting

Histopathological impact of SARS-CoV-2 on the liver:Cellular damage and long-term complications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso rodriguez-Espada Moises Salgado-de la Mora Briana Mariette rodriguez-Paniagua Nathaly Limonde la Rosa Monica Itzel Martinez-Gutierrez Santiago Pastrana-Brandes Nalu Navarro-Alvarez Department of Molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico Department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEM Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),primarily impacts the respiratory tract and can lead to severe outcomes such as acute respiratory distress syndrome,multiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its impact on the hepatobiliary system remains *** liver injury is commonly indicated by reduced albumin and elevated bilirubin and transaminase levels,the exact source of this damage is not fully *** mechanisms for injury include direct cytotoxicity,collateral damage from inflammation,drug-induced liver injury,and ischemia/***,evidence often relies on blood tests with liver enzyme *** this comprehensive review,we focused solely on the different histopathological manifestations of liver injury in COVID-19 patients,drawing from liver biopsies,complete autopsies,and in vitro liver *** present evidence of the direct impact of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry mechanisms and the actual presence of viral particles in liver samples resulting in a variety of cellular changes,including mitochondrial swelling,endoplasmic reticulum dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encompassing necrosis,steatosis,cholestasis,and lobular *** also discuss the emergence of long-term complications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for improving patient recovery and guiding decision-making.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzyme 2 Histopathology Liver biopsies Liver autopsy In vitro